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Embryonic Stem Cell Research:
Debate and Controversy




               Leigh Kemp
The Science

 Derived from embryos
 Stems cells are undifferentiated, thus
 allowing them to be used for cell
 regeneration in adult patients
 Cell culture of preimplantation-stage
 embryos, which are placed in a nutrient-
 rich Petri dish and grown
 The cells divide and spread over the
 surface of the Petri dish
The Science

 The inner surface is often coated with a
 “feeder layer” of treated, non-dividing
 mouse cells
   Encourage growth, provide nutrients
 Researchers have devised ways to grow
 stem cells without mouse feeder cells
   Decreases risk of virus transfer from the cell of
   a mouse to human cells
 The stem cells are sub-cultured over a
 period of months, generating millions of
 new cells
The Science

  Scientists control the differentiation of
  these “pluripotent” (all-purpose) stem
  cells in more specialized types of cells
    Changing of the chemical composition of the
    “culture medium” in the Petri dish that feeds
    the cells
    Altering of the surface of the Petri dish
    Insertion of certain genes into the cells
  Stem cells differentiate into specialized
  cells, such as those of heart muscle,
  blood cells, or neurons
Controversy
 Ethical issues:
   When is an embryo or fetus considered a living
   person?
   What legal status, if any, does an embryo
   have?
 Medical or scientific issues:
   Are embryonic stem cells the best stem cells
   for medical purposes of regeneration and repair
   or tissue?
   Are there any medical risks inherent in the use
   of embryonic stem cells?
The Controversy: Pro
 Embryonic stem cells are undifferentiated, and
 thus can be used to restore or regenerate
 damaged tissue
 The harvesting of embryos before implantation in
 is not unethical – the embryos are not viable
 Embryos cannot feel pain
   Harvesting of stem cells from embryos is not murder or
   unethical
 Reprogramming of adult stem cells is inefficient,
 holds some risk of tumors due to DNA disruption
 Provides hope for the treatment of or greater
 understanding of Alzheimer’s disease, Parkinson’s
 disease, ALS, cancer, heart disease, genetic
 defects, and spinal cord injury
The Controversy: Neg
 Embryonic stem cells have not been
 adequately researched, and the dangers
 inherent in their medical use are largely
 unknown
 The harvesting of embryonic stem cells
 requires the death of an embryo
   This harvesting often requires an induced
   abortion; constitutes murder
   Where harvesting does not require induced
   abortion, such as excess in IVF, harvesting still
   requires the death of an embryo
 Donated embryos are in limited supply
Alternatives

 Stem cells derived from the bone
 marrow of adults can be
 reprogrammed to become pluripotent
 like embryonic stem cells
 Donation of adult stem cells between
 blood relatives
 Stem cells derived from amniotic fluid
 during amniocentesis
Moving Forward
 Should the Federal Government fund
 embryonic stem cell research?
 Are adult stem cells or embryonic stem
 cells more feasible for therapy and
 research purposes?
 Can embryonic stem cells be harvested in
 a humane and ethical manner?
 What legal rights does an embryo have?
Works Cited
Bethesda, MD. "Stem Cell Basics: What Are Embryonic Stem Cells?" Stem
   Cell Information. The National Institutes of Health, 13 Sept. 2010. Web.
   14 Nov. 2012. <http://stemcells.nih.gov/info/basics/basics3.asp>.
Imperial College London. "Amniotic fluid yields alternatives to embryonic
   stem cells.“ ScienceDaily, 2 Jul. 2012. Web. 14 Nov. 2012.
Rugnetta, Michael, and Michael Peroski. "A Life Sciences
   Crucible." American Progress. Center for American Progress, 16 Jan.
   2009. Web. 14 Nov. 2012.
   <http://www.americanprogress.org/issues/technology/report/2009/01/16/5
   466/a-life-sciences-crucible/>.
Rugnetta, Michael, and Michael Peroski. "A Life Sciences Crucible." Center
   for American Progress. Center for American Progress, 16 Jan. 2009. Web.
   14 Nov. 2012.
   <http://www.americanprogress.org/issues/technology/report/2009/01/16/5
   466/a-life-sciences-crucible/>.
"Timeline: A Brief History of Stem Cell Research." Science Progress.
   Timeline: A Brief History of Stem Cell Research, 16 Jan. 2009. Web. 14
   Nov. 2012. <http://scienceprogress.org/2009/01/timeline-a-brief-history-
   of-stem-cell-research/>.

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Embryonic stem cell research

  • 1. Embryonic Stem Cell Research: Debate and Controversy Leigh Kemp
  • 2. The Science Derived from embryos Stems cells are undifferentiated, thus allowing them to be used for cell regeneration in adult patients Cell culture of preimplantation-stage embryos, which are placed in a nutrient- rich Petri dish and grown The cells divide and spread over the surface of the Petri dish
  • 3. The Science The inner surface is often coated with a “feeder layer” of treated, non-dividing mouse cells Encourage growth, provide nutrients Researchers have devised ways to grow stem cells without mouse feeder cells Decreases risk of virus transfer from the cell of a mouse to human cells The stem cells are sub-cultured over a period of months, generating millions of new cells
  • 4. The Science Scientists control the differentiation of these “pluripotent” (all-purpose) stem cells in more specialized types of cells Changing of the chemical composition of the “culture medium” in the Petri dish that feeds the cells Altering of the surface of the Petri dish Insertion of certain genes into the cells Stem cells differentiate into specialized cells, such as those of heart muscle, blood cells, or neurons
  • 5. Controversy Ethical issues: When is an embryo or fetus considered a living person? What legal status, if any, does an embryo have? Medical or scientific issues: Are embryonic stem cells the best stem cells for medical purposes of regeneration and repair or tissue? Are there any medical risks inherent in the use of embryonic stem cells?
  • 6. The Controversy: Pro Embryonic stem cells are undifferentiated, and thus can be used to restore or regenerate damaged tissue The harvesting of embryos before implantation in is not unethical – the embryos are not viable Embryos cannot feel pain Harvesting of stem cells from embryos is not murder or unethical Reprogramming of adult stem cells is inefficient, holds some risk of tumors due to DNA disruption Provides hope for the treatment of or greater understanding of Alzheimer’s disease, Parkinson’s disease, ALS, cancer, heart disease, genetic defects, and spinal cord injury
  • 7. The Controversy: Neg Embryonic stem cells have not been adequately researched, and the dangers inherent in their medical use are largely unknown The harvesting of embryonic stem cells requires the death of an embryo This harvesting often requires an induced abortion; constitutes murder Where harvesting does not require induced abortion, such as excess in IVF, harvesting still requires the death of an embryo Donated embryos are in limited supply
  • 8. Alternatives Stem cells derived from the bone marrow of adults can be reprogrammed to become pluripotent like embryonic stem cells Donation of adult stem cells between blood relatives Stem cells derived from amniotic fluid during amniocentesis
  • 9. Moving Forward Should the Federal Government fund embryonic stem cell research? Are adult stem cells or embryonic stem cells more feasible for therapy and research purposes? Can embryonic stem cells be harvested in a humane and ethical manner? What legal rights does an embryo have?
  • 10. Works Cited Bethesda, MD. "Stem Cell Basics: What Are Embryonic Stem Cells?" Stem Cell Information. The National Institutes of Health, 13 Sept. 2010. Web. 14 Nov. 2012. <http://stemcells.nih.gov/info/basics/basics3.asp>. Imperial College London. "Amniotic fluid yields alternatives to embryonic stem cells.“ ScienceDaily, 2 Jul. 2012. Web. 14 Nov. 2012. Rugnetta, Michael, and Michael Peroski. "A Life Sciences Crucible." American Progress. Center for American Progress, 16 Jan. 2009. Web. 14 Nov. 2012. <http://www.americanprogress.org/issues/technology/report/2009/01/16/5 466/a-life-sciences-crucible/>. Rugnetta, Michael, and Michael Peroski. "A Life Sciences Crucible." Center for American Progress. Center for American Progress, 16 Jan. 2009. Web. 14 Nov. 2012. <http://www.americanprogress.org/issues/technology/report/2009/01/16/5 466/a-life-sciences-crucible/>. "Timeline: A Brief History of Stem Cell Research." Science Progress. Timeline: A Brief History of Stem Cell Research, 16 Jan. 2009. Web. 14 Nov. 2012. <http://scienceprogress.org/2009/01/timeline-a-brief-history- of-stem-cell-research/>.