This document summarizes stem cell basics. It defines stem cells as unspecialized cells that can renew themselves and differentiate into specialized cell types. There are several types of stem cells including embryonic, adult, fetal and induced pluripotent stem cells. The unique properties of all stem cells are their ability to divide, renew themselves and differentiate. Potential uses of stem cells include testing new drugs, generating cells and tissues for therapies, and developing a renewable source of cells and tissues for transplant. However, significant challenges remain to safely and effectively use stem cells for therapies.
A stem cell is a "blank" cell that can give rise to multiple tissue types such as a skin, muscle, or nerve cell.
Under certain physiologic or experimental conditions, they can be induced to become tissue- or organ-specific cells with special functions.
iPSCs are pluripotent; unlike ESC, iPSCs are not derived from the embryo, but instead created from differentiated cells in the lab through a process ā cellular reprogramming.
A stem cell is a "blank" cell that can give rise to multiple tissue types such as a skin, muscle, or nerve cell.
Under certain physiologic or experimental conditions, they can be induced to become tissue- or organ-specific cells with special functions.
iPSCs are pluripotent; unlike ESC, iPSCs are not derived from the embryo, but instead created from differentiated cells in the lab through a process ā cellular reprogramming.
What are stem cells? This presentation provides an overview of multiple different stem cells including embryonic stem cells, mesenchymal stem cells, cancer stem cells, induced pluripotent stem cells, hematopoietic stem cells and neural stem cells.
Imagine that you have been told you have an illness that cannot be cured or what if your body has been irreversibly paralysed. There is no hope. But there is a science that could change that. Itās Called Stem Cell Research and itās an important step in the medical revolution. But it comes with controversies as it uses Human Embryosā as Raw Material.
But something astounding happened in the year 2006 that removed the usage of surplus embryos from the equation altogether. Itās about a brand new technology that can turn back the clock on your body cells. This is cutting edge of science where new developments are happing all the time. The iPSCs could be the potential medicine of 21st century. So what are stem cells? Why do they Matter? What are iPSCs and how it changed the biological rules?
it gives detail or you can say brief introduction of iPS cells , what are they , how can be obtained , what are the future possibilities of iPS cells what promise it made to upcoming future technology to medical health
What are stem cells? This presentation provides an overview of multiple different stem cells including embryonic stem cells, mesenchymal stem cells, cancer stem cells, induced pluripotent stem cells, hematopoietic stem cells and neural stem cells.
Imagine that you have been told you have an illness that cannot be cured or what if your body has been irreversibly paralysed. There is no hope. But there is a science that could change that. Itās Called Stem Cell Research and itās an important step in the medical revolution. But it comes with controversies as it uses Human Embryosā as Raw Material.
But something astounding happened in the year 2006 that removed the usage of surplus embryos from the equation altogether. Itās about a brand new technology that can turn back the clock on your body cells. This is cutting edge of science where new developments are happing all the time. The iPSCs could be the potential medicine of 21st century. So what are stem cells? Why do they Matter? What are iPSCs and how it changed the biological rules?
it gives detail or you can say brief introduction of iPS cells , what are they , how can be obtained , what are the future possibilities of iPS cells what promise it made to upcoming future technology to medical health
The complete, compiled presentation on stem cell research. The contents include background history along with the introduction, different stem cell types, cultivation process, stem cell cloning and potential uses, the negative aspects and ethical concerns regarding stem cell therapy. Different examples of the useful work in stem cell therapy field has also been mentioned.
Stem cells are the cells which have the capability to differentiate into any cells of the body when provided with right stimulus and environment. This presentation teaches about stem cells, characteristics, types and cultivation of stem cells in artificial environment. Sample practice questions are also provided in the end to review the concept learned from this presentation.
Stem cells are the promising cells that are capable to differentiate into any deserved cell type. By using stem cells we can generate tissues and even organs that can be used in multiple disciplines as drug testing, as a source used for organ transplantation...etc.
Stem cells
Undifferentiated cells capable of self-renew and to differentiate into different cell types or tissues during embryonic development and throughout adulthood.
Have possibility to become a specialised cell.
Have the ability to divide continuously and develop into various other kinds of cells.
Have immune potential and can help to treat a wide range of medical problems.
Discovery of stem cells lead to a whole new branch of medicine known as Regenerative medicine.
Blood production agency. all types of blood cellls are produced in it. to understand it is the need of this era. it also will help in the physiology of blood making mechanism.
Stem cells are unspecialized cells that are thought to be able to reproduce themselves indefinitely and under the right conditions, to develop into a wide variety of mature cells with specialized functions.
Epistemic Interaction - tuning interfaces to provide information for AI supportAlan Dix
Ā
Paper presented at SYNERGY workshop at AVI 2024, Genoa, Italy. 3rd June 2024
https://alandix.com/academic/papers/synergy2024-epistemic/
As machine learning integrates deeper into human-computer interactions, the concept of epistemic interaction emerges, aiming to refine these interactions to enhance system adaptability. This approach encourages minor, intentional adjustments in user behaviour to enrich the data available for system learning. This paper introduces epistemic interaction within the context of human-system communication, illustrating how deliberate interaction design can improve system understanding and adaptation. Through concrete examples, we demonstrate the potential of epistemic interaction to significantly advance human-computer interaction by leveraging intuitive human communication strategies to inform system design and functionality, offering a novel pathway for enriching user-system engagements.
DevOps and Testing slides at DASA ConnectKari Kakkonen
Ā
My and Rik Marselis slides at 30.5.2024 DASA Connect conference. We discuss about what is testing, then what is agile testing and finally what is Testing in DevOps. Finally we had lovely workshop with the participants trying to find out different ways to think about quality and testing in different parts of the DevOps infinity loop.
UiPath Test Automation using UiPath Test Suite series, part 3DianaGray10
Ā
Welcome to UiPath Test Automation using UiPath Test Suite series part 3. In this session, we will cover desktop automation along with UI automation.
Topics covered:
UI automation Introduction,
UI automation Sample
Desktop automation flow
Pradeep Chinnala, Senior Consultant Automation Developer @WonderBotz and UiPath MVP
Deepak Rai, Automation Practice Lead, Boundaryless Group and UiPath MVP
GraphRAG is All You need? LLM & Knowledge GraphGuy Korland
Ā
Guy Korland, CEO and Co-founder of FalkorDB, will review two articles on the integration of language models with knowledge graphs.
1. Unifying Large Language Models and Knowledge Graphs: A Roadmap.
https://arxiv.org/abs/2306.08302
2. Microsoft Research's GraphRAG paper and a review paper on various uses of knowledge graphs:
https://www.microsoft.com/en-us/research/blog/graphrag-unlocking-llm-discovery-on-narrative-private-data/
Search and Society: Reimagining Information Access for Radical FuturesBhaskar Mitra
Ā
The field of Information retrieval (IR) is currently undergoing a transformative shift, at least partly due to the emerging applications of generative AI to information access. In this talk, we will deliberate on the sociotechnical implications of generative AI for information access. We will argue that there is both a critical necessity and an exciting opportunity for the IR community to re-center our research agendas on societal needs while dismantling the artificial separation between the work on fairness, accountability, transparency, and ethics in IR and the rest of IR research. Instead of adopting a reactionary strategy of trying to mitigate potential social harms from emerging technologies, the community should aim to proactively set the research agenda for the kinds of systems we should build inspired by diverse explicitly stated sociotechnical imaginaries. The sociotechnical imaginaries that underpin the design and development of information access technologies needs to be explicitly articulated, and we need to develop theories of change in context of these diverse perspectives. Our guiding future imaginaries must be informed by other academic fields, such as democratic theory and critical theory, and should be co-developed with social science scholars, legal scholars, civil rights and social justice activists, and artists, among others.
"Impact of front-end architecture on development cost", Viktor TurskyiFwdays
Ā
I have heard many times that architecture is not important for the front-end. Also, many times I have seen how developers implement features on the front-end just following the standard rules for a framework and think that this is enough to successfully launch the project, and then the project fails. How to prevent this and what approach to choose? I have launched dozens of complex projects and during the talk we will analyze which approaches have worked for me and which have not.
Let's dive deeper into the world of ODC! Ricardo Alves (OutSystems) will join us to tell all about the new Data Fabric. After that, Sezen de Bruijn (OutSystems) will get into the details on how to best design a sturdy architecture within ODC.
2. Stem Cell Basics
ā¢ I. Introduction: What are stem cells/ Research
ā¢ II.What are the unique properties of all stem cells?
ā¢ III. Types of stem cells
ā¢ IV.
What are the similarities and differences between embr
ā¢ V. What are the potential uses of stem cells?
3. Introduction
ā¢ Stem cells are cells that have the remarkable
potential to develop into many different cell
types in the body during early life and growth
ā¢ In addition, in many tissues they serve as a
sort of internal repair system, dividing
essentially without limit to replenish other
cells as long as the person or animal is still
alive
4. ā¢ When a stem cell divides, each new cell has the
potential either to remain a stem cell or become
another type of cell with a more specialized
function, such as a muscle cell, a red blood cell, or a
brain cell
ā¢ Stem cell research.
Reseach on stem cells with a primary goal to
identify how undifferentiated stem cells become
the differentiated cells that form the tissues and
organs
5. ā¢ Scientists know that turning genes on and off is
central to this process. Some of the most serious
medical conditions, such as cancer and birth
defects, are due to abnormal cell division and
differentiation.
ā¢ A research for more complete understanding of the
genetic and molecular controls of these processes
may yield information about how such diseases
arise and suggest new strategies for therapy
6. Stem cells are distinguished from other cell
types by two important characteristics.
ā¢ i. They are unspecialized cells capable of renewing
themselves through cell division, sometimes after
long periods of inactivity
ā¢ ii. Under certain conditions, they can be induced to
become tissue- or organ-specific cells with special
functions.
7. ā¢ In some organs, such as the gut and bone
marrow, stem cells regularly divide to repair
and replace worn out or damaged tissues
ā¢ In other organs, however, such as the
pancreas and the heart, stem cells only divide
under special conditions.
8. II.
What are the unique properties of all stem cells?
ā¢ All stem cellsāregardless of their sourceāhave
three general properties:
ii. They are capable of dividing and renewing
themselves for long periods
iv.They are unspecialized
vi.They can give rise to specialized cell types.
9. Potency specifies the differentiation potential (the
potential to differentiate into different cell types) of
the stem cell
ā¢ Totipotent (a.k.a omnipotent) stem cells can differentiate into embryonic
and extraembryonic cell types. Such cells can construct a complete, viable
organism. These cells are produced from the fusion of an egg and sperm
cell.
ā¢ Pluripotent stem cells are the descendants of totipotent cells and can
differentiate into nearly all cells, i.e. cells derived from any of the three
germ layers.
ā¢ Multipotent stem cells can differentiate into a number of cells, but only
those of a closely related family of cells.
ā¢ Oligopotent stem cells can differentiate into only a few cells, such as
lymphoid or myeloid stem cells.
ā¢ Unipotent cells can produce only one cell type, their own,but have the
property of self-renewal which distinguishes them from non-stem cells
(e.g. muscle stem cells).
10. Types of stem cells
ā¢ Often based on where in the body or what stage in
development they come from
11. 1. Embryonic Stem Cells
ā¢ Embryonic stem cells are derived from very
early embryos and can in theory give rise to all
cell types in the body.
ā¢ However, coaxing these cells to become
a particular cell type in the laboratory is not
trivial.
ā¢ Furthermore, embryonic stem cells carry the
risk of transforming into cancerous tissue
after transplantation
12. The morula's cells are totipotent, able to become all
tissues and a placenta.
13. 2. Adult Stem Cells or Tissue-specific
Stem Cells
ā¢ Many adult tissues contain stem cells that can
replace cells that die or restore tissue after injury.
ā¢ Skin, muscle, intestine and bone marrow, for
example, each contain their own stem cells. In the
bone marrow, billions of new blood cells are made
every day from blood-forming stem cells
14. ā¢ Adult stem cells are tissue-specific, meaning they
are found in a given tissue in our bodies and
generate the mature cell types within that
particular tissue or organ.
ā¢ It is not clear whether all organs, such as the heart,
contain stem cells. The term āadult stem cellsā is
often used very broadly and may include fetal and
cord blood stem cells
15. a. Fetal Stem Cells
ā¢ As their name suggests, fetal stem cells are
taken from the fetus.
ā¢ The developing baby is referred to as a fetus
from approximately 10 weeks of gestation.
ā¢ Most tissues in a fetus contain stem cells that
drive the rapid growth and development of the
organs
16. ā¢ Like adult stem cells, fetal stem cells are generally
tissue-specific, and generate the mature cell types
within the particular tissue or organ in which they
are found.
17. b. Cord Blood Stem Cells
ā¢ At birth the blood in the umbilical cord is rich in
blood-forming stem cells.
ā¢ The applications of cord blood are similar to those
of adult bone marrow and are currently used to
treat diseases and conditions of the blood or to
restore the blood system after treatment for
specific cancers.
ā¢ Like the stem cells in adult bone marrow, cord
blood stem cells are tissue-specific
18. ā¢ To be used in cell transplant treatments the
cells will most likely need to be directed into a
more mature cell type, both to be
therapeutically effective and to minimize risk
that cancers develop.
ā¢ There are currently no treatments using
embryonic stem cells accepted by the medical
community.
19. 3. Induced Pluripotent Stem Cells
(iPS cells)
ā¢ In 2006, scientists discovered how to āreprogramā
cells with a specialized function (for example, skin
cells) in the laboratory, so that they behave like an
embryonic stem cell.
ā¢ These cells, called induced pluripotent cells or iPS
cells, are created by inducing the specialized cells to
express genes that are normally made in embryonic
stem cells and that control how the cell functions.
20. ā¢ Shinya Yamanaka and his colleagues at
Kyoto University used the transcription factors
Oct3/4, Sox2, c-Myc, and Klf4 to induce
epithelial cells to be like embryonic stem cells.
21. ā¢ Embryonic stem cells and iPS cells share many
characteristics, including the ability become the
cells of all organs and tissues, but they are not
identical and can sometimes behave slightly
differently.
ā¢ IPS cells are a powerful method for creating
patient- and disease-specific cell lines for research.
However, the techniques used to make them need
to be carefully refined before they can be used to
generate iPS cells suitable for safe and effective
therapies
22. V. Potential uses of stem cells
ā¢ Human stem cells could be used to test new drugs.
For example, new medications could be tested for
safety on differentiated cells generated from
human pluripotent cell lines.
ā¢ Generation of cells and tissues that could be used
for cell-based therapies.
e.g Today, donated organs and tissues are often used
to replace ailing or destroyed tissue, but the need
for transplantable tissues and organs far outweighs
the available supply
23. ā¢ Stem cells, directed to differentiate into specific cell
types, offer the possibility of a renewable source of
replacement cells and tissues to treat diseases
including, spinal cord injury, burns, heart disease,
diabetes, osteoarthritis, and rheumatoid arthritis.
25. To be useful for transplant purposes, stem
cells must be reproducibly made to:
ā¢ -Proliferate extensively and generate sufficient
quantities of tissue.
ā¢ -Differentiate into the desired cell type(s).
ā¢ -Survive in the recipient after transplant.
ā¢ -Integrate into the surrounding tissue after
transplant.
ā¢ -Function appropriately for the duration of the
recipient's life.
26. To summarize
ā¢ Stem cells offer exciting promise for future
therapies, but significant technical hurdles
remain that will only be overcome through
years of intensive research