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ASIC Development for Energy Resolved
 Spectral Counting and Imaging of X-rays
       S. Azman, W. Dang, C. Gheorghe, M. Gjetanger, T.M. Johansen,
          D. Meier, S. Mikkelsen, G. Mæhlum, J. Talebi, T. Ødegaard


                 Gamma Medica – Ideas (Norway) AS

                          CERN, 4.-6. April 2011




dirk.meier@gm-ideas.com         2011-April, CERN, SpecX-Ray Workshop   1
ASIC Designs Overview




    dirk.meier@gm-ideas.com   2011-April, CERN, SpecX-Ray Workshop   2
Radiation Detector Design and Development for Science

Science: e.g. space, physics
                                     Requirements,
                                      Preliminary
JAXA, BepiColombo                    Specifications         ASIC wafer

                                        Design
                                       Simulation




                                    Implementation,
                                 Rule checks, simulation
ATHENA                           Manufacture, Foundry
                                                             Radiation sensor
                                       Assembly

                                       Integration




                                         Tests,
                                    Verification and
                                      Validation




       dirk.meier@gm-ideas.com    2011-April, CERN, SpecX-Ray Workshop    3
Abstract – ASIC for Spectral X-ray Photon Counting


 We describe an integrated circuit (IC) for spectral counting and imaging of
 polychromatic x-rays.


 The circuit has been designed for the readout of cadmium telluride (CdTe) radiation
 sensors with up to 64 pixel electrodes. Each readout channel contains a charge
 sensitive amplifier, up to 6 discriminators and 6 counters which increment when the
 amplitude exceeds a given threshold. The energy dynamic range is about 120 keV.
 Subsequently we designed and assembled camera prototypes from 1D-linear arrays of
 CdTe read out by 32 ASICs. We have tested the cameras with imaging phantoms and
 polychromatic x-rays in a micro-computed tomography (microCT) setup. We studied
 the use of the cameras for material separation, especially with gadolinium and iodine
 based contrast agents, for medical imaging. The presentation will focus on the ASIC
 design specifications which were originally set for industrial scanning, but also discuss
 the requirements for x-ray microCT and medical imaging.




    dirk.meier@gm-ideas.com             2011-April, CERN, SpecX-Ray Workshop     4
Spectral X-ray Photon Counting - Principle




    dirk.meier@gm-ideas.com   2011-April, CERN, SpecX-Ray Workshop   5
Spectral X-ray Photon Counting - Principle




    dirk.meier@gm-ideas.com   2011-April, CERN, SpecX-Ray Workshop   6
ASIC Channel Architecture – 1 out of 32/64




Mikkelsen et al. (2008), Proc. IEEE
NSS



     dirk.meier@gm-ideas.com          2011-April, CERN, SpecX-Ray Workshop   7
ASIC Specifications




     dirk.meier@gm-ideas.com   2011-April, CERN, SpecX-Ray Workshop   8
ASIC Floorplan, Padframe, Block Diagram




     dirk.meier@gm-ideas.com   2011-April, CERN, SpecX-Ray Workshop   9
ASIC Block Diagram




    dirk.meier@gm-ideas.com   2011-April, CERN, SpecX-Ray Workshop   10
Spectral X-ray Photon Counting – Applications



    Security
     e.g. explosives
    Food safety
     e.g. foreign objects
    Separtion & sorting
     e.g. metals, waste....
    NDT
    Medical
     e.g. contrast agents
    Physics research



    dirk.meier@gm-ideas.com   2011-April, CERN, SpecX-Ray Workshop   11
Spectral X-ray Counting Detector




X-ray Line Camera

Modules: CdTe + ASICs

Wang et al. (2009), Proc. IEEE NSS


    dirk.meier@gm-ideas.com          2011-April, CERN, SpecX-Ray Workshop   12
Radiation Sensor - CdTe Crystal with Electrodes




                                                                                       -500V
 3 mm




                                  0.4 mm Anode Pitch




        dirk.meier@gm-ideas.com            2011-April, CERN, SpecX-Ray Workshop   13
Spectral X-ray Counting Detector - Specifications




    dirk.meier@gm-ideas.com   2011-April, CERN, SpecX-Ray Workshop   14
Photographs of X-ray Line Detector




    dirk.meier@gm-ideas.com   2011-April, CERN, SpecX-Ray Workshop   15
Photographs of X-ray Line Detector




    dirk.meier@gm-ideas.com   2011-April, CERN, SpecX-Ray Workshop   16
X-Ray Line Camera - Hardware Details


    External COUNT signal
     synchronized with conveyor belt
     or CT system
    1500 frames/seconds maximum
     (0.67 ms frames)
    Short dead time between frames
     (40us)
    Interface to PC through National
     Instruments I/O card




     dirk.meier@gm-ideas.com       2011-April, CERN, SpecX-Ray Workshop   17
Example Material Identification – Luggage Phantom




Grey scale image based on          Color coded based on the ratio of
attenuation at one energy          attenuation at two energies, [80,100]
                                   keV and [35,50] keV




    dirk.meier@gm-ideas.com   2011-April, CERN, SpecX-Ray Workshop   18
Food Safety - Pieces of Glass in Raisins




     Grey scale image based on           Dual-energy
     attenuation at one energy           information, enhanced to ’see’
                                         only glass and eliminate raisins



    dirk.meier@gm-ideas.com      2011-April, CERN, SpecX-Ray Workshop   19
Material Separation – Hard Disk Drive




   Grey scale image based on              Regions color coded based on
   attenuation at one energy              attenuation ratio between high
                                          and low energy

    dirk.meier@gm-ideas.com    2011-April, CERN, SpecX-Ray Workshop   20
Count Rate and Spectra


                                                       Mono-energetic x-rays




                                                                     Customer data




    dirk.meier@gm-ideas.com   2011-April, CERN, SpecX-Ray Workshop      21
Spectral Distortion in Photon Counting Detector



    Comparison between
    • GM-I Spectral Photon
      Counting Detector
    • AMTEK CdTe
      Spectrometer

    Effects:
    • Energy resolution
    • Pulse pileup
    • Characteristic x-ray
    • Charge sharing



     dirk.meier@gm-ideas.com   2011-April, CERN, SpecX-Ray Workshop   22
Charge Sharing


                                                              Customer data
  80 keV
  Summed Count rate          Summed energy




   dirk.meier@gm-ideas.com   2011-April, CERN, SpecX-Ray Workshop    23
Spectra with Gd Contrast Agent


2.8                                   Water
                                      PMMA
                                      POM
2.4                                   PTFE
                                      Cortical bone
                                      Iodine solution
 2                                    Gd solution


1.6


1.2


0.8


0.4                                                                                                  Wang, 2011
       30    40   50     60      70     80     90       100
                       Energy (keV)


            Energy-dependent x-ray attenuation


            dirk.meier@gm-ideas.com                           2011-April, CERN, SpecX-Ray Workshop      24
CT Phantom Images and Energy Thresholds Trimming




   dirk.meier@gm-ideas.com   2011-April, CERN, SpecX-Ray Workshop   25
Summary



       We have built a X-ray Line Camera capable of Spectral X-ray Photon
       Counting. The design is based on CdTe custom made ASICs.

       The prototype cameras allow one to study the potentials
       of spectral x-ray photon counting.

       It is important to understand and improve:

       • Spectral response vs. count rate
            – Charge sharing in CdTe
            – Rate capability of CdTe pixels and ASIC, especially for CT
       • Threshold uniformity and trimming




   dirk.meier@gm-ideas.com        2011-April, CERN, SpecX-Ray Workshop   26
References




[1] S. Mikkelsen et al. (2008), ”An ASIC for Multi-Energy X-ray Counting”, Proc. IEEE NSS 2008.


[2] X. Wang et al. (2009), ”A Digital Line-Camera for Energy Resolved X-ray Photon Counting”,
Proc. IEEE MIC 2009.


[3] X. Wang et al. (2011), “Material Separation in X-ray CT with Energy Resolved Photon
Counting Detectors", Medical Physics (0094-2405), 3/1/2011. Vol.38,Iss.3;p.1534-1546.

[4] X.Wang et al. (2011), “MicroCT with energy-resolved photon-counting detectors2011“, Phys.
Med. Biol. 56 2791–2816.




      dirk.meier@gm-ideas.com                2011-April, CERN, SpecX-Ray Workshop          27
Acknowledgments



   We like to thank our customers and collaborators.

   and

   X. Wang, E. Frey, K. Taguchi, B.M.W. Tsui at Johns Hopkins
   University

   D. Wagenaar at Gamma Medica, Northridge

   B. Sundal at Corentium, Norway

                              Thank you




    dirk.meier@gm-ideas.com         2011-April, CERN, SpecX-Ray Workshop   28

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Spectral x-ray photon counting

  • 1. ASIC Development for Energy Resolved Spectral Counting and Imaging of X-rays S. Azman, W. Dang, C. Gheorghe, M. Gjetanger, T.M. Johansen, D. Meier, S. Mikkelsen, G. Mæhlum, J. Talebi, T. Ødegaard Gamma Medica – Ideas (Norway) AS CERN, 4.-6. April 2011 dirk.meier@gm-ideas.com 2011-April, CERN, SpecX-Ray Workshop 1
  • 2. ASIC Designs Overview dirk.meier@gm-ideas.com 2011-April, CERN, SpecX-Ray Workshop 2
  • 3. Radiation Detector Design and Development for Science Science: e.g. space, physics Requirements, Preliminary JAXA, BepiColombo Specifications ASIC wafer Design Simulation Implementation, Rule checks, simulation ATHENA Manufacture, Foundry Radiation sensor Assembly Integration Tests, Verification and Validation dirk.meier@gm-ideas.com 2011-April, CERN, SpecX-Ray Workshop 3
  • 4. Abstract – ASIC for Spectral X-ray Photon Counting We describe an integrated circuit (IC) for spectral counting and imaging of polychromatic x-rays. The circuit has been designed for the readout of cadmium telluride (CdTe) radiation sensors with up to 64 pixel electrodes. Each readout channel contains a charge sensitive amplifier, up to 6 discriminators and 6 counters which increment when the amplitude exceeds a given threshold. The energy dynamic range is about 120 keV. Subsequently we designed and assembled camera prototypes from 1D-linear arrays of CdTe read out by 32 ASICs. We have tested the cameras with imaging phantoms and polychromatic x-rays in a micro-computed tomography (microCT) setup. We studied the use of the cameras for material separation, especially with gadolinium and iodine based contrast agents, for medical imaging. The presentation will focus on the ASIC design specifications which were originally set for industrial scanning, but also discuss the requirements for x-ray microCT and medical imaging. dirk.meier@gm-ideas.com 2011-April, CERN, SpecX-Ray Workshop 4
  • 5. Spectral X-ray Photon Counting - Principle dirk.meier@gm-ideas.com 2011-April, CERN, SpecX-Ray Workshop 5
  • 6. Spectral X-ray Photon Counting - Principle dirk.meier@gm-ideas.com 2011-April, CERN, SpecX-Ray Workshop 6
  • 7. ASIC Channel Architecture – 1 out of 32/64 Mikkelsen et al. (2008), Proc. IEEE NSS dirk.meier@gm-ideas.com 2011-April, CERN, SpecX-Ray Workshop 7
  • 8. ASIC Specifications dirk.meier@gm-ideas.com 2011-April, CERN, SpecX-Ray Workshop 8
  • 9. ASIC Floorplan, Padframe, Block Diagram dirk.meier@gm-ideas.com 2011-April, CERN, SpecX-Ray Workshop 9
  • 10. ASIC Block Diagram dirk.meier@gm-ideas.com 2011-April, CERN, SpecX-Ray Workshop 10
  • 11. Spectral X-ray Photon Counting – Applications Security e.g. explosives Food safety e.g. foreign objects Separtion & sorting e.g. metals, waste.... NDT Medical e.g. contrast agents Physics research dirk.meier@gm-ideas.com 2011-April, CERN, SpecX-Ray Workshop 11
  • 12. Spectral X-ray Counting Detector X-ray Line Camera Modules: CdTe + ASICs Wang et al. (2009), Proc. IEEE NSS dirk.meier@gm-ideas.com 2011-April, CERN, SpecX-Ray Workshop 12
  • 13. Radiation Sensor - CdTe Crystal with Electrodes -500V 3 mm 0.4 mm Anode Pitch dirk.meier@gm-ideas.com 2011-April, CERN, SpecX-Ray Workshop 13
  • 14. Spectral X-ray Counting Detector - Specifications dirk.meier@gm-ideas.com 2011-April, CERN, SpecX-Ray Workshop 14
  • 15. Photographs of X-ray Line Detector dirk.meier@gm-ideas.com 2011-April, CERN, SpecX-Ray Workshop 15
  • 16. Photographs of X-ray Line Detector dirk.meier@gm-ideas.com 2011-April, CERN, SpecX-Ray Workshop 16
  • 17. X-Ray Line Camera - Hardware Details  External COUNT signal synchronized with conveyor belt or CT system  1500 frames/seconds maximum (0.67 ms frames)  Short dead time between frames (40us)  Interface to PC through National Instruments I/O card dirk.meier@gm-ideas.com 2011-April, CERN, SpecX-Ray Workshop 17
  • 18. Example Material Identification – Luggage Phantom Grey scale image based on Color coded based on the ratio of attenuation at one energy attenuation at two energies, [80,100] keV and [35,50] keV dirk.meier@gm-ideas.com 2011-April, CERN, SpecX-Ray Workshop 18
  • 19. Food Safety - Pieces of Glass in Raisins Grey scale image based on Dual-energy attenuation at one energy information, enhanced to ’see’ only glass and eliminate raisins dirk.meier@gm-ideas.com 2011-April, CERN, SpecX-Ray Workshop 19
  • 20. Material Separation – Hard Disk Drive Grey scale image based on Regions color coded based on attenuation at one energy attenuation ratio between high and low energy dirk.meier@gm-ideas.com 2011-April, CERN, SpecX-Ray Workshop 20
  • 21. Count Rate and Spectra Mono-energetic x-rays Customer data dirk.meier@gm-ideas.com 2011-April, CERN, SpecX-Ray Workshop 21
  • 22. Spectral Distortion in Photon Counting Detector Comparison between • GM-I Spectral Photon Counting Detector • AMTEK CdTe Spectrometer Effects: • Energy resolution • Pulse pileup • Characteristic x-ray • Charge sharing dirk.meier@gm-ideas.com 2011-April, CERN, SpecX-Ray Workshop 22
  • 23. Charge Sharing Customer data 80 keV Summed Count rate Summed energy dirk.meier@gm-ideas.com 2011-April, CERN, SpecX-Ray Workshop 23
  • 24. Spectra with Gd Contrast Agent 2.8 Water PMMA POM 2.4 PTFE Cortical bone Iodine solution 2 Gd solution 1.6 1.2 0.8 0.4 Wang, 2011 30 40 50 60 70 80 90 100 Energy (keV) Energy-dependent x-ray attenuation dirk.meier@gm-ideas.com 2011-April, CERN, SpecX-Ray Workshop 24
  • 25. CT Phantom Images and Energy Thresholds Trimming dirk.meier@gm-ideas.com 2011-April, CERN, SpecX-Ray Workshop 25
  • 26. Summary We have built a X-ray Line Camera capable of Spectral X-ray Photon Counting. The design is based on CdTe custom made ASICs. The prototype cameras allow one to study the potentials of spectral x-ray photon counting. It is important to understand and improve: • Spectral response vs. count rate – Charge sharing in CdTe – Rate capability of CdTe pixels and ASIC, especially for CT • Threshold uniformity and trimming dirk.meier@gm-ideas.com 2011-April, CERN, SpecX-Ray Workshop 26
  • 27. References [1] S. Mikkelsen et al. (2008), ”An ASIC for Multi-Energy X-ray Counting”, Proc. IEEE NSS 2008. [2] X. Wang et al. (2009), ”A Digital Line-Camera for Energy Resolved X-ray Photon Counting”, Proc. IEEE MIC 2009. [3] X. Wang et al. (2011), “Material Separation in X-ray CT with Energy Resolved Photon Counting Detectors", Medical Physics (0094-2405), 3/1/2011. Vol.38,Iss.3;p.1534-1546. [4] X.Wang et al. (2011), “MicroCT with energy-resolved photon-counting detectors2011“, Phys. Med. Biol. 56 2791–2816. dirk.meier@gm-ideas.com 2011-April, CERN, SpecX-Ray Workshop 27
  • 28. Acknowledgments We like to thank our customers and collaborators. and X. Wang, E. Frey, K. Taguchi, B.M.W. Tsui at Johns Hopkins University D. Wagenaar at Gamma Medica, Northridge B. Sundal at Corentium, Norway Thank you dirk.meier@gm-ideas.com 2011-April, CERN, SpecX-Ray Workshop 28