Spectral imaging and iterative reconstruction techniques are redefining the rules of clinical CT. These new techniques allow for ultra-low dose CT scans at diagnostic quality with up to 95% dose reduction compared to standard CT. They also enable artifact reduction and improved tissue characterization. Spectral imaging using dual energy CT generates multiple datasets that can be used to create material-specific images like iodine and water images, improving detection and characterization of lesions. Iterative reconstruction further reduces image noise improving low dose imaging. Together these techniques are opening new dimensions in CT imaging capabilities.
(June 22nd, 2021) Introducing Vilber’s Product Line of Gel Imaging SystemsScintica Instrumentation
Overview:
In this webinar, Alexis will introduce the Fusion fluorescence and chemiluminescence systems manufactured by Vilber. The Fusion systems are the ideal multimodal imaging platform designed for molecular biology laboratories. They cover the spectrum of chemiluminescence, multiplexing fluorescence and chemifluorescence applications. The system offers the ultimate speed and sensitivity across all DNA, RNA and protein-based applications. The Fusion is advanced in the technology it uses to take images and the ease at which users can process and analyze them. The Fusion system is ideal for publication, quantification, and documentation grade imaging.
The Fusion systems are ideal for quantification grade imaging. Chemiluminescent Western blot data poses distinct challenges in producing quantifiable and reproducible data. Most of these issues are a result of low-dynamic range of detection and difficulty in accurately determining the limit of detection. Fusion systems eliminate all these issues thanks to a High Sensitivity Reading (HSR) camera technology that delivers reliable dynamic range, linearity, and unsurpassed sensitivity for the lowest limit of detection. The advanced camera technology reduces noise allowing faint signals to stand out from the surrounding background.
Further the Fusion systems can deliver consistent and reproducible data, independently of a chemiluminescence time course. The chemiluminescence intensity/time profile consists of an initial rise period up to a prolonged emission at a pseudo-plateau level and a decline. VILBER Fusions Automatic imaging mode compensates the time course of the chemiluminescence reaction by adjusting the exposure time while maintaining the larger possible image dynamic.
VILBER is a leading life science company developing and manufacturing fluorescence and chemiluminescence imaging systems for applications ranging from small animal to cell biology research. Founded in 1954, Vilber is a leader in the molecular imaging sector, equipping more than 20,000 laboratories worldwide. An estimated 60,000 researchers use their products every day in over 100 countries.
Learning Objectives:
Gel imaging standard workflow
Chemiluminescence vs. fluorescence imaging
What makes the Vilber systems unique?
Multiplexing capabilities
Image analysis
triple scan protocol (Dr. Gross) - a new and effective protocol for 3D planni...Michael Gross
triple scan protocol (Dr. Gross) - a new and effective protocol for 3D planning and guided surgery of partially edentulous cases
Cortex guide - complete service for advanced 3D planning and guided surgery of dental implants
A multispectral image is one that captures image data from two or more ranges of frequencies along the spectrum, such as visible light and infrared energy.
In multispectral images, the same spatial region is captured multiple times using different imaging modalities.
Overview of Integrated Detector Electronics products including Application Specific Integrated Circuits, ROICs and low noise amplifiers for radiation detection.
Dual energy CT in radiotherapy: Current applications and future outlookWookjin Choi
Dual energy CT in radiotherapy: Current applications and future outlook
Wouter van Elmpt, Guillaume Landry, Marco Das, Frank Verhaegen
Department of Radiation Oncology (MAASTRO), GROW – School for Oncology and Developmental Biology, Maastricht University Medical Centre, The Netherlands; Department of Medical Physics, Faculty of Physics, Ludwig-Maximilians-Universität München, Garching b. München, Germany; Department of Radiology, GROW – School for Oncology and Developmental Biology, Maastricht University Medical Centre, The Netherlands; and Medical Physics Unit, Department of Oncology, McGill University, Montréal, Canada
(June 22nd, 2021) Introducing Vilber’s Product Line of Gel Imaging SystemsScintica Instrumentation
Overview:
In this webinar, Alexis will introduce the Fusion fluorescence and chemiluminescence systems manufactured by Vilber. The Fusion systems are the ideal multimodal imaging platform designed for molecular biology laboratories. They cover the spectrum of chemiluminescence, multiplexing fluorescence and chemifluorescence applications. The system offers the ultimate speed and sensitivity across all DNA, RNA and protein-based applications. The Fusion is advanced in the technology it uses to take images and the ease at which users can process and analyze them. The Fusion system is ideal for publication, quantification, and documentation grade imaging.
The Fusion systems are ideal for quantification grade imaging. Chemiluminescent Western blot data poses distinct challenges in producing quantifiable and reproducible data. Most of these issues are a result of low-dynamic range of detection and difficulty in accurately determining the limit of detection. Fusion systems eliminate all these issues thanks to a High Sensitivity Reading (HSR) camera technology that delivers reliable dynamic range, linearity, and unsurpassed sensitivity for the lowest limit of detection. The advanced camera technology reduces noise allowing faint signals to stand out from the surrounding background.
Further the Fusion systems can deliver consistent and reproducible data, independently of a chemiluminescence time course. The chemiluminescence intensity/time profile consists of an initial rise period up to a prolonged emission at a pseudo-plateau level and a decline. VILBER Fusions Automatic imaging mode compensates the time course of the chemiluminescence reaction by adjusting the exposure time while maintaining the larger possible image dynamic.
VILBER is a leading life science company developing and manufacturing fluorescence and chemiluminescence imaging systems for applications ranging from small animal to cell biology research. Founded in 1954, Vilber is a leader in the molecular imaging sector, equipping more than 20,000 laboratories worldwide. An estimated 60,000 researchers use their products every day in over 100 countries.
Learning Objectives:
Gel imaging standard workflow
Chemiluminescence vs. fluorescence imaging
What makes the Vilber systems unique?
Multiplexing capabilities
Image analysis
triple scan protocol (Dr. Gross) - a new and effective protocol for 3D planni...Michael Gross
triple scan protocol (Dr. Gross) - a new and effective protocol for 3D planning and guided surgery of partially edentulous cases
Cortex guide - complete service for advanced 3D planning and guided surgery of dental implants
A multispectral image is one that captures image data from two or more ranges of frequencies along the spectrum, such as visible light and infrared energy.
In multispectral images, the same spatial region is captured multiple times using different imaging modalities.
Overview of Integrated Detector Electronics products including Application Specific Integrated Circuits, ROICs and low noise amplifiers for radiation detection.
Dual energy CT in radiotherapy: Current applications and future outlookWookjin Choi
Dual energy CT in radiotherapy: Current applications and future outlook
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Increasing Amorphous Selenium Thickness in Direct Conversion Flat-Panel Image...David Scaduto
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Methods: We compare imaging performance of a conventional FPI with 200 μm a-Se conversion layer to a prototype FPI with 300 μm a-Se layer. Both detectors are evaluated in a Siemens MAMMOMAT Inspiration prototype digital breast tomosynthesis (DBT) system using low-energy (W/Rh 28 kVp) and high-energy (W/Cu 49 kVp) x-ray spectra. Detectability of iodinated lesions in dual-energy images is evaluated using an iodine contrast phantom. Effects of beam obliquity are investigated in projection and reconstructed images using different reconstruction methods. The ideal observer signal-to-noise ratio is used as a figure-of-merit to predict the optimal a-Se thickness for CE lesion detectability without compromising conventional full-field digital mammography (FFDM) and DBT performance.
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Conclusion: Increasing a-Se thickness in direct conversion FPI from 200 μm to 300 μm improves lesion detectability in CE breast imaging with virtually no cost to conventional FFDM and DBT.
This work was partially supported by a research grant from Siemens Healthcare.
The Use of Achieve Circular Mapping Catheter Significantly Reduces Procedure ...Jc Templar
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Department of Cardiology, Centre Hospitalier Universitaire Nord, Marseille, France
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View recorded webinars:
http://bit.ly/particlewebinars
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.
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iMinds The Conference: Johan de Mey
1. Redefining the Rules of clinical CT
Imaging with Spectral Imaging and
Iterative Reconstruction techniques
Johan de Mey PhD. MD Head of Radiology Department
Koenraad Nieboer MD Head of Emergency Radiology
Nico Buls PhD. MSc Medical Imaging and Physical Sciences
Gert Van Gompel PhD. MSc Medical Imaging and Physical Sciences
Toon Van Cauteren MSc Medical Imaging and Physical Sciences
2. Multislice CT and clinical outcome
What makes a good CT?
accuracy
Spatial
Resolution
Temporal Coverage
perfusion
Workflow Dose
Characterization
3. Low Dose CT = quality ?
1980 – 2007: Dose optimalisation
More images
Higher resolution
2008 - …: Dose optimalisation
Less dose??? Functional???
Iterative recon Dual energy
4. Noise suppression
The straightforward way…
increase # photons, increase patient dose (mAs)
10 mAs 60 mAs 120 mAs
CTDIv = 0,8 mGy CTDIv = 5 mGy CTDIv = 10 mGy
6. Does the age of the patient at time of
exposure affect the patient risk?
Children are 2-10 x more sensitive!
Hall Pediatric Radiology Apr 2002 pg 226
10. Female 45
Acute dyspnea, suspicion pulmonary
embolism
Scan Parameters
Range 26 cm Ni: 30
120KV ASiR: 40%
CTDIv 7.44 (mGy)
E 2.7 (mSv)
0.625 mm
1.25 mm
1.25 mm
11. Body packers: low dose CT / GSI
ECR EPPOS: C-2068 ECR 2011 K. H. Nieboer, N. Buls, J. de Mey, G. Van Gompel; Brussels/BE, The use of iterative
reconstruction in ultra low dose computed tomography for bodypacker screening
12. VeoTM – future in dose reduction
= Model Based Iterative Reconstruction
REAL 3D
SYSTEM
OPTICS
SYSTEM NOISE
STATISTICS
14. Iterative – impact on image noise
100
90
N 80
FBP
o 70
Relative Noise (SD)
i 60
s 50
e 40 ASIR50
30
20
10
VEO
0
0 50 100 150 200 250 300 350 400 450 500
tube current - relative radiation dose
Tube current
15. Resolution at standard dose
Catphan 504 phantom
CTDIvol = 12.5 mGy
FBP ASIR 50% VEO
Performance at 6 lp/cm and 8 lp/cm
16. Ultra low dose Chest follow-up with VEO
4mAs, 0.06mSv*
FBP ASiR Veo
“Typical CXR effective dose is about 0.06 mSv.”
Source: Health Physics Society.
http://www.hps.org/publicinformation/ate/q2372.html * Determined by internal organ dosimetry on a humanoid phantom
17. Chest CT with Veo – Cystic Fibrosis 26y
CDTIvol = 0.10 mGy
Effective dose = 0.05 mSv*
* Obtained by EUR-16262 EN, using a chest factor of 0.017*DLP
Conversions of CTDI or DLP to effective dose are only rough estimations for children
29. Conclusion: Modal based Iterative reconstruction:
1. >95% dose reduction CT at plain film dose +/- 0.06 mSv
1. 70% dose reduction No quality loss
1. 50% dose and low KVp No quality loss + 50 % contrast reduction
1. 40% dose reduction Better image, less artifacts
1. Equal dose and low KVp Up to 60% contrast reduction
30. Dual energy…spectral imaging:
Need for at least two datasets on different energy level
Discovery CT750 HD
Dual tube
Fast switching tube
Making two scans
Dual layer detector
Photon counting
31. Dual energy…spectral imaging:
Need for at least two datasets on different energy level
Discovery CT750 HD
Dual tube
FOV max 33 cm
Spectral filter on 140
Making two scans
Time Difference
FOV 50 cm
Dual layer detector
Research Real Time
Photon counting
Future ?
32. Photon energy with Tungsten? What is dual energy?
120 KV scan Mean 61.1 KeV
80 KV scan Mean 49.9 KeV 140 KV scan Mean 66.1 KeV
35. From 2 datasets to 101 datasets? Is this real?
Phantom data
Qualitative comparison DECT
<-> literature (NIST)
ECR: B-851 Monday 14.00
G. Van Gompel, N.Buls, K. Nieboer, J. de Mey
Accuracy estimation of spectral attenuation curves obtained by dual energy
36. Clinical use?
Cadaver blood vessels
Filled with CM concentration, GSI scan
ROI2: water + CM
ROI3: soft plaque
ROI4: calcified plaque
37. „Relative‟ dose reduction? (No need for non-CE scans)
Contrast reduction? (Higher contrast in image)
Iodine
Water
250
CNRD @ iodineconc 1mgI/ml
200
1 mg I / ml 2
1.8
150 1.6 120
1.4
CT value (HU)
kV
1.2
CNRD
100 1 GSI v2
0.8
0.6
50 0.4
0.2
0
0
40 60 80 100 120 140
30 50 70 90 110 130
Photon energy (keV)
energy (keV)
38. Pleural effusion: Exudate >< transudate?
ECR EPOS: C-1996 Y. De Brucker, N. Buls, G. Van Gompel, F. Vandenbroucke, H. Nieboer, T. De Keukeleire, J.
de Mey; Brussels/BE Characterization of pleural effusion using dual energy CT: feasibility study.
39. Phantom size on quantitative iodine measurement:
dual energy CT >< standard CT.
Obtained CT-values (HU)
120 keV GSI 70 keV
Ø 23 cm 291 9 310 6
Ø 17 cm 325 5 315 8
Ø 17 cm + t 318 9 314 5
range 34 5
VAR 10.9% 1.6%
40. Standard
Phantom size on quantitative iodine measurement:
spectral CT >< standard CT.
Standard Spectral
120 kV DECT at 70 keV
43. S GSI: spectral imaging
Subsegmental pulmonary embolism
Clinical value
• Pulmonary embolism was not
Embolism depicted during 1st reading on
standard images
• MD Iodine shows clearly a hypo
perfusion on the left.
• 2nd reading confirms pulmonary
embolism resulting from a small
thrombus in a small pulmonary
vessel
• GSI allows physicians to
detect pulmonary embolism by
showing subtle lung perfusion
defect
44. Pulmonary Embolism
Clinical value
• Pulmonary embolism was
not depicted during 1st
reading on standard images
• MD Iodine shows clearly a
hypo perfusion in left lung
resulting from a pulmonary
embolism. Hypo perfusion
could not be seen on
standard CT image
Iodine Based Images 70 keV images with lung window
• 2nd reading confirms
pulmonary embolism resulting
from a small thrombus in a
small pulmonary vessel
• GSI allows physicians to
detect pulmonary embolism
by showing subtle lung
perfusion defect
70 keV Monochromatic Images 70 keV Monochromatic Images
Images Courtesy of Dr. Jean Louis Sablayrolles; Centre Cardiologique du Nord
45.
46. Standard 120 kV acquisition
GSI: Artefact reduction Monochromatic with MARs
47. Iliac Stent Bleeding
Clinical value
• Endoleak is better
visualized on low energy
(55 keV) images (green
Arrows)
80 keV MD Water (Iodine)
• MD Iodine suggests Iodine
leak
• GSI allows physicians to
better visualize bleeding
vs. conventional CT
MD Iodine (Water) 55 keV
Images Courtesy of Pr Dacher, CHU de Rouen
48. Metal Artifact Reduction: Spine
• GSI acquisition allows to
create a spectrum of
monochromatic images
where beam hardening is
highly reduced
• In this case the radiologist
could recover information
previously hidden by the
beam hardening
70 keV image 110 keV images
Images Courtesy of Dr. Sablayrolles, CCN, France
49. Conclusion: New dimensions in CT
Statistical iterative reconstruction: important dose reduction
- Dose reduction up to 50% and same quality
- Scanning at low KVp and contrast reduction
- In some cases alternative for plain film
Spectral imaging and real iterative rec.: a new dimension in CT
- Ultra low dose at diagnostic quality up to 95% reduction
- Artifact reduction and high quality images
- Characterization and differentiation
- Contrast amount and concentration reduction
Thank you for your attention