This document discusses different types of space-related problems that can occur in the mixed dentition stage, including lack of space, excess space, premature tooth loss, localized space loss, crowding, spacing, and missing teeth. It provides details on the causes and typical treatment approaches for each type of problem. For issues like crowding, options like distal molar movement using appliances, use of extraoral headgear, and early serial extraction are outlined. Specific appliance and treatment approaches are described for managing various space issues in the mixed dentition stage.