Biology of tooth movement /certified fixed orthodontic courses by Indian dent...Indian dental academy
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Biochemical mediators. kavitha /certified fixed orthodontic courses by Indian...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Role of polycystin 1 in bone remodeling- orthodontic tooth movement study in ...EdwardHAngle
Objective: To test the hypothesis that polycystin-1 (PC1) is involved in orthodontic tooth movement as a mechanical sensor.
Materials and Methods: The response to force application was compared between three mutant and four wild-type 7-week-old mice. The mutant mice were PC1/Wnt1-cre, lacking PC1 in the craniofacial region. An orthodontic closed coil spring was bonded between the incisor and the left first molar, applying 20 g of force for 4 days. Micro–computed tomography, hematoxylin and eosin staining, and tartrate-resistent acid phosphatase (TRAP) staining were used to study the differences in tooth movement among the groups.
Results: In the wild-type mice the bonded molar moved mesially, and the periodontal ligament (PDL) was compressed in the compression side. The compression side showed a hyalinized zone, and osteoclasts were identified there using TRAP staining. In the mutant mice, the molar did not move, the incisor tipped palatally, and there was slight widening of the PDL in the tension area. Osteoclasts were not seen on the bone surface or on the compression side. Osteoclasts were only observed on the other side of the bone—in the bone marrow.
Conclusions: These results suggest a difference in tooth movement and osteoclast activity between PC1 mutant mice and wild-type mice in response to orthodontic force. The impaired tooth movement and the lack of osteoclasts on the bone surface in the mutant working side may be related to lack of signal from the PDL due to PC1 deficiency.
Orthodontics-Periodontics Relationship
ntroduction
Biological basis for orthodontic therapy
Periodontal tissue response to orthodontic force
Effects of orthodontic tooth movement on the periodontium
Orthodontic tooth movement in adults with periodontal tissue breakdown
Specific factors associated with orthodontic tooth movement
Implants and orthodontic therapy
Systematics of combined ortho – perio treatment
Periodontally Accelerated Osteogenic Orthodontics (PAOO)
Minor periodontal surgery and orthodontic treatment
Review of literature
Tooth movement induced by orthodontic force application is
characterized by changes in the cells and tissue. When exposed to varying degrees of magnitude, frequency,
and duration of mechanical loading, cells and tissue show
extensive macroscopic and microscopic changes.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
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Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
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Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
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NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
2. Introduction
Tooth movement by orthodontic force application is
characterized by remodeling changes in dental and
paradental tissues.
Orthodontic force has been defined as “force applied to
teeth for the purpose of effecting tooth movement,
generally having a magnitude lower than an orthopedic
force.”
3. Theories of orthodontic tooth movement
Orthodontic tooth movement has been defined as “the result
of a biologic response to interference in the physiologic
equilibrium of the dentofacial complex by an externally
applied force.”
This quest to find biologic foundation of force-induced tooth
movement led to the proposal of 2 main mechanisms for tooth
movement—
the application of pressure and tension to the PDL
bending of the alveolar bone.
Ref:-Proffit WR, Fields HW,Contemporary orthodontics.5th edition
4. The pressure-tension theory
Sandstedt (1904), Oppenheim (1911), and Schwarz
(1932)
a tooth moves in the periodontal space by generating a
“pressure side” and a “tension side.”
Ref:-Proffit WR, Fields HW,Contemporary orthodontics.5th edition
Pressure side Tension side
Blood flow ↓ ↑
Cell
replication
↓ ↑
Fiber
production
↓ ↑
Oxygen level ↓ ↑
CO2 level ↑ ↓
5.
6.
7. Schwarz concluded that the forces delivered as part of
orthodontic treatment should not exceed the capillary
bed blood pressure (20-25 g/cm2 of root surface).
If one exceeds this pressure, compression could cause
tissue necrosis through “suffocation of the strangulated
periodontium.”
Ref:-Schwarz AM. Tissue changes incident to orthodontic tooth movement. Int J Orthod 1932;18:331-52
8.
9. Reitan observed that
(1) hyalinization occurred in the PDL after the application
of even minimal force,
(2) more hyalinization occurred after application of force
if a tooth had a short root;
(3) during translation of a tooth, very little hyalinization
was observed.
Ref:-Reitan K. Some factors determining the evaluation of force is orthodontics. Am J Orthod 1957;43:32-45.
10.
11. Bone remodeling consists of loss of bone mass at PDL pressure
areas and apposition at tension areas.This succession of events
formed the central theme of the pressure-tension hypothesis.
Baumrind considered the PDL to be a continuous hydrostatic
system and suggested that any force delivered to it would be
transmitted equally to all regions.
Ref:-Mostafa YA, Weaks-Dybrig M, Osdoby P. Orchestration of tooth movement. Am J Orthod 1983;83:245-50.
12.
13. The bone-bending theory
Farrar1888,
Baumrind and Grimm, when an orthodontic appliance is activated,
forces delivered to the tooth are transmitted to all tissues near force
application. These forces bend bone, tooth, and the solid structures
of the PDL.
Bone was found to be more elastic than the other tissues and to
bend far more readily in response to force application. These
processes are accelerated while the bone is held in the deformed
position.
Ref-Farrar JN. Irregularities of the teeth and their correction. Vol 1.
New York: DeVinne Press; 1888. p. 658.
14.
15. With the help of this theory authors could explain facts such
as
(1)the relative slowness of en-masse tooth movement, when
much bone flexion is needed for the rapidity of alignment of
crowded teeth, and when thinness makes bone flexion easier;
(2)the rapidity of tooth movement toward an extraction site; and
(3)the relative rapidity of tooth movement in children, who have
less heavily calcified and more flexible bones than adults.
Ref-Baumrind S. A reconsideration of the property of the pressure
tension hypothesis. Am J Orthod 1969;55:12-22.
16. Bioelectric signals in orthodontic tooth movement
Bassett and Becker,1962
They demonstrated that the concave side of orthodontically treated
bone is electronegative and favors osteoblastic activity, whereas the
areas of positivity or electrical neutrality—convex surfaces—showed
elevated osteoclastic activity.
It has been proposed by Davidovitch et al that a physical relationship
exists between mechanical and electrical perturbation of bone. Bending
of bone causes 2 classes of stress-generated electrical effects.
Ref-Basset CAL, Becker RO. Generation of electric potentials by bone
in response to mechanical stress. Science 1962;137:1063-5.
19. Borgens investigated this phenomenon in bone fracture
sites by inducing electric current for healing purposes.
No correlation
However, he observed generation of endogenous ionic
currents evoked in intact and damaged mouse bones,
and classified these currents as stress-generated
potentials or streaming potentials, rather than
piezoelectric currents.
20. In contrast to piezoelectric spikes, the streaming potentials had long
decay periods.
This finding led him to hypothesize that the mechanically stressed
bone cells themselves, not the matrix, are the source of the electric
current.
According to this explanation, an electric double layer surrounds
bone, where electric charges flow in coordination with stress related
fluid flow.
These stress-generated potentials might affect the charge of cell
membranes and of macromolecules in the neighborhood.
21. Davidovitch et al suggested recently that piezoelectric potentials
result from distortion of fixed structures of the periodontium—
collagen, hydroxyapatite, or bone cell surface.
But in hydrated tissues, streaming potentials predominate as the
interstitial fluid moves.
They further reported that mechanical perturbations of about 1
minute per day are apparently sufficient to cause an osteogenic
response, perhaps due to matrix proteoglycan related strain
memory.
22. SIGNALING MOLECULES AND METABOLITES IN
ORTHODONTIC TOOTH MOVEMENT
Arachidonic acid metabolites
Arachidonic (eicosatetraenoic) acid, the main component of
phospholipids of the cell membrane, is released due to the action of
phospholipase enzymes.
The released acid can be metabolized by 2 pathways—
1. the cyclooxygenase pathway (with the help of cyclooxygenase enzymes
producing prostaglandins and thromboxanes) and
2. the lipooxygenase pathway leading to release of leukotriens and
hydroxyeicosatetraenoic acids.
23. Prostaglandins in tooth movement
Yamasaki et al found an increase in osteoclast numbers and
their capacity to form a ruffled border and effect bone
resorption after a local injection of prostaglandins(PGE1 and
PGE2) into the paradental tissues of rodents.
This association was demonstrated by the reduced rate of tooth
movement after the administration of indomethacin.
PGE2 also stimulates osteoblastic cell differentiation and new
bone formation, coupling bone resorption in vitro.
24. GROWTH FACTOR ACTION
transforming
growth factor β (TGFβ)
enhance osteoclast differentiation in haemopeotic cells
insulin-like growth factor
(IGF)
Influence cal.influx & DNA synthesis,
Stimulate osteoblastic function
Platelets derived growth
factor (PDGF)
activation of phospholipase A2-release of arachidonic acid, which,, leads to
formation of prostaglandins and leucotriens via cyclooxygenase and lipooxygenase
activity
M-CSF is the most potent in stimulating bone-marrow cells to produce osteoclasts, followed
by GM-CSF, IL-3, and G-CSF.
CYTOKINES ACTION
IL-1 Directly stimulate osteoclastic function through IL-1 type 1 receptor expressed by
osteoclasts
IL-8 PDL tension site, a triggering factor for bone remodeling
Tumor necrosis
factor
(TNF)alpha
directly stimulates the differentiation of osteoclast progenitors to osteoclasts in the
presence of macrophage colony-stimulating factor (M-CSF).
gamma
interferon
(IFNγ)
Evokes the synthesis of other cytokines, such as IL-1 and TNFα.
26. Application of
mechanical force
Movement of PDL
fluids
strain in cells and
ECM
transduction of
mechanical
forces to the
nucleus
Release of
neuropeptides
Interaction with
endothelial cells
circulating
leukocyte
Plasma
extravasation
diapedesis
release of signal
molecules
Interaction of
paradental cells
with the signal
molecules
Activation of the
cells
Recent model for pathway of tooth movement (jones et al,1991)
27. Conclusion
Rapid advances in all biological fields have enabled us to
better understand the mechanisms involved in orthodontic
tooth movement.
It is evident that, at different stages of tooth movement,
different combinations of cell-cell and cell-matrix interactions
occur;these determine the nature of the remodeling changes.
The research trend is now directed toward elucidating
molecular level interactions during these events.
A better understanding of the relationship between genes and
transcription factors in controlling bone and PDL remodeling
will expand our knowledge, and might strengthen our clinical
capabilities.
28. References:-
Proffit WR, Fields HW,Contemporary orthodontics.5th edition
Farrar JN. Irregularities of the teeth and their correction. Vol 1.New York: DeVinne
Press; 1888. p. 658.
Baumrind S. A reconsideration of the property of the pressure tension hypothesis.
Am J Orthod 1969;55:12-22.
Basset CAL, Becker RO. Generation of electric potentials by bone in response to
mechanical stress. Science 1962;137:1063-5.
Reitan K. Tissue behavior during orthodontic tooth movement.Am J Orthod
1960;46:881-90.
Mostafa YA, Weaks-Dybrig M, Osdoby P. Orchestration of tooth movement. Am J Orthod
1983;83:245-50.
Editor's Notes
orthopedic force is defined as “force of higher magnitude in relation to an orthodontic force, when delivered via teeth for 12 to 16 hours a day, is supposed to produce a skeletal effect on the maxillofacial complex.”glossary of ortho terms >300gm (orthodontic force-20-150gm)
Orthodontic tooth movement differs markedly from physiological dental drift or tooth eruption.
Paradental-including dental pulp, periodontal ligament (PDL), alveolar bone, and gingiva.
Acc 2 profit orthodontic tooth movement has been defined as
D research work by sandstedt,Oppenheim & Schwartz lead d foundation of pressure tension theory.
This theory explains that a tooth moves in the periodontal space by generating a “pressure side” and a “tension side.”
1-compressed PDL contains necrotic (hyalinized) zone,wch is being removed by cells from surrounding viable PDL
2-stretched PDL,new bony trabeculae seen extending into widened PDL space in direction of applied force
A-normal perfusion of PDL,
B-compressed PDL-dec amt of perfusion/bld flow through compressed area
C-heavy force almost completely obliterate bld flow in compressed area,
area said to be hyalinised becoz of its resemblance to hyaline cartilage
On d Side away from direction of tooth movement,d pdl space is enlarged & bld vessel dilate.
Expanded vessel seen on tension side
Increased magnitude of pressure causes total occlusion of bld vessel nd a sterile necrosis of PDL tissue.
When d bld flow is totally cut off,differentiation of osteoclast wid in d pdl space is not possible.
After a delay of several days,osteoclast wid in adjacent marrow spaces attack d underside of d lamina dura in d process called undermining resorption
The first sign of hyalinization is the presence of pyknotic nuclei in cells, followed by areas of acellularity, or cell-free zones.
The resolution of the problem starts when cellular elements such as macrophages, foreign body giant cells, and osteoclasts from adjacent undamaged areas invade the necrotic tissue.
These cells also resorb the underside of bone immediately adjacent to the necrotic PDL area and remove it together with the necrotic tissue.
This process is known as undermining resorption.
Undermining resorption” because it occurs on the underside of lamina dura, not between lamina dura and the root.
frontal resorption (where osteoclasts line up in the margin of the alveolar bone adjacent to the compressed PDL, producing direct bone resorption)
Baumrind drew support for this concept from Pascal’s law.
He further stated that the presence of fibers in the PDL does not modify the operation of this law, because of the concomitant existence of a continuous body of liquefied ground substance.
When a teeth is subjected to force,quick displacement of the tooth within the pdl space is prevented by d incompressible tissue fluid.
Instead d force is transmitted to d alveolar bone which bends in response.
Farrar was the first to suggest, that alveolar bone bending plays a pivotal role in orthodontic tooth movement.
Zengo Bassett Becker supported d theory by dere experiment on dog mandible 4 canine tipping
These authors further stated that“reorganization proceeds not only at the lamina dura of the alveolus, but also on the surface of every trabaculum within the corpus of bone.”
In areas of PDL tension, the interfacing bone surface assumes a concave configuration, in which the molecules are compressed,
whereas, in zones of compressed PDL, the adjacent alveolar bone surface becomes convex.
Epker and Frost described the change in shape of the alveolar bone circumference resulting from stretching the PDL fibers.
Secondary remodeling changes: Bony changes also takes place elsewhere to maintain the width or thickness of alveolar bone.
In 1962, Bassett and Becker proposed that, in response to applied mechanical forces, there is generation of electric potentials in the stressed tissues
These potentials might charge macromolecules that interact with specific sites in cell membranes or mobilize ions across cell membranes.
Alveolar bone bending deforms d crystalline structure resulting in production of electric signal.
These electric signals change bone metabolism and stimulate osteoblast & osteoclast cell differentiation,which ultimately results in tooth movement.
The word Piezoelectric is derived from the Greek piezein, which means to squeeze or press, and piezo, which is Greek for “push”.
Piezoelectricity is a phenomenon observed in many crystalline materials, in which a deformation (by mechanical stress) of a crystal structure produces a flow of electric current as electrons are displaced from 1 part of the lattice to another.
Apart from inorganic crystals, it was found that organic crystals could also exhibit piezoelectricity.
Piezoelectric signals have two unusual characteristics:
•Quick decay rate.
•When the force is released, the electrons flow in the opposite direction
He found no correlation to what have been proposed as piezoelectric effects
as d dispersion of current is unpredictable
due to the complexity of distribution of mineralized and nonmineralized matrices.
A quick decay rate shd not happen once ortho t/t is over
(the electrokinetic effects that arise when the electrical double layer overlying a charged surface is displaced)
Arachidonic acid is main component of cell membrane wchich get metabolized to produce pg & leukotriene molecules by cox nd lipoxygenase pathway
Von Euler first discovered pg & Harell et al suggested that prostaglandins are important
mediators of mechanical stress,
Klein & riasz,1970 reported first time d involvement of pg in ortho tooth movement
Indomethacin-an anti-inflammatory agent and a specific inhibitor of prostaglandin synthesis.
Pg inc intracellular camp level & calcium accumulation hich modulate & activate ostroclastic activity
The early phase of orthodontic tooth movement always involves an acute inflammatory response.
These migratory cells produce various cytokines, the local biochemical signal molecules, that interact directly or indirectly with the entire population of native paradental cells
Macrophage,granulocyte
Sutherland and Rall established the second-messenger basis for hormone actions in 1958
first messenger (PTH,platelets derived gr factor,interleukin,other cytokine) binds to a specific receptor on the cell membrane and produces an intracellular chemical second messenger.
This second messenger then interacts with cellular
enzymes, evoking a response, such as protein synthesis. Two main second-messenger systems are now recognized—the cyclic nucleotide pathway and the phosphatidyl inositol (PI) dual signaling system.
These systems mobilize internal calcium stores and activate protein kinase C, respectively.
The activation of specific protein kinases, together with an increase in intracellular calcium concentrations, might trigger a number of protein phosphorylation events. This response might comprise motility,contraction, proliferation,synthesis, and secretion.
It has been concluded that inflammation of paradental tissues occur every time they are exposed to an orthodontic force, whether the magnitude is light or heavy.
after the application of mechanical forces PDL fluids move from areas of compression into areas of tension.
● resulting in A gradual development of strain in cells and ECM in involved paradental tissues.
● Direct transduction of this mechanical forces to the nucleus of strained cells through the cytoskeleton, leading to activation of specific genes.
● there occurs Release of neuropeptides (nociceptive and vasoactive) from paradental afferent nerve endings.
● Interaction of these neuropeptides with endothelial cells cause
● Adhesion of circulating leukocyte to activated endothelial cells &
● Plasma extravasation from dilated blood vessels.
● leukocytes migrate by diapedesis into the extravascular space.
● these migrated leukocytes release signal molecules (cytokines, growth factors, and CSFs)
● Interaction of various types of paradental cells with the signal molecules cause
● Activation of the cells to participate in the modeling and remodeling of the paradental tissues.