This document discusses tablet coating defects, their causes, and remedies. It begins with an introduction to tablet coating and why it is done. Common coating defects are then described such as blistering, cratering, pitting, blooming, blushing, orange peel, sticking, picking, color variation, bridging, erosion, and twinning. The causes and remedies for each defect are provided. Critical parameters for successful tablet coating are also listed, including nozzle spacing, spray pattern, spray speed, droplet size, drying temperature, and air speed. References on tablet coating and manufacturing defects are included at the end.
Hard gelatin capsules - a detailed studyTeny Thomas
The presentation involves a descriptive study on hard gelatin capsules which includes the production of the hard gelatin capsule shell, size of the capsules, capsule filling machines and the finishing techniques. The presentation also involves the special techniques of capsule formulation and the quality control tests of hard gelatin capsules
The chapter deals with the preformulation studies that have to be considered while designing a dosage form and developing a formulation that is suitable for a patient. Here, physical and chemical properties of a drug substance are studied along with biopharmaceutical classification of drugs. Also a detailed study on the application of preformulation studies in different dosage forms are also studied.
Hard gelatin capsules - a detailed studyTeny Thomas
The presentation involves a descriptive study on hard gelatin capsules which includes the production of the hard gelatin capsule shell, size of the capsules, capsule filling machines and the finishing techniques. The presentation also involves the special techniques of capsule formulation and the quality control tests of hard gelatin capsules
The chapter deals with the preformulation studies that have to be considered while designing a dosage form and developing a formulation that is suitable for a patient. Here, physical and chemical properties of a drug substance are studied along with biopharmaceutical classification of drugs. Also a detailed study on the application of preformulation studies in different dosage forms are also studied.
A comprehensive interpretation of pellets based on their definitions, advantages, disadvantages, mechanism of pellet formation and growth, pelletization techniques, formulation requirements, and the equipment system for manufacture of pellets.
A detailed study on every aspects of parenteral :- introduction, preformulation factors, essential requirements, vehicles and additives, isotonicity, production procedure, facilities, and controls, container and closure selection and finally the quality control evaluation of parenterals.
Liquid oral topic in Industrial Pharmacy contains many topics like solution, elixirs, syrups, emulsion, and suspension. This topic includes general introduction, types, formulation, components, uses, and Quality control tests. These are also beneficial in other subjects like Pharmaceutics.
The presentation deals with a detailed study of soft gelatin capsules. this involves the production of soft gelatin capsule based on the importance of base adsorption factor and minim/gram factor. also quality control studies was also elaborated.
A comprehensive interpretation of pellets based on their definitions, advantages, disadvantages, mechanism of pellet formation and growth, pelletization techniques, formulation requirements, and the equipment system for manufacture of pellets.
A detailed study on every aspects of parenteral :- introduction, preformulation factors, essential requirements, vehicles and additives, isotonicity, production procedure, facilities, and controls, container and closure selection and finally the quality control evaluation of parenterals.
Liquid oral topic in Industrial Pharmacy contains many topics like solution, elixirs, syrups, emulsion, and suspension. This topic includes general introduction, types, formulation, components, uses, and Quality control tests. These are also beneficial in other subjects like Pharmaceutics.
The presentation deals with a detailed study of soft gelatin capsules. this involves the production of soft gelatin capsule based on the importance of base adsorption factor and minim/gram factor. also quality control studies was also elaborated.
BIOGRUND - Film Coating - Troubleshooting GuideBIOGRUND
Possible causes and remedies for 10 problem cases, which can occur during a film coating process. Every coating process is a challenge.
We take a look on the following most frequent 10 problem cases!
It is an interesting material for all drug enthusiasts around the world. a lot of effort was put into it and I hope that it will benefit everyone in the slide share family.
Tablet coating engineering is one of the prominent topics in pharmaceutical field.
This slide will help pharmacy student to become familiar with coating technology
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
Follow us on: Pinterest
Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
2. Flow of Seminar
Introduction to tablet coating
Need to coat a tablet
Problems and Remedies for tablet
coating
Critical parameters for successful
coating of tablets
3. Tablet coating
Tablet coating is the application of coating material
to the exterior of a tablet with the intention of
conferring benefits and properties to a dosage form
over the uncoated variety.
8-May-18 NIPER Ahmedabad 3
5. Why To Coat a tablet..??
Bitter taste or unpleasant odour.
Protecting the drug from surroundings (Stability).
Handling & ease of ingesting by patients.
Mechanical protection from breakage.
Light incompatibility
Environmental Oxidation.
In-elegant core.
Modifying the drug release profile.
Product identity.
8-May-18 NIPER Ahmedabad 5
6. PROBLEMS AND REMEDIES FOR TABLET COATING
BLISTERING
It is local detachment of film from the substrate forming blister.
Reason: Entrapment of gases in or underneath the film due to overheating
either during spraying or at the end of the coating run
Causes Remedies
Effect of temperature on the
strength, elasticity and adhesion of
the film.
Use mild drying condition.
8-May-18 NIPER Ahmedabad 6
7. CRATERING
• It is defect of film coating whereby volcanic-like craters appears exposing the
tablet surface
• Reason: The coating solution penetrates the surface of the tablet, often at the
crown where the surface is more porous, causing localized disintegration of the
core and disruption of the coating.
Causes Remedies
Inefficient drying.
Higher rate of application of coating
solution.
Use efficient and optimum drying
conditions.
Increase viscosity of coating
solution to decrease spray
application rate.
8-May-18 NIPER Ahmedabad 7
Exposed tablet surface
area due to craters
8. PITTING
It is defect whereby pits occur in the surface of a tablet core without any
visible disruption of the film coating.
Reason: Temperature of the tablet core is greater than the melting point of
the materials used in the tablet formulation.
Causes Remedies
• Inappropriate drying (inlet air )
temperature.
Modifying the drying (inlet air)
temperature such that the
temperature of the tablet core is not
greater than the melting point of the
batch of additives used.
8-May-18 NIPER Ahmedabad 8
9. BLOOMING
It is defect where coating becomes dull immediately or after prolonged storage
at high temperatures.
Reason: It is due to collection on the surface of low molecular weight
ingredients included in the coating formulation. In most circumstances the
ingredient will be plasticizer.
Cause Remedy
High concentration and low
molecular weight of plasticizer.
Decrease plasticizer concentration
and increase molecular weight of
plasticizer.
8-May-18 NIPER Ahmedabad 9
Dull coat
10. BLUSHING
• It is defect best described as whitish specks or haziness in the film
• Reason: It was thought to be due to precipitation of polymer worsened by the
use of high coating temperature.
Causes Remedies
• High coating temperature.
• Use of sorbitol in formulation
which causes largest fall in the
thermal gelation temperature of the
polymers
Decrease the drying air
temperature.
Avoid use of sorbitol with the
polymers.
8-May-18 NIPER Ahmedabad 10
Whitish specks
11. ORANGE PEEL/ROUGHNESS
• It is surface defect resulting in the film being rough and nonglossy.
Appearance is similar to that of an orange.
• Reason: Inadequate spreading of the coating solution before drying
Causes Remedies
• Rapid Drying
• High solution viscosity
Use mild drying conditions.
Use additional solvents to decrease
viscosity of solution.
8-May-18 NIPER Ahmedabad 11
12. STICKING AND PICKING
• Sticking involves sticking of the tablets with each other and with pan walls.
• Picking is the case of sticking involves adhering of some portion of coated
layer to pan or to another tablet at the point of contact.
8-May-18 NIPER Ahmedabad 12
Causes Remedies
• Higher rate of application of coating
solution
• Inefficient drying.
Use optimum and efficient drying
conditions.
Increase the inlet air temperature.
Decrease the rater of application of
coating solution by increasing
viscosity of coating solution.
13. COLOUR VARIATION:
• A defect which involves variation in colour of the film.
• Reason: Alteration of the frequency and duration of appearance of tablets
in the spray zone or the size/shape of the spray zone.
8-May-18 NIPER Ahmedabad 13
Causes Remedies
• Improper mixing, uneven spray
pattern, insufficient coating,
migration of soluble dyes-
plasticizers and other additives
during drying.
Go for geometric mixing,
reformulation with different
plasticizers and additives or use
mild drying conditions.
14. BRIDGING:
• Coating fills in the letter or logo on the tablet .
Causes Remedies
• Poor logo design
• Improper application of coating
solution
• Improper atomization pressure
• High percentage of solid in coating
solution
• High coating viscosity
Increase plasticizer contents or
change plasticizer concentration
Reduce viscosity of coating
solution
8-May-18 NIPER Ahmedabad 14
15. EROSION
• The coating solution gets removes from the surface of the tablets due to
friction amongst themselves.
8-May-18 NIPER Ahmedabad 15
Causes Remedies
• Over-wetted tablet surface
• Inadequate drying
• Lack of tablet surface strength
Control drying rate & temparature
16. TWINNING:
• This term is used when two tablets stick together.
• Reason: Common problem when shape of tablet is capsule shaped.
8-May-18 NIPER Ahmedabad 16
Causes Remedies
• Coating suspension can not be
evaporated.
Reducing spray rate
Increasing pan speed
**In some cases, it is necessary to alter the design of the tooling by very slightly changing
radius.
The change is almost impossible to see (minor), but it solves the twinning problem.
17. Critical parameters to be optimized during coating
• Distance of sprayer from bed (nozzle spacing)
• Spray pattern,
• Spray speed,
• Droplet size,
• Drying temperature (Inlet-outlet)
• Speed of air
8-May-18 NIPER Ahmedabad 17
18. References:
1. Lachman L, Lieberman HA, Joseph LK. The Theory and Practice of Industrial
Pharmacy. Varghese Publishing House; Mumbai; Third Edition: 297-321, 293-345,
346-373.
2. Remington J. Remington: The Science and Practice of Pharmacy; Nineteenth
Edition: Volume II 1615-1641
3. Abhinav singh Rana, S.L. Hari kumar, Manufacturing defects of tablets - a review,
Journal of Drug Delivery & Therapeutics; 2013, 3(6), 200-206
4. Aulton M. Pharmaceutics: The Science of Dosage Form Design; International
Student Edition: 304-321, 347-668.
8-May-18 NIPER Ahmedabad 18