Capsules are solid dosage forms where the drug is enclosed within a shell, typically made of gelatin. There are two main types - hard gelatin capsules which contain powders, granules, or pellets and release their contents rapidly; and soft gelatin capsules which contain liquids or pastes and provide rapid release. Capsules offer advantages like masking unpleasant tastes and smells, easy swallowing, and sustained or delayed release depending on the formulation. They are manufactured through processes like dipping, spinning, drying, stripping, trimming, and joining. Finished capsules are evaluated for content uniformity, disintegration time, moisture content, and dissolution.
This document provides information on soft and hard gelatin capsules. It discusses the classification of capsules, the components and production process of soft gelatin capsules, and the structure, manufacturing, filling principles, and sealing of hard gelatin capsules. Soft gelatin capsules are one-piece and can encapsulate liquids, while hard gelatin capsules have a separate cap and body that are filled and then sealed. The production processes aim to precisely control factors like thickness, moisture levels, and fill weight to produce high quality capsules.
Capsules can be either hard gelatin or soft gelatin shells enclosing solid or liquid drugs. Hard gelatin capsules consist of two pieces - a body and cap - and contain powders, while soft gelatin capsules are one-piece and hermetically sealed, containing liquids. Capsules offer benefits like being tasteless, odorless, easy to administer and swallow, and allow flexible dosing. They also protect unstable drugs and allow combination therapies. However, hygroscopic and concentrated solutions may not be suitable for capsules. Capsules are manufactured through various processes including dipping, spinning, drying, filling, and sealing. Quality tests evaluate weight variation, content uniformity, dissolution, and disintegration
Capsules are solid dosage forms that enclose medicinal substances within a small gelatin shell. There are two main types of gelatin capsules: hard capsules, which consist of a body and cap, and soft capsules, which have a softer shell. Capsules offer advantages like masking unpleasant tastes, allowing powders to dissolve quickly, and providing flexibility in dosing. They are produced by dipping pins in a melted gelatin mixture. Various sizes are available for different doses. The process of filling capsules involves preparing the formulation, selecting the capsule size, filling the shells, and cleaning the finished capsules.
Hard gelatin capsules are solid dosage forms where medicaments are enclosed in gelatin shells. They have advantages like easy swallowing, taste masking, and rapid drug release. Capsules are filled using semi-automatic or automatic machines that employ various techniques like piston tamping or vibratory filling. After filling, capsules are polished, evaluated for quality parameters like weight variation and content uniformity, and packaged and stored properly. Modern filling machines can fill thousands of capsules per hour.
Hard and soft gelatin capsules are commonly used solid oral dosage forms. Recent advancements include non-gelatin capsules made from HPMC or starch which provide alternatives for people with gelatin allergies. The manufacturing process for hard gelatin capsules involves dipping pins in gelatin solution to form shells, drying the shells, stripping them from the pins, trimming, joining, and polishing. Soft gelatin capsules are manufactured using various processes like plate, rotary die, or reciprocating die methods. Quality control checks are performed during manufacturing and evaluation includes testing for stability, content uniformity, disintegration, and dissolution.
Hard gelatin capsules are solid dosage forms where medicaments are enclosed in gelatin shells composed of two sections called caps and bodies. Capsules offer advantages like easy swallowing, taste masking, and protection from light. They are manufactured by dipping stainless steel pins in gelatin solution, spinning to distribute gelatin uniformly, drying, stripping caps and bodies, trimming, and joining. Capsules are filled using machines that separate caps from bodies, fill powder into bodies using various techniques like auger filling or piston tamping, scrape excess powder, replace caps, and seal capsules. Finished capsules are evaluated for tests like disintegration, dissolution, content uniformity and weight variation.
This document provides information on soft and hard gelatin capsules. It discusses the classification of capsules, the components and production process of soft gelatin capsules, and the structure, manufacturing, filling principles, and sealing of hard gelatin capsules. Soft gelatin capsules are one-piece and can encapsulate liquids, while hard gelatin capsules have a separate cap and body that are filled and then sealed. The production processes aim to precisely control factors like thickness, moisture levels, and fill weight to produce high quality capsules.
Capsules can be either hard gelatin or soft gelatin shells enclosing solid or liquid drugs. Hard gelatin capsules consist of two pieces - a body and cap - and contain powders, while soft gelatin capsules are one-piece and hermetically sealed, containing liquids. Capsules offer benefits like being tasteless, odorless, easy to administer and swallow, and allow flexible dosing. They also protect unstable drugs and allow combination therapies. However, hygroscopic and concentrated solutions may not be suitable for capsules. Capsules are manufactured through various processes including dipping, spinning, drying, filling, and sealing. Quality tests evaluate weight variation, content uniformity, dissolution, and disintegration
Capsules are solid dosage forms that enclose medicinal substances within a small gelatin shell. There are two main types of gelatin capsules: hard capsules, which consist of a body and cap, and soft capsules, which have a softer shell. Capsules offer advantages like masking unpleasant tastes, allowing powders to dissolve quickly, and providing flexibility in dosing. They are produced by dipping pins in a melted gelatin mixture. Various sizes are available for different doses. The process of filling capsules involves preparing the formulation, selecting the capsule size, filling the shells, and cleaning the finished capsules.
Hard gelatin capsules are solid dosage forms where medicaments are enclosed in gelatin shells. They have advantages like easy swallowing, taste masking, and rapid drug release. Capsules are filled using semi-automatic or automatic machines that employ various techniques like piston tamping or vibratory filling. After filling, capsules are polished, evaluated for quality parameters like weight variation and content uniformity, and packaged and stored properly. Modern filling machines can fill thousands of capsules per hour.
Hard and soft gelatin capsules are commonly used solid oral dosage forms. Recent advancements include non-gelatin capsules made from HPMC or starch which provide alternatives for people with gelatin allergies. The manufacturing process for hard gelatin capsules involves dipping pins in gelatin solution to form shells, drying the shells, stripping them from the pins, trimming, joining, and polishing. Soft gelatin capsules are manufactured using various processes like plate, rotary die, or reciprocating die methods. Quality control checks are performed during manufacturing and evaluation includes testing for stability, content uniformity, disintegration, and dissolution.
Hard gelatin capsules are solid dosage forms where medicaments are enclosed in gelatin shells composed of two sections called caps and bodies. Capsules offer advantages like easy swallowing, taste masking, and protection from light. They are manufactured by dipping stainless steel pins in gelatin solution, spinning to distribute gelatin uniformly, drying, stripping caps and bodies, trimming, and joining. Capsules are filled using machines that separate caps from bodies, fill powder into bodies using various techniques like auger filling or piston tamping, scrape excess powder, replace caps, and seal capsules. Finished capsules are evaluated for tests like disintegration, dissolution, content uniformity and weight variation.
This document provides information on capsules, including definitions, advantages, disadvantages, types (hard gelatin and soft gelatin capsules), and manufacturing processes. It defines capsules as solid preparations with shells containing a single dose of active ingredients. Hard gelatin capsules are made of gelatin and can contain powders, granules, or pellets, while soft gelatin capsules contain liquids, suspensions, or semisolids. The manufacturing of both types involves processes like dipping, drying, trimming, and filling. Specifications for gelatin and requirements for capsules in compendia are also outlined.
Capsules are a solid dosage form with a drug substance enclosed in a water soluble shell made of gelatin. They come in both hard and soft forms. Capsules have advantages like masking unpleasant tastes and smells, allowing sustained release, and being economical and easy to handle. However, hygroscopic drugs cannot be filled in capsules as they may absorb water and break. Capsules come in various standard sizes depending on their capacity. Soft gelatin capsules can have different shapes and their contents include liquids or solids dissolved in excipients to form a paste. They are sealed during the combined filling and sealing operation on machines.
This document discusses soft gelatin capsules (softgels). Softgels consist of a liquid or semi-solid matrix inside a one-piece gelatin shell. The shell contains gelatin, water, and a plasticizer, and can be colored and flavored. Softgels are commonly used to deliver lipophilic liquids, hydrophilic liquids, suspensions, and other formulations. They are manufactured using a rotary die process where gelatin ribbons are sealed around liquid doses to form capsules. Softgels offer benefits like improved drug absorption, patient acceptability, and stability compared to other dosage forms.
1. The document discusses different types of capsules including hard gelatin capsules and soft gelatin capsules.
2. Hard gelatin capsules contain medicaments in dry powder form enclosed in a hard shell, while soft gelatin capsules contain liquids, suspensions, or semisolids in a soft soluble shell.
3. The production, filling, finishing, and quality control testing of hard gelatin capsules is described in detail. Methods for ensuring uniformity of weight and content are outlined.
In the manufacture of pharmaceuticals, encapsulation refers to a range of dosage forms—techniques used to enclose medicines—in a relatively stable shell known as a capsule, allowing them to, for example, be taken orally or be used as suppositories. The two main types of capsules are:
Hard-shelled capsules, which contain dry, powdered ingredients or miniature pellets made by e.g. processes of extrusion or spheronization. These are made in two halves: a smaller-diameter “body” that is filled and then sealed using a larger-diameter “cap”.
Soft-shelled capsules, primarily used for oils and for active ingredients that are dissolved or suspended in oil.
Capsules are solid dosage forms that enclose the drug substance within a soluble shell or envelope, primarily for oral delivery. There are two main types: hard gelatin capsules that contain solid medicines, and soft gelatin capsules that contain liquid or semi-solid medicines. Hard gelatin capsules are manufactured through a dipping, spinning, drying, and joining process to form two-piece capsules. Soft gelatin capsules are produced through plate or rotary die processes that fill and seal liquid-filled shells simultaneously. Both types require drying and may be polished before storage.
Capsules are tasteless, odorless and can easily be
administered.
Combination of powders we can use
There are attractive in appearance.
The drugs having un-pleasant odor and taste are
enclosed in a tasteless shell.
They can be filled quickly and conveniently.
Physician can change the dose and combination of drug
according to patient requirement.
They are economical.
They are easy to handle and carry.
Hard and soft gelatin capsules are two types of capsules used for drug delivery. Hard capsules contain dry ingredients and disintegrate quickly once swallowed. They are made by dipping pins in gelatin solutions to form two-piece shells. Soft capsules contain liquids or semi-solids and have plasticized gelatin shells that are manufactured using plate, rotary die, or reciprocating processes. Both types of capsules are evaluated for stability, content uniformity, and disintegration time.
The document discusses capsules and their manufacturing process. It describes hard gelatin capsules and their production, including dipping pins in gelatin solution, drying, stripping capsules off pins, trimming, joining, polishing and sorting. The key steps in filling hard capsules are separating caps and bodies, filling bodies with powder, replacing caps, cleaning, and ejecting. Quality tests evaluate thickness, size, moisture content, and solubility. Soft gelatin capsules and pellets are also briefly mentioned.
This document provides information about packing soft gelatin capsules. It discusses the advantages and disadvantages of soft gel capsules. The anatomy and composition of the capsule shell and content are described. The manufacturing process involves making the gelatin mass, filling the capsules, drying and packaging them. Quality is ensured through ingredient specifications, in-process testing of shell thickness, fill weight and moisture levels. Finished products are tested for appearance, assay, content uniformity and microbiology. Vegicaps are introduced as an animal-free alternative with benefits such as being natural and free of animal derivatives.
hard and soft gelatin capsule shell manufacturing. preparation of shell fluid, preparation of fill material and manufacturing process. machineries and equipment for capsule manufacturing. stability and quality control
A presentation on Hard Gelatin CapsuleFaruk Hossen
This document presents information on a student group project about hard gelatin capsules. It includes sections on the introduction, parts of capsules, types of capsules focusing on hard gelatin capsules. Details are provided on the ingredients, sizes, criteria, differences between hard and soft gelatin capsules. The document also discusses the formulation of gelatin, manufacturing process, filling methods, advantages, disadvantages, evaluation methods and concludes with thanks.
This document discusses key concepts in preformulation testing. It begins by defining preformulation as investigating the physical and chemical properties of a drug substance alone and combined with excipients. The overall goal is to generate information useful for developing stable and safe dosage forms.
It then outlines some of the main steps in preformation process including assessing organoleptic properties, purity, particle size, melting point, stability, excipient compatibility, solubility, polymorphism, pH and salt formation. Specific tests are mentioned for many of these areas.
The document emphasizes that preformulation is important for aiding drug candidate selection, product design, decreasing time to market, and ensuring overall safety and efficacy of the final product
The document discusses capsules and the capsule manufacturing process. It provides details on:
- The parts of capsules including the cap and body.
- The two main types of capsules - hard gelatin capsules and soft gelatin capsules.
- The manufacturing process for hard gelatin capsules including dipping, spinning, drying, filling, sealing and cleaning steps.
- Capsule sizes ranging from size 000 to size 5.
- The production of soft gelatin capsules using plate, rotary die and Accogel processes.
These defects can cause serious injury and harm. When this occurs, you should speak with our product liability attorneys in Denver. You may have a viable claim to file a product liability lawsuit against the negligent manufacturer.Capsules are solid dosage forms in which the drug substance is enclosed within either a hard or soft soluble shell. Generally the shells are formed from gelatin. The capsule may be regarded as “container” drug delivery system, which provides a tasteless/odorless dosage form without the need of a secondary coating step, as may be required for tablets.Capsules are one of the essential components of the pharmaceutical sector. They are mainly used to hold dry powder or little pellets of medication and are made using specific machinery and techniques. The capsule's production method entails pharmaceutically active ingredients, additives, and a cover. Every pharmaceutical business understands capsule manufacturing takes time, and the reason is the critical measures.
Capsules are solid dosage forms that enclose medicinal substances within a small gelatin shell. There are two main types of gelatin capsules: hard capsules, which consist of a body and cap, and soft capsules, which have a softer shell. Capsules offer advantages like masking unpleasant tastes, allowing powders to dissolve quickly, and providing flexibility in dosing. They are filled by preparing a formulation that may include active ingredients, diluents, lubricants, and glidants. The powder is then filled into capsule shells of appropriate sizes and polished.
This document summarizes the manufacturing and evaluation of hard and soft gelatin capsules. It discusses the types of gelatin used, the parts of capsules, and methods for manufacturing empty and filled capsules. Hard gelatin capsules are made through dipping, spinning, drying, stripping, trimming and joining processes. Soft gelatin capsules can be made via plate, rotary die or reciprocating die methods. The document also covers important gelatin specifications, tests for capsule stability, content uniformity, disintegration and dissolution. Evaluation ensures the quality and performance of gelatin capsules.
Solid unit dosage forms the drug is enclosed within the water-soluble shell or an envelope either a hard or soft shell. Shell is typically made of gelatin primarily intended for oral delivery and provides a rapid release of contents.
Generally, the shells are formed from gelatin.
This document discusses hard and soft gelatin capsules. It defines capsules as solid dosage forms where the drug substance is enclosed within soluble gelatin shells. Hard gelatin capsules consist of two pieces (cap and body) while soft gelatin capsules have a single flexible shell. The document describes the production process for hard capsules including dipping, drying, stripping, filling and quality control tests. It also covers the composition, advantages and packaging of capsules.
This document discusses hard and soft gelatin capsules. It defines capsules as solid dosage forms where the drug substance is enclosed within soluble gelatin shells. Hard gelatin capsules consist of two pieces (cap and body) while soft gelatin capsules have a single flexible shell. The document describes the production process for hard capsules including dipping, drying, and filling steps. It also discusses advantages like taste masking and disadvantages like incompatibility with hygroscopic drugs. Quality control tests for capsules include disintegration, weight variation, and dissolution testing.
This document provides information on capsules, including definitions, advantages, disadvantages, types (hard gelatin and soft gelatin capsules), and manufacturing processes. It defines capsules as solid preparations with shells containing a single dose of active ingredients. Hard gelatin capsules are made of gelatin and can contain powders, granules, or pellets, while soft gelatin capsules contain liquids, suspensions, or semisolids. The manufacturing of both types involves processes like dipping, drying, trimming, and filling. Specifications for gelatin and requirements for capsules in compendia are also outlined.
Capsules are a solid dosage form with a drug substance enclosed in a water soluble shell made of gelatin. They come in both hard and soft forms. Capsules have advantages like masking unpleasant tastes and smells, allowing sustained release, and being economical and easy to handle. However, hygroscopic drugs cannot be filled in capsules as they may absorb water and break. Capsules come in various standard sizes depending on their capacity. Soft gelatin capsules can have different shapes and their contents include liquids or solids dissolved in excipients to form a paste. They are sealed during the combined filling and sealing operation on machines.
This document discusses soft gelatin capsules (softgels). Softgels consist of a liquid or semi-solid matrix inside a one-piece gelatin shell. The shell contains gelatin, water, and a plasticizer, and can be colored and flavored. Softgels are commonly used to deliver lipophilic liquids, hydrophilic liquids, suspensions, and other formulations. They are manufactured using a rotary die process where gelatin ribbons are sealed around liquid doses to form capsules. Softgels offer benefits like improved drug absorption, patient acceptability, and stability compared to other dosage forms.
1. The document discusses different types of capsules including hard gelatin capsules and soft gelatin capsules.
2. Hard gelatin capsules contain medicaments in dry powder form enclosed in a hard shell, while soft gelatin capsules contain liquids, suspensions, or semisolids in a soft soluble shell.
3. The production, filling, finishing, and quality control testing of hard gelatin capsules is described in detail. Methods for ensuring uniformity of weight and content are outlined.
In the manufacture of pharmaceuticals, encapsulation refers to a range of dosage forms—techniques used to enclose medicines—in a relatively stable shell known as a capsule, allowing them to, for example, be taken orally or be used as suppositories. The two main types of capsules are:
Hard-shelled capsules, which contain dry, powdered ingredients or miniature pellets made by e.g. processes of extrusion or spheronization. These are made in two halves: a smaller-diameter “body” that is filled and then sealed using a larger-diameter “cap”.
Soft-shelled capsules, primarily used for oils and for active ingredients that are dissolved or suspended in oil.
Capsules are solid dosage forms that enclose the drug substance within a soluble shell or envelope, primarily for oral delivery. There are two main types: hard gelatin capsules that contain solid medicines, and soft gelatin capsules that contain liquid or semi-solid medicines. Hard gelatin capsules are manufactured through a dipping, spinning, drying, and joining process to form two-piece capsules. Soft gelatin capsules are produced through plate or rotary die processes that fill and seal liquid-filled shells simultaneously. Both types require drying and may be polished before storage.
Capsules are tasteless, odorless and can easily be
administered.
Combination of powders we can use
There are attractive in appearance.
The drugs having un-pleasant odor and taste are
enclosed in a tasteless shell.
They can be filled quickly and conveniently.
Physician can change the dose and combination of drug
according to patient requirement.
They are economical.
They are easy to handle and carry.
Hard and soft gelatin capsules are two types of capsules used for drug delivery. Hard capsules contain dry ingredients and disintegrate quickly once swallowed. They are made by dipping pins in gelatin solutions to form two-piece shells. Soft capsules contain liquids or semi-solids and have plasticized gelatin shells that are manufactured using plate, rotary die, or reciprocating processes. Both types of capsules are evaluated for stability, content uniformity, and disintegration time.
The document discusses capsules and their manufacturing process. It describes hard gelatin capsules and their production, including dipping pins in gelatin solution, drying, stripping capsules off pins, trimming, joining, polishing and sorting. The key steps in filling hard capsules are separating caps and bodies, filling bodies with powder, replacing caps, cleaning, and ejecting. Quality tests evaluate thickness, size, moisture content, and solubility. Soft gelatin capsules and pellets are also briefly mentioned.
This document provides information about packing soft gelatin capsules. It discusses the advantages and disadvantages of soft gel capsules. The anatomy and composition of the capsule shell and content are described. The manufacturing process involves making the gelatin mass, filling the capsules, drying and packaging them. Quality is ensured through ingredient specifications, in-process testing of shell thickness, fill weight and moisture levels. Finished products are tested for appearance, assay, content uniformity and microbiology. Vegicaps are introduced as an animal-free alternative with benefits such as being natural and free of animal derivatives.
hard and soft gelatin capsule shell manufacturing. preparation of shell fluid, preparation of fill material and manufacturing process. machineries and equipment for capsule manufacturing. stability and quality control
A presentation on Hard Gelatin CapsuleFaruk Hossen
This document presents information on a student group project about hard gelatin capsules. It includes sections on the introduction, parts of capsules, types of capsules focusing on hard gelatin capsules. Details are provided on the ingredients, sizes, criteria, differences between hard and soft gelatin capsules. The document also discusses the formulation of gelatin, manufacturing process, filling methods, advantages, disadvantages, evaluation methods and concludes with thanks.
This document discusses key concepts in preformulation testing. It begins by defining preformulation as investigating the physical and chemical properties of a drug substance alone and combined with excipients. The overall goal is to generate information useful for developing stable and safe dosage forms.
It then outlines some of the main steps in preformation process including assessing organoleptic properties, purity, particle size, melting point, stability, excipient compatibility, solubility, polymorphism, pH and salt formation. Specific tests are mentioned for many of these areas.
The document emphasizes that preformulation is important for aiding drug candidate selection, product design, decreasing time to market, and ensuring overall safety and efficacy of the final product
The document discusses capsules and the capsule manufacturing process. It provides details on:
- The parts of capsules including the cap and body.
- The two main types of capsules - hard gelatin capsules and soft gelatin capsules.
- The manufacturing process for hard gelatin capsules including dipping, spinning, drying, filling, sealing and cleaning steps.
- Capsule sizes ranging from size 000 to size 5.
- The production of soft gelatin capsules using plate, rotary die and Accogel processes.
These defects can cause serious injury and harm. When this occurs, you should speak with our product liability attorneys in Denver. You may have a viable claim to file a product liability lawsuit against the negligent manufacturer.Capsules are solid dosage forms in which the drug substance is enclosed within either a hard or soft soluble shell. Generally the shells are formed from gelatin. The capsule may be regarded as “container” drug delivery system, which provides a tasteless/odorless dosage form without the need of a secondary coating step, as may be required for tablets.Capsules are one of the essential components of the pharmaceutical sector. They are mainly used to hold dry powder or little pellets of medication and are made using specific machinery and techniques. The capsule's production method entails pharmaceutically active ingredients, additives, and a cover. Every pharmaceutical business understands capsule manufacturing takes time, and the reason is the critical measures.
Capsules are solid dosage forms that enclose medicinal substances within a small gelatin shell. There are two main types of gelatin capsules: hard capsules, which consist of a body and cap, and soft capsules, which have a softer shell. Capsules offer advantages like masking unpleasant tastes, allowing powders to dissolve quickly, and providing flexibility in dosing. They are filled by preparing a formulation that may include active ingredients, diluents, lubricants, and glidants. The powder is then filled into capsule shells of appropriate sizes and polished.
This document summarizes the manufacturing and evaluation of hard and soft gelatin capsules. It discusses the types of gelatin used, the parts of capsules, and methods for manufacturing empty and filled capsules. Hard gelatin capsules are made through dipping, spinning, drying, stripping, trimming and joining processes. Soft gelatin capsules can be made via plate, rotary die or reciprocating die methods. The document also covers important gelatin specifications, tests for capsule stability, content uniformity, disintegration and dissolution. Evaluation ensures the quality and performance of gelatin capsules.
Solid unit dosage forms the drug is enclosed within the water-soluble shell or an envelope either a hard or soft shell. Shell is typically made of gelatin primarily intended for oral delivery and provides a rapid release of contents.
Generally, the shells are formed from gelatin.
This document discusses hard and soft gelatin capsules. It defines capsules as solid dosage forms where the drug substance is enclosed within soluble gelatin shells. Hard gelatin capsules consist of two pieces (cap and body) while soft gelatin capsules have a single flexible shell. The document describes the production process for hard capsules including dipping, drying, stripping, filling and quality control tests. It also covers the composition, advantages and packaging of capsules.
This document discusses hard and soft gelatin capsules. It defines capsules as solid dosage forms where the drug substance is enclosed within soluble gelatin shells. Hard gelatin capsules consist of two pieces (cap and body) while soft gelatin capsules have a single flexible shell. The document describes the production process for hard capsules including dipping, drying, and filling steps. It also discusses advantages like taste masking and disadvantages like incompatibility with hygroscopic drugs. Quality control tests for capsules include disintegration, weight variation, and dissolution testing.
Presentation2Non Sterile manufacturing Process Technology Capsules(hard & sof...AjayGhuge9
Non-sterile manufacturing processes are used to produce hard and soft gelatin capsules. Hard capsules consist of two pieces that fit together, while soft capsules have a flexible plasticized gelatin shell. The production process for hard capsules involves dipping pins in gelatin solution, drying and stripping the shells, trimming, filling powdered drugs, and quality control testing. Soft capsules are filled with liquid or suspension and the single-piece shells contain additional plasticizers and preservatives. Both types of capsules are packaged and stored properly to protect from moisture and ensure quality.
Non Sterile manufacturing Process Technology Capsules(hard & soft).pptxAjayGhuge9
Non-sterile manufacturing processes are used to produce hard and soft gelatin capsules. Hard capsules consist of two pieces that fit together, while soft capsules have a flexible plasticized gelatin shell. The production process for hard capsules involves dipping pins in gelatin solution, drying and stripping the shells, trimming, filling powdered drugs, and quality control testing. Soft capsules are filled with liquid or suspension and the single-piece shells contain additional plasticizers and preservatives. Both types of capsules are packaged and stored properly to protect from moisture and ensure quality.
Capsules are solid dosage forms that enclose medicinal or inert substances within a soluble shell, usually made of gelatin. There are two main types: hard gelatin capsules and soft gelatin capsules. Hard capsules have two cylindrical sections that are joined together, while soft capsules are one-piece shells containing liquids or semisolids. Capsules offer advantages like rapid drug release, flexibility in formulation, and taste masking, but have disadvantages related to size limitations, moisture control issues, and potential difficulty swallowing large sizes. Quality control tests evaluate attributes like shape, size, disintegration time, and drug content uniformity.
Capsules are solid dosage forms that contain a drug enclosed within a hard or soft soluble shell, usually made of gelatin. There are two main types: hard gelatin capsules, which consist of two pieces that are joined, and soft gelatin capsules, which have a soft, one-piece shell. Capsules offer benefits like being tasteless, odorless, and easy to administer, and allow for flexible dosing. However, some drugs are not suitable for capsules due to stability issues. Capsules are manufactured through various processes depending on the type, including dipping, spinning, drying, filling, and sealing. They must pass quality tests like weight variation and content uniformity testing.
This document provides information on hard gelatin capsules and the capsule manufacturing process. It discusses that capsules contain medications enclosed in either hard or soft gelatin shells, and are intended for oral administration. Hard gelatin capsules are made from two pieces - a cap and body - that are manufactured using a dipping process to coat pins in gelatin solution, then dried, trimmed, and joined. The capsules are filled either manually using punch or tray methods, or automatically using filling machines that rectify, fill, and seal the capsules.
This document discusses capsules, including definitions, types (hard gelatin and soft gelatin), and manufacturing processes. It notes that capsules enclose medicinal substances within a shell, usually made of gelatin. Hard gelatin capsules are made through a dipping process where gelatin is used to form two halves that are later joined. Soft gelatin capsules use a concentric nozzle process to simultaneously form the shell and fill it. The document provides details on quality control and the various sizes of capsules used for humans.
This document discusses capsules as a pharmaceutical dosage form. It describes capsules as solid dosage forms where medicinal agents are enclosed within gelatin shells. The document outlines the advantages and disadvantages of capsules, as well as characteristics such as sizes, shapes, and ability to mask tastes. It also discusses the production of hard and soft gelatin capsules, including details on gelatin production, capsule filling methods, and properties of empty capsule shells.
Capsules are solid dosage forms that enclose drug substances within hard or soft soluble shells, usually made of gelatin. There are two main types - hard gelatin capsules, which have two pieces, and soft gelatin capsules, which are one-piece and hermetically sealed. Capsules offer advantages like being tasteless, odorless, and easy to administer, and allow for flexible dosing. Key steps in production include dipping, spinning, drying, stripping, trimming, joining, and filling. Capsules are evaluated for weight variation, content uniformity, and dissolution.
1. Capsules are solid dosage forms that enclose one or more active ingredients in a soluble gelatin shell for oral administration. Hard capsules use gelatin and contain dry powders, while soft capsules contain oils or liquids dissolved in oils.
2. Capsules are manufactured through rotary die or reciprocating die processes that form, fill, seal and cut the gelatin shells. The gelatin used is type A or B derived from animal collagen.
3. Finished capsules are tested for attributes like size, shape, weight uniformity, content uniformity, and dissolution. Soft gelatin capsules provide benefits like protecting unstable ingredients and increasing bioavailability but have certain material limitations.
This document discusses hard shell and soft shell capsules. It defines capsules as solid dosage forms containing medicinal agents enclosed in gelatin shells. Hard shell capsules are made of two rigid gelatin shells joined together, while soft shell capsules contain plasticizers like glycerin added to the gelatin. The document describes the manufacturing processes of both types of capsules and compares their advantages and disadvantages as drug delivery systems.
Capsules are solid dosage forms that enclose the drug substance within a soluble shell, usually made of gelatin. There are two main types: hard gelatin capsules and soft gelatin capsules. Hard capsules have a two-piece shell and are made through a dipping and drying process to form the capsule halves, which are then trimmed, joined, and polished. They can encapsulate various solid and semisolid drugs. Soft capsules have an outer shell surrounding a liquid or semisolid inner fill and provide various advantages over traditional capsules like easy swallowing and improved bioavailability.
DEFINITION
Capsules are solid preparations with hard and soft shells of various shapes and capacities, usually containing a single dose of active ingredients.
Capsules are solid dosage forms that contain active ingredients or substances enclosed in gelatin shells. There are two main types: hard gelatin capsules that contain dry powders or granules, and soft gelatin capsules that contain liquids, suspensions, or paste-like formulations. Hard capsules are prepared by dipping pins in gelatin solutions to form shells, then filling and joining the capsules. Soft capsules use gelatin shells made with plasticizers to contain liquid or semi-liquid fillings. Both types provide benefits like taste-masking and targeted drug release, but have limitations like incompatibility with certain active ingredients.
Capsules are solid dosage forms that contain active ingredients or substances enclosed in gelatin shells. There are two main types: hard gelatin capsules that contain dry powders or granules, and soft gelatin capsules that contain liquids, suspensions, or paste-like formulations. Hard capsules are prepared by dipping pins in gelatin solutions to form shells, then filling and joining the capsules. Soft capsules use gelatin shells made with plasticizers to contain liquid or semi-liquid fillings. Both types provide benefits like taste-masking and targeted drug release, but have limitations like incompatibility with certain active ingredients.
The document discusses various techniques for scaling up capsule production in a pilot plant setting. It describes the basic manufacturing process for hard and soft gelatin capsules. For hard capsules, this involves mixing ingredients, granulation, capsule making, filling, and packaging. Soft capsules involve formulating liquid or semi-solid fills and using various manufacturing methods like plate, rotary die press, or bubble processes to encapsulate the fills. Key considerations for scale-up include powder flow properties and lubricant distribution for hard capsule filling.
This document discusses considerations for dosage form design, including reasons drugs are incorporated into dosage forms, types of dosage forms, and information needed for preformulation studies. It covers drug degradation mechanisms, drug instability, stability studies, and approaches to stabilize drugs. Factors in dosage form design include therapeutic use, administration route, patient age and condition. Common oral dosage forms are tablets and capsules, while injections can be used for emergency or inability to take oral medications. Design must also consider issues like difficulty swallowing, multiple medication therapy in elderly patients, and performulation studies to characterize the drug substance.
This document discusses pharmacokinetics and biotransformation. It covers the four main stages of pharmacokinetics: absorption, distribution, metabolism, and excretion. Metabolism, or biotransformation, involves enzymatic conversion of drugs by the liver and involves two phases - phase I and phase II reactions. Phase I introduces or exposes functional groups through oxidation, reduction or hydrolysis. Phase II involves conjugation through acetylation, methylation, glucuronidation or sulphation. Cytochrome P450 enzymes and microsomal enzymes are involved in phase I reactions. Factors like enzyme induction and inhibition can impact drug metabolism and clearance. Drugs and metabolites are primarily excreted through the kidneys
The document discusses powders as a pharmaceutical dosage form. It defines powders as finely divided solid drugs or chemicals meant for internal or external use. It describes various methods of preparing powders, including spatulation, trituration, geometric dilution, sifting, and tumbling. Powders are classified based on their intended use, such as bulk powders, simple/compound powders, powders in capsules/cachets, and compressed powders. Weighing techniques and packaging of powders are also outlined.
The document discusses various topics related to pharmacokinetics and drug administration and absorption. It defines key terms like pharmacokinetics, bioavailability, and first-pass effect. It describes different routes of drug administration like oral, sublingual, rectal, inhalation, and parental with their advantages and disadvantages. It explains different mechanisms of drug absorption including passive diffusion, active transport, and facilitated diffusion. It also lists factors that can affect drug absorption like molecular weight, lipid solubility, ionization, dosage form, and gastrointestinal conditions.
The document discusses various pharmaceutical dosage forms and drug delivery systems categorized by route of administration including oral, parenteral, topical, rectal, and others. It describes solid dosage forms like tablets and capsules as well as liquid forms including solutions, suspensions, and emulsions. Modified and controlled release delivery systems are also outlined. The document provides examples of different dosage forms and delivery technologies.
- Pharmacokinetics is the study of how the body affects drugs through absorption, distribution, metabolism, and excretion. Pharmacodynamics is the study of how drugs affect the body through their mechanisms and effects.
- Common routes of drug administration include oral, sublingual, rectal, and inhalation. Oral administration is easy but can cause first pass metabolism. Sublingual administration avoids first pass metabolism but is not suitable for frequent use. Rectal administration is suitable for children and vomiting but can cause irritation.
- Drugs are absorbed through passive diffusion, active transport, and facilitated diffusion. Absorption is affected by factors like lipid solubility, ionization, dosage form, blood flow,
This document provides an overview of dosage form design and formulation considerations. It discusses the need for dosage forms to safely deliver accurate drug doses. Key points covered include preformulation studies to characterize drug substances, approaches to incorporating different physical forms of drugs into dosage forms, and general design considerations for factors like therapeutic use, patient age and condition, and stability. The document also outlines various dosage form types and reasons for their use.
it describes the bony anatomy including the femoral head , acetabulum, labrum . also discusses the capsule , ligaments . muscle that act on the hip joint and the range of motion are outlined. factors affecting hip joint stability and weight transmission through the joint are summarized.
How to Make a Field Mandatory in Odoo 17Celine George
In Odoo, making a field required can be done through both Python code and XML views. When you set the required attribute to True in Python code, it makes the field required across all views where it's used. Conversely, when you set the required attribute in XML views, it makes the field required only in the context of that particular view.
বাংলাদেশের অর্থনৈতিক সমীক্ষা ২০২৪ [Bangladesh Economic Review 2024 Bangla.pdf] কম্পিউটার , ট্যাব ও স্মার্ট ফোন ভার্সন সহ সম্পূর্ণ বাংলা ই-বুক বা pdf বই " সুচিপত্র ...বুকমার্ক মেনু 🔖 ও হাইপার লিংক মেনু 📝👆 যুক্ত ..
আমাদের সবার জন্য খুব খুব গুরুত্বপূর্ণ একটি বই ..বিসিএস, ব্যাংক, ইউনিভার্সিটি ভর্তি ও যে কোন প্রতিযোগিতা মূলক পরীক্ষার জন্য এর খুব ইম্পরট্যান্ট একটি বিষয় ...তাছাড়া বাংলাদেশের সাম্প্রতিক যে কোন ডাটা বা তথ্য এই বইতে পাবেন ...
তাই একজন নাগরিক হিসাবে এই তথ্য গুলো আপনার জানা প্রয়োজন ...।
বিসিএস ও ব্যাংক এর লিখিত পরীক্ষা ...+এছাড়া মাধ্যমিক ও উচ্চমাধ্যমিকের স্টুডেন্টদের জন্য অনেক কাজে আসবে ...
This presentation was provided by Steph Pollock of The American Psychological Association’s Journals Program, and Damita Snow, of The American Society of Civil Engineers (ASCE), for the initial session of NISO's 2024 Training Series "DEIA in the Scholarly Landscape." Session One: 'Setting Expectations: a DEIA Primer,' was held June 6, 2024.
A workshop hosted by the South African Journal of Science aimed at postgraduate students and early career researchers with little or no experience in writing and publishing journal articles.
ISO/IEC 27001, ISO/IEC 42001, and GDPR: Best Practices for Implementation and...PECB
Denis is a dynamic and results-driven Chief Information Officer (CIO) with a distinguished career spanning information systems analysis and technical project management. With a proven track record of spearheading the design and delivery of cutting-edge Information Management solutions, he has consistently elevated business operations, streamlined reporting functions, and maximized process efficiency.
Certified as an ISO/IEC 27001: Information Security Management Systems (ISMS) Lead Implementer, Data Protection Officer, and Cyber Risks Analyst, Denis brings a heightened focus on data security, privacy, and cyber resilience to every endeavor.
His expertise extends across a diverse spectrum of reporting, database, and web development applications, underpinned by an exceptional grasp of data storage and virtualization technologies. His proficiency in application testing, database administration, and data cleansing ensures seamless execution of complex projects.
What sets Denis apart is his comprehensive understanding of Business and Systems Analysis technologies, honed through involvement in all phases of the Software Development Lifecycle (SDLC). From meticulous requirements gathering to precise analysis, innovative design, rigorous development, thorough testing, and successful implementation, he has consistently delivered exceptional results.
Throughout his career, he has taken on multifaceted roles, from leading technical project management teams to owning solutions that drive operational excellence. His conscientious and proactive approach is unwavering, whether he is working independently or collaboratively within a team. His ability to connect with colleagues on a personal level underscores his commitment to fostering a harmonious and productive workplace environment.
Date: May 29, 2024
Tags: Information Security, ISO/IEC 27001, ISO/IEC 42001, Artificial Intelligence, GDPR
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Training: ISO/IEC 27001 Information Security Management System - EN | PECB
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Article: https://pecb.com/article
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Walmart Business+ and Spark Good for Nonprofits.pdfTechSoup
"Learn about all the ways Walmart supports nonprofit organizations.
You will hear from Liz Willett, the Head of Nonprofits, and hear about what Walmart is doing to help nonprofits, including Walmart Business and Spark Good. Walmart Business+ is a new offer for nonprofits that offers discounts and also streamlines nonprofits order and expense tracking, saving time and money.
The webinar may also give some examples on how nonprofits can best leverage Walmart Business+.
The event will cover the following::
Walmart Business + (https://business.walmart.com/plus) is a new shopping experience for nonprofits, schools, and local business customers that connects an exclusive online shopping experience to stores. Benefits include free delivery and shipping, a 'Spend Analytics” feature, special discounts, deals and tax-exempt shopping.
Special TechSoup offer for a free 180 days membership, and up to $150 in discounts on eligible orders.
Spark Good (walmart.com/sparkgood) is a charitable platform that enables nonprofits to receive donations directly from customers and associates.
Answers about how you can do more with Walmart!"
Executive Directors Chat Leveraging AI for Diversity, Equity, and InclusionTechSoup
Let’s explore the intersection of technology and equity in the final session of our DEI series. Discover how AI tools, like ChatGPT, can be used to support and enhance your nonprofit's DEI initiatives. Participants will gain insights into practical AI applications and get tips for leveraging technology to advance their DEI goals.
How to Build a Module in Odoo 17 Using the Scaffold MethodCeline George
Odoo provides an option for creating a module by using a single line command. By using this command the user can make a whole structure of a module. It is very easy for a beginner to make a module. There is no need to make each file manually. This slide will show how to create a module using the scaffold method.
1. Prepared by
Mrs. Ashwini P
. Shewale
M.Pharm
(PDEA’S Shankarrao Ursal Collegeof
Pharmacy,Kharadi)
1
2. CAPSULES
Unit solid dosage form thedrug is enclosed within watersoluble shell or
an envelope either a hard or soft shell. Shell is typically made of gelatin
primarily intended fororal delivery provide a rapid releaseof contents.
2
3. Advantages :
3
1.The drug having unpleasant odour & taste can be
administered byenclosing them in a tasteless shell.
2.Smooth becomeveryslipperywhen moist &can beeasily
swallowed.
3.They are economical.
4.Easy to handle & carry.
5.Release the medicamentas and when desired in GIT.
6.Theyare made up from gelatin hence theyare
therapeutically inert.
7.Theyareattractive inappearance.
8.Available invarioussizes .
9. Microencapsulation provides thesustained release
dosageform.
4. Disadvantages:
4
⚫1. The hygroscopic drugs cannot be filled in capsules.
Theyabsorbwaterpresent in thecapsuleshell & make
itvery brittle, which ultimately breaks intopieces.
⚫2.Theconcentrated preparation which need previous
dilution are unsuitable for capsules because it may
lead to irritation in stomach if administered as such.
5. GELATINE
protein, prepared from hydrolysis of collagen (animal bones and
skin)
type A : PH = 7-9, pig skin
type B : PH = 5, animal bones
TYPEA - Derived from acid treated precursor that exhibits an iso electric
point at pH-9. It is manufactured mainly from pork skin.
TYPE B - Derived from alkali treated precursor that exhibits an iso electric
point at pH-4.7. It is manufactured mainly from animal bones.
POSSESSES 4 ESSENTIAL PROPERTIES
•stablewhen dry
•subject to microbial degradationwhen moist
•digested
• absorbed
5
6. MANUFACTURE OF EMPTY GELATIN
CAPSULES:
Steps involved in making empty gelatin capsules…
⚫ Dipping
⚫ Spinning
⚫ Drying
⚫ Stripping
⚫ Trimming
⚫ Joining
⚫ Polishing
6
8. • Once raw materials have been received and released by Quality
Control, the gelatin and hot demineralized water are mixed
under vacuum in Stainless Steel Gelatin Melting System.
• From receiving tanks, the gelatin solution is transferred to
stainless steel feed tanks.
• Dyes, opacifants, and any needed water are added to the gelatin
in the feed tanks to complete the gelatin preparation procedure.
• From the feed tank, the gelatin is gravity fed to Dipper section.
8
9. Dipping : Pairs of the stainless steel pins are dipped into the
dipping solution to simultaneously form the caps and bodies for
12sec. The dipping solution is maintained at a temperature of
about 50º C in a heated, jacketed dipping pan & pins are at 22ºc.
Spinning : The pins are rotated to distribute the gelatin over the
pins uniformly and to avoid the formation of a bead at the
capsule ends it is rotated 2½ times by moving upward.
Drying : The gelatin is dried by a blast of cool air to form a hard
shells. The pins are moved through a series of air drying kilns,
Here gently moving air which is precisely controlled for volume,
temperature, and humidity, removes the exact amount of
moisture from the capsule halves. 9
10. Stripping : Aseries of bronze jaws strip the cap and body portions of
the capsules from the pins.
Trimming and joining: The stripped cap and body portions are
trimmed to the required length by stationary knives. The cap and
body lengths are precisely trimmed to a ±0.15 mm tolerance.
After trimming to the right length, the cap and body portion are
joined.
⚫Finished capsules are pushed onto a conveyer belt which carries
them out to a container.
⚫Capsule quality is monitored throughout the production process
including size, moisture content, single wall thickness, and color.
⚫ Capsules are sorted and visually inspected on specially designed
Inspection Stations.
⚫Perfect capsules are imprinted with the client logo on high-speed
10
14. Excipients used in the filling of capsules:
14
1. Diluents: e.g. Lactose, mannitol , sorbitol , starch
2.Absorbents: e.g. magnesiumoxides, magnesium
carbonates, Calciumoxides, Calciumcarbonates,
Kaolin
3.Glidants: Talc, magnesium stearate, calcium stearate
4. Antidusting agents: inertedibleoil.
15. Hard Gelatin Capsules
15
⚫ Advantages
⚫ tastelessand odorless
⚫ swallowing iseasy
⚫ flexibility in formulating
⚫ uniquely suitable for blinded clinical trials
⚫ useful forextemporaneouscompounding by pharmacist
⚫ Disadvantages
⚫ tend to be moreexpensive toproduce than tablets
⚫ not suitable for highly solublesalts
Processing of capsules:
1.Filling of capsules
2. Cleaning & polishing
3. Sealing of capsules
17. Capsule filling machine (Hand operated) Itconsists of:—
1. A bed having 200-300 holes
2. A loading tray having 200-300 holes
3. A powder tray
4. A pin plate having 200-300 pins
5. A sealing plate having a rubbertop
6. A lever
7. A cam handle
Polishing
Pan Polishing : Acela-cota pan is used todustand polish.
Cloth Dusting : Capsule are rubbed with cloth.
Brushing : Capsuleare feed undersoft rotating brush.
17
18. Locking and Sealing of Capsules :
Banding – Placing gelatin color bands at the meeting point of caps and the bodies.
Moistening – Moistening the inner surface of caps with lukewarm gelatin solution.
Spot Welding – Spot welding the joints which leaves a ring like appearance at the
point of sealing
Thermal welding – Applying wetting sol. At the meeting points which causes
lowering of M.P at applied area. Finally they are sealed at a temp. 40-45ºc.
By using Coni-snap capsules – Grooves help to lock the caps with the bodies.
Storage: Finished capsules normally contain an equilibrium moisture content
of 13-16%. To maintain a relative humidity of 40-60% when handling and
storingcapsules
18
19. Soft Gelatin Capsules (Softgels)
• consist of acontinuous gelatin shell surrounding a liquid
core
• formed, filled, and sealed in one operation
• shells are softened platizised by addition of glycerin or
polyhydric alcohol (ex. sorbitol), Maycontain preservetive.
• oblong, spherical, elliptical in shape. Enclosed
oils,suspention,food concentarate,opthalmic products.
19
25. Sr.No. Hard Gelatin Capsule Soft gelatin capsule
1. Hard Gelatin Capsule shell
consists of two parts 1. Body 2.
Cap
Soft gelatin capsule shell become a single
unit after sealing the two halves of the
capsules
2. They are cylindrical in shape They are available in round , oval & tube
like shapes
3. The contents of a hard gelatin
capsules usually consist of the
medicaments is the form of
powder, beads or granules
The contents of soft gelatin capsules
usually consists of liquids or solids
dissolved or dispersed in suitable
excipients to give a paste like consistency .
4. These are prepared from gelatin
,Titanium dioxide, coloring
agents and Plasticizer
These are prepared from gelatin plasticizer
(Glycerin or Sorbitol ) and a preservative
5. Capsules are sealed after they are
filled to ensure that the
medicaments may not come out
of the capsule due to rough
handling
Filing and sealing of soft gelatin capsules
are done in a combined operation on
machines
25
26. EVALUTION OF CAPSULES:
(1) Content uniformity
(2) Disintegration test .
(3)Weight variation test
(4)Dissolution test.
(5)Moisture permeation test:
26
27. Content uniformity:
27
The amount of active ingredient should be within the
range of 85% to 115% of the label amount for 9 of 10
capsules, with no unit outside the range of 70% to
125% of label amount.
28. Disintegration test for capsules:
Place 1 capsule in each of the 6tubes of the basket &
suspend the assembly in water at 37℃ ± 2ºC,which is
repeatedly immersed 30 times per minute.
The capsules pass the test if no residue of drug or
other than fragments of shell remains on No. 10 mesh
screen of the tubes.
28
29. ⚫ Weight variation test: 20 capsules are taken at random and
weighed. Their average weight is calculated, then each capsule is
weighed individually and their weight is noted. The capsule passes
the test if the weight of individual capsule falls with in 90-110% of
the average weight.
⚫ Moisture permeation test:
⚫ Acc. to U.S.P the unit dose container is packed along with
dehydrated pellets, which have the property of changing color in the
presence of moisture. The weight of test capsule is compared with
the under test capsules. Diff. in weights gives the amount of moisture
absorbed.
29
30. Dissolution test for capsules:
Place 1000ml of water having a temp. of 36.5º to 37.5º into the
vessel. Place specified number of capsules in basket 7 adjust
the speed to 100 rpm.
Withdraw req. volume for every 10min time interval. Filter and
determine the amount of active ingredient.
The sample passes the test if the amount of active ingredients
in the solution is not less than 70% of the stated amount.
30
31. PACKING & STORAGE OF CAPSULES:
31
Capsules should be packed well closed glass & plastic container
& stored at temp. not exceeding 30ºc. Capsules are
individually protected by enclosing in strip & blister
packaging.
In strip packing the capsule is hermetically sealed within the
strips of an aluminum or plastic film.
In blister packs, a press on the blister forces the capsule
through the backing strip.
.
32. Special applications of capsules
32
1.Enteric Coated Capsules:- a Coating of cellacephate (cellulose
acetate phthalate) and mixture of waxes with fatty acids or their
esters is given.
2. Sustained release capsules :- Finely powdered drug first
converted to pellets .pellets are coated with protective coating
that delay the release of drug.30% uncoated pellets 30% coated
pellets that release drug at 4 hr & 8 hr interval & 10% neutral
pellets to fill the capsule.
3.Rectal Capsules:-soft gelatin capsules as substitute for rectal &
vaginal suppositories. Pear shaped
4. Capsule containing ophthalmic ointments:- Ophthalmic
ointments are sterile to keep that ointment sterile during their
storage & later use it is required to be filled in a single dose
container. Intended for single application to eye. The capsule is
puncture with sterile needle a& instilled into eye & shell is
discarded
33. Angle of repose
The maximum angle between the surface of pile of
powder and the horizontal surface is called as angle of
repose.
tan θ = 2h
D
tan θ = 25O
tan θ= 50O
h
D
33