This document presents a case study of a 31-year-old female patient diagnosed with systemic lupus erythematosus (SLE) and depression. She presented with symptoms of sadness, fever, malar rash, and headache over the past few months. Laboratory tests confirmed elevated ESR and ANA levels. She was treated with intravenous methylprednisolone and oral prednisone, azathioprine, and clonazepam. Her symptoms improved with treatment. The goals of treatment were outlined as preventing recurrence, eliminating depression symptoms, and managing acute and chronic aspects of SLE to prevent organ damage and complications.

1. CASE PRESENTATION
SLE with Depression
By-
Nagaraju B
dr.bnr2011@gmail.com

2. Patient Name -XXX
IP No -13305/13
DOA - 1/12/13
DOD - 3/12/13
Department - Med
Unit -IV
Age - 31years
Sex - Female
Weight - 56kgs, Height - 158 cms

3. SUBJECTIVE
CHIEF COMPLAINT:
with c/o Sadness: 3months
Fever : 2 months
Malar rash : 45 days
Headache : 45 days
HISTORY OF PRESENTING ILLNESS:
* Patient with sadness ,low mood , loss of interest, decreased
sleep , suicidal tendency for 3 months
* Patient was apparently asymptomatic 2 months back when
she developed fever associated with generalized body pains,
rash on palms, back and arms, joint pains, anorexia,
sleeplessness and headache.
* Patient presented to a local hospital, treated
symptomatically, fever was relieved on medication and was
discharged. 10-15 days later she developed malar rash, and
persistent fever. Then, she rushed to KIMS hospital with
fever and malar rash.

4. HISTORY OF PRESENTING ILLNESS:
• Fever was intermittent, low grade, on and off, no
chills/rigors, associated joint pains mostly involving large
joints [non migratory and non-fleeting] From day-1 of
fever, she developed macular erythema on palms, upper
back and extensor aspect of arms and 10-15 days later she
developed malar rash, which is slightly raised
erythematous rash on cheek and nose, precipitated by sun
exposure and non-pruritic.
• No s/o purpuria , no oro-genital eruptions or scaly lesions
on another part of the body.
PREVIOUS HISTORY:
 No h/o DM/HTN/TB/Asthma/Epilepsy. Mother expired 3
months back. Feels guilt and herself responsible for the event
married since 1 year

5. PASTMEDICATIONHISTORY/ALLERGY:
No past h/o exposure to c/o TB, mite bite, tick bite, or exposure to
rats or cats.
No history s/o malaria, chikungunya, dengue, typhoid.
No history of visual disturbances, altered sensorium & no
complaints s/o motor or sensory impairment No h/o cough or
dyspnea No history of drug allergy No h/o similar complaints in the
past.
FAMILY HISTORY:
No f/h/o DM, HTN, ASTHAMA, TB
 H/o Frequent quarrel with husband
 H/o Skipping meals
 H/o Crying always at home
 H/o Suicidal tendency (CONSUMING TABLETS)
 Interpersonal problems with her husband and mother-in-law

6. PERSONAL HISTORY:
Diet-Mixed; Appetite-Decreased; Sleep-Decreased
Bowel-Regular; Bladder-Normal; Habits-None
Menstrual history-menarche at 13, cycles regular,
4/30, no dysmenorrhea, no clots. No similar
complaints in the family
OBJECTIVE
PHYSICAL EXAMINATION :
Patient is conscious, coherent, cooperative,
comfortably sitting on bed, well oriented to time,
place & person. Normal hair Malar rash on face
,macular erythema on palms and back, non-discoid,
non-bleachable. No oro-genital ulcers.

7. Eyes appear normal. O/e URT normal. No
congestion or secretions noted
VITAL SIGNS:
BP - 110/80mmHg PR - 80 bpm
RR - 16cpm Temp- 100°F.
P[+], I[-], C[-], C[-], L[-], E[-]

8. SYSTEMS :
P/A - soft ,no tenderness, no organomegaly, BS+
RS- NVBS+, no Adv sounds
CVS - S1,S2 heard, no murmurs
CNS -Normal
Muskulo-skeletal system examination-no swelling or redness or
tenderness over large or small joints, no limitation of movements at
joints, no pain, no stiffness
PROVISIONAL DIAGNOSIS :
Depression with
? Pyrexia
? Connective tissue disorder
? Granulomatous disease for evaluation
? Enteric fever
? Malignancy

9. TEST TEST VALUE NORMAL VALUE
Hb (g/dl) 10.7% 13-18
ESR 28 0-20
Total leucocytes counts
(cells/cmm)
1,700/cu.mm 4000-11000
N (%) 69% 40-75
L (%) 10% 20-45
E (%) 10% 1-6
M (%) 5% 2-10
B (%) 6% 0-1
Platelets (cells/cmm) 89,000 1.5-4.0 lakh/cmm
Bl. U (mg/dl) 17mg/dl 12-40mg/dl
Sr. Cr (mg/dl) 0.8mg/dl 0.2-1.4mg/dl
Urine Routine Sugar: Nil Albumin: +
Urine Microscopy Pc: 0-1 Ep: 1-2 cells
LABORATORY INVESTIGATIONS

10. TEST TEST VALUE NORMAL VALUE
LFT
TB 1.08mg/dl 0.4-1.2 mg/dl
DB 0.2mg/dl Up to 0.4 mg/dl
AST/SGOT 14.5iu/L 8-40 iu/L
ALT/SGPT 16.8iu/L 8-40 iu/L
ALP 91iu/L Up to 120iu/L
Total protein 6.6-8.3 gm/dl
Albumin 4.3g/dl 3.5-5 .5 gm/dl
Globulin 2.4g/dl 2.3-3.5 gm/dl
Urine Routine
Urine Microscopy
Sugar: Nil Albumin: +
Pc: 0-1 Ep: 1-2 cells

11. TEST TEST VALUE NORMAL VALUE
Ser. Cl- 100 Up to 103 mEq/L
Ser. Na+ 145 136-145mmol/L
Ser. K+ 3.3 3.5-5.1 mmol/L
PS - Normocytic normochromic, leucopenia,
lymphopenia
VDRL Non-reactive
Widal Negative
HBsAg/HAV/HCV/HEV/HIV Negative
Dengue card& serology Negative
ANA - POSITIVE (2.975)
Anti ds DNA Antibodies- Positive (233 iu/ml)
CXR/USG-Abd&Pelvis NAD

12. ASSESMENT
Based on the subjective & objective evidence the
patient was diagnosed to have SYSTEMIC
LUPUS ERYTHEMATOSIS with DEPRESSION

13. GOALS OF TREATMENT
 To prevent recurrence (depression)
 Eliminate depression with complete remission of
symptoms
 Treatment include management of acute and chronic
 Goals are preventing progressive loss of organ
function, minimizing disease disabilities, preventing
complication from therapy.

14. BRAND NAME GENEROIC NAME DOSE FREQU
ENCY
DATE DATE
END
Inj. Solumedrol Methyl Prednisolone 1g iv 0-1-0 1/12 3/12
Inj Lorzep Lorazepam 2mg iv sos 1/12 3/12
MEDICINE ON DISCHARGE
Tab. Wysolone Prednisolone 40mg 1-0-1 4/12 15/12
Tab. Azoran Azathioprine 50mg 1-0-1 4/12 15/12
Tab. Clozep Clonazepam 0.5mg 0-0-1 4/12 15/12
MEDICINE ON REVIEW DT: 16/12/13
Tab. Azoran Azathioprine 50mg 1-0-1 16/12 30/12
Tab. Wysolone Prednisolone 40mg 1-0-1 16/12 30/12
Tab. Pantodac Pantoprazole 40mg 1-0-1 16/12 30/12
Tab Nexito Escitalopram 10mg 1-0-1 16/12 30/12
MEDICATION CHART

15. PROGRESS NOTE:
From Day-1 to 3:
Patient was feeling better from Day-3.
Patient was discharged and advised to take
Azathioprine 5omg, Clonazepam 0.5mg and
Prednisolone 40mg for 2 weeks.
At Review on 16/12/13:
Patient cell count improved, rash faded
comparatively, but complained alopecia, GI
symptoms. Patient was to take Prednisolone 40mg
bd, Azathioprine50mg bd, Pantoprazole 40mg bd
and Escitalopram 10mg bd.

16. Suggestion to Physician-
SLE
• No drug interaction is found.
• Methyl Prednisolone would have been given 1g i.v for
every 3 days instead of consecutively for 3 days.
• Iron supplements might have been added in the
prescription, since patient is anemic.
• Antipyretic/Analgesics would have been advised for
symptomatic relief for patient’s feel better.
• At least on review, MVI&MM might have been advised, as
Patient was c/o alopecia.
DEPRESSION
• No suggestion is required to be given in this regard.
PLAN

17. Advice to patient-
SLE
• Adhere to medication.
• Maintain hygiene.
• Regular follow-up.
• Drink plenty of water.
• Consume fresh fruits and vegetables.
• Avoid exposure to sunlight or artificial UV light.
• Seek medical attention immediately, if exacerbations occurs.
• Take more protein containing foods like beans, nuts, peas.
• Co-operate with the Physician till remission of treatment/ Diagnosis
and treatment.
• Take orange juice and iron rich foods like chicken, meat, egg and
green leafy vegetables like spinach and beetroot.
DEPRESSION
• Family has been advised to arrange Counseling, Couple-focused
therapy, Family therapy, Hypnotherapy, Music therapy, Behavioral
activation and interpersonal therapy is recommended as a
treatment option for patients with depression

18. THANKYOU…