The document discusses hydrocephalus and the use of shunt systems to treat it. Hydrocephalus is a condition where cerebrospinal fluid builds up in the brain, increasing pressure. If left untreated it can be fatal. A shunt system works by draining excess fluid from the ventricles of the brain to other parts of the body through a series of catheters and a valve that regulates flow. Programmable shunt valves allow doctors to adjust pressure settings non-invasively. The document also profiles individuals living with hydrocephalus and shunts, including a race car driver who has undergone over 20 brain surgeries.
This is my senior seminar research project for my BS Physics, at the University of Texas at Arlington. Hydrocephalus is something that is incredibly personal to me, as my husband has had 20 brain surgeries and has been permanently disabled since 2011. In his honor, I created an awareness ribbon for Hydrocephalus that is now used worldwide.
This project is for educational purposes only. Please use the references on the last slide to find the original images for your own use. The information presented here has been obtained by reading several papers published in the medical community.
Do not crop and use any of the images of tattoos, artwork, or people. These are pictures that have been shared with me by people in the Facebook Hydrocephalus community.
Papers referenced:
1 CHRISTOPH MIETHKE GMBH & CO. KG, "proGAV® 2.0: IN TOUCH WITH YOU," , .
2 Ian Piper, "Raised Intracranial Pressure After Head Injury" (2000) .
3 Erwin M Brown, Richard J Edwards and Ian K Pople, "Conservative Management of Patients with Cerebrospinal Fluid Shunt Infections," Neurosurgery 58 (4), 65 (2006).
4 CHRISTOPH MIETHKE GMBH & CO. KG, "proGAV 2.0® Instructions for Use," , .
5 Dr Y. Rajalakshmi, Guide to Physiology, edited by Anonymous (S. Chand Publishing, Ram Nagar, New Delhi, 2010), pp. 157.
6 Roberta Di Terlizzi and Simon Platt, "The function, composition and analysis of cerebrospinal fluid in companion animals: Part I – Function and composition," The Veterinary Journal 172 (3), 422-431 (2006).
7 Romy Scholz et al., "Efficacy and safety of programmable compared with fixed anti-siphon devices for treating idiopathic normal-pressure hydrocephalus (iNPH) in adults – SYGRAVA: study protocol for a randomized trial," Trials 19 (1), 1-10 (2018).
8 Ulrich-W Thomale et al., "Shunt survival rates by using the adjustable differential pressure valve combined with a gravitational unit (proGAV) in pediatric neurosurgery," Childs Nerv Syst 29 (3), 425-431 (2013).
9 Marek Czosnyka et al., Cerebrospinal Fluid Dynamics, in Pediatric Hydrocephalus, edited by Giuseppe Cinalli, Christian Sainte-Rose and Wirginia June Maixner, (Springer Milan, Milano, 2005), pp. 47-63.
10 Sandip Chatterjee and L. Harischandra, "Cerebrospinal fluid shunts – How they work: The basics," Neurology India 66 (1), 24 (2018).
11 Edi Azali Hadzri et al., "Effects of irregular cerebrospinal fluid production rate in human brain ventricular system," AIP Conference Proceedings 1440 (1), 659-664 (2012).
This is my senior seminar research project for my BS Physics, at the University of Texas at Arlington. Hydrocephalus is something that is incredibly personal to me, as my husband has had 20 brain surgeries and has been permanently disabled since 2011. In his honor, I created an awareness ribbon for Hydrocephalus that is now used worldwide.
This project is for educational purposes only. Please use the references on the last slide to find the original images for your own use. The information presented here has been obtained by reading several papers published in the medical community.
Do not crop and use any of the images of tattoos, artwork, or people. These are pictures that have been shared with me by people in the Facebook Hydrocephalus community.
Papers referenced:
1 CHRISTOPH MIETHKE GMBH & CO. KG, "proGAV® 2.0: IN TOUCH WITH YOU," , .
2 Ian Piper, "Raised Intracranial Pressure After Head Injury" (2000) .
3 Erwin M Brown, Richard J Edwards and Ian K Pople, "Conservative Management of Patients with Cerebrospinal Fluid Shunt Infections," Neurosurgery 58 (4), 65 (2006).
4 CHRISTOPH MIETHKE GMBH & CO. KG, "proGAV 2.0® Instructions for Use," , .
5 Dr Y. Rajalakshmi, Guide to Physiology, edited by Anonymous (S. Chand Publishing, Ram Nagar, New Delhi, 2010), pp. 157.
6 Roberta Di Terlizzi and Simon Platt, "The function, composition and analysis of cerebrospinal fluid in companion animals: Part I – Function and composition," The Veterinary Journal 172 (3), 422-431 (2006).
7 Romy Scholz et al., "Efficacy and safety of programmable compared with fixed anti-siphon devices for treating idiopathic normal-pressure hydrocephalus (iNPH) in adults – SYGRAVA: study protocol for a randomized trial," Trials 19 (1), 1-10 (2018).
8 Ulrich-W Thomale et al., "Shunt survival rates by using the adjustable differential pressure valve combined with a gravitational unit (proGAV) in pediatric neurosurgery," Childs Nerv Syst 29 (3), 425-431 (2013).
9 Marek Czosnyka et al., Cerebrospinal Fluid Dynamics, in Pediatric Hydrocephalus, edited by Giuseppe Cinalli, Christian Sainte-Rose and Wirginia June Maixner, (Springer Milan, Milano, 2005), pp. 47-63.
10 Sandip Chatterjee and L. Harischandra, "Cerebrospinal fluid shunts – How they work: The basics," Neurology India 66 (1), 24 (2018).
11 Edi Azali Hadzri et al., "Effects of irregular cerebrospinal fluid production rate in human brain ventricular system," AIP Conference Proceedings 1440 (1), 659-664 (2012).
RHD is prevalent in India, many patients requires valve replacement. understanding of prosthetic valve anatomy, morphology and early detection of valve related complication is very important for saving life. TTE and TEE are important tool for identifying these complications.
Slides for a talk by Vincent Pellegrino (ECMO Director at The Alfred ICU) on ECPR. For videocast and audio only versions of this talk go to the RAGE podcast (http://ragepodcast.com/ecpr-vincent-pellegrino/) or The Alfred ICU's INTENSIVE blog (http://intensiveblog.com/ecpr-vin-pellegrino/).
Coronary artery bypass grafting (CABG) is a type of surgery that improves blood flow to the heart. It's used for people who have severe coronary heart disease (CHD), also called coronary artery disease.
RHD is prevalent in India, many patients requires valve replacement. understanding of prosthetic valve anatomy, morphology and early detection of valve related complication is very important for saving life. TTE and TEE are important tool for identifying these complications.
Slides for a talk by Vincent Pellegrino (ECMO Director at The Alfred ICU) on ECPR. For videocast and audio only versions of this talk go to the RAGE podcast (http://ragepodcast.com/ecpr-vincent-pellegrino/) or The Alfred ICU's INTENSIVE blog (http://intensiveblog.com/ecpr-vin-pellegrino/).
Coronary artery bypass grafting (CABG) is a type of surgery that improves blood flow to the heart. It's used for people who have severe coronary heart disease (CHD), also called coronary artery disease.
Information from Kelley Whisler: Sean is my nephew, he and his twin sister Kaitlyn were born 10 weeks premature. He has Cerebral Palsy due to brain trauma at birth (like having a stroke on both sides of his brain) and acidosis due to his heart not converting to self-sufficiency at birth (PDA non-closure / therefore not enough oxygen in blood to brain/body). He also has some vision disability, due to ROP (retinopathy of prematurity - retina did not fully develop) as well as the stroke affected the vision area of his brain, which makes it hard for him to process what he does see. My sister made this powerpoint for me to share with my students as they have taken both Sean & Kaitlyn into their hearts, and they have wanted to know and understand what was happening with them.
Information from Kelley Whisler: Sean is my nephew, he and his twin sister Kaitlyn were born 10 weeks premature. He has Cerebral Palsy due to brain trauma at birth (like having a stroke on both sides of his brain) and acidosis due to his heart not converting to self-sufficiency at birth (PDA non-closure / therefore not enough oxygen in blood to brain/body). He also has some vision disability, due to ROP (retinopathy of prematurity - retina did not fully develop) as well as the stroke affected the vision area of his brain, which makes it hard for him to process what he does see. My sister made this powerpoint for me to share with my students as they have taken both Sean & Kaitlyn into their hearts, and they have wanted to know and understand what was happening with them.
An aneurysmal origin subarachnoid hemorrhage.
Sudden sharp onset of headache with a history of trauma can help in the diagnosis, more commonly occurs in females than males. the leading cause of this condition is recreational drug use, smoking, high Blood Pressure basically anything that can raise the Blood Pressure and put more pressure on the arteries may produce this condition. Newer treatment options involve the use of flow diverters currently it has been approved only for a large aneurysm, studies are in progress for its progress for the smaller aneurysms.
Combining Cardiovascular, Respiratory and Neurobehavioral Endpoints for Effic...InsideScientific
An essential webinar for preclinical scientists that wish to learn how to integrate hemodynamic, respiratory and neurological measurements to study multiple biological systems simultaneously while benefiting from more efficient data collection and workflow in the laboratory.
In this case study webinar sponsored by Data Sciences International, Dr. Brian Roche of Charles River Laboratories and Jason Payseur of GlaxoSmithKline discuss advantages and challenges pertaining to the combination of physiologic monitoring technologies to collect respiratory, cardiovascular and neurological endpoints from a single animal subject.
Specifically, Dr. Roche presents an evaluation of the AllayTM restraint technology utilized in DSI Respiratory solutions versus other commonly used methods. Complimented with implantable telemetry, Dr. Roche shows how he examined the effects of each method on various cardiopulmonary parameters and discusses the benefits and challenges associated with the use of the AllayTM restraint. Jason Payseur presents his assessment of a novel rodent model that examines cardiovascular, respiratory and neurobehavioral endpoints at the same time. He investigates the surgical feasibility of this model and tests its reliability in measuring multiple physiologic endpoints using tool compounds with known physiological effects, caffeine and chlorpromazine.
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Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
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Skulls, tattoos, & racecars
1.
2. Skulls, Tattoos and Race Cars: Understanding Hydrocephalus and Shunts Desiree Bates
3. Skulls, Tattoos and Race Cars: Understanding Hydrocephalus and Shunts Desiree Bates
4. 99.13% Water
0.87% Both organic and inorganic solids:
Produced within the ventricles of the brain and
partially by the choroid plexus, and is absorbed by
the dural venous sinuses
Skulls, Tattoos and Race Cars: Understanding Hydrocephalus and Shunts Desiree Bates
5. Skull
(hard and rigid with a fixed volume)
Brain Tissue Vascular System (arteries
& blood)
CSF
Skulls, Tattoos and Race Cars: Understanding Hydrocephalus and Shunts Desiree Bates
6. Skulls, Tattoos and Race Cars: Understanding Hydrocephalus and Shunts Desiree Bates
7. •
•
•
•
•
•
•
Skulls, Tattoos and Race Cars: Understanding Hydrocephalus and Shunts Desiree Bates
•
•
•
•
•
•
The skull limits the expansion of fluid: Increased fluid means increased pressure on the brain
Fatal if left untreated
11. Over 400 types of shunts
3 main parts:
• Proximal (Ventricular) catheter
• Distal catheter
• Shunt valve
Fig 10: Lateral view of shunt system
Fig 9: Frontal view of shunt system
Fig 8: Major components of a shunt system
Skulls, Tattoos and Race Cars: Understanding Hydrocephalus and Shunts Desiree Bates
12. • Drains excess fluid from the ventricles
• Made from silicon rubber
• May be coated with barium for x-ray visibility
• Sometimes antibiotic impregnated (rifampicin
and clindamycin)
• 15 cm - 23 cm in length
• Inner diameter 1.0-1.6mm
• External diameter 2.1-3.2 mm
• May be straight, flanged, or J-shaped
Skulls, Tattoos and Race Cars: Understanding Hydrocephalus and Shunts Desiree Bates
13. • Routed from the burr hole in the
skull
• Made from silicon rubber
• May be coated with barium for x-
ray visibility
• 90 cm - 120 cm in length
• Inner diameter 0.7-1.3mm
• External diameter 2.1-2.5 mm
Skulls, Tattoos and Race Cars: Understanding Hydrocephalus and Shunts Desiree Bates
14. Distal end of the catheter can be
routed to the:
• Heart: Ventriculoatrial (VA) shunt
• Lungs: Ventriculopleural (VPLS)
shunt
• Abdomen: Ventriculoperitoneal
(VP) shunt
Skulls, Tattoos and Race Cars: Understanding Hydrocephalus and Shunts Desiree Bates
15. • Regulate flow of CSF from ventricles
• Nearly 200 types of shunt valves
• Operation based on Hydrostatic Pressure:
𝐻𝑆𝑃 = 𝜌𝑔ℎ
If patient is in horizontal position, less
fluid flows (2 drops/min). If in vertical
position, more fluid flows (4drops/min)
Skulls, Tattoos and Race Cars: Understanding Hydrocephalus and Shunts Desiree Bates
16. • Function based on opening pressure (OP) and closing pressure (CP) of the
valve
Differential Pressure: DP = ICP + HSP – IAP
OP < DP: valve opens
CP < DP: valve closes
*ICP Intracranial Pressure, *IAP Intraabdominal Pressure
• Types include: Slit valves, Mitre valves, Diaphragm valves, Ball-in-cone
valves
• Ball-in-cone (Ball-spring valve) most efficient: offers maximum flow when
DP > OP
Skulls, Tattoos and Race Cars: Understanding Hydrocephalus and Shunts Desiree Bates
17. • Designed to avoid over-drainage resulting from change in HSP (siphoning)
• Referred to as anti-siphoning devices
• Three types:
• Suction controlled devices – contains a flexible membrane valve that
regulates pushing pressure (PP) and sucking pressure (SP). When PP > SP,
CSF flows. When PP < SP, no CSF flows
• Flow reducing devices – CSF flow based on differential pressure
• Gravitational valve – uses metal ball to regulate flow across opening
Skulls, Tattoos and Race Cars: Understanding Hydrocephalus and Shunts Desiree Bates
18. proGAV 2.0® with ShuntAssistant®
• Hybrid valve: proGAV Combines DPV with HSV to avoid
siphoning
• Able to regulate OP with posture changes
The bow spring controls the OP of the ball-in-cone valve.
The tension of the spring (OP) is controlled by turning the
rotor.
The tantalum ball defines the OP of the valve, and the
sapphire ball ensures the valve is fully closed.
SAPPHIRE BALL
BOW SPRING
ROTOR
CONNECTOR UNDER
THE SILICONE CATHETER
TANTALUM BALL
SAPPHIRE BALL
ADJUSTABLE UNIT
GRAVITATIONAL
UNIT
Skulls, Tattoos and Race Cars: Understanding Hydrocephalus and Shunts Desiree Bates
19. proGAV 2.0® with ShuntAssistant®
When patient is in the vertical position:
a) Gravitational unit closes
b) When: 𝑊𝑒𝑖𝑔ℎ𝑡 𝑇𝑎𝑛𝐵𝑎𝑙𝑙 < 𝑂𝑃𝐺𝑟𝑎𝑣𝑈𝑛𝑖𝑡
Fluid flows freely
Skulls, Tattoos and Race Cars: Understanding Hydrocephalus and Shunts Desiree Bates
20. proGAV 2.0® with ShuntAssistant®
When patient is in the horizontal position, the gravitational unit
stays open, allowing fluid to flow freely
Fig 21: ShuntAssistant in horizontal position
Fig 22: ShuntAssistant in horizontal position
Fig 23: Adjustable (Differential Pressure) DP-unit a) closed, b) open
Skulls, Tattoos and Race Cars: Understanding Hydrocephalus and Shunts Desiree Bates
21. proGAV 2.0® with
ShuntAssistant®
IVP Intraventricular pressure
𝑃𝐿 Opening pressure in horizontal position
(adjustable DP-unit only)
𝑃𝑆 Opening pressure in vertical position
(adjustable DP-unit + gravitational unit)
𝑃𝐵 Pressure in the abdominal cavity
𝑃 𝐻 Hydrostatic pressure
Skulls, Tattoos and Race Cars: Understanding Hydrocephalus and Shunts Desiree Bates
22. proGAV 2.0® with ShuntAssistant®
• DPV controlled externally with a magnetic “Compass”
• Rotorbrake makes a clicking sound when released/locked
• Shunt valve is MRI safe up to 3 Tesla
Skulls, Tattoos and Race Cars: Understanding Hydrocephalus and Shunts Desiree Bates
23. proGAV 2.0® with ShuntAssistant®
Skulls, Tattoos and Race Cars: Understanding Hydrocephalus and Shunts Desiree Bates
24. Skulls, Tattoos and Race Cars: Understanding Hydrocephalus and Shunts Desiree Bates
25. • Diagnosed with spontaneous Hydrocephalus at age 12
• Had 15 shunt related surgeries in 3 years
• Shunt was a free flowing shunt: the only way to regulate the amount of CSF was
to change his position from sitting/standing to lying down
• Received first programmable shunt in 2006
• Brain tear and damage from multiple surgeries left him permanently disabled in
2010
• Has had a total of 20 brain surgeries to date
• Current shunt is a programmable proGAV 2.0® with ShuntAssistant®
Skulls, Tattoos and Race Cars: Understanding Hydrocephalus and Shunts Desiree Bates
26. Skulls, Tattoos and Race Cars: Understanding Hydrocephalus and Shunts Desiree Bates
27. Skulls, Tattoos and Race Cars: Understanding Hydrocephalus and Shunts Desiree Bates
28. Skulls, Tattoos and Race Cars: Understanding Hydrocephalus and Shunts Desiree Bates
29. Skulls, Tattoos and Race Cars: Understanding Hydrocephalus and Shunts Desiree Bates
30. Skulls, Tattoos and Race Cars: Understanding Hydrocephalus and Shunts Desiree Bates
31. Skulls, Tattoos and Race Cars: Understanding Hydrocephalus and Shunts Desiree Bates
32. Skulls, Tattoos and Race Cars: Understanding Hydrocephalus and Shunts Desiree Bates
33. Skulls, Tattoos and Race Cars: Understanding Hydrocephalus and Shunts Desiree Bates
34. Skulls, Tattoos and Race Cars: Understanding Hydrocephalus and Shunts Desiree Bates
35. Skulls, Tattoos and Race Cars: Understanding Hydrocephalus and Shunts Desiree Bates
Dick Wagner
Former lead guitarist for Aerosmith, Alice Cooper,
and Kiss
Gabby Giffords
Former member of the US House
of Representatives
George Visger
Former defensive lineman for the
San Francisco 49ers
36. Skulls, Tattoos and Race Cars: Understanding Hydrocephalus and Shunts Desiree Bates