The document summarizes a cosmetic face lift product called Global Lift. It contains three key active ingredients - a biomimetic peptide derived from Elafin, Menyanthes trifoliata extract, and black pepper extract - which work together to target the aging marker progerin. Clinical studies showed using Global Lift for 28 days reduced sagging of the jawline and wrinkles by up to 18% and lowered the mean sagging skin index by 12.5%, representing a youthful appearance 5-6 years younger. The product's anti-aging technology is based on targeting progerin at the cellular level to reverse signs of aging.

1. The first global face lift* range to restore the
youthful facial contours
OVAL SHAPE · NECK · CHEEKBONES -

2. Technical Development
2

3. Mature skin Photoaged mature skin
SEM575, Courage & Khazaka
3
Skin firmness vs age
Men
Women
Age range (years)
Moderateorsevereelastosis(%)
-4%
-8%
1SILAB data base
-8%
2 Panel: 19vol. 59±7 with mature skin vs 19vol. 59±10 with photoaged mature skin.
Age range2Age range1
Real (Cutometry)
Perceived (Medic. Eval.)
50-59 (healthy) 50-59 (photoaged)
RealFirmess(cutometry%)
Firmess(cutometry%)
Overrest.

4. Up to the age of 50, loss is slight and progressive. From the age of 50s this
loss increases due to loss of firmness and elasticity.
The sun has a notable effect on the loss of firmness and ages the skin by 10
years.
There is no correlation between the loss of real firmness and the visual
symptoms of sagging skin (perceived firmness).
4
Skin firmness vs age
Mature skin Photoaged mature skin

5. 5
Epidermis
Papillary
Dermis
Reticular
Dermis
Reticular dermis= Dense tissue
Funct. Comp.: Collagen and elastin
Resistance, support
Extrinsic aging (UV)
Deep wrinkles, loose skin
Skin histology. Function
Papillary dermis = Connective tissue
Funct. Comp.: Collagen and elastin
Elasticity, deformability
Intrinsic aging (R.L) and extrinsic aging
(UV)
Median wrinkles, lack of elasticity.

6. 6
Pro-collagen
Anti-photoageing
Anti-age
Papillary dermis
(Intrincis ageing)
Reticular dermis
(Extrinsec ageing)
Anti-elastase
The cosmetic face lift of the future

7. The cosmetic face lift of the future
Components:
1. Active substances that stimulate the synthesis of the basic dermal
elements
1. To stimulate the collagen production
2. To protect the elastin from its degeneration.
2. Active substances that reverse photoaging in the profound dermis
(permitting the recovery of 10 years of youth).
3. Next-generation anti-age components that reverse the general aging of
the skin.
Pro-youth strategies
7

8. Aging
8
Determinado por factores de estrés
(Rayos UV, Factores genéticos, Radicales
libres, fallos en el ADN, etc.).
Se refiere al estado de salud de
nuestras células, es decir cuando la
apariencia no corresponde a la
edad cronológica.
Determinado por la edad.
Esta evolución de la piel no
puede evitarse, es decir el ciclo
normal de la vida:
Nacer, Crecer, Envejecer ...
CHRONOLOGICAL
“Real Age”
BIOLOGICAL· SENESCENCE
“Apparent Age”
Determined by age. This dermal
process cannot be avoided,
and is part of the normal life
cycle: being born, growing up
and aging …
Determined by stress factors (UV
radiation, genetic factors, free
radicals, DNA failures, etc.) This refers
to the state of health of our cells, i.e.,
when one’s appearance does not
match one’s chronological age.

9. Aging
9
10
20
30
40
50
60
70
90
80
10 20 30 40 50 60 70 80 90 REAL AGE
APPARENTAGE
BIOLOICALAGEING
CHRONOLOGICAL AGEING
IDEAL CONDITIONS
PRO-YOUTH STRATEGIES
EXTRINSIC FACTORS
Sun, Stress, Tabaco, Free radicals

10. Telomerase agents
They artificially lengthen the life expectancy of adult cells
(new and old).
Stem cells
They promote the generation of new cells from stem cells.
(cosmet. It is applicable to tissues that already contain
them).
Anti-senescence marker therapies
They reverse aging in old cells and delay aging in young
ones.
10
Pro-youth strategies

11. Their size and shape is different
- reduction in their functional capacity, which is responsible for the
signs of age.
- they have lost their capacity to replicate themselves or divide.
+ greater resistance to mutation processes (neoplasias) or cell
death.
11
Adult cell
Senescent cell
“The phase when adult
cells evolve to a senescent
stage”
Senescence

12. 12
“A molecule/structure present in
all senescent cells.”
The marker that is currently giving promising results in combating
age is PROGERIN.
PROGERIN is an alteration of the protein laminA and it plays a
part in the premature aging disease, Progeria or Hutchinson-
Gilford Syndrome.
Senescence markers

13. Lamin A is a protein responsible for maintaining
the cell nucleus structure. It degenerates with
time and is converted into progerin, a toxic,
disfunctional protein that produces
malformations in the nucleus structure.
With respect to cells this leads to an alteration in
their functioning, which is reduced to a state of
low-functionality or senescence.
With respect to skin it leads to the dreaded
signs of age (apparent or biological age).
13
Senescence markers
Progerin.
The concentration of progerin gives us an idea of the biological
age(health) of the cells.
Nuclear membrane
Lamin A

14. 14
Morphological differences in the nuclear membrane in young
and senescent cells
Cell nucleus from a donor
aged 9
Cell nucleus from a donor
aged 96

15. 15
Morphological differences of the nuclear membrane in healthy
cells and Hutchinson–Gilford Syndrome cells
Cell nucleus from a young
healthy donor
Cell nucleus from a donor
with Hutchinson–Gilford
Syndrome

16. In the skin, progerin is present in the skin in fibroblasts and keratinocytes
It is estimated that progerin accumulates at a rate of 3% per year and
increases with age (from the age of 55).
starting with the papillary dermis and
gradually spreading to the reticular
dermis.
16
Progerin and skin

17. GLOBAL LIFT [ProGEN-in] is an exclusive technology developed
by SKEYNDOR® that is based on anti-senescence marker
therapies.
A global anti-age strategy designed to achieve a facial
redefining effect, which restores the fullness of the jaw line and
attenuates submental fat in mature skin.
It is targeted at: progerin, a cell aging marker which makes it
possible to estimate the biological age of the cells.
The ultimate objective: to improve the functioning of cells with a
slow metabolism, which results in a loss of thickness, firmness and
resilience in the tissues, found in mature and/or photoaged skin.
17

18. 18
[ProGEN-in] TECHNOLOGY IS BASED ON THE EFFECTS OF THREE SPECIFIC
ACTIVE SUBSTANCES:
-Biomimetic peptide derived from Elafin, winner of the
Innovation Zone Best Ingredient Award 2012 at In-cosmetics®,
Barcelona 2012. An enzymatic inhibitor with anti-progerin and
anti-elastase activity that combats flaccidity in mature skin.
-Menyanthes trifoliata extract, a potent next-generation
antioxidant that protects the cellular Vitamin C content, a key
cofactor in improving the quality and quantity of collagen in the
skin.
- α-glucans and black pepper (Piper nigrum)
rhamnogalacturonans. Molecules that act on the profound
dermis –reticular dermis- and improves the skin’s mechanical
properties (supportive), particularly in prematurely photoaged
skin.
[ProGEN-in]
TECHNOLOGY

19. 19
Papillary dermis
(Intrincis ageing)
Reticular dermis
(Extrinsec ageing)
Menyanthes trifoliata ext.
Pro-collagen
Black pepper extract
Reticular anti-photoageing
Peptide biomim. elafin
Anti-progerin
Anti-elastase
[ProGEN-in]
TECHNOLOGY

20. Scientific evidence
20
1Alaria algae extract
+262%
+44%
0%
66 years
35 years
IN VITRO TEST ON THE PRODUCTION OF PROGERIN IN
HUMAN KERATINOCYTES1
Progerin(pp/ugproteins)
Control Algae ext. 0.1 Algae ext. 1.0
Dose
The marker levels are
reduced in mature cells (66
years) to the levels of cells
that are 30 years younger
[ProGEN-in]
TECHNOLOGY

21. 21
In-vitro test. Anto-progerin effect on the
functionality of mature human keratinocytes*
High recovery of general cellular functionality (ribosomes, mitochondria
and proteosomes)
[ProGEN-in]
TECHNOLOGY
*Alaria Algae extract.

22. In-vitro test. Effect on the functionality
of photoaged human reticular
fibroblasts*
22
Non irradiated control
Adhesion:+++ (100%)
Contraction:+++ (100%)
Migration: +++ (100%)
Irradiated UVA control
Adhesion:+ (65%)
Contraction : + (32%)
Migration : ++ (75%)
UVA + Piper Nigrum ext.
Adhesion:++ (83%)
Contraction :++ (83%)
Migration : +++ (94%)
*α-glucans and black pepper (Piper nigrum) rhamnogalacturonans.
Recover of the reticular cells funcionality on photoaged skins.
[ProGEN-in]
TECHNOLOGY

23. 23
[ProGEN-in]
TECHNOLOGY
Clinical study. In-vivo Fringe
Projection
Equipo de proyección de franjas Proyección de franjas sobre zona a evaluar
Digitalización de imagen y cálculo de aéreas
23
Fringe projection equipment Fringe projection in area to be evaluated
Image digitalisation and calculation of regions

24. 1Biomimetic peptide.
24
• Placebo
•Péptido biomimético de la Elafina 2%
[ProGEN-in]
TECHNOLOGY
Clinical study. In-vivo Fringe
Projection Technique1
•Placebo
•Biomimetic peptide

25. 25
After 28 days there is a significant reduction
(up to -18%) in the facial contour
-18%
Clinical study.
SAGGING of jaw line2
2 Menyanthes Ext.
25
[ProGEN-in]
TECHNOLOGY

26. 26
After 28 days there is a significant reduction
(up to -18%) in jowls
-18%
Clinical study.
SAGGING of jaw line2
[ProGEN-in]
TECHNOLOGY
2 Menyanthes Ext.

27. 27
After 28 days there is a significant reduction in wrinkles due to sagging
Clinical study.
Wrinkles caused by sagging1
1Biomimetic peptide.
27
[ProGEN-in]
TECHNOLOGY

28. 28
After 28 and 56 days there is a slight to moderate reduction in facial
ptosis
FACIAL ptosis: observation of the number and
depth of skin folds in the ear surrounding the
ear when the patient is lying down.
Clinical study.
Anti-gravity effect1
1Biomimetic peptide.
28
[ProGEN-in]
TECHNOLOGY

29. Global Lift.
Clinical study subject
to medical control
A specialist evaluated 20 volunteers aged between 50 and 69, and determined their Mean
Sagging Skin Index (MSSI) before and after treatment with Global Lift*, based on:
All the volunteers had slight to moderate sagging of the face, cheeks and neck: 1 to 3.5 on a scale of 0
(without) to 4 (very significant).
The improvement in firmness was assessed objectively with the non-parametric Wilcoxon Exact Test
comparing the results of D0 and D28.
Empirical formula
IFM= (Sum of score obtained for
cheeks/jaw line and neck) / 2
0 = IFM No sagging
0 < IFM ≤ 1 Slight
1 < IFM ≤ 2 Moderate
2 < IFM ≤ 3 Significant
3 < IFM ≤ 4 Very significant
and the table
Sagging tissue scale.
0-Firm skin (terse, perfect adapted to muscle, immediate return)
1-Slight sagging (terse, small wrinkles when pressed, immediate return)
2- Moderate sagging (small wrinkles, median when pressed, slow but complete
return).
3-Sagging skin (wrinkles without pressing, partial detachment of muscle, slow and
incomplete return).
4-Extremely loose skin (large wrinkles, total detachment of muscle, no return).
*In-use test: 20 volunteers Treatment: Antigravity Lifting Programme (4 sessions)
+Redefining cream + Redefining eye contour cream
29

30. FIRMING EFFECT
MEAN SAGGING SKIN INDEX (MSSI)
Volunteers D0 D28

D28-D0
Reactive
volunteers
Ref. Surname/name
Face Neck  Face Neck 
1 MI/ES 3 3 3 2 3 2,5 -0.5 +
2 PE/LU 2 3 2,5 2 3 2,5 0 -
3 CO/CA 1 1 1 0 1 0,5 -0.5 +
4 CO/AN 1 2 1,5 1 2 1,5 0 -
5 BR/ME 1 1 1 0 1 0,5 -0.5 +
6 TO/MO 2 3 2,5 1 2 1,5 -1 +
7 RO/AN 2 2 2 1 2 1,5 -0.5 +
8 PE/MD 2 3 2,5 1 3 2 -0.5 +
9 JA/MA 1 1 1 0 0 0 -1 +
10 VI/NU 3 4 3,5 2 4 3 -0.5 +
11 MO/MA 1 2 1,5 0 1 0,5 -1 +
12 MU/MA 2 3 2,5 2 3 2,5 0 -
13 GA/RO 1 2 1,5 0 1 0,5 -1 +
14 PE/IS 2 3 2,5 2 3 2,5 0 -
15 MI/VI 2 3 2,5 1 3 2 -0.5 +
16 PE/IR 3 3 3 3 3 3 0 -
17 MO/AN 1 1 1 0 1 0,5 -0.5 +
18 CO/MA 1 1 1 0 1 0,5 -0.5 +
19 MI/EL 1 2 1,5 0 2 1 -0.5 +
20 PE/MP 3 4 3,5 3 4 3,5 0 -
30
Global Lift.
Clinical study subject
to medical control
*In-use test: 20 volunteers Treatment: Antigravity Lifting Programme (4 sessions)
+Redefining cream + Redefining eye contour cream

31. 31
“After 28 days of treatment, there is a reduction in the Mean Sagging
Skin Index (MSSI) of 12.5% in the whole panel and 15% in the quartile
of most reactive volunteers (70%), which is statistically significant
(p<0.001).”
It is concluded that thanks to the Global Lift*
treatment, the skin is rejuvenated by 5 to 6 years on
average in terms of apparent sagging.
Global Lift.
Clinical study subject
to medical control.
Results
*In-use test: 20 volunteers Treatment: Antigravity Lifting Programme (4 sessions)
+Redefining cream + Redefining eye contour cream

32. 32
Global Lift.
Self-evaluation.
Results.
*In-use test: 20 volunteers Treatment: Antigravity Lifting Programme (4 sessions)
+Redefining cream + Redefining eye contour cream
Younger skin’s appearance
Jowls smoothed
Global firming effect
Restores facial fullness
Attenuation of flaccidity folds/wrinkles
Cosmetic lfiting effect
Smoothed eye contour (circles-puffiness)
Percentage of positive opinions

33. Based on anti-age clinical studies that have been revised.
Skin flaws in women from a certain age. Association with
hormonal deficits.
Does not take into account the firming/lifting effect combined
with global aging.
At present soya and their derivatives are associated with mid
value lines.
33
Global Lift vs. Platinum
Platinum is focused at:

34. 34
Salon treatment
ANTI-GRAVITY LIFTING
PROGRAMME
RESTORES FULLNESS TO THE FACE
AND NECK

35. 35
Activating Firming Gel
An emollient non-oily gel that
facilitates facial massage in
the salon. With tensor and
firming properties.
Active substances:
Menyanthes trifoliata,
Clhorella Vulgaris, Probiotic
Lysate, Amino Acidos.
Anti-gravity Serum
A serum formulated for
producting a global lifting
effect on the skin. Specially
developed for treating loose,
mature and prematurely
photoaged skin. With
hydrolysed collagent and
organic silicon which
consolidate the skin’s
suppoprtive properties.
Active substances: Biomimetic
peptide derived from Elafin,
Black Pepper, Collagen,
Organic Silicon.
Immediate Lift Action Mask
A lifting-effect Mask for the face
and neck, with a wrinkle-ironing
effect. Its patch-like format gives
spectacular and immediate
firming results, with great
professionalism and
effectiveness.
Active substances: Yeast cell
lysate, Asian Centella, Aloe Vera.
Lift Contour Cream
A face and neck cream
based on [ProGEN-in] anti-
age technology. An
advanced cosmetic for a
global firming effect that
restores fullness to the face.
Active substances: [ProGEN-in]
Tech., Algae Ext., Lupin Ext.

36. 36
Home treatment

37. 37
Lift Contour Face and Neck Cream
Firming· Redefining · Anti-wrinkle Treatment
Effects:
• Firms the skin and reduces wrinkles.
• Cosmetic lifting effect.
• Restores the fullness of a youthful face.
Active substances:
• [ProGEN-in] technology.
• Alaria algae extract.
• Lupin extract.
Presented in two different textures, depending on the skin type:
• Dry skins: with a rich, creamy texture.
• Normal to combination skins: with a lighter, non-oily texture.

38. 38
Lift Definition Eye Contour Cream
Triple orbicular effect, [ProGEN-in] technology
Effects:
• Firms the skin and reduces wrinkles.
• Attenuates eye bags.
• Relieves congestion in eyelids and eye bags.
Active substances:
• [ProGEN-in] technology.
• Alaris algae extract.
• Buckwheat.
• Firming anti-wrinkle lipopeptide.

39. Sales argument
Key points
39

40. Main sales arguments for differentiation
Global Lift Eternal Corrective
Recommended age
50s
From 35
40s
From 35 From 40
Skin type
Mature skin with loss of firmness
and wrinkled due to sagging.
Photoaged skin.
Globally aged skin Mature skin with deep
wrinkles and expression lines
Final consumer profile
Women who want to rejuvenate
their faces and attenuate
wrinkles caused by sagging.
Women on high-protein diets.
Women who want to recover
a globally younger face
(radiance, wrinkles, sagging,
moisturising, nutrition, etc.).
Women who do not want
minimally invasive surgery.
Maintenance after injecting
hyaluronic acid and botox.
Active substances
Exclusive [ProGEN-in] technology Liposome stem cells of plant
origin
Botox-like peptides, snake
venom and hyaluronic accid
filler
Benefit
Restores the facial fullness of
youth.
Better defined contours in JAW
LINE · NECK · CHEEKBONES
Restores a globally more
youthful face
The result is face with fewer
wrinkles, more fullness and
terser skin
40

41. 41
Thank you for
your attention