Corrective, Global and Eternal

2. WHY DO WE AGE?
Various factors:

3. EXTERNALINTERNAL
40% 60%
CAUSES OF AGEING

4. BIOLOGICAL ENVIRONMENTAL
Genetic
Hormonal
Sun, Pollution
Tobacco smoke
CAUSES OF AGEING

5. RESULTS OF AGEING

6. COSMETIC RESPONSE
REGENERATION REPAIR CORRECTION

7. REGENERATION

8. REPAIR

9. CORRECTION

10. SKEYNDOR PROPOSE
REGENERATION

11. SKEYNDOR PROPOSE
CORRECTIONREPAIR

12. eternal
line

13. All the cells in the same organism:
Have the same genetic system, DNA.
(instruction manual )
Are differentiated.
(specialised for one specific function and place)
Have a limited capacity to multiply themselves.
(btw 30 and 50 copies)
The copies have exactly the same characteristics as the original. (specialisation
and age)

14. Stem cells
Can multiply themselves
an endless number of times.
They produce new daughter cells
without any record of age or damage.

15. Uttwiler Spätlauber

16. YOUNG AGED

17. The secret of its longevity
Studies of the epigenetic factors
of the stem cells extracted from
the Spätlauber reveal the
tremendous regenerative
capacity of this apple variety.
This regenerative capacity could pass on to the fruits,
giving them the secret of withstanding the passage of time.

18. Eternal line
Active ingredient : stem cells
(of plant origin)
Proven efficiency in the treatment of epidermal
stem cells and in dermal fibroblasts.
Active ingredient acknowledged by the 2008 Innovation
Award (European Cosmetic Academy).

19. LUPIN EXTRACT
Redensifies the
dermis and
increases the
synthesis of high
quality collagen.
OIL SOLUBLE
JAMBU EXTRACT
Reinforces the
biomechanical
functions of the
dermis and
reorganises the
collagen.
OIL SOLUBLE
SEA FENNEL
EXTRACT
OIL SOLUBLE
MARINE
LAVENDER
EXTRACT
HYALURONIC
ACID +
ORGANIC
SILICON
Strong free radical
action Relaxes muscular
contractions –
BOTOX effect
Increase
significantly the
synthesis of high
quality collagen.

20. Summary
Product source Malus domesticus var. Uttwiler Spätlauber
PhytoCellTec to produce apple stem cells
Maintenance and protection of skin stem cells
Results show: - protection of stem cells against UV-irradiation
- growth promotion of stem cells
- increase of life span of hair follicle stem cells
- reduction of skin wrinkles

25. Eternal Cream
Cream with plant origin stem cell
nanoliposomes. Formulated to
compensate the loss of the vital
substrate and to restore the skin’s
volume lost with age at the deepest
levels. The face appears fuller, smoother
and firmer.

26. Eternal
Intensive serum

27. Eternal
body repair serum
For areas of thin skin. For instance
under the arms inner thighs, the
cleavage area.

28. Eternal
icy eye cream

29. Eternal
professional pack

30. Eternal to emphasize…
Produced through development in co-operation of state-of-
the-art Swiss technology.
Extract of a Swiss plant species (apple)
Developed with nanotechnology
Air-less packagings that prevent the proliferation of bacteria
and conserve the active ingredients
Enriched with active ingredients that are effective
throughout the three layers of the skin.
Two textures for all skin types.

31. ”Always beautiful, forever
young”

34. THE INVESTIGATION
It has taken 3 years research, more than 25
tested substances and a study of about 200
combinations for the SKEYNDOR
Laboratories to create CORRECTIVE.
CORRECTIVE LINE

36. AGENTS NEURAL-INHIBITORS
LAVANDULA STOECHAS
ACMELLA OLERACEA

37. PRE SYNAPTIC PEPTIDES
ACETYL HEXAPEPTIDE-8 or “botuline-like”
PENTAPEPTIDE-18
x x

38. POST-SYNAPTIC PEPTIDES
VIPER'S VENOM
ACETYL HEXAPEPTIDE-30,

39. • Cosmetic
HYALURONIC ACID
SKIN FILLING SUBSTANCES
CORRECTIVE ACTIVES

40. Dried spheres Swallow spheres
MECHANISM:Penetrate and swallow into the skin
Cosmetic HYALURONIC ACID

42. MAIN ACTIVE INGREDIENTS
• Internal tissue redensifiers
• Skin filling substances
• Neural-inhibitor agents
• Skin-lifting peptides with pre- synaptic
activity.
• Skin-lifting peptides with post-synaptic
activity. The ultimate concept in anti-ageing.
CORRECTIVE ACTIVES

43. MAIN ACTIVE INGREDIENTS
Skin filling substances
Neural-inhibitor agents
Internal tissue redensifiers
Skin-lifting peptides
CORRECTIVE ACTIVES
Skin-lifting peptides
Skin filling substances
Neural-inhibitor agents
Internal tissue
redensifiers

44. Biological solution with muscle-relaxing peptides
Solution based on muscle-relaxing peptides with complementary
action, that creates a more intense and longer-lasting skin-lifting
action.
Dosage discs + Fill-in Hyaluronic
Lyophylized matrix of polysaccharides that intensifies the attachment
and absorption of active ingredients in the skin. Together with the
concentrated hyaluronic acid solution with fill-in effect.
Pearl based regenerating mask
Micronised pearl mask. With nutritive, softening, depigmentating
action that improves the skin's resistance, by delaying the
appearance of wrinkles and other signs of ageing.
CORRECTIVE TREATMENT FOR WRINKLES AND EXPRESSION LINES

45. Expression Lines Serum
Facial serum for treating expression lines and wrinkles. It combines muscle relaxing
active ingredients with fill-in substances.
Instant Wrinkle Filler Cream
Facial cream for filling wrinkles and expression lines. It combines skin fill-in
substances containing active ingredients with muscle relaxing properties.

46. Eye Expression Lines Eraser
Anti-wrinkle treatment cream with fill-in effect for eye contour.
Instant Lip Contour Filler
Lip contour cream with fill-in substances and muscle relaxing active ingredients, for
softening wrinkles around the lips.

47. Wrinkle analysis: Quantirides® Technique:
Female Volunteer 1, before and after treatment
D28D0

48. 3) Fotografías Voluntaria 1
Patas de gallo
Entrecejo
D0
D0
D28
D28
IN VIVO EFFICACY: CLINICAL RESULTS

49. 3) Pictures Booth Treatment (1session)
IN VIVO EFFICACY: CLINICAL RESULTS

50. 3) Pictures Booth Treatment (1session)
IN VIVO EFFICACY: CLINICAL RESULTS

51. 3) Pictures Booth Treatment (1session)
IN VIVO EFFICACY: CLINICAL RESULTS

52. 3) Pictures Booth Treatment (1session)
IN VIVO EFFICACY: CLINICAL RESULTS

54. Cell...

55. Specific stress-related factors (UV
radiation, genetic factors, free radicals,
DNA errors...)
It refers to the state of health of
our cells, i.e., when one’s
appearance is not in keeping with
one’s chronological age.
Determined by age.
This evolution of the
skin is unstoppable,
and forms part of the
normal cycle of life.
CHRONOLOGICAL BIOLOGICAL or SENESCENT

56. A senescent cell is one
which...
- has lost its capacity to replicate itself or
divide.
- is resistant to the processes of mutation or
cell death.
- acts like a retired cell with reduced functional
capacity and appears to be old

57. Lamin A is is converted into progerin, a
toxic, protein that produces malformations
in the membrane of the nucleus.
When the membrane of the nucleus
deformed-
The cells are reduced to a state of low-
functionality or senescence.
With respect to skin it leads to the dreaded
signs of age (apparent or biological age).
57
Senescence markers
Progerin.

59. Senescence markers
Chromosomatic aging
Intrinsic TELOMERE EROSION
Extrinsic DAMAGE TO THE DNA

60. Epidermis
Papillary
Dermis
Reticular
Dermis
Papillary Dermis = Connective tissue
Func. Comp.: Collagen and elastin
Resilience, elasticity, deformability
Intrinsic aging (L.R.) and extrinsic aging (UV)
Median wrinkles, loss of elasticity.
Reticular Dermis= Dense tissue
Func. Comp.: Collagen and elastin
Resistance, support
Extrinsic aging (UV)
Deep wrinkles, loose skin
Skin histology. Function

61. The cosmetic face lift of the future
Components:
1. Active substances that stimulate the synthesis of
1. Collagen production
2. To protect the elastin from its degeneration.
2. Agents that reverse photoaging in the profound dermis (permitting the
recovery of 10 years of youth).
3. Next-generation anti-age components that reverse the general aging of
the cells
Global lift based on pro youth sratagies
61

64. Aging
64
10
20
30
BIOLOGICALAGE0
50
ee
60
70
90
80
10 20 30 40 50 60 70 80 90 REAL AGE
A
BIOLOICALAGEING
CHRONOLOGICAL AGEING
IDEAL CONDITIONS
PRO-YOUTH STRATEGIES
EXTRINSIC FACTORS
Suffacn, Stress, Tabaco, Free radicals
EXTERNAL FACTORS

66. THE [PROGEN-IN] TECHNOLOGY IS BASED ON THE EFFECTS OF THREE
SPECIFIC ACTIVE SUBSTANCES:
-A biomimetic peptide derived from Elafin, winner of the Innovation
Zone Best Ingredient Award 2012 at In-cosmetics®, Barcelona 2012. This
is an enyzymatic inhibitor with an anti-progerin and anti-elastase effect that
combats flaccid tissue in mature skin.
-Menyanthes trifoliata extract, a potent next-generation antioxidant that
protects cellular vitamin C content, an essential cofactor in improving the
quality and quantity of collagen in the skin.
- α-glucans and Black Pepper (Piper nigrum) rhamnogalacturonans.
These molecules act on the profound dermis (reticular dermis) to improve
the skin’s mechanical properties (supportive), particularly in prematurely
photo-aged skin.
[ProGEN-in]
TECHNOLOGY

67. Biomimetic peptide derived from Elafin
ANTI-FLACCID EFFECT
- Inhibits progerin synthesis
- Inhibits the activity of elastase
- Regulates the cohesion of the
epidermis
- Increases the contractility of
fibroblasts

68. MENYANTHES TRIFOLIATE - BOG
BEAN
Preserves Vit C for collagen
formacion
Absorbs peroxynitrate a cellular
toxin
Contains triterpenes
Powerful anti oxidant

69. In-vitro test. Effect on the functionality
of photoaged human reticular
fibroblasts*
69
Non irradiated control
Adhesion:+++ (100%)
Contraction:+++ (100%)
Migration: +++ (100%)
Irradiated UVA control
Adhesion:+ (65%)
Contraction : + (32%)
Migration : ++ (75%)
UVA + Piper Nigrum ext.
Adhesion:++ (83%)
Contraction :++ (83%)
Migration : +++ (94%)
*α-glucans and black pepper (Piper nigrum) rhamnogalacturonans.
Recover of the reticular cells funcionality on
photoaged skins.
[ProGEN-in]
TECHNOLOGY

70. 70
Papillary dermis
(Intrincis ageing)
Reticular dermis
(Extrinsec ageing)
Menyanthes trifoliata ext.
Pro-colagen
Piper nigrum ext.
Reticular anti-photoageing
Peptide biomim. elafin
Anti-progerin
Anti-elastase
[ProGEN-in]
TECHNOLOGY

72. Global Lift demonstrates positive results with respect to facial
architecture parameters
Younger skin
EFFICACY TEST SUBJECT TO MEDICAL CONTROL*
Global firming effect
Redefined facial contour
Attenuation of wrinkles caused by loose skin
Lifting effect
Attenuation of eye contour (eye bags, dark circles)
Reduction in submental fat
Percentage of positive opinions
* In-Use Test: 20 volunteers, 28 days. Treatment: Antigravity Lifting Programme
(4 sessions)
* Redefining cream + Redefining eye contour cream

73. Anti-gravity lifting programme
Restores fullness to the contours of the face and neck
in the salon

74. Activating Firming Gel
A non-oily emollient gel that
facilitates facial massage in
the cabin. With tensor and
firming properties.
Active substances:
Menyanthes trifoliata,
Clhorella Vulgaris, Probiotic
Lysate, Amino Acids.
Anti-Gravity Serum
A serum formulated to
produce a global lifting effect
on the skinl. Specially
formulated for treating loose,
mature and photoaged skins.
Contains hydrolysed collagen
and organic silicon which
strengthen the skin’s
supportive properties.
Active substances:
Biomimetic peptide derived
from Elafin, Black Pepper,
Collagen, Organic Silicon.
Immediate Lift Action
Mask
A lifting mask for the face and
neck with a wrinkle-ironing
effect. It patch-like format
gives spectacular and
immediate firming results in a
professional and effective
manner.
Active substances: Yeast Cell
Lysate, Asian Centella, Aloe
Vera.
Lift Contour Cream
A face and neck cream based
on the [ProGEN-in] anti-age
technology. Advanced
cosmetics for a global
firming effect that restore
fullness to the facial contour.
Active substances:
[ProGEN-in]Tech., Algae
Ext., Lupin Ext.
in the salon

75. Lift Contour Face & Neck Cream
Global, firming effect, [ProGEN-in] technology.
Active substances: [ProGEN-in] Tech., Algae Ext., Lupin Ext.
Presented in two textures, depending on the skin type:
Dry skins: a rich, creamy texture and normal to combination skins: a lighter, non-oily texture.
at home
Lift Definition Eye Contour Cream
Triple orbicular effect, [ProGEN-in] technology.
Active substances: [ProGEN-in] Tech., Alga Ext., Buckwheat, Firming, anti-wrinkle lipopeptide.

76. 76
Lift Definition Eye Contour Cream
Triple orbicular effect, [ProGEN-in] technology
Effects:
• Firms the skin and reduces wrinkles.
• Attenuates eye bags.
• Relieves congestion in eyelids and eye bags.
Active substances:
• [ProGEN-in] technology.
• Alaris algae extract.
• Buckwheat.
• Firming anti-wrinkle lipopeptide.

77. ACTIVE
SUBSTANCE
EFFECT
CLHORELLA
VULGARIS
Anti-elastase, anti-collagenase.
A green microalga, rich in proteins, vitamins and carotenes.
PROBIOTIC
LYSATE
Stimulates the skin’s defences.
Vitamins from the B group, trace elements (the lysate kills
the bacteria but conserves most of their activity).
COLLAGEN Moisturising and filler.
A protein forming part of the skin’s structure that makes the
skin elastic.
ASIAN
CENTELLA
Anti-age repair agent.
Has healing and renovating properties. It binds amino acids
to the collagen structure due to the effects of its triterpenes.

78. ACTIVE
SUBSTANCE
EFFECT
BUCKWHEAT Has a specific effect on submental fat.
Anti-oedematous draining effect. Rich in rutin, a
substance used to improve the blood circulation.
LUPIN
EXTRACT
Redensifies the dermis.
Increases high quality collagen synthesis. Increases
the firmness and elasticity of the facial contour.
ALOE VERA Moisturises, soothes and nourishes the skin.
Contains minerals and vitamins C and E, which have a specific
repairing effect on photo-aged skin.
ORGANIC
SILICON
Increases the skin’s firmness and elasticity.
Plays a part in regenerating collagen and elastin.
Increases the cohesion of the extracellular matrix.

79. Commercial arguments
79

80. Cross-Selling with other products
• Recommend Global Lift with Ssuplemets Antiedad
Reafirmante, rich in Collágen and Resveratrol.
80
Objetive: increase
lines of sale

81. • Two textures of home treatment creams ideal for all the clients summer and
winter.
• One treatment cream for the face and the neck.
• Treats the 3 problem areas of the face, cheeks ,neck and jawline.
• Immediate visible results with the salon treatment thanks to the mask with the
IRONING EFFECT.
• Eye cream is multi-tasking.
81
SALES ARGUMENTS

82. STEP BY STEP CABIN TREATMENT

83. 1. Remove all traces of makeup
from the face with SKEYNDOR’s
special eye makeup remover
product. Exfoliate with the most
appropriate SKEYNDOR exfoliation
product.
2. To improve the treatment result,
massage the trapezius muscle and
cervical area to relax the neck and
relieve tension.
3. Apply the Activating Firming Gel
following the recommended
firming massage or use the
hydroelectricophoresis current for
6 to 8 minutes at negative polarity.
4. Apply the Anti-gravity serum and
ensure it penetrates in full with a
brisk massage or apply the
electroporation current for 6 to 8
minutes.
5. Remove all traces of surplus
product and apply the Immediate
Lift Action Mask, ensuring it
covers the face.
Leave on for 20 to 25 minutes and
remove in one piece.
6. End the treatment with the Lift
Contour Cream. Apply the
necessary quantity, depending on
the skin type.
TRATAMIENTO PASO A PASO