This document summarizes the history of retinol in skincare products from its discovery in 1937 to present innovations. It traces key milestones like the first clinical studies in Europe in 1937, launches of retinol-containing Skeyndor products from 1990-2014, and the introduction of the retinol alternative bakuchiol in 2009. The document also provides details on the metabolic activity, forms, and effectiveness of retinol and retinoid-like substances. It describes a new Skeyndor product called Power Retinol that combines retinol, bakuchiol, and soy extract for triple retinoid activity, maximum stability, and minimum side effects.

1. 25 Years
Innovating

2. A Journey through History of Retinol
Nobel Prize for
discovering the
Retinol structure.
1937
First clinical studies
in Europe
1990
1990
First SKEYNDOR
launch.
Gel/Cream with Pure
Retinol.
Primera fórmula
SKEYNDOR con
Retinol unido a la
Vitamina C. VITAMIN
C Eye Contour.
1998
First SK-RETINOL
launch of multi-line
with encapsulated or
derived (palmitate)
Pure Retinol
1300IU/g.
1999
Primera fórmula
SKEYNDOR
“retinoid-like” con
“botox-like” + HA.
2004
Launch of SKEYNDOR
ETERNAL with
encapsulated Pure
Retinol or derived
(palmitate) 1300IU/g.
2009 2014
First SKEYNDOR formula
with BAKUCHIOL
(CORRECTIVE). Pioneering
brand in Europe of
introducing this formula
for professional use.
2010
Launch of POWER
RETINOL,
25th anniversary of this
molecule in SKEYNDOR’S
history with triple
stabilised Pure Retinol
5000IU/g.
First SKEYNDOR
Retinol formula
with Vitamin C.
VITAMIN C Eye
Contour
First "Retinoid-like"
SKEYNDOR formula
with "botox-like" and
HA

3. Plataforma Molecular
Increases the brand’s SCIENTIFIC EXPERTISE.
Attracts new consumers who are more price sensitive.
Easy communication. There are no barriers, no specific
brands to transmit, favouring the whole distribution chain.
The POWER ranges combine together and complement
other treatments.
Makes it possible to look for new targets and new uses.
Cosmetics by weight, according to concentration %.

4. Lines Segmentation
-
+
Price

5. Technical
Development

6. A new generation
of Pure Retinol

7. RETINOIDS
RETINOIDS have been used in beauty products since the 80s. Originally
retinoids were applied in aesthetics medicine to treat problems caused by
acne, and later it was discovered that retinoids have a very interesting
regenerative anti-ageing effect. Since then retinoids application purpose
was extended.

8. METABOLIC ACTIVITY OF RETINOIDS
Application Genetic and molecular level Functional and structural level Consumer level
Wrinkles/
Firmness
+Increase in collagen synthesis
- reduction of collagen degradation
+Reorganisation of collagen and
elastin in papillary dermis
-Reduced wrinkles and lines
+Improved firmness and
elasticity
Texture/
Thickness/
Acne
+Increase in epidermal GAGs
+Increase epidermal proliferation
+Epidermis thickening
+Softened micro-relief
-Reduction of the skin’s rough
texture
Colour/Skin
tone
-Reduced tyrosinase activity
-Reduced tissue melanin
-Inhibition melanosome transfer
-Reduced blemishes
+Uniform tone
Retinoids repair and rejuvenate the ECM
(EXTRACELLULAR MATRIX)

9. VITAMIN A
Vitamin A has three forms of oxidation:
Retinol (alcohol), act as precursors of the acid.
Retinal (aldehyde), act as precursors of the acid.
Retinoic (acid). The unic biologically active.
Retinoic acid has high cutaneous toxicity, therefore the skin tends to
convert itself and store cell membranes in the form of retinol or its esters,
which have a better toxicological profile and greater stability.

10. VITAMIN A
The biological effectiveness of the different forms of Vitamin A is different
according to the transformations that are needed to convert it into the
active form.
In order to be able to compare the retinoid activity of the products
containing Vitamin derivatives, we use the IU (international activity
units).

11. VITAMIN A IN COSMETICS
In cosmetics the use of Vitamin A acid is forbidden due to its high toxicity, but its
precursor forms are authorised, and the most usual one is the alcohol format
(retinol).
Even so, it has some limitations.
According to the recommendations by the Scientific Committee on Consumer
Safety (SCCS) and the World Health Organisation (WHO), it is not advisable to use
3000IU/g in regularly used cosmetics creams.

12. VITAMIN A IN COSMETICS
It has clear advantages over its esters:
Greater skin absorption;
faster retinoic acid metabolism;
clinically safe;
similar toxicological profile;
natural transformation into its esters by the epidermal cells.
There are numerous clinical studies showing that :
Effective clinical dose: over 3000IU/g of retinol in cosmetic products have a visible
anti-ageing effect after 8 weeks of treatment with 2 applications/day.
Tolerated clinical dose: over 2000-2500IU/g it is possible to observe side effects
(manifestation of retinoid effects) in certain individuals.

13. DECLARATION OF RETINOID EFFECTS
When the dose of retinoids exceeds the skin’s storage and control capacity, this
triggers a complex skin appearance, known as retinoid erythema or manifestation
of retinoid effects.
It appears during the first days of treatment and is characterised by dryness,
scaling and finally, erythema and inflammation, and it can be extend continuously
until the treatment with retinoids is removed.
PHOTOSENSITIVITY
Recent clinical studies (2013) reveal that retinoids are not photosensitive
per se.
The current tendency is to think that the photosensitivity of retinoids is
caused by their effect on the skin –retinoid erythema- when used in
inappropriate doses, and therefore it is not recommended to use these
products while exposed to the sun’s rays, is maintained.

14. “RETINOID-LIKE” SUBSTANCES
The “retinoid-like” substances are those which do not belong to the
retinoid family but can behave like them in some aspects.
Over the last 20 years, scientific cosmetics has focused on finding and
studying “retinoid-like” substances which, unlike retinoids, have a better
toxicological profile and improved molecular stability.

15. “RETINOID-LIKE” SUBSTANCES
On a scientific and molecular level the great alternative in terms of a retinol
substitute is bakuchiol, with a genetic expression profile almost identical to that of
retinol, and it is stable and not photosensitive.
On a commercial level other alternatives have appeared, mainly aqueous HS
extracts –selected hydrosoluble substances- from leguminosea like Frigol makusta
(Vigna acontifolia), Soy (Glycine Max) or Lucerne (Medicago Sativa),…. which have
obtained cosmetic results similar to those obtained with the recommended
cosmetic doses of retinoids (3000IU/gr).

16. POWER RETINOL is the result of in-depth research into
retinoids and substances with retinoid or retinoid-like activity.
Its mission is to rejuvenate aged skin by natural causes or by
photo-ageing, sun.

17. SKEYNDOR launches a new formula to the market, based on
the synergy of three active ingredients that are expertly
combined to obtain a unique complex with surprising results.
Three active ingredients have been carefully selected due to
their distinctive rejuvenating activity, their unique ability to
enhance each other synergically and producing a surprising
anti-ageing result without side effects.

18. It is an extraordinary complex with great “retinoid” activity, made up of a
retinoid, Retinol, together with two “retinoid-like” substances,
Bakuchiol and the HS soy extract, which also boosts the repairing and
rejuvenating activity of the retinol; one stabilises it and the other one reduces
its side effects.

19. Pure retinol, an excellent rejuvenating element
that can repair and recover the architecture and
qualities of young skin.
[ PURE RETINOL
DERMAL REGENERATOR ]

20. The BAKUCHIOL molecule can act like retinol on a genetic
stimulation level, and also it is a great retinol stabiliser, which
allows retinol-based products to be developed to maintain their
effectiveness for longer.
Bakuchiol is an oil-soluble
molecule that is extracted and
purified from the leguminosae
Psoralea corylifolia.
MOLECULAR STABILISER ]

21. The HS soy extract, selected hydrosoluble extract (HS), on a functional level
can produce a rejuvenating effect similar to that produced by retinoids, and
with advantages that it can reduce the appearance of the manifestation of
retinoid effects and therefore reduce the side effects associated with
retinoids.
[ HS SOY EXTRACT
MINIMISES SIDE EFFECTS ]

22. ACTIVE
INGREDIENT
ACTIVITY STABILITY SIDE EFFECTS
RETINOL Retinoid No Yes
BAKUCHIOL Retinoid –like
Yes.
Stabilises retinol
No
HS SOY EXTRACT Retinoid –like Yes
No
Reduces retinol side
effects
POWER RETINOL 3x Retinoid Yes No
TRIPLE REJUVENATING EFFECTIVENESS, MAXIMUM STABILITY, MINIMUM SIDE EFFECTS
Extraordinary SKEYNDOR formula with triple “retinoid” activity:

23. Product

24. Pure Concentrated Retinol
0.15%
5.000 IU
Organic Calendula Oil
Amber Extract Mask
Intensive Antioxidant
Cream. SPF15
Treatment in institute
INTENSIVE REPAIRING
PROFESSIONAL PROGRAMME

25. PURE CONCENTRATED RETINOL
Biological anti-ageing solution with
pure concentrated retinol.
Main components: Pure retinol
0.15% (5000 IU/g), Bakuchiol 1.0%,
HS soy extract.
ORGANIC CALENDULA OIL
Golden fluid with softening
properties, and which helps to
control the redness caused by
retinoids. Rice in carotenoids
(Vitamin A precursors).
Main components: Pure Marigold
oil (organic).
AMBER EXTRACT MASK
Mask with amber extract, a
fascinating material with
antioxidant and conditioning
properties, and able to preserve
our skin’s beauty.
Main components: Amber extract.
INTENSIVE ANTIOXIDANT CREAM
A cream with a high concentration
of antioxidant extracts and active
ingredients, formulated to protect
the substances sensitive to free
radicals and also soften the signs of
skin ageing. SPF 15.
Main components: Antioxidant
extracts (pomegranate, grape,
Picea excelsa), Coenzyme Q10, Vit.
C derivative.

26. Intensive repairing professional programme
1. Cleanse the skin around the eyes,
and on the face, neck and cleavage
with the SKEYNDOR make-up
removal line most suited to the skin
type. Tone and normalise the skin’s
pH with the THERMAL
CONCENTRATE WATER by
AQUATHERM.
2. Remove the excess of dead cells with
the Skeyndor Peeling. Wet your hands,
work with circular movements and
remove with plenty of water. Reinforce
the deep cleansing stage if necessary
with the EXFOLIANT CLEANSING GEL.
3. Start the intensive repair program.
Apply about 4 ml of PURE
CONCENTRATED RETINOL (4 to 5
sprays). Optionally, help the product
penetrate the skin using the
MESOSCIENCE equipment by
SKEYNDOR, using the
ELECTROPORATION current.
4 Next mix one part of the AMBER
EXTRACT MASK with a few drops of
ORGANIC CALENDULA OIL, (3 drops
for oily skins and about 8 drops for dry
skin). Massage face,, neck and
cleavage, remodelling the whole face.
5. Apply the rest of the AMBER
EXTRACT MASK over the face, neck
and cleavage in a fine layer and
leave for 15 minutes.
6. After this time has elapsed, smooth
the skin and remove any excess
product with damp sponges. Tone and
finish the treatment with a small
amount of INTENSIVE ANTIOXIDANT
CREAM.
1 2
3 4
5 6

27. Home care
INTENSIVE REPAIRING CREAM / EMULSION
* In vivo test (Clinical assessment, 64 volunteers, 8 weeks, x2applications/day, 0.1% Pure retinol)
• Rejuvenating activity on wrinkles and blemishes*.
•Do not use more than two times a day.
• Do not sun bathe without appropriate protection.
• Safe cosmetic, minimum side effects.
ACTIVE INGREDIENTS
• Pure retinol 0.06% (2000 IU/g).
• Bakuchiol 0.75%.
•HS soy extract.
It is available in two different textures according to the skin type:
• Normal to dry skins: rich texture.
• Mixed to oily skins: lighter, non-oily texture.
Available in a 50 ml. airless dosing tube.

28. Home care
INTENSIVE REPAIRING SERUM-IN-CREAM
• Rejuvenating action on wrinkles and blemishes*.
• immediate perfecting effect for pigmentation.
• Do not use more than two times a day.
• Do not sun bathe without appropriate protection.
• Safe cosmetic, minimum side effects.
ACTIVE INGREDIENTS
• Pure retinol 0.09% (3000 IU/g).
• Bakuchiol 1.0%.
•HS soy extract.
Available in 30 ml. airless dosing tube.
* In vivo test (Clinical assessment, 64 volunteers, 8 weeks, x2applications/day, 0.1% Pure retinol)

29. WARNINGS for using RETINOL
•Do not use more than two times a day.
In the home treatment products, it is important not to exceed the total daily dose of
6000 IU:
2 applications/day Cream or Emulsion (3gx2000IU/g)
2 applications/day Serum-in-Cream (2gx3000IU/g)
1 application/day Serum + Cream or Emulsion (3000IU+2000IU)
or the sporadic daily dose of 3000 IU:
the Serum-in-Cream + Cream or Emulsion should not be used in the same
application.

30. Results

31. Product
recommendations

32. Line Recommendations and Skin Type
Line Main Target Effect
Skins with blemishes or
lifeless skins
Brightens / Unifies
Skins with marks and/or
photo-aged skins Restores / Rebuilds
Mature and/or
photo-aged skins
Re-pulps / Redensifies
Flaccid skins Reaffirms / Tightens
Skins with wrinkles Smoothes / Corrects

33. Line Recommendations and Signs of Ageing
FLACCID SKIN
WRINKLES
MARKS BLEMISHES
FURROWS/
EXPRESSION
LINES
Prof.
Ttmnt.
Support
Ttmnt.
Prof.
Ttmnt.
Support
Ttnmt.
Prof.
Ttmnt.
Support
Ttnmt.
Prof.
Ttmnt.
Support
Ttmnt.
Mature and /or
photo-aged skins
Young, photo-
aged skins

34. The Formula for Perfect Skin
RE C+ HA
+ Skins with blemishes and/or
wrinkles
+ Fine and/or dehydrated skins
+ Lifeless and/or stressed skins

35. Skeyndor Face Creams
-
+ PREMIUM SEGMENT
MEDIUM SEGMENT
AFFORDABLE SEGMENT
BEST VALUE FOR MONEY

36. Skeyndor Professional Treatment
-
+
MEDIUM SEGMENT
PREMIUM SEGMENT
BEST VALUE FOR MONEY

37. Key Factors
Maximum concentration of PURE RETINOL 0.15% in one single professional
session *. Cream and emulsion 0.06% and Serum-In-Cream 0.09%.
Formula with great retinoid strength. Synergy of three ingredients with great
rejuvenating power.
Maximum cosmetic stabilization.
Effecctive on wrinkles and blemishes**.
Safe cosmetic, minimum side effects. The concentrations of retinol and other
active substances, have been established by toxicology experts according to
European recommendations.
The formula is packaged in PE-AL airless multi-layer packages to guarantee the
quality of the product.

38. Marketing
Support

39. Professional Catalogue
Includes Step by Step

40. Consumer
Leaflet

41. Display
Stand

42. Window or
inside Display

43. Sachette Samples

44. Youtube Video Channel

45. Flickr Channel Images
POWER
RETINOL

46. Advertisement