WHAT WORKS FOR ONE PERSON, DOESN’T NECESSARILY WORK FOR ALL. MEDICAL AESTHETICS IS NO EXCEPTION. SPORTS AND EXERCISE IS NO EXCEPTION. We are all different, both physically and genetically, and we are different in the way that we respond to aging, skincare and exercise. Some of these differences are due to our lifestyle and the environment we live in, but recent scientific advances have shown that VARIATIONS IN OUR DNA ALSO HAVE A BIG PART TO PLAY. Although you can’t change your genetics, science now has proven you can dramatically change how your genes affect your skin. Your DNA determines when you start showing signs of aging how quickly and at what rate your concerns could worsen, which is unique to you.   Genetics creates a new class of ANTI-AGING technology.   The luxury of a customized ANTI-AGING professional treatment PROGRAM made specifically for you. Suisse Life Science use natively genetics and a report in order to provide you a DNA-personalized treatment. NO MORE GUESSWORK, no more buying products that feel like they might help. There is no one size fits all for our customers. We replaced anti-aging guesswork with GENETICALLY-DESIGNED cosmeceuticals OTC (over-the-counter) and nutricosmetics supplements. DNAge is scientifically-created to CALCULATE YOUR GENE-EXPRESSION AGE (younger or older than your birth-certificate age?) www.idna.works

1. Your [iD]
GENETIC REPORT
[iD]LC01942/DNAge

2. GENE-EXPRESSION AGE
VISIBLE SIGNS BIOLOGICAL EFFECTS
soft skin
[1]
balanced tone and elasticity maintenance
[1]
severely increased adipose tissue
[2]
oily skin
[2]
trend to acne in adulthood
[2]
possible appearance of small furrows or wrinkles on your face and
body
[3]
possible predisposition to hypersensitive and reactive skin
[4]
potential loss of subcutaneous fat on the face resulting in the
appearance of wrinkles and skin folds
[5]
dry and rough skin
[6]
cracks
[6]
flaking phenomena
[6]
sensitive to climatic factors changes, air conditioning … skin
[6]
correct cell regeneration
[1]
protection against external agents
[1]
maintenance of firmness
[1]
strong alteration of the hydro-lipid film barrier protection in the
form of subcutaneous fat accumulation
[2]
possible accumulation of free radicals (risk of damage)
[3]
increased oxidative stress
[3]
minor capacity of elimination of toxic substances
[3]
normal production of nitric oxide
[4]
correct results of vascularization and oxygenation processes
[4]
normal cellular repair processes
[4]
potential alteration in the production of pro-inflammatory
cytokines
[5]
reduced ability of the skin to retain water
[6]
skin dehydration
[6]
[ ] brackets indicates the number of the area in which the effect of which it refers.
100% OPTIMAL NO RISK (+ +) MINIMUM SUPPORT NEEDED (--) [++ - -]
0% MAXIMUM RISK (- -) MAXIMUM SUPPORT NEEDED (++) [- - ++]
The scale [iD] DNA index® ranges from 0 to 100.
Your [iD]DNA index*
59%
Determined upon the basis of genetic testing combined with your lifestyle self-optimisation
[1] Wrinkling (firmness + elasticity) ……………………………………………………………………………………………………………………reduced risk
[2] Moisturisation (hyaluronic acid potential) ……………………………………………………………………………………………medium risk
[3] Skin Hydration (hydro-lipid film) ……………………………………………………………………………………………………………increased risk
[4] Free radicals damage …………………………………………………………………………………………………………… medium risk
[5] Regeneration (vascolarisation + oxygenation) …………………………………………………………………reduced risk
[6] Sensivity + Inflammation …………………………………………………………………………………………………………………………………………reduced risk
*[ID]DNA® index is the benchmark of the Swiss patent pending concept [ID]DNA®
ultra-custom, showing your scoring in terms of GENES vs. LIFESTYLE. [ID]DNA®
index is created on your genetics, balanced by the interference of individual habits by
anamnestic self-assessment. Your area [ID]DNA® index will be processed by the Science
of [DNA] f(x)™ to get your recommended treatment plan.

3. YOUR [iD] GENETIC PROFILE
Gene Cromosome Genotype
FLG Filaggrin 1q21.3 II
MMP3 Stromelysin-1 also called matrix metalloproteinase 3 11q22.2 6A/6A
ELN Elastin 7q11.23 -/A
PPARG Cellular receptor PPARG 3p25.2 CC
SOD Superoxide dismutase 2 6q25.3 TC
GSTT Glutathione S-transferase T-1 22q11.23 DEL
GSTM Glutathione S-transferase M-1 1p13.3 DEL
NOS3 Endothelial nitric oxide synthase 7q36.1 5/5
TNFα Endothelial nitric oxide synthase α 6p21.33 GG
EMILIN1 Emilin 1 2p23.3 GG
COL3a1 Collagen 2q32.2 GG
GPX Glutathione peroxidase 3p21.31 CT
HAS1 Hyaluronic acid synthetase 19q13.41 GG
GENETIC EVALUATION DECODING KEY
OPTIMAL genetic function
ALTERED genetic function
ADVERSE genetic function

4. OUTCOME Your [iD]DNA index*
59%
Determined upon the basis of genetic testing combined with youre lifestyle self-optimisation
[AREA 6]
SENSIVITY + INFLAMMATION
reduced risk 80%
[AREA 5]
REGENERATION
(vascolarisation + oxygenation)reduced risk 78%
[AREA 4]
FREE RADICALS DAMAGE
medium risk 48%
[AREA 3]
SKIN HYDRATION
(hydro-lipid film)increased risk 30%
[AREA 2]
MOISTURISATION
(hyaluronic acid potential)medium risk 42%
[AREA 1]
WRINKLING
(firmness + elasticity)reduced risk 70%

5. The ultra-personalized treatment plan on your genetic identity
[iD]DNA index [iD]DNA index TARGET Your DNA recommends
70% 76%
The genetic test highlighted a reduced susceptibility to chrono-aging.
This means that your skin properly protects against external agents and will
tend to remain more supple, firm and soft.
[iD]DNA index [iD]DNA index TARGET Your DNA recommends
42% 42%
The genetic variant analyzed predispose to a reduced state of hydration. Your
skin is less able to retain water, appearing less tonic. Your genetics also expose
skin to the risk of developing intense dryness phenomena and loss of relaxing
capacity.
[iD]DNA index [iD]DNA index TARGET Your DNA recommends
30% 42%
The genetic variant we detected predisposes to an increased accumulation of
adipose tissue.
Therefore you may experience alterations in the lipid film with typical
manifestations of oily skin and acne.
[1] Wrinkling (firmness + elasticity) ……………………………………………………………………………………………………………………reduced risk
[2] Moisturisation (hyaluronic acid potential) ……………………………………………………………………………………medium risk
[3] Skin Hydration (hydro-lipid film) ……………………………………………………………………………………………………………………increased risk

6. [iD]DNA index [iD]DNA index TARGET Your DNA recommends
48% 48%
The genetic variants we detected predispose to a severe reduction in
detoxifying abilities.
Your body may not be able to effectively remove toxins introduced from the
outside, causing buildup.
It could also lead to a reduction in the mechanisms of protection against
cellular oxidative stress induced by free radicals. These phenomena cause
premature skin aging.
[iD]DNA index [iD]DNA index TARGET Your DNA recommends
78% 84%
Your advantageous genetics predispose to good protection of the endothelium
of blood vessels and to regular processes of vasodilation and oxygenation.
[iD]DNA index [iD]DNA index TARGET Your DNA recommends
80% 86%
Your advantageous genetics predispose to proper inflammatory response; this
provides good control of the inflammatory phenomena and of photo-aging.
[4] Free radicals damage ……………………………………………………………………………………………………………………medium risk
[5] Regeneration (vascolarisation + oxygenation) ……………………………………………………………………………reduced risk
[6] Sensivity + Inflammation ……………………………………………………………………………………………………………………reduced risk

7. FREE RADICALS DAMAGE
Free radicals are chemically unstable and highly reactive molecules that may cause damage to
important biological components of our body, such as DNA, proteins, and lipids. They may be
introduced through smoking, a poor diet, breathing polluted air, but they may also be produced by
your own body.
Even exposure to the sun increases the production of free radicals, due to the effect of ultraviolet
rays on skin cells.
The damage caused by free radicals contributes significantly to skin aging because it destroys
healthy cells and damages tissues. Polyunsaturated fatty acids, the main constituent of the
stratum corneum, are particularly susceptible to attack by these molecules (lipid peroxidation).
Moreover, free radicals cause depolymerization of polysaccharides, such as hyaluronic acid, which
at skin level causes a premature aging of cells. UVA rays penetrate the dermis damaging the
collagen and elastic fibers: the new fibers that are formed may show alterations that make the
tissue opaque, wrinkled, and not very compact.
When the production of free radicals exceeds our ability to eliminate them, a harmful biological
state called oxidative stress arises.
Stress, pollution, medications, poor nutrition, insufficient sleep, and ultraviolet rays are factors that
damage our skin because they are the cause of free radicals that attack our body.
Even alcohol and smoking encourage the invasion of free radicals, therefore these substances
should be avoided or at least reduced. For this reason a smoker’s face usually has drier skin and
more wrinkles when compared to a non-smoker.
Our body has developed several protective mechanisms such as enzymes that absorb these
radicals before they may damage cells. This genetic screening evaluates genetic variations that
may lead to lower efficiency in the mechanisms of protection against free radicals.
AREA [4]
Area 4 - [iD]DNA index*
48%
Determined upon the basis of genetic testing combined with your lifestyle self-optimisation
AREA SITUATION
medium risk

8. GENETICAL GUIDANCE FOR YOUR TREATMENT PLAN
The genetic variants we detected predispose to a severe reduction in detoxifying abilities.
Your body may not be able to effectively remove toxins introduced from the outside, causing buildup.
It could also lead to a reduction in the mechanisms of protection against cellular oxidative stress induced by
free radicals. These phenomena cause premature skin aging.
Individual behavior is a very important factor, which may have a decisive role in delaying skin aging.
From the analysis of your eating habits we did not detect any behavior that may act negatively increasing
the risk of aging due to oxidative stress phenomena.
We therefore recommend you maintain, also in the future, the good habits that you are already applying,
avoiding smoking, and drinking excessive amounts of coffee and alcohol.
To ensure proper detoxifying abilities is also important to eat at least 5 servings of fruits and vegetables
every day.
The best international scientific references recommend you a corrective treatment based on these
suggestions.
Juveleven® is the guardian of your genomic integrity, by protecting and repairing DNA damage: cell
rejuvenation by over 10 years*.
Dermcom® is a functional ingredient, made in Switzerland, that can reverse the aging process by stimulating
the communication between keratinocytes and fibroblasts in aged skin: skin firmness improves (+13%) and
collagen (+115%) and elastin (+25%) contents increase*.
Copper tripeptide-1 is a patented bio-mimetic tri-peptide that promotes healthy skin, stimulating collagen
and elastin synthesis.
New solar protection 50+ filter, that last al the day log. Just one drop to protect your DNA from UVA and
UVB rays damage.
Revitalin PF® is a functional ingredient, made in Switzerland, to outsmart skin's internal clock for youthful,
glowing skin. Clinically tested to boost daily energy levels when skin needs it most.*
Moreover, to improve the aspects analyzed in this area, the treatment should also include caprylic/capric
triglyceride (and) teprenone, ceramide 3 (and) ceramide 6 II (and) ceramide 1 (and) phytosphingosine.
VISIBLE SIGNS BIOLOGICAL EFFECTS
POSSIBLE APPEARANCE OF SMALL FURROWS OR WRINKLES
ON YOUR FACE AND BODY
POSSIBLE ACCUMULATION OF FREE RADICALS (RISK OF
DAMAGE)
INCREASED OXIDATIVE STRESS
MINOR CAPACITY OF ELIMINATION OF TOXIC SUBSTANCES
AREA [4]
*all clinical data refers to in vitro ed in vivo clinical studies for claim substantiations by the manufacturers, from their product dossier. Data used for internal training on treatment
functionalities and outcomes presentation. Available evidence documentation on request.

9. SNP DETAIL
Gene
SOD Superoxide dismutase 2
The SOD2 gene encodes the manganese superoxide dismutase
(MnSOD), an enzyme localized in the mitochondrial matrix, which is
the first line of defense of cells against free radicals. MnSOD
catalyzes the dismutation of superoxide (a dangerous reactive
oxygen species) in oxygen and hydrogen peroxide. Its role is to
protect the cell from oxidative stress caused by free radicals.
These are, in fact, the basis for many degenerative diseases and are
among the most important factors responsible for photo-aging.
A polymorphism at the level of this gene may cause a reduced
detoxifying ability, oxidative stress, and the accumulation of free
radicals.
Your DNAge highlighted the presence of the CT variant of the
SOD2 enzyme. The presence of this variant assures an intermediate
detoxifying action to the SOD2 enzyme.
Cromosome Genotype
6 TC
Locus Telomere localisation
6q25.3 25.3
AREA [4]

10. SNP DETAIL
Gene
GSTM Glutathione S-transferase M1
GSTT Glutathione S-transferase T-1
The genes GSTM1 and GSTT1 encode for the glutathione S-
transferase proteins, a family of detoxifying isoenzymes which
catalyze the conjugation of various toxic molecules with
glutathione, rendering them less reactive and more easily to
eliminate from the body. Their role is therefore to protect us from
harmful substances, preventing their accumulation.
The specific task of these enzymes consists in the detoxification of
carcinogens, such as those contained in cigarette smoke, and of
harmful substances, such as benzopyrene, polycyclic aromatic
hydrocarbons, solvents, medicines, and heavy metal ions, such as
cadmium, gold, copper, nickel, mercury and zinc.
Your DNAge highlighted the presence of a deletion polymorphism
(D) in both genes. These variants cause altered activity of
detoxification enzymes. Subsequently, the elimination of toxins
may be less effective allowing their accumulation in the body.
Cromosome Genotype
1p13.3 DEL
22q11.23 DEL
AREA [4]

11. SNP DETAIL
Gene
GPX Glutathione peroxidase
The enzyme glutathione peroxidase (GPx) plays a key role in the
regulation of cellular redox balance. Its antioxidant role helps to
protect the cells, counteracting the accumulation of free radicals
and fighting oxidative stress in skin.
An optimum antioxidant barrier may protect against damage
caused by environmental pollution, ultraviolet rays, cigarette
smoking, and poor nutrition. A polymorphism at this gene level
may cause a reduced detoxifying ability, oxidative stress, and
accumulation of free radicals.
Your DNA test highlighted e presence of the CT variant. With this
variant, the GPX enzyme will have an intermediate antioxidant
activity and it will therefore be more difficult to counteract the
accumulation of free radicals.
Cromosome Genotype
3 CT
Locus Telomere localisation
3p21.31 21.31
AREA [4]

12. GENES vs LIFESTYLE
HOW MUCH OF YOUR SKIN AGING CAN YOU
ACTUALLY CONTROL?
While genetics do play a large role in how quickly you will age, recent research has started to show
that the habits you develop and choices you make throughout life might be even more telling, so –
with your genetically-customised anti-aging plan – you have control over how your skin ages.
Research found that, in some people, up to 40 percent of factors that age you could be NON-
GENETIC.
Major aging factors are smoke and stress.
Stress is no good for your beauty, from causing acne to hair loss. The stress hormone cortisol also
breaks down collage, and less collagen means weaker skin and more wrinkles, so STRESS CAN
MAKE YOU LOOK 3 TO 6 YEARS OLDER.
But here’s some good news: a July 2014 study form UC San Francisco is the first to show that
although stress accelerates cellular aging, a healthy lifestyle – specifically eating healthy foods,
exercising and getting quality sleep – can reduce the damaging effects on a cellular level. The
study partecipants who exercised, slept well and ate well has less telomere shortening than
the one who didn’t maintain healthy lifestyles, even when they had similar level of stress.
Genetics play a huge role in determining the length of your telomeres and the rate at which they
shorten, but both sun damage and stress have been connected with accelerating this rate. If you
choose to eat poorly, smoke and routinely get tan, then no matter how great your skin genes are,
it’s going to catch up with you. On the other hand, if you’re looking at your mother and thinking
she looks older than her actual age, then act NOW to change the future.
for your healthy diet, discover DNADiet, the nutritional plan written in your DNA

13. DNA-RECOMMENDED ACTIVE INGREDIENTS
CLINICAL PRESCRIPTION
TOPICAL INGREDIENTS NUTRITIONAL INGREDIENTS
ACETIL HEXAPEPTIDE-50
CAPRYLIC/CAPRIC TRIGLYCERIDE (AND) TEPRENONE
CERAMIDE 3 (AND) CERAMIDE 6 II (AND) CERAMIDE 1 (AND)
PHYTOSPHINGOSINE
CHRYSANTHUS BULB EXTRACT
COPPER TRIPEPTIDE-1
DIMETHILMETHOXY CHROMANOL
GLYCOPROTEINS, GLUTAMIC ACID, VALINE, THREONINE
SOY ISOFLAVONES
ISOTHIOCYANATES
L-ASCORBIC ACID 15%
OZONIZED OLEIC ACID
PHYTOCELLTEC MALUS DOMESTICA
PROANTHOCYANIDIN PHOSPOLIPID COMPLEX
TRIPEPTIDE-10 CITRULLINE
HYALURONIC ACID
SODIUM HYALURONATE CROSSPOLYMER
BIOSACCHARIDE GUM-1
SACCARINE ISOMERATE
ACETYL TETRAPEPTIDE PLATINIUM
NIACINAMIDE
POLLEN EXTRACT (AND) GLYCINE SOJA
DMAE-DIMETHYLAMINOETHANOL
GLYCINE SOYA PROTEIN (AND) SUPEROXIDE DISMUTASE (AND)
SODIUM DEXTRAN SULFATE
OLIGOPEPTIDE-34
SUPEROXIDE DISMUTASE
ACETYL DECAPEPTIDE-3
ACETYL GLUTAMYL HEPTAPEPTIDE-1
ACETYL HEXAPEPTIDE-8
ACETYL TETRAPEPTIDE-2
ACETYL TETRAPEPTIDE-5
ALPHA-LIPOIC ACID
ELLAGIC ACID
NIACIN (VITAMIN B3)
SUPEROXIDE DISMUTASIS 560 UI
VITAMIN C
VITAMIN D
BIOTIN (VITAMIN H)

14. SUGGESTED BIOACTIVE INGREDIENTS
ACETIL HEXAPEPTIDE-50
Juveleven® is the guardian of your genomic integrity, by protecting and repairing DNA damage
and delays senescence: cell rejuvenation by over 10 years*. Key element in preserving the vital
code. Reverts senescence in fibroblasts.
ACETYL DECAPEPTIDE-3
CG-Rejuline® is a bio-mimetic complex, which prevents the formation of expression lines and
wrinkles, promoting active cell regeneration. It's a new technology that revitalise and regenerate
your skin. CG-Rejuline® strengthens elasticity and improves skin quality, inducing the synthesis of
collagen type I and elastin.
ACETYL GLUTAMYL HEPTAPEPTIDE-1
SNAP-8® is a bio-mimetic epta-peptide safe hi-tech alternative solution to Botox®. Bye, bye
Botox®: SNAP-8® reduces wrinkles up to - 63%, after 28 days application*, without needles.
Maximum efficacy for frown lines, crow's feet, expression wrinkles.
ACETYL HEXAPEPTIDE-8
Argireline® is a bio-mimetic hexapeptide, specific for the correction of eye contour concerns. It
relieves congestion in the eye area; it is active against the formation of edema (swelling) caused
by compromised hemodynamics, against faulty lymphatic circulation, or against high capillary
permeability. This peptide regulates the loss of skin elasticity and the risk of formation of bags
under the eyes. It also reduces dark circles. Clinical tests show that it reduces bags under the eyes
in only 14 days*.
ACETYL TETRAPEPTIDE PLATINIUM
Platinum peptide is a bioconjugated high-tech nanoparticle clinically tested for +280% collagen III
synthesis increase, +250% collagen I synthesis increase, -61% wrinkles reduction, +47% skin
elasticity, +33% skin hydration, after just 30 days application*.
ACETYL TETRAPEPTIDE-2
Uplevity® hi-tech peptide counteract the force of gravity, by increasing collagen and functional
elastin synthesis, and cellular support. It provides a better structure to the dermis improving the
quality of mature skin. Clinically tested for +47,3% collagen I synthesis, +21,7% elastin synthesis.
Uplevity® peptide further contributes to skin firmness by overexpressing genes involved in cellular
cohesion, that are the interface between the actin cytoskeleton and extracellular matrix (ECM)*.

15. Discover how science and innovation of your [iD]DNA® ultra-custom can help you fight signs of aging
Rather than simply focus on an analysis of your skin health, your [iD]DNA® ultra-custom provides active ingredients (choosen only
from the latest biotech breakthrough and covered by third party scientific studies) recommentations, directly related to your individual
requirements. We’ve been studying modern genetics and all the latest cosmetic engineering releases to open up the possibility to provide
you with an ultra-custom treatment, unique to you.
Our scientific references library is able to define the relationship between the active ingredients and the different genes variations of
your genetics.
In order to perform WORLD-CLASS GENOMAPPING, we’re in partnership with Geneticlab, one of the most advanced European
medical genetics labs; Geneticlab provides its genetic services to more than 500 clinics and public hospitals in Europe, with about
500.000 DNA tests a year. Not satisfied of the DNA tests on the market, we implemented brand new proprietory genetic panels, strongly
backed by third party international scientific references, to identify the relationship between individual genes variations and the
biological systems causing signs of aging and imperfections. Our advanced international R&D, in cooperation with experts of any single
area of treatment, have been selecting the most safest and advanced biotech and cosmetic engineering latest breakthrough. We adopt a
new active complex, only if it’s covered by third party in vitro and in vivo scientific study, and if it’s not controversial the correlation
between the active ingredients effect and the biological system at the roots of the imperfection. Treatment formulation is then calibrated
on individual genetic variations.
Geneticlab is a diagnostic center, qualified in the Italian Regional Quality System. It participates annually to the External Quality
Assessment program (EQA), organized by authorities recognized by Italian Ministry of Health.
Geneticlab is a laboratory that holds the following certification:
• ISO 9001
• ISO 13485
• ISO 15189
• accreditation Italian Society of Human genetics (SIGU)
• CE marking medical device swab oral autocollection.
For the concept [iD]DNA ultra-custom® of Suisse Life Science S.A., Geneticlab provides services only with the latest SEQUENOM
sequentiating platform MassArray Genotyping Analyzer 4 (state-of-the-art MALDI-TOFF mass spectrometry), the leading technology
for SNP genotyping, with the highest data quality (accuracy 99,7%). These kind of service is not available for the common DNA test
you find on the consumers market.
Dr. Cristina Lapucci
Specialist in Medical Genetics
Director of laboratory for Human Genetics

16. KEY TERMS EXPLAINED (GLOSSARY)
ALLELE
Normally humans possess two copies of each chromosome, one inherited from the father and one from the mother. Each of
two or more alternative forms of a gene that are found at the same place on a chromosome and control variations of the
same character defines the term allele. If two alleles are equal to each other the individual is homozygous for that character,
if they are different the individual is heterozygous.
AMINO ACIDS
Amino acids are the molecules that build up proteins and are the basis of all life processes, absolutely necessary for any
metabolic process. Our organism is able to synthesize certain amino acids needed to build proteins, but is not able to build
others, which are therefore called essential and must be introduced with food.
CELL
The cell is the functional unit of all living beings. Humans are composed of approximately 100 trillion cells that make up
tissues and organs.
CELL METABOLISM
Cell metabolism is the chemical process that occurs in the cell in order to produce the energy needed for its functioning.
CELLULAR REPAIR
Cellular repair is a process through which the body is able to renew and replace the cells that compose it.
COLLAGEN
Collagen is the most important and abundant structural protein present in humans. It constitutes 30% of the total body
protein. Its mission is to support our body by protecting the soft tissues and connecting them with the skeleton.
DNA (DEOXYRIBONUCLEIC ACID)
DNA is the fundamental molecule for any form of life on Earth. It is the genetic material of every living being, as it contains
all the necessary information for life. From a genetic perspective, all humans are very similar, although in each gene, one may
find small variations that determine important differences.
ELASTIN
Elastin, along with collagen, it is one of the most important skin proteins. Its task is to ensure elasticity to tissues and organs,
rendering the possibility of deformation without damage when subjected to mechanical stress.
ESTROGENS
Estrogens are the main female sex hormones. They promote the formation of secondary sexual characteristics such as
breasts and enlargement of the pelvis and are involved in various menstrual cycle phenomena.
FREE RADICALS
Free radicals are chemically unstable and highly reactive molecules which may cause damage to DNA, proteins, and lipids.
They may be introduced through smoking, poor diet, and polluted air but they may also be produced by the body.
GENE
Genes are the fundamental hereditary unit of living beings. Genes correspond to portions of the genetic code localized in
specific positions within the DNA sequence and contain all the information necessary for the production of proteins.
GENETIC PREDISPOSITION
Genetic predisposition is an increased genetic likelihood to develop a particular condition during lifetime. The genetic test
identifies a predisposition which may be expressed or not depending on the interaction with environmental factors which
may influence gene expression.
GENOMICS
A specialized branch of science that studies the genome.
GENOTYPE
Genotype is a combination of the alleles of a gene present in an individual. An organism is referred to as being homozygous
at a specific locus when it carries two identical copies of the gene that determine a given trait. If not so, it is referred to as
being heterozygous.
HOMOZYGOUS

17. Homozygous is the term which defines an individual who has received the same form (allele) of the gene from both parents
and therefore has two identical alleles.
INFLAMMATION
Inflammation is a defense mechanism developed by the body in the presence of illness, injury, infection, or in the presence of
proteins responsible for allergic reactions. Redness or swelling around a wound or an infected area indicates, for example,
that a process of damage repair is taking place.
NUCLEOTIDE
Nucleotides are the four bases that make up DNA, resulting in the sequences that constitute genes. There are four versions:
guanine, adenine, thymine and cytosine.
POLYMORPHISM
Polymorphism is a genetic variation which has a high frequency in the population. The genetic variation may be determined
by substitutions, deletions, or insertions of bases in DNA.
PROTEINS
Proteins are molecules formed by one or more amino acid chains. Proteins differ mainly in the sequence of amino acids that
compose them. Furthermore, the amino acid sequence determines the folding of the protein in a specific three-dimensional
structure which confers specific activity. They have structural and mechanical functions; they are involved in metabolic
processes (enzymes), in the transmission of cellular signals, and in immune response processes.
SNP
SNP is the most common type of variation found within a gene that determines major differences between an organism and
another. A SNP may lead to an alteration, either positive or negative, in the efficiency of a biological process.
VITAMINS
Organic molecules essential for normal metabolism, growth, development and for the regulation of cell function. A vitamin
can activate specific enzymes.
WATER RETENTION
Water retention is the accumulation of fluid in the interstitial spaces (those between cells) that may cause abnormal swelling
of the tissues (edema) in certain areas of the body such as abdomen, thighs, buttocks, and ankles.
[iD] DNA®, CLINICare® and all its brands, trademarks, products and materials belong exclusively to Suisse Life Science SA and are to be
used for informational purposes only. All our distributors, franchisees, licensees and partners are authorised to use our content, but it
does not assign them the right to any ownership of our content, testing products, processes or methods.

18. SCIENTIFIC REFERENCES
1. The important role of stratum corneum lipids for the cutaneous barrier function. van Smeden J, Janssens M, Gooris GS, Bouwstra JA. Biochim
Biophys Acta. 2013 Nov 16. doi:pii: S1388-1981(13)00248-5. 10.1016/j.bbalip.2013.11.006.
2. Connective tissue biochemistry of the aging dermis. Age-associated alterations in collagen and elastin.Uitto J.Clin Geriatr Med. 1989 Feb;5(1):127-
47. Review.
3. Effect of the sun on visible clinical signs of aging in Caucasian skin. Flament F, Bazin R, Laquieze S, Rubert V, Simonpietri E, Piot B. Clin Cosmet
Investig Dermatol. 2013 Sep 27;6:221-32. doi: 10.2147/CCID.S44686.
4. 5,7-Dimethoxyflavone, an activator of PPARα/γ, inhibits UVB-induced MMP expression in human skin fibroblast cells.Kim JK, Mun S, Kim MS,
Kim MB, Sa BK, Hwang JK.Exp Dermatol. 2012 Mar;21(3):211-6. doi: 10.1111/j.1600-0625.2011.01435.x.
5. Peroxisomes in dermatology. Part I.Smith KJ, Dipreta E, Skelton H.J Cutan Med Surg. 2001 May-Jun;5(3):231-43. Epub 2001 May 17. Review.
6. The role of manganese superoxide dismutase in skin aging. Treiber N, Maity P, Singh K, Ferchiu F, Wlaschek M, Scharffetter-Kochanek
K.Dermatoendocrinol. 2012 Jul 1;4(3):232-5. doi: 10.4161/derm.21819.
7. Effects of cigarette smoke extracts on the growth and senescence of skin fibroblasts in vitro. Yang GY, Zhang CL, Liu XC, Qian G, Deng DQ.Int J
Biol Sci. 2013 Jun 28;9(6):613-23. doi: 10.7150/ijbs.6162. Print 2013.
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