THE NU SKIN OPPORTUNITY<br />Richard J. DeAgazio<br />Ruby Executive<br />www.stayyoung.nsedreams.com<br />
THE NU SKIN OPPORTUNITY<br />The world’s leading anti-aging company is addressing the sources of aging, not just the signs...
TRADITION OF INNOVATION<br /><ul><li>Nu Skin 180
Galvanic Spa
Scanner
Nano
g3
TruFace essence ultra</li></ul>3<br />
What is ageLOC?<br />SIGNS<br />Developing products that address the sources of aging, not just the signs and symptoms.<br />
D. James Morré, PhDDepartment of Medicinal Chemistry and Molecular Pharmacology<br />andDorothy M. Morré, PhD<br />Departm...
Identified a NOX which increases with age Nicotinamide adenine dinucleotideOXidase, a hydroquinone oxidase<br />
1/2 O2<br />H2O<br />NOX<br />2 O2<br />S<br />SH<br />Protein<br />Protein<br />Outside<br />S<br />SH<br />Plasma Membra...
GENESIS OF AGELOC<br />The arNOX discovery helped explain…<br />Why Some People Look Years Younger Than They Really Are.<b...
HUMAN GENOME<br />Our genome encodes for:<br />our looks<br />our size<br />how our bodies work<br />our health<br />our b...
Genes impact structure and function of the body<br />Health or Beauty Index<br />YEARS<br />
After 20 yrs Human Genome Sequenced<br /><ul><li>2003 discovery after 20 years of research: 25,000 – 30,000 genes form the...
Twenty Labs with hundreds of scientists (United States, the United Kingdom, France, Germany, Japan and China),
$3 billion</li></li></ul><li>GATCGACTCCTCCTGGVGCAGCGTGAATATCGATAGAGATCCCTTCGAGGATCGACTCCCTTCCTGGVGCAGCGTGAATATCGATAGAGATCC...
Nu Skin Enterprises Center for Anti-Aging Research (NSE:CAAR)<br />
NSE:CAAR Anti-Aging Genetic Experts<br />Published over 300 scientific papers, and their insights have changed the way agi...
NSE: Center for Anti-Aging Research<br /><ul><li>Experts in the study of the ultimate source of aging; our genes. 
30 Years of pioneering anti-aging research.
Their work both details the genetic basis of aging, and demonstrates that biological aging is no longer considered an inex...
ULTIMATE SOURCE OF AGING = GENE EXPRESSION<br /><ul><li>As you age, your genes don’t change
Which genes are turned on and off does change (e.g. gene expression).
Expression levels are influenced by your environment (stress, nutrition, etc…)</li></li></ul><li>IDENTICAL TWINS ARE DIFFE...
It turns out that while the genes are identical, the level at which gene is turned on and off changes based on environment...
Elastin<br />arNOX<br />To better understand aging, we need to know the expression level for every gene. <br />…in a singl...
Gene Expression Profiling 101<br />Young Skin Fibroblast (Hypothetical)<br />Gene 1<br />arNOX<br />Gene 2<br />Elastin<br...
Elastin<br />arNOX<br />The expression level for every gene in a single experiment!<br />DNA Microarray Gene Map<br />Key<...
NuSkinageLOC Approach<br /><ul><li>Identify Youth Gene Clusters (YGC’s), and understand  their youthful expression patterns
Target  - Investigate the effect different ingredients have on YGC’s.
Reset  - Develop formulae that reset these YGC’s back to their youthful state, thus restoring the youthful biochemistry of...
Tissue specific
 Act as master regulators of aging.</li></li></ul><li>
Younger Than Chronological Age<br />
In additional to understanding the genetic basis of aging in Humans, mice, fruit flies, yeast and roundworms are also frui...
Gene Expression Profiling 101<br />Young Skin Fibroblast (Hypothetical)<br />Gene 1<br />arNOX<br />Gene 2<br />Elastin<br...
Gene Expression Profiling 101<br />Young Skin<br />Old Skin<br />arNOX (0)<br />Elastin (8)<br />arNOX (8)<br />Elastin (0...
INTELLIGENT<br />BIOINFORMATICS <br />DATABASE<br />YOUTH GENE CLUSTERS<br />
Map of Aging Genetics (Whole Genome)<br /><ul><li>Huge Proprietary Database
Over 25 Million aging related genetic changes and growing.
Bio-Informatics on this database yields the genetic map of the aging process
Shows us the path we need to take</li></li></ul><li>ageLOC Process<br /><ul><li>Identifying Youth Gene Clusters (YGC’s), a...
Targeting  - Cataloging the effect different ingredients have on YGC’s.
Resetting  - Developing formulas that reset these YGC’s back to their youthful state, thus restoring the youthful biochemi...
Identifying Changes (Old vs. Young YGC Profile)<br />Old Skin<br />Young Skin<br />A<br />B<br />A<br />B<br />D<br />C<br...
Targeting & Resetting YGC<br />Once you map the changes, you can screen for ingredients and formulas that reverse these ch...
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Nuskin Opportunity Dec09

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Nuskin Opportunity Dec09

  1. 1. THE NU SKIN OPPORTUNITY<br />Richard J. DeAgazio<br />Ruby Executive<br />www.stayyoung.nsedreams.com<br />
  2. 2. THE NU SKIN OPPORTUNITY<br />The world’s leading anti-aging company is addressing the sources of aging, not just the signs and symptoms.<br />
  3. 3. TRADITION OF INNOVATION<br /><ul><li>Nu Skin 180
  4. 4. Galvanic Spa
  5. 5. Scanner
  6. 6. Nano
  7. 7. g3
  8. 8. TruFace essence ultra</li></ul>3<br />
  9. 9. What is ageLOC?<br />SIGNS<br />Developing products that address the sources of aging, not just the signs and symptoms.<br />
  10. 10. D. James Morré, PhDDepartment of Medicinal Chemistry and Molecular Pharmacology<br />andDorothy M. Morré, PhD<br />Department of Foods and Nutrition<br />Purdue University, West Lafayette, Indiana<br />ARNOX, AN AGING ENZYME: 1ST AGELOC SOURCE OF AGING<br />
  11. 11. Identified a NOX which increases with age Nicotinamide adenine dinucleotideOXidase, a hydroquinone oxidase<br />
  12. 12. 1/2 O2<br />H2O<br />NOX<br />2 O2<br />S<br />SH<br />Protein<br />Protein<br />Outside<br />S<br />SH<br />Plasma Membrane<br />Q10<br />Q10H2<br />Inside<br /> Quinone<br />Reductase<br />NAD(P)+<br />NAD(P)H<br /> + H+<br />arNOX Generates Superoxide O2-<br />-<br />2 O2<br />A powerful free-radical generator<br />
  13. 13. GENESIS OF AGELOC<br />The arNOX discovery helped explain…<br />Why Some People Look Years Younger Than They Really Are.<br />
  14. 14. HUMAN GENOME<br />Our genome encodes for:<br />our looks<br />our size<br />how our bodies work<br />our health<br />our behaviors<br />Our longevity<br />
  15. 15. Genes impact structure and function of the body<br />Health or Beauty Index<br />YEARS<br />
  16. 16. After 20 yrs Human Genome Sequenced<br /><ul><li>2003 discovery after 20 years of research: 25,000 – 30,000 genes form the human genome
  17. 17. Twenty Labs with hundreds of scientists (United States, the United Kingdom, France, Germany, Japan and China),
  18. 18. $3 billion</li></li></ul><li>GATCGACTCCTCCTGGVGCAGCGTGAATATCGATAGAGATCCCTTCGAGGATCGACTCCCTTCCTGGVGCAGCGTGAATATCGATAGAGATCCCTTCGAGAAAGTGATCGACTCCCTTCCTGGVGCAGCGTGAATATCGATAGAGATCCCTTCGAGAAAGTGATCGACTCCCTTCCTGGVGCAGCGTGAATATCGATAGAGATCCCTTCGAGAAAGTGATCGACTCCCTTCCTGGVGCAGCGTGAATATCGATAGAGATCCCTTCGAGAAAGTGATCGACTCCCTTCCTGGVGCAGCGTGAATATCGATAGAGATCCCTTCGAGAAAGTGATCGACTCCCTTCCTGGVGCAGCGTGAATATCGATAGAGATCCCTTCGAGAAAGTGATCGACTCCCTTCCTGGVGCAGCGTGAATATCGATAGAGATCCCTTCGAGAAAGTGATCGACTCCCTTCCTGGVGCAGCGTGATCGACTCCCTTCCTGGVGCAGCGTGAATATCGATAGAGATCCCTTCGAGAAAGTGATCGACTCCCTTCCTGGVGCAGCGTGAATATCGATAGAGATCCCTTCGAGAAAGTGAATATCGATAGAGATCCCTTCGAGAAAGTGATCGACTCCCTTCCTGGVGCAGCGTGAATATCGATAGAGATCCCTTCGAGAAAGTGATCGACTCCCTTCCTGGVGCAGCGTGAATATCGATAGAGATCCCTTCGAGAAAGTGATCGACTCCC---TTCCTGGVGCAGCGTGAATATCGATAGAGATCCCTTCGAGAAAGT<br />AAAGT<br />The Human Genome consistsof at least 25,000 – 30,000 genes<br />
  19. 19. Nu Skin Enterprises Center for Anti-Aging Research (NSE:CAAR)<br />
  20. 20. NSE:CAAR Anti-Aging Genetic Experts<br />Published over 300 scientific papers, and their insights have changed the way aging is viewed. <br />
  21. 21. NSE: Center for Anti-Aging Research<br /><ul><li>Experts in the study of the ultimate source of aging; our genes. 
  22. 22. 30 Years of pioneering anti-aging research.
  23. 23. Their work both details the genetic basis of aging, and demonstrates that biological aging is no longer considered an inexorable or inevitable process. </li></li></ul><li>Genetics 101<br />nucleus<br />Cell<br />DNA (stored on chromosomes)<br />
  24. 24.
  25. 25. ULTIMATE SOURCE OF AGING = GENE EXPRESSION<br /><ul><li>As you age, your genes don’t change
  26. 26. Which genes are turned on and off does change (e.g. gene expression).
  27. 27. Expression levels are influenced by your environment (stress, nutrition, etc…)</li></li></ul><li>IDENTICAL TWINS ARE DIFFERENT<br /><ul><li>How is this possible, as their genes are the same?
  28. 28. It turns out that while the genes are identical, the level at which gene is turned on and off changes based on environmental factors (e.g. gene expression). This causes the differences you can see.</li></li></ul><li>Yellow shows where the twins have similar gene regulation. Red and Green indicate differences (up and down regulation).<br />
  29. 29. Elastin<br />arNOX<br />To better understand aging, we need to know the expression level for every gene. <br />…in a single experiment.<br />
  30. 30. Gene Expression Profiling 101<br />Young Skin Fibroblast (Hypothetical)<br />Gene 1<br />arNOX<br />Gene 2<br />Elastin<br />Gene 3<br />Collagen<br />Gene 4<br />MMP<br />DNA<br />mRNA<br />Microarray (e.g. Gene Chip)<br />Young Skin<br />Key<br />arNOX (0)<br />Elastin (8)<br /> - High Activity<br /> - Medium Activity<br /> - Low Activity<br />Collagen (6)<br />MMP (2)<br /> - Off<br />
  31. 31.
  32. 32. Elastin<br />arNOX<br />The expression level for every gene in a single experiment!<br />DNA Microarray Gene Map<br />Key<br />Over 25000 Genes<br /> - High Activity<br /> - Medium Activity<br /> - Low Activity<br /> - Off<br />
  33. 33. NuSkinageLOC Approach<br /><ul><li>Identify Youth Gene Clusters (YGC’s), and understand their youthful expression patterns
  34. 34. Target - Investigate the effect different ingredients have on YGC’s.
  35. 35. Reset - Develop formulae that reset these YGC’s back to their youthful state, thus restoring the youthful biochemistry of a cell.</li></li></ul><li>What is a Youth Gene Cluster (YCG)<br /><ul><li>These are groups of genes (e.g. clusters) that work together to exert a specific function in a tissue associated with youthfulness.
  36. 36. Tissue specific
  37. 37. Act as master regulators of aging.</li></li></ul><li>
  38. 38. Younger Than Chronological Age<br />
  39. 39. In additional to understanding the genetic basis of aging in Humans, mice, fruit flies, yeast and roundworms are also fruitful models for the genetic/aging scientist<br />
  40. 40. Gene Expression Profiling 101<br />Young Skin Fibroblast (Hypothetical)<br />Gene 1<br />arNOX<br />Gene 2<br />Elastin<br />Gene 3<br />Collagen<br />Gene 4<br />MMP<br />DNA<br />mRNA<br />Old Skin Fibroblast (Hypothetical)<br />Gene 1<br />arNOX<br />Gene 2<br />Elastin<br />Gene 3<br />Collagen<br />Gene 4<br />MMP<br />DNA<br />mRNA<br />
  41. 41. Gene Expression Profiling 101<br />Young Skin<br />Old Skin<br />arNOX (0)<br />Elastin (8)<br />arNOX (8)<br />Elastin (0)<br />Changes with Aging<br />Collagen (6)<br />MMP (2)<br />Collagen (2)<br />MMP (4)<br />By comparing the two, you can understand the genetic changes associated with aging<br />Key<br /> - High Activity<br /> - Medium Activity<br />Down regulation<br />Up regulation<br />No Change<br /> - Low Activity<br /> - Off<br />
  42. 42.
  43. 43. INTELLIGENT<br />BIOINFORMATICS <br />DATABASE<br />YOUTH GENE CLUSTERS<br />
  44. 44. Map of Aging Genetics (Whole Genome)<br /><ul><li>Huge Proprietary Database
  45. 45. Over 25 Million aging related genetic changes and growing.
  46. 46. Bio-Informatics on this database yields the genetic map of the aging process
  47. 47. Shows us the path we need to take</li></li></ul><li>ageLOC Process<br /><ul><li>Identifying Youth Gene Clusters (YGC’s), and understanding their youthful expression level
  48. 48. Targeting - Cataloging the effect different ingredients have on YGC’s.
  49. 49. Resetting - Developing formulas that reset these YGC’s back to their youthful state, thus restoring the youthful biochemistry of a cell.</li></li></ul><li>How Do We Target and Reset YGC’s - Remember the Gene Chip?<br />Key<br /> - High Activity<br />DNA Microarray Gene Map<br /> - Medium Activity<br />Over 20000 Genes<br /> - Low Activity<br /> - Off<br />
  50. 50. Identifying Changes (Old vs. Young YGC Profile)<br />Old Skin<br />Young Skin<br />A<br />B<br />A<br />B<br />D<br />C<br />C<br />D<br />By comparing the two, you can understand the genetic changes associated with aging<br />Key<br /> - High Activity<br /> - Medium Activity<br /> - Low Activity<br /> - Off<br />
  51. 51.
  52. 52. Targeting & Resetting YGC<br />Once you map the changes, you can screen for ingredients and formulas that reverse these changes<br />Young Skin<br />A<br />B<br />Old Skin<br />A<br />B<br />AGING<br />Post Application<br />C<br />D<br />A<br />B<br />ageLOC<br />D<br />C<br />C<br />D<br />Key<br /> - High Activity<br /> - Medium Activity<br /> - Low Activity<br /> - Off<br />
  53. 53. ageLOC Process<br /><ul><li>Identifying Youth Gene Clusters (YGC’s), and understanding their youthful expression level
  54. 54. Targeting - Cataloging the effect different ingredients have on YGC’s.
  55. 55. Resetting - Developing formulas that reset these YGC’s back to their youthful state, thus restoring the youthful biochemistry of a cell.</li></li></ul><li>SECOND GENERATION AGELOC PRODUCTS<br />
  56. 56. Gene Activity in Skin Cells<br />DNA Microarray Gene Map<br />Over 25000 Genes<br />
  57. 57. For Human Skin: 4 YGCs identified<br />Cell Turnover<br />Pigment<br />Hydration<br />SkinStructure<br />AQP3<br />POMC<br />20+ GENES<br />35+ GENES<br />20+ GENES<br />COL7A1<br />IL1B<br />TIMP1<br />IL1B<br />60+ GENES<br />IL6<br />SOD2<br />PPARG<br />MT2A<br />TNFA<br />TXNRD1<br />
  58. 58. ageLOC Science<br />Four YGCs Identified<br />Pigment<br />Signs of Aging<br />Hydration<br />Fine Lines & Wrinkles<br />Youth Gene Clusters<br />Cellular Turnover<br />Youthful SkinStructure<br />Discoloration<br />Skin Structure<br />Skin Tone<br />Hydration<br />Texture, Smoothness<br />Radiance<br />Pore Size<br />
  59. 59. Changes in gene activity patterns yield tissue changes as we age<br />“Interventions can impact gene activity patterns even late in life and may reverse skin aging”*<br />*Adler, Chang et al. Cell Cycle 2008;7(5):556-559<br />
  60. 60. “THE PROOF IS IN THE PUDDING”<br />Meaning: The true value or quality of something can only be judged when it&apos;s put to use.<br />“Nu Skin has never developed a product that delivers these kindof results before (both in clinical results and user perception”<br />Dr. Helen Knaggs, PhD <br /> VP of NuSkin R&D<br />
  61. 61. ageLOC Summary<br />Nu Skin Enterprises Center for Anti-Aging Research (NSE:CAAR) brings together experts in the field of anti-aging genetics<br />Only we can Identify Youth Gene Clusters (YGC) <br />AgeLOC Science Targets the Ultimate Sources of Aging<br />Only Nu Skin understand how to Reset Youth Gene Clusters to their youthful state<br />Over the next 10 years as the ageLOC approach matures, its full impact will be realized on many more products - enabling Nu Skin to stay years ahead of our competition<br />
  62. 62.
  63. 63. Nutritional Intervention affects age related gene expression and can Reverse Aging <br />Lee et al, Science 1999;285(5432):1390-3; Colman et al, Science 2009;325:201-204<br />
  64. 64. AGELOC OBJECTIVE: LIFESPAN VS. HEALTH or BEAUTY SPAN<br />Health or Beauty Index<br />YEARS<br />
  65. 65. Richard J. DeAgazio<br />THANK YOU<br />www.stayyoung.nsedreams.com<br />rdeagazio@rcn.com<br />617-413-9777<br />
  66. 66. THANK YOU<br />

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