This document discusses skin aging and methods for face revitalization. It summarizes a study that evaluated the efficacy of the medical device MD-Tissue as a face revitalizer. Fifteen female volunteers received weekly injections of MD-Tissue in their nasolabial folds for six weeks. Photographic documentation and skin elasticity measurements were taken before, during, and after treatment. The results showed an average increase in skin elasticity after 3 weeks of treatment, with values returning to baseline after 6 weeks. Self-evaluations completed by the volunteers also demonstrated improvements in wrinkle reduction and skin quality from the treatment.
This document discusses current techniques in aesthetic oculoplastic surgery. It covers topics such as the aging face process, basic principles of aesthetic eye surgery, and both surgical and non-surgical procedures. Surgical procedures discussed include browlifts, blepharoplasty of the upper and lower eyelids, and fat removal. Non-surgical options include dermal fillers, chemical peels, laser resurfacing, radiofrequency, botulinum toxin injections, and newer modalities like plasma skin regeneration and stem cell therapy. Botulinum toxin is discussed in more detail, explaining its production, subtypes, and use for reducing dynamic wrinkles.
The document discusses an innovative cell-based skin treatment called SPRS Therapy. It involves taking a skin biopsy from a patient, isolating and cultivating their dermal fibroblasts, then injecting those fibroblasts back into the patient's skin. This is meant to address skin aging by stimulating collagen, elastin, and hyaluronic acid production from the patient's own cells. Clinical trials showed the treatment was safe and effectively increased skin thickness and elasticity while reducing wrinkles over 12 months. The company has several patents covering the diagnostic and treatment methods.
Cellulite is caused by fat deposits under the skin that give a dimpled appearance, especially on thighs and buttocks. It is most common in women due to hormonal factors. While many treatments claim to reduce cellulite, medical studies found no significant difference between cellulitic fat and normal fat. Endermologie and body wraps provide temporary water loss but effects are not long lasting. Liposuction and lipodissolve are more effective at permanently removing fat deposits that cause cellulite.
The document discusses cellulite, including its history, physiology, causes, grading stages, medical evaluation and treatments. It notes that cellulite is caused by fat deposits under the skin that give a dimpled appearance, mostly seen in women due to hormones. Early medical studies found no difference between cellulite fat and normal fat. A growing multi-billion dollar industry markets various anti-cellulite products and devices, though many claims lack scientific evidence and some products were found to have no effect or risks. Endermologie treatments showed some temporary reduction in body circumference in studies but require many sessions and ongoing maintenance.
CASE
“ So, Doctor, Can
You Fix This? ”
A Case Involving
a Medical Spa
1 5
Dr. Franz Goyzueta, a Bolivian - born physician with a medical
offi ce on Broadway in upper Manhattan, leaned back in his big
offi ce chair and refl ected on what had happened over the past
few months. He had embarked on an ambitious effort to expand
his practice of over 15 years beyond oncology, internal medicine,
and osteoporosis. In Spring 2005, he established a medical spa
named Magique Medical Spa.
Dr. Goyzueta offered a full range of non - surgical, advanced
cosmetic treatments for the face (e.g., laser hair removal, anti -
wrinkle treatments, chemical peels, and microdermabrasion), for
the body (e.g., anti - cellulite treatments, abdominal and pelvic
mesotherapy, and stretch mark removal), and for the hair (e.g.,
hair loss prevention therapy) in the Queens location. A menu
of services and a description of different types of medical spa
treatments appear in Exhibits 15/1 and 15/2 . Dr. Goyzueta found
that non - laser intense pulsed light (IPL) treatments to eliminate
This case was written by Frederick D. Greene, Carolyn E. Predmore, and Janet
L. Rovenpor, all from Manhatten College. It is intended as a basis for classroom
discussion rather than to illustrate either effective or ineffective handling of an
administrative situation. Used with permission from Janet Rovenpor.
both15.indd 717both15.indd 717 11/11/08 12:26:47 PM11/11/08 12:26:47 PM
C A S E 1 5 : “ S O , D O C T O R , C A N Y O U F I X T H I S ? ”7 1 8
Ex
hi
bi
t
15
/1
:
M
ag
iq
ue
M
ed
ic
al
S
pa
’s
M
en
u
of
S
er
vi
ce
s
(t
ri
fo
ld
b
ro
ch
ur
e,
e
xt
er
io
r)
both15.indd 718both15.indd 718 11/11/08 12:26:48 PM11/11/08 12:26:48 PM
7 1 9
Ex
hi
bi
t
15
/1
:
C
on
tin
ue
d
(t
ri
ol
d
br
oc
hu
re
,
in
te
ri
or
)
“ S O , D O C T O R , C A N Y O U F I X T H I S ? ”
both15.indd 719both15.indd 719 11/11/08 12:26:51 PM11/11/08 12:26:51 PM
C A S E 1 5 : “ S O , D O C T O R , C A N Y O U F I X T H I S ? ”7 2 0
Exhibit 15/2: A Glossary of Medical Spa Treatments
Aromatherapy – The therapeutic use of plant essential oils.
Botox – BOTOX® is a formulation of botulinum toxin type A. It is derived from the bacterium
Clostridium botulinum. This bacterium produces a protein that blocks the release of acetycholine
and relaxes muscles. Botox works by weakening the muscles of facial expressions. Once the rest-
ing tones of the treated muscles are weakened, the pull on the muscles relaxes and the overlying
skin fl attens.
Cellulite Treatments – Cellulite treatment programs use advanced technology to combine subatmos-
pheric pressure with a state-of-the-art mechanical massage to enhance a slimmer, trimmer fi gure
and eliminate rippling effects of cellulite.
Chemical Peels – Facial peels are used to reduce wrinkling, especially that which is associated with
sun d ...
The document summarizes a cosmetic face lift product called Global Lift. It contains three key active ingredients - a biomimetic peptide derived from Elafin, Menyanthes trifoliata extract, and black pepper extract - which work together to target the aging marker progerin. Clinical studies showed using Global Lift for 28 days reduced sagging of the jawline and wrinkles by up to 18% and lowered the mean sagging skin index by 12.5%, representing a youthful appearance 5-6 years younger. The product's anti-aging technology is based on targeting progerin at the cellular level to reverse signs of aging.
Babizhayev MA (2017) Treatment of Skin Aging and Photoaging with Innovative O...Mark Babizhayev
Babizhayev MA (2017) Treatment of Skin Aging and Photoaging with Innovative Oral Dosage Forms of Non-Hydrolized Carnosine and Carcinine. Int J Clin Dermatol Res. 5(5), 116-143.
This document discusses current techniques in aesthetic oculoplastic surgery. It covers topics such as the aging face process, basic principles of aesthetic eye surgery, and both surgical and non-surgical procedures. Surgical procedures discussed include browlifts, blepharoplasty of the upper and lower eyelids, and fat removal. Non-surgical options include dermal fillers, chemical peels, laser resurfacing, radiofrequency, botulinum toxin injections, and newer modalities like plasma skin regeneration and stem cell therapy. Botulinum toxin is discussed in more detail, explaining its production, subtypes, and use for reducing dynamic wrinkles.
The document discusses an innovative cell-based skin treatment called SPRS Therapy. It involves taking a skin biopsy from a patient, isolating and cultivating their dermal fibroblasts, then injecting those fibroblasts back into the patient's skin. This is meant to address skin aging by stimulating collagen, elastin, and hyaluronic acid production from the patient's own cells. Clinical trials showed the treatment was safe and effectively increased skin thickness and elasticity while reducing wrinkles over 12 months. The company has several patents covering the diagnostic and treatment methods.
Cellulite is caused by fat deposits under the skin that give a dimpled appearance, especially on thighs and buttocks. It is most common in women due to hormonal factors. While many treatments claim to reduce cellulite, medical studies found no significant difference between cellulitic fat and normal fat. Endermologie and body wraps provide temporary water loss but effects are not long lasting. Liposuction and lipodissolve are more effective at permanently removing fat deposits that cause cellulite.
The document discusses cellulite, including its history, physiology, causes, grading stages, medical evaluation and treatments. It notes that cellulite is caused by fat deposits under the skin that give a dimpled appearance, mostly seen in women due to hormones. Early medical studies found no difference between cellulite fat and normal fat. A growing multi-billion dollar industry markets various anti-cellulite products and devices, though many claims lack scientific evidence and some products were found to have no effect or risks. Endermologie treatments showed some temporary reduction in body circumference in studies but require many sessions and ongoing maintenance.
CASE
“ So, Doctor, Can
You Fix This? ”
A Case Involving
a Medical Spa
1 5
Dr. Franz Goyzueta, a Bolivian - born physician with a medical
offi ce on Broadway in upper Manhattan, leaned back in his big
offi ce chair and refl ected on what had happened over the past
few months. He had embarked on an ambitious effort to expand
his practice of over 15 years beyond oncology, internal medicine,
and osteoporosis. In Spring 2005, he established a medical spa
named Magique Medical Spa.
Dr. Goyzueta offered a full range of non - surgical, advanced
cosmetic treatments for the face (e.g., laser hair removal, anti -
wrinkle treatments, chemical peels, and microdermabrasion), for
the body (e.g., anti - cellulite treatments, abdominal and pelvic
mesotherapy, and stretch mark removal), and for the hair (e.g.,
hair loss prevention therapy) in the Queens location. A menu
of services and a description of different types of medical spa
treatments appear in Exhibits 15/1 and 15/2 . Dr. Goyzueta found
that non - laser intense pulsed light (IPL) treatments to eliminate
This case was written by Frederick D. Greene, Carolyn E. Predmore, and Janet
L. Rovenpor, all from Manhatten College. It is intended as a basis for classroom
discussion rather than to illustrate either effective or ineffective handling of an
administrative situation. Used with permission from Janet Rovenpor.
both15.indd 717both15.indd 717 11/11/08 12:26:47 PM11/11/08 12:26:47 PM
C A S E 1 5 : “ S O , D O C T O R , C A N Y O U F I X T H I S ? ”7 1 8
Ex
hi
bi
t
15
/1
:
M
ag
iq
ue
M
ed
ic
al
S
pa
’s
M
en
u
of
S
er
vi
ce
s
(t
ri
fo
ld
b
ro
ch
ur
e,
e
xt
er
io
r)
both15.indd 718both15.indd 718 11/11/08 12:26:48 PM11/11/08 12:26:48 PM
7 1 9
Ex
hi
bi
t
15
/1
:
C
on
tin
ue
d
(t
ri
ol
d
br
oc
hu
re
,
in
te
ri
or
)
“ S O , D O C T O R , C A N Y O U F I X T H I S ? ”
both15.indd 719both15.indd 719 11/11/08 12:26:51 PM11/11/08 12:26:51 PM
C A S E 1 5 : “ S O , D O C T O R , C A N Y O U F I X T H I S ? ”7 2 0
Exhibit 15/2: A Glossary of Medical Spa Treatments
Aromatherapy – The therapeutic use of plant essential oils.
Botox – BOTOX® is a formulation of botulinum toxin type A. It is derived from the bacterium
Clostridium botulinum. This bacterium produces a protein that blocks the release of acetycholine
and relaxes muscles. Botox works by weakening the muscles of facial expressions. Once the rest-
ing tones of the treated muscles are weakened, the pull on the muscles relaxes and the overlying
skin fl attens.
Cellulite Treatments – Cellulite treatment programs use advanced technology to combine subatmos-
pheric pressure with a state-of-the-art mechanical massage to enhance a slimmer, trimmer fi gure
and eliminate rippling effects of cellulite.
Chemical Peels – Facial peels are used to reduce wrinkling, especially that which is associated with
sun d ...
The document summarizes a cosmetic face lift product called Global Lift. It contains three key active ingredients - a biomimetic peptide derived from Elafin, Menyanthes trifoliata extract, and black pepper extract - which work together to target the aging marker progerin. Clinical studies showed using Global Lift for 28 days reduced sagging of the jawline and wrinkles by up to 18% and lowered the mean sagging skin index by 12.5%, representing a youthful appearance 5-6 years younger. The product's anti-aging technology is based on targeting progerin at the cellular level to reverse signs of aging.
Babizhayev MA (2017) Treatment of Skin Aging and Photoaging with Innovative O...Mark Babizhayev
Babizhayev MA (2017) Treatment of Skin Aging and Photoaging with Innovative Oral Dosage Forms of Non-Hydrolized Carnosine and Carcinine. Int J Clin Dermatol Res. 5(5), 116-143.
This document discusses different types of intradermal fillers used for minimally invasive treatment of facial aging. It categorizes fillers as biodegradable and non-permanent (such as collagen and hyaluronic acid), semi-permanent (such as poly methyl methacrylate and poly-L-lactic acid), and permanent (such as silicone). The document reviews various commercial products made from these materials and their effectiveness in treating facial aging by filling volume loss and smoothing lines and wrinkles. Skin testing is important for fillers from animal sources to check for allergic reactions.
New Technologies for Successfully Managing Ocular Surface InflammationJessica Griego
This document discusses new technologies for managing ocular surface inflammation. It begins by defining ocular surface disease and noting its prevalence. Various causes of ocular surface disease are described, including infectious, immune-related, traumatic/systemic, and iatrogenic factors. Current treatment paradigms focus on passive therapies to reduce inflammation like bandage contact lenses and topical steroids, but these can delay healing. Emerging options aim to control inflammation, prevent tissue damage, and stimulate regenerative healing using amniotic membrane biologics which promote healing and reduce inflammation. Cryopreserved amniotic membrane is presented as a safe and effective option to treat various ocular surface conditions.
The document discusses ocular drug delivery systems. It begins by outlining the composition of tear fluid and how drugs administered via the eye are typically absorbed. It then categorizes various ocular drug delivery systems including conventional, vesicular, particulate, and implant-based systems. Specific examples like liposomes, niosomes, ocular inserts and implants are described in further detail. Key advantages and disadvantages of different systems are provided. Testing parameters for ocular thin films are also listed.
This document provides an overview of common cosmetic surgical and non-surgical procedures. It discusses facial aging factors and how skin type is analyzed. Non-surgical procedures like fillers and botulinum toxin are described, with fillers being used to minimize wrinkles and treat facial atrophy. The most common filler types are listed. Surgical procedures like brow lifts and rhinoplasty are outlined, detailing techniques, recovery times, and potential complications. Overall, the document serves as an introduction to analyzing the face and various aesthetic options available.
Plastic surgery is a medical specialty focused on reconstructing and transforming the body through surgical techniques. It is divided into reconstructive and cosmetic surgery. Reconstructive surgery aims to repair deformities from accidents, trauma, or congenital defects. Cosmetic surgery seeks to change parts of the body for aesthetic reasons or in some cases for medical reasons. Common cosmetic procedures include facelifts, breast augmentation, liposuction, and rhinoplasty. It is important to carefully select a qualified plastic surgeon and clinic for cosmetic procedures.
Wound Management in Domiciliary Palliative Care wan zuraini
Basic teaching on wound management seen in home care / domiciliary palliative care in Malaysia. Spesifically describe management of pressure ulcer at home.
The document discusses two implantable medical devices used in the eye: phakic lenses and subconjunctival implants. Phakic lenses are implanted during surgery to correct vision without removing the natural lens. Subconjunctival implants made of biodegradable polymers like PLGA and PLC can provide sustained drug delivery to lower intraocular pressure for glaucoma treatment overcoming issues with eye drops. Animal studies found both implants to be biocompatible with minimal inflammation and no evidence of toxicity.
Cosmetic surgery can help alter or improve physical features that people are unhappy with, whether due to accidental injuries, birth defects, or other issues. Procedures are either reconstructive to improve conditions or elective to change appearances. Eyelid surgery or blepharoplasty removes excess fat and skin around the eyes to give a smoother, more youthful look. The procedure takes one to two hours under local or general anesthesia with small incisions made in natural eyelid folds. A neck lift improves neck appearance by removing excess skin and fat, tightening muscles, and using Botox to treat fullness; it is done under anesthesia with incisions made below the ears and chin to lift and anchor the skin.
P.D. Hinduja Hospital and Medical Research Centre, celebrated as Mumbai's foremost healthcare hub, is synonymous with excellence. Acknowledged as the city's best hospital, it hosts a stellar plastic surgery department, home to the best plastic and cosmetic surgeons in Mumbai.
The document describes a clinical study on 681 patients that evaluated the efficacy of the homeopathic remedy MADE® in treating wrinkles and skin slackening. The study found MADE® to be an effective alternative to conventional pharmacological treatments, showing good results in preventing and treating wrinkles and skin slackening, especially in patients aged 30-40 and 40-50.
jc scar and laser.pptx journal club scar treatmentMalaM67
This study assessed the efficacy and safety of combined CO2-IPL and single light IPL in treating hypertrophic scars. 138 patients with hypertrophic scars were randomized to receive either 3 sessions of combined CO2-IPL or single IPL treatment over 10-14 week intervals. Clinical assessment using the POSAS scale found that the combined CO2-IPL treatment resulted in significantly lower POSAS scores compared to single IPL, indicating greater improvement in scar characteristics. 100% of patients treated with CO2-IPL expressed satisfaction with results compared to 84% for single IPL. The combination of CO2-IPL was found to be a safe and effective alternative for treatment of hypertrophic sc
This document provides information on eye disorders, specifically cataracts and glaucoma. It defines cataracts as a lens opacity and discusses causes, types, symptoms, and treatment including medication and surgery. For glaucoma, it describes the condition as optic nerve damage related to intraocular pressure, lists types, discusses evaluation and treatment with medication, laser procedures, and nursing care post-surgery. The document aims to educate on these common age-related eye conditions.
This document discusses ways to achieve healthier, younger looking skin. It describes the three main causes of skin aging as photoaging from UV exposure, gravitational aging from tissue stretching, and volumetric aging from fat and muscle loss. The number one culprit for skin aging is identified as UV light. Ways to slow aging discussed include regular sunscreen use, antioxidants, retinoids, and the three R's - relax with botulinum toxin, refill with dermal fillers, and resurface with various laser and chemical peel procedures. Specific product recommendations and before/after photos are provided.
Nu Skin has over 30 years of experience in anti-aging research with a large in-house science team and collaborations with research institutions. Their approach focuses on targeting the sources rather than just the symptoms of aging. Key innovations include identifying gene clusters related to aging of facial skin in 2009 and body skin in 2011. Testing of their AgeLoc Me product line in 2014 involved over 200 safety tests, 50 clinical studies, and validation of results through over 200 third-party studies.
Nu Skin has over 30 years of experience in anti-aging research with a large in-house science team and collaborations with research institutions. Their approach focuses on targeting the sources rather than just the symptoms of aging. Key innovations include identifying gene clusters related to aging of facial skin in 2009 and body skin in 2011. Testing of their AgeLoc Me product line in 2014 involved over 200 safety tests, 50 clinical studies, and validation of results through over 200 third-party studies.
Nu Skin has over 30 years of experience in anti-aging research with a large in-house science team and collaborations with research institutions. Their science focuses on targeting the sources rather than just the symptoms of aging. Key innovations include identifying gene clusters related to aging of facial skin in 2009 and body skin in 2011. Testing of their AgeLoc Me product line in 2014 involved over 200 safety tests, 50 clinical studies, and validation of results through over 200 third-party studies.
Dr. Patrick Treacy Euromedicom Lectures 2014
REVERSAL OF A DERMAL FILLER INDUCED FACIAL ARTERY OCCLUSION
Dr Patrick Treacy discusses the factors to consider to avoid adverse events after the use of a dermal filler as well as the best methods of treating complications, including steroids and hyaluronidase
THE ‘BOTOX PARADOX’: IS IT EFFECTIVE
FOR DEPRESSION?
Patrick Treacy considers the conflicting evidence of botulinum toxin use as a therapy for depression, and proposes that it all comes down to where the toxin is injected
COMBINING THERAPIES FOR THE AGEING FACE:
THE DUBLIN LIFT
Dr Patrick Treacy presents a novel method for full facial rejuvenation, which combines a number of treatments to obtain the most optimum results
Formulation, Development and Evaluation of Herbal Antiaging Creamijtsrd
In this study creams were formulated based on the anti aging properties of herbal extracts and its evaluation. Ocimum tenuiflorum used as an active ingredients and extract as a Antibacterial property in these study cream are formulated by oil in water emulsion method. The cream were formulated with Aloeveragel, stearic acid, honey, Glycerin, olive oil, rose oil. The Stability for cream was performed at accelerated condition i.e. 40°C ± 2°C.If can be concluded that herbal creams without side effects having anti bacterial property can be used as provision of a barrier to protect the skin and avoid aging of the skin. Suchita Ghokhale | Dr. Smita T | Roshani Nimgire | Kashi S Ojha | Ujwala Namsale | Anam Mulla "Formulation, Development and Evaluation of Herbal Antiaging Cream" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-5 , August 2022, URL: https://www.ijtsrd.com/papers/ijtsrd50672.pdf Paper URL: https://www.ijtsrd.com/pharmacy/other/50672/formulation-development-and-evaluation-of-herbal-antiaging-cream/suchita-ghokhale
This document provides information on various aesthetic procedures used to treat signs of aging. It discusses the layers of skin and how aging affects the skin. Intrinsic and extrinsic aging factors are described. Common signs of facial aging are listed. Minimally invasive procedures like chemical peels, microdermabrasion, mesotherapy, microneedling, non-surgical facelifts using botox and fillers, thread lifts, and lasers are summarized in terms of how they work, indications, and potential benefits and risks. The importance of training and managing patient expectations is emphasized throughout.
Acne vulgaris is a common chronic inflammatory skin condition that affects the pilosebaceous units. It has a prevalence of 9.4% worldwide and most commonly affects adolescents. The pathophysiology involves increased sebum production, abnormal keratinization, Propionibacterium acnes bacteria, and inflammation. Clinical features include comedones, papules, pustules, nodules, and scarring. Treatment involves a combination of topical retinoids and antibiotics. For severe acne, oral isotretinoin may be used. While acne typically improves by age 25, some experience persistence into adulthood.
El documento describe la composición de CELLFOOD, un suplemento nutricional. Contiene una amplia variedad de minerales, aminoácidos, enzimas y electrolitos que proporcionan nutrientes esenciales para el cuerpo. Al tomar CELLFOOD, algunas personas pueden experimentar una "crisis de curación" en la que el cuerpo elimina toxinas acumuladas, lo que puede causar síntomas temporales de desintoxicación. Esto es un signo positivo de que el cuerpo se está limpiando a profundidad. Siguiendo las
I. Un estudio prospectivo evaluó el efecto de Rowatinex® en 50 pacientes tratados con litotripsia para cálculos renales o ureterales.
II. A los 14 días, el 60% de pacientes estaban libres de cálculos y el 82% a los 28 días.
III. Los resultados para el alivio de dolor también fueron excelentes, con un 82% libres de dolor a los 14 días y un 94% a los 28 días.
This document discusses different types of intradermal fillers used for minimally invasive treatment of facial aging. It categorizes fillers as biodegradable and non-permanent (such as collagen and hyaluronic acid), semi-permanent (such as poly methyl methacrylate and poly-L-lactic acid), and permanent (such as silicone). The document reviews various commercial products made from these materials and their effectiveness in treating facial aging by filling volume loss and smoothing lines and wrinkles. Skin testing is important for fillers from animal sources to check for allergic reactions.
New Technologies for Successfully Managing Ocular Surface InflammationJessica Griego
This document discusses new technologies for managing ocular surface inflammation. It begins by defining ocular surface disease and noting its prevalence. Various causes of ocular surface disease are described, including infectious, immune-related, traumatic/systemic, and iatrogenic factors. Current treatment paradigms focus on passive therapies to reduce inflammation like bandage contact lenses and topical steroids, but these can delay healing. Emerging options aim to control inflammation, prevent tissue damage, and stimulate regenerative healing using amniotic membrane biologics which promote healing and reduce inflammation. Cryopreserved amniotic membrane is presented as a safe and effective option to treat various ocular surface conditions.
The document discusses ocular drug delivery systems. It begins by outlining the composition of tear fluid and how drugs administered via the eye are typically absorbed. It then categorizes various ocular drug delivery systems including conventional, vesicular, particulate, and implant-based systems. Specific examples like liposomes, niosomes, ocular inserts and implants are described in further detail. Key advantages and disadvantages of different systems are provided. Testing parameters for ocular thin films are also listed.
This document provides an overview of common cosmetic surgical and non-surgical procedures. It discusses facial aging factors and how skin type is analyzed. Non-surgical procedures like fillers and botulinum toxin are described, with fillers being used to minimize wrinkles and treat facial atrophy. The most common filler types are listed. Surgical procedures like brow lifts and rhinoplasty are outlined, detailing techniques, recovery times, and potential complications. Overall, the document serves as an introduction to analyzing the face and various aesthetic options available.
Plastic surgery is a medical specialty focused on reconstructing and transforming the body through surgical techniques. It is divided into reconstructive and cosmetic surgery. Reconstructive surgery aims to repair deformities from accidents, trauma, or congenital defects. Cosmetic surgery seeks to change parts of the body for aesthetic reasons or in some cases for medical reasons. Common cosmetic procedures include facelifts, breast augmentation, liposuction, and rhinoplasty. It is important to carefully select a qualified plastic surgeon and clinic for cosmetic procedures.
Wound Management in Domiciliary Palliative Care wan zuraini
Basic teaching on wound management seen in home care / domiciliary palliative care in Malaysia. Spesifically describe management of pressure ulcer at home.
The document discusses two implantable medical devices used in the eye: phakic lenses and subconjunctival implants. Phakic lenses are implanted during surgery to correct vision without removing the natural lens. Subconjunctival implants made of biodegradable polymers like PLGA and PLC can provide sustained drug delivery to lower intraocular pressure for glaucoma treatment overcoming issues with eye drops. Animal studies found both implants to be biocompatible with minimal inflammation and no evidence of toxicity.
Cosmetic surgery can help alter or improve physical features that people are unhappy with, whether due to accidental injuries, birth defects, or other issues. Procedures are either reconstructive to improve conditions or elective to change appearances. Eyelid surgery or blepharoplasty removes excess fat and skin around the eyes to give a smoother, more youthful look. The procedure takes one to two hours under local or general anesthesia with small incisions made in natural eyelid folds. A neck lift improves neck appearance by removing excess skin and fat, tightening muscles, and using Botox to treat fullness; it is done under anesthesia with incisions made below the ears and chin to lift and anchor the skin.
P.D. Hinduja Hospital and Medical Research Centre, celebrated as Mumbai's foremost healthcare hub, is synonymous with excellence. Acknowledged as the city's best hospital, it hosts a stellar plastic surgery department, home to the best plastic and cosmetic surgeons in Mumbai.
The document describes a clinical study on 681 patients that evaluated the efficacy of the homeopathic remedy MADE® in treating wrinkles and skin slackening. The study found MADE® to be an effective alternative to conventional pharmacological treatments, showing good results in preventing and treating wrinkles and skin slackening, especially in patients aged 30-40 and 40-50.
jc scar and laser.pptx journal club scar treatmentMalaM67
This study assessed the efficacy and safety of combined CO2-IPL and single light IPL in treating hypertrophic scars. 138 patients with hypertrophic scars were randomized to receive either 3 sessions of combined CO2-IPL or single IPL treatment over 10-14 week intervals. Clinical assessment using the POSAS scale found that the combined CO2-IPL treatment resulted in significantly lower POSAS scores compared to single IPL, indicating greater improvement in scar characteristics. 100% of patients treated with CO2-IPL expressed satisfaction with results compared to 84% for single IPL. The combination of CO2-IPL was found to be a safe and effective alternative for treatment of hypertrophic sc
This document provides information on eye disorders, specifically cataracts and glaucoma. It defines cataracts as a lens opacity and discusses causes, types, symptoms, and treatment including medication and surgery. For glaucoma, it describes the condition as optic nerve damage related to intraocular pressure, lists types, discusses evaluation and treatment with medication, laser procedures, and nursing care post-surgery. The document aims to educate on these common age-related eye conditions.
This document discusses ways to achieve healthier, younger looking skin. It describes the three main causes of skin aging as photoaging from UV exposure, gravitational aging from tissue stretching, and volumetric aging from fat and muscle loss. The number one culprit for skin aging is identified as UV light. Ways to slow aging discussed include regular sunscreen use, antioxidants, retinoids, and the three R's - relax with botulinum toxin, refill with dermal fillers, and resurface with various laser and chemical peel procedures. Specific product recommendations and before/after photos are provided.
Nu Skin has over 30 years of experience in anti-aging research with a large in-house science team and collaborations with research institutions. Their approach focuses on targeting the sources rather than just the symptoms of aging. Key innovations include identifying gene clusters related to aging of facial skin in 2009 and body skin in 2011. Testing of their AgeLoc Me product line in 2014 involved over 200 safety tests, 50 clinical studies, and validation of results through over 200 third-party studies.
Nu Skin has over 30 years of experience in anti-aging research with a large in-house science team and collaborations with research institutions. Their approach focuses on targeting the sources rather than just the symptoms of aging. Key innovations include identifying gene clusters related to aging of facial skin in 2009 and body skin in 2011. Testing of their AgeLoc Me product line in 2014 involved over 200 safety tests, 50 clinical studies, and validation of results through over 200 third-party studies.
Nu Skin has over 30 years of experience in anti-aging research with a large in-house science team and collaborations with research institutions. Their science focuses on targeting the sources rather than just the symptoms of aging. Key innovations include identifying gene clusters related to aging of facial skin in 2009 and body skin in 2011. Testing of their AgeLoc Me product line in 2014 involved over 200 safety tests, 50 clinical studies, and validation of results through over 200 third-party studies.
Dr. Patrick Treacy Euromedicom Lectures 2014
REVERSAL OF A DERMAL FILLER INDUCED FACIAL ARTERY OCCLUSION
Dr Patrick Treacy discusses the factors to consider to avoid adverse events after the use of a dermal filler as well as the best methods of treating complications, including steroids and hyaluronidase
THE ‘BOTOX PARADOX’: IS IT EFFECTIVE
FOR DEPRESSION?
Patrick Treacy considers the conflicting evidence of botulinum toxin use as a therapy for depression, and proposes that it all comes down to where the toxin is injected
COMBINING THERAPIES FOR THE AGEING FACE:
THE DUBLIN LIFT
Dr Patrick Treacy presents a novel method for full facial rejuvenation, which combines a number of treatments to obtain the most optimum results
Formulation, Development and Evaluation of Herbal Antiaging Creamijtsrd
In this study creams were formulated based on the anti aging properties of herbal extracts and its evaluation. Ocimum tenuiflorum used as an active ingredients and extract as a Antibacterial property in these study cream are formulated by oil in water emulsion method. The cream were formulated with Aloeveragel, stearic acid, honey, Glycerin, olive oil, rose oil. The Stability for cream was performed at accelerated condition i.e. 40°C ± 2°C.If can be concluded that herbal creams without side effects having anti bacterial property can be used as provision of a barrier to protect the skin and avoid aging of the skin. Suchita Ghokhale | Dr. Smita T | Roshani Nimgire | Kashi S Ojha | Ujwala Namsale | Anam Mulla "Formulation, Development and Evaluation of Herbal Antiaging Cream" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-5 , August 2022, URL: https://www.ijtsrd.com/papers/ijtsrd50672.pdf Paper URL: https://www.ijtsrd.com/pharmacy/other/50672/formulation-development-and-evaluation-of-herbal-antiaging-cream/suchita-ghokhale
This document provides information on various aesthetic procedures used to treat signs of aging. It discusses the layers of skin and how aging affects the skin. Intrinsic and extrinsic aging factors are described. Common signs of facial aging are listed. Minimally invasive procedures like chemical peels, microdermabrasion, mesotherapy, microneedling, non-surgical facelifts using botox and fillers, thread lifts, and lasers are summarized in terms of how they work, indications, and potential benefits and risks. The importance of training and managing patient expectations is emphasized throughout.
Acne vulgaris is a common chronic inflammatory skin condition that affects the pilosebaceous units. It has a prevalence of 9.4% worldwide and most commonly affects adolescents. The pathophysiology involves increased sebum production, abnormal keratinization, Propionibacterium acnes bacteria, and inflammation. Clinical features include comedones, papules, pustules, nodules, and scarring. Treatment involves a combination of topical retinoids and antibiotics. For severe acne, oral isotretinoin may be used. While acne typically improves by age 25, some experience persistence into adulthood.
Similar to Revitalización del rostro con colágeno (20)
El documento describe la composición de CELLFOOD, un suplemento nutricional. Contiene una amplia variedad de minerales, aminoácidos, enzimas y electrolitos que proporcionan nutrientes esenciales para el cuerpo. Al tomar CELLFOOD, algunas personas pueden experimentar una "crisis de curación" en la que el cuerpo elimina toxinas acumuladas, lo que puede causar síntomas temporales de desintoxicación. Esto es un signo positivo de que el cuerpo se está limpiando a profundidad. Siguiendo las
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Este documento describe un estudio clínico sobre el tratamiento de la celulitis mediante mesoterapia homeopática y fitoterapia. El estudio incluyó 1,564 pacientes tratados entre 1991 y 1994 con una mezcla homeopática llamada Lipodistrofin inyectada mediante mesoterapia, complementada con tratamientos dietéticos, de ejercicio y aplicaciones tópicas. Los resultados mostraron mejoras en la pérdida de peso, disminución del diámetro de la cintura y síntomas relacionados con la celulitis, sin efectos
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Physiological Regulating Medicine (PRM) is the latest integration between Conventional Medicine and Homeopathic Medicine. PRM integrates classic Homeopathy with a new therapeutic concept - the restoration of physiological conditions through molecules such as hormones, neuropeptides, interleukins and growth factors in homeopathic dilutions corresponding to physiological concentrations. The method includes current knowledge on Homeopathy, Homotoxicology, the Psycho-Neuro-Endocrine-Immune axis, and nutrition. PRM offers injectable formulations for the control of nociceptive, neuropathic and mixed pain that can be injected into acupuncture points with excellent therapeutic results and no side effects.
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1. The extracellular matrix (ECM) represents the basic system of living organisms, where nourishment, control, and management of cells takes place through mutual information exchange.
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This study aimed to determine the safety and efficacy of three popular mesotherapy cocktails in treating localized fat deposits in Filipino women. Sixty subjects received injections of one of three cocktails - phosphatidylcholine and organic silicium (PC-OS), phaphatidylcholine, tiratricol and L-carnitine (PC+L), or the homeopathic formula Omeoformula 1. Measurements and blood tests showed PC-OS and Omeoformula 1 were comparable in reducing arm circumference and had fewer adverse effects than PC+L. Overall, mesotherapy was deemed safe and effective for reducing localized fat deposits with some benefit to HDL and LDL cholesterol levels.
Este estudio experimental evaluó los efectos de un preparado homeopático llamado Musclebig en parámetros antropométricos y dinamométricos de 32 culturistas masculinos. Los participantes fueron asignados aleatoriamente a un grupo tratado con inyecciones de Musclebig o a un grupo control. Tras 12 semanas, el grupo tratado mostró aumentos estadísticamente significativos en su índice de masa corporal, masa magra y fuerza de resistencia, así como una disminución en la grasa corporal, en comparación con el
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Revitalización del rostro con colágeno
1. PHYSIOLOGICAL REGULATING MEDICINE 2012
E. Falconi Klein
CLINICAL
SKIN AGING
The aging of the skin – especially the
one of the face – is a growing concern
for most people, regardless of their age.
Patients can be very young, looking for
tips to prevent wrinkles, or they can be
middle-aged, desiring to look younger
or at least keep their appearance un-
changed. On other occasions patients
start treatments when they are elderly,
and have finally decided to do some-
thing for themselves.
– Skin aging depends on several factors:
biological senescence and genetic he-
ritage (chrono-aging), photo-aging due
to UV rays, and finally on lifestyle (diet,
alcohol, smoking, pollution and oxida-
tive stress).
The appearance of the aged skin varies
depending on the prevalence of chro-
no- or of photo-aging (1, 2, 3): the se-
nile skin is pale and dry, thin, floppy,
hypo-elastic and finely wrinkled, whe-
reas the photo-aged skin is rough, pat-
ched and crossed by deep wrinkles, the
skin is anelastic and the horny layer is
thickened; the smokers’ skin is also sal-
low and dull.
WRINKLES AND THEIR
PATHOPHYSIOLOGY
The causes that lead to the formation of
the wrinkles are – in addition to chro-
nological aging as a whole – the de-
gradation of the elastic fibers and the
alteration of the collagen ones (caused
by the sun), muscle and joint move-
ments, and the force of gravity.
The formation of wrinkles is affected by
these factors to different extents and –
consequently – also in the classification
of the aging degree.
The classification of the signs of aging
conducted by Kligman (1) can help to
identify the various stages of the aging
process: linear wrinkles, glyphic wrin-
kles, creases, lines of articulation, na-
solabial folds (4).
Linear wrinkles result from linear con-
traction of the mimic muscles of the fa-
ce, when they lose tone and elasticity.
At first they are temporary folds and fur-
rows, then they mark the face increa-
singly, following the muscle movement.
For instance, the "crow's feet", around
the eyes; the "wrinkles of wonder",
parallel to the front; the "thinker’s wrin-
kles", vertical at the center of the eye-
brows, the "smoker's wrinkles" that sur-
round the mouth.
All gradually become more marked in
relation to the photo-induced damage.
Glyphic wrinkles – which other authors
define as skin texture – are lines that
form square or rhomboid areas on the
skin surface; with aging they become
more evident, they are particularly no-
ticeable on the cheeks of the elderly
with photo-damaged skin.
Creases – better known as "the folds of
SUMMARY
In our society there is a major interest in the
treatment of ageing skin with revitalizers that
stimulate new collagen production and that
can enhance face luminosity and freshness
without damaging the health of the patients
treated.
The aim of this study is to demonstrate the
efficacy of the medical device MD-Tissue as
a face revitalizer. Fifteen female volunteers
have been treated with weekly injections for
six consecutive weeks; the evaluation has
concerned only the nasolabial folds.
– A photographic documentation with Visio-
face® Quick has been carried out and the
volume of the wrinkle has been calculated;
during the treatment period of the elasticity
has also been measured. The Collagen
Medical Device MD-Tissue has been per-
fectly tolerated by all volunteers.
It has proven an average capacity in the
improvement of the skin elasticity and a good
capacity in the reduction of the wrinkle
volume.
SKIN AGING - FACE
REVITALIZATION - COLLAGEN MEDICAL
DEVICE MD-TISSUE, VISIOFACE®
QUICK,
ELASTICITY, WRINKLE VOLUME
KEY WORDS
15
FACE REVITALIZATION
- BIOLIFTING WITH MD-TISSUE
Art. Falconi-GB:Art. Pavelka 02/11/12 09.32 Pagina 15
2. 16
PHYSIOLOGICAL REGULATING MEDICINE 2012
sleep" – develop late, caused by the
head resting on the pillow while slee-
ping.
Their vertical course crosses the verti-
cal mimetic muscle lines, especially on
the forehead and cheeks.
The lines of articulation are those found
in places where there is a hinge move-
ment (ankles, elbows, wrists, etc.); exi-
sting since the birth, they become mo-
re marked and increase in other zones
too (neck, trunk, etc.) with senility.
They are not very much considered
from the point of view of cosmetology
and dermatology, nevertheless.
Finally, the nasolabial folds, which ha-
ve been taken into consideration in this
article, and the folds of muscle-skin la-
xity that appear when the collagen and
elastic texture is no longer able to co-
unteract the force of gravity and present
themselves as a falling of the skin due
to the force of gravity.
The loosening skin is the outward visi-
ble result of the degradation of the con-
nective tissue in which collagen, elastin,
fibronectin and proteoglycans have lost
their cohesion, their strength and abi-
lity to respond to elastic stimuli.
This phenomenon is connected to aging
or to prolonged sun exposure, or even
to weight loss following a state of obe-
sity (4).
Revitalizers are very suitable for patients
who want a natural treatment which
does not change the facial expression.
The possibility of using a revitalizing
such as MD-Tissue could offer many ad-
vantages. It is a product that has been
planned for soft tissues, able to create
a defense barrier against free radicals
and to counteract the physiological
aging of connective tissue (5).
These are all properties required for the
use of a good tissue revitalizer.
Homeopathized collagen has been
used since the 90s (Kollagen D6, D8)
and after the first encouraging results,
more revitalizing substances have been
added.
Thus, the product MADE was born; it
contains Collagen D8/D30, Hyaluroni-
dase D8/D30 and Magnesium D6 (6).
Collagen D8/D30 works by stimulating
the production of endogenous collagen,
because – according to the law of the
Arndt-Schultz reverse effect – weak sti-
muli (diluted doses) excite the biologi-
cal activity.
The Hyaluronidase D8/D30, acting with
the mechanism of the inverse effect, en-
courages greater compactness of the
basic substance reducing wrinkles and
toning the skin.
Magnesium D6 stimulates the produc-
tion of exogenous collagen too.
– MADE also contains enzymatic ca-
talysts, which act on the cellular respi-
ration, drainers and organotherapy me-
dicines with toning and revitalizing ef-
fects (6).
THE TUNNELING TECHNIQUE
Tunneling represents an infiltrative tech-
nique which consists in introducing the
needle (in this study it was used the
27G needle) for its entire length almost
tangentially to the skin surface, so to ta-
ke wrinkles or nasolabial folds for their
entire length.
Once introduced the needle, one starts
to inject the substance and simulta-
neously pulls the syringe in a retrogra-
de sense until the needle comes out.
– The purpose of this paper is to de-
monstrate the effectiveness of the me-
dical device MD-Tissue, measuring ob-
jective parameters before, during and
after the treatment of fifteen volunteers
aged between 33 and 50 years.
In addition to the photographic docu-
mentation of the wrinkles with the pho-
tographic method Visioface®
Quick,
measurements of skin elasticity are per-
formed with the elastomer.
All the equipment above described was
kindly made available by BIOBASIC Eu-
rope Srl, Milan (Italy).
MATERIAL AND METHODS
– MD-Tissue
Fields of application known so far:
MD-Tissue is intended to improve the
movement, helping to contain the
physiological deterioration of joints and
tissue and counterbalance the effects of
a variety of causes including:
- Aging
- Postural defects
- Concomitant chronic diseases
- Trauma and injuries
- Polluting agents.
MD-Tissue is a medical device useful
for facilitating mobility, counteracting
the physiological aging of connective
tissue, whose primary therapeutic treat-
ment consists in the following func-
tions:
1. Barrier
2. Lubricant
3. Mechanical support in the case phar-
macological therapy.
– We recommend the use of MD-Tissue
to be undertaken by qualified health
professionals.
– Treatment protocol
Two treatments for the first 2 weeks, 1
treatment until improvement of
symptoms (8-10 sessions on average).
If necessary, continue with one treat-
ment every other week for a maximum
of 10 sessions. Chronic pathologies:
continue with 1 treatment a week for 1
month until improvement of symptoms,
and subsequently 1 treatment a month.
- via intradermal injection: the area of
application must be sterile; introduce
the needle to a depth of 1-3 mm.
- via periarticular injection: the area of
application must be sterile; introduce
the needle in the proximity of the joint
to a depth of 2-4 mm.
– Method of administration
For this use of the medical device, it is
recommended to use the following ma-
terials and accessories:
- Material to ensure skin asepsis: dispo-
Art. Falconi-GB:Art. Pavelka 02/11/12 09.32 Pagina 16
3. 17
PHYSIOLOGICAL REGULATING MEDICINE 2012
sable gloves, iodine based solution, al-
coholic solution, sterile gauzes, ethyl
chloride spray.
- Sterile needles (27G)
- Syringes (5 or 10 cc), depending on
the amount of solution to be injected.
– Contraindications / Side Effects
No case of hypersensitivity to MD-Tis-
sue has been reported.
Patients with known hypersensitivity to
the component or the excipients must
be previously undergo injecting test in
the arm and kept under observation for
one hour.
– Protocol applied for revitalization
with MD-Tissue
Before proceeding with the treatment all
the volunteers signed an informed con-
sent.Then an allergological test with in-
tracutaneous injection of a small
amount of MD-Tissue was performed on
all the volunteers in order to exclude a
possible sensitization.
None of the 15 volunteers had any ad-
verse reaction to MD-Tissue.
– After a phase of clinical observation
lasting 30 minutes – which is generally
sufficient to exclude immediate type I
allergic reactions – basal measurements
have been taken (time 0, T0) by perfor-
ming a measurement of the skin elasti-
city of the nasogenian fold and a pho-
tograph of the face performed with the
Visioscan®
was also taken.
It was decided to apply a pattern that is
frequently chosen in various protocols
for anti-aging revitalization of the face.
The injective treatment with MD-Tissue
was performed once a week for 6 con-
secutive weeks.
At each session it was injected intrader-
mally a 2ml vial of MD-Tissue in the na-
sogenian folds, following linearly the
nasogenian fold with the tunneling
technique.
Some volunteers have called for the ap-
plication of an anesthetic cream prior
to receiving this treatment.
The needle used was 27G.
After the 3rd session and prior to the 4th
session, intermediate measurements (ti-
me 3 weeks, T3) were taken with pho-
to-documentation and measurement of
the elasticity, so to be able to better as-
sess the progress of the treatment.
At the end of the treatment (after the 6th
session) – 7 days after the last treatment
– the latest measurements were carried
out, always with photo-documentation
and measurement of the elasticity.
– Self-evaluation form
At the end of the treatment, the volun-
teers filled out a self-evaluation form.
The votes are comprised between 0 and
10, where 0 is equivalent to "not at all"
and 10 to "very much." The evaluation
is expressed spontaneously, in writing
and kept reserved by the patient to
avoid any influence from the doctor.
The questions that have been chosen for
this experiment are the following:
1. To what extent do you think that
the product reduces the visibility
of the expression lines?
2. To what extent do you think that
the product reduces the visibility
of micro wrinkles?
3. To what extent do you think that
your wrinkles are less deep?
4. To what extent do you think that
the product increases skin elasti-
city?
5. To what extent do you think that
the product increases your skin
brightness?
6. To what extent do you think that
your skin looks fresher / revitali-
zed?
7. To what extent do you think that
that the product increases your
skin firmness?
8. To what extent do you think that
the product increases your skin
smoothness?
9. To what extent do you think that the
product improves your skin texture?
TAB. 1
Long term skin elasticity.
Long term skin elasticity
Volunteer
n. t0 t 3 weeks t 6 weeks
1 0,8123 0,8129 0,7092
2 0,6720 0,6786 0,7213
3 0,8785 0,8591 0,8088
4 0,6879 0,7143 0,7398
5 0,6906 0,7990 0,6931
6 0,7642 0,8412 0,8526
7 0,7500 0,8452 0,8400
8 0,7654 0,8168 0,8000
9 0,8265 0,8022 0,8387
10 0,8406 0,8300 0,8377
11 0,7721 0,8128 0,6633
12 0,7893 0,8084 0,8280
13 0,8150 0,7738 0,6606
14 0,7686 0,8254 0,6812
15 0,8030 0,8138 0,8067
Average 0,776 0,802 0,765
Dev. STD 0,0584572575 0,0480712665 0,0716924682
∆% 3,4 -1,3
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4. 18
PHYSIOLOGICAL REGULATING MEDICINE 2012
mis and that the recovery distensibility
briefs about the conditions of the ela-
stic fibers (4).
– Photographic documentation
The photographic documentation was
performed with the computer systemVi-
sioface®
Quick (full face photo analy-
sis), CK electronic GmbH Koeln (Ger-
many).
RESULTS
– Results of the measurement of skin
elasticity
The results of the measurements of skin
elasticity carried out on 15 volunteers
at T0 (before treatment with revitalizing
MD-Tissue) at T3 (1 week after the 3rd
treatment, i.e before the 4th) and at T6
(1 week after the 6th and final treat-
ment) are presented.
– The measurement was always perfor-
med on the nasogenian folds.
TAB. 1 lists all the numerical results of the
15 volunteers with their values at T0, T3
andT6.
– Overall, there was a slight increase in
skin elasticity after 3 weeks of treatment,
and after 6 weeks, the values return al-
most to baseline. The average of the va-
10. To what extent do you think that
your skin looks healthier?
11. To what extent do you think that
the product gives your skin a
"comfortable" feeling?
In the interpretation of the results it was
decided to unify some votes to avoid da-
ta loss.
– The votes 9 and 10 are considered
"very good"; 7 and 8 "good"; 6 "fair"; 3,
4 and 5 "poor".
– Skin elasticity
Skin elasticity is defined as the ability of
the skin to stretch without breaking down,
then returning to its original shape.
It has been measured with the elastomer
(Cutometer®
MPA 580, Courage-Khazaka
Electronic GmbH, Koeln, Germany).
Applied to the skin, this device performs
a suction of a part of the skin and the
height reached by the aspirated layer re-
fers to its degree of tensile distensibility;
repeating several times the same ma-
neuver, a further increase of skin dis-
tensibility can be observed – defined as
tensile stretching, which is evaluated
and recorded by the device.
The latest and most refined dermatolo-
gical-physiological research could find
that distensibility reflects the state of
health of the collagen fibers of the der-
lues which initially was 0.776 increa-
ses on average to 0.802 after 3 weeks
and then lowers again to 0.765.
After 3 weeks of treatment, 11 out of 15
volunteers (73.33%) show greater ela-
sticity compared to the beginning.
Only 4 volunteers (number 3, 9, 10, 13)
(26.33%) show a lowering of elasticity
after the first three treatments.
After 6 weeks of treatment 9 voluntary
out of 15 (60%) have greater elasticity
than at the beginning, while 6 volun-
teers (number 1, 3, 10, 11, 13, 14)
(40%) have a lowering of the elasticity
under values of T0.
TAB. 2 represents graphically the results
recorded by the volunteers (1-15).
– Results of photographic documenta-
tion Visioface®
Quick
The volume and depth of wrinkles were
studied withVisioface®
Quick and the da-
ta processing was performed with the
program Skin Surface Analyzer SSA.
From the front picture of the complete fa-
ce it is chosen a small area located on the
right or left nasogenian fold of each pa-
tient, this selected rectangular area cor-
responds to the "surface" of the wrinkle.
The "depth" of the wrinkle is measured
in AU (Adimensional Unit).
It is a measurement scale created on a
colorimetric basis to give depth to the
selected area.
TAB. 2
Skin elasticity,
graphical
representation for
each patient.
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
0,8500
0,8000
0,7500
0,7000
t0 t 3 weeks t 6 weeks
0,6500
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5. 19
LA MEDICINA BIOLOGICA OTTOBRE - DICEMBRE 2012
The "volume" of the wrinkle is the result
of the following calculation:
Volume of the wrinkle (mm (2)) = AU x
height (mm) x width (mm) x depth.
The volume of wrinkles was reduced
by a total of 2.7% after 3 weeks and
13.4% after 6 weeks of treatment.
The values ranged from 0% to 28.9%.
– Results of self-assessment
Here below are shown the 11 questions
along with the opinions expressed in
votes and in percentage to which the 15
patients of the trial replied:
1. To what extent do you think that the
product reduces the visibility of the
expression lines?
– The ability to reduce the visibility
of the expression lines is conside-
red by 80% of patients "good", by
6.67% "fair" and by 13.33% “poor”.
2. To what extent do you think that the
product reduces the visibility of mi-
cro wrinkles?
– The ability to reduce the visibility
of micro wrinkles is considered by
13.33% of patients "very good", by
53.33% "good", by 20% "fair" and
by 13.33% "poor".
3. To what extent do you think that
your wrinkles are less deep?
– The perception of less deep wrin-
kles is for 6.67% of patients "very
good", for 80% "good" and for
13.33% "poor".
4. To what extent do you think that the
product increases the skin elasticity?
– The increase in the skin elasticity
is perceived by 86.67% of patients
to be "good" and by 13.33% "fair".
5. To what extent do you feel that the
product increases the brightness of
your skin?
– The increase in brightness is held
“very good” by 13.33% of the pa-
tients, “good” by 66.67%, “fair” by
6.67% "fair" and “poor” by 13.33%.
6. To what extent do you think that
your skin looks fresher / revitalized?
– The perception of a fresh and re-
vitalized skin is for 13.33% of pa-
tients "very good", for 66.67%
"good" and for 20% "fair”.
7. To what extent do you think that
the product increases your skin
firmness?
– The increase in firmness is con-
sidered by 6.67% of patients "very
good", by 73.33% "good" and by
20% "fair".
8. To what extent do you think that
the product increases your skin
smoothness?
– The increase in smoothness is
perceived by 6.67% of patients as
"very good", by 60% "good" and
by 33.33% "fair".
9. To what extent do you think that
the product improves your skin
texture?
–The improvement in the skin tex-
ture is considered by 6.67% of pa-
tients "very good", by 46.67%
"good" and by 46.67% "fair".
10. To what extent do you think that
your skin looks healthier?
–The perception of a healthier skin
is for 6.67% of patients "very
good", for 80% "good" and for
13.33% "fair”.
11. To what extent do you think that
the product gives your skin a
TAB. 3
Wrinkle volume
mm2
2 X A.U. with
decrease
percentage of each
patient after 6-week
treatment.
Wrinkle volume mm2
X A.U.
Volunteer
n. t0 t 3 weeks t 6 weeks %
1 0,4500 0,4500 0,3200 -28,9
2 0,2400 0,2000 0,2200 -8,3
3 0,1000 0,0900 0,0900 -10,0
4 0,1300 0,1600 0,1000 -23,1
5 0,8100 0,8500 0,7200 -11,1
6 0,2800 0,2300 0,2400 -14,3
7 0,2300 0,2300 0,1900 -17,4
8 0,2100 0,2500 0,2000 -4,8
9 0,1700 0,1900 0,1700 0,0
10 0,0800 0,0900 0,0800 0,0
11 0,3800 0,3600 0,3200 -15,8
12 0,1100 0,1000 0,1000 -9,1
13 0,5300 0,4000 0,4800 -9,4
14 0,2200 0,2400 0,2000 -9,1
15 0,1600 0,1500 0,1200 -25,0
Average 0,273 0,266 0,237
Dev. STD 0,19722 0,19449 0,17182
∆% -2,7 -13,4
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6. 20
LA MEDICINA BIOLOGICA OTTOBRE - DICEMBRE 2012
"comfortable" feeling?
– The perception of a sense of
"comfort" is for 6.67% of patients
"very good", for 73.33% "good",
for 13.33% "fair" and for 6.67%
"poor".
DISCUSSION
The aim of this study was to demonstra-
te the effectiveness of the medical de-
vice MD-Tissue as facial revitalizer.
15 patients – 33-50 years – were eva-
luated; first they underwent an allergy
test with the provocation of a small in-
tracutaneous wheal to exclude sensiti-
zation to the product.
MD-Tissue showed an acceptability of
100%, none of the patients experienced
discomfort or side effects.
Consequently, they were administered
weekly injections of MD-Tissue (2.0
ml), exclusively in the nasogenian
folds. At the beginning of the treatment
(T0), after 3 weeks (T3) and after 6
weeks (T6) a photographic documenta-
tion was performed using Visioface®
Quick and the measurement of elasti-
city using the elastomer (Cutometer Co-
urage - Khazaka).
At the end of the treatment the patients
completed a self-evaluation question-
naire.
After 3 weeks of treatment the elasticity
values showed an improvement of
73.33% and have achieved a total im-
provement of 3.4%; after 6 weeks of
treatment they stabilized at 60%.
In order to achieve more indicative va-
lues, further measurements and – abo-
ve all – a higher number of patients may
be required.
However, the effect is present and ela-
sticity in this work was higher after 3
weeks than after 6 weeks of treatment.
As for the photographic documentation
obtained through the deviceVisioface®
Quick and the data calculation achie-
ved with the Skin Surface Analyzer SSA,
results were highly positive.
The overall improvement of the patients,
with a lowering of the wrinkle volume
calculated by the Skin Surface Analyzer,
was of -2.7% after 3 weeks and -13.4%
after 6 weeks with peak improvements
in the depth of wrinkles even reaching
28.9%.
– This very satisfactory result is also re-
flected in the data interpretation found
in the patients’ self-assessment que-
stionnaire and in their happiness:
80% considered "good" the reduction
of the visibility of the expression lines;
they considered that the wrinkles on the
face are less deep, and their skin heal-
thier.
86, 67% considered "good" the increa-
se in elasticity; 73.33% judged as
"good"; 6.67% as "very good" the in-
crease in the skin compactness; they al-
so thought that the product gives a fee-
ling of comfort.
66.67% considered "good" and
13.33% "very good" the increase in skin
brightness; they also thought the skin
looked fresher and more revitalized.
In conclusion we can confirm that the
medical device MD-Tissue revealed to be
a reliable and safe product for the face re-
vitalization.
– This can lead to several different uses
in aesthetic medicine.The fluid texture of
the product is definitely very suitable for
the treatment of the neck, décolletage and
back of the hands.
Face applications can include several
techniques such as the treatment with mi-
cro wheals, injections in acupuncture
points, eye zone and forehead rejuvena-
tion. í
References
1. Kligman L. - Photoaging: manifestations, preven-
tion and treatment. Clin Geriatr Med 1989;5: 235-
251.
2. Gilchrest B.A. - Skin aging and photoaging: an
overview. J Am Acad Dermatol 1989; 21: 510-
513.
3. Kang S., Fisher G.J., Voorhees J.J. - Photoaging:
pathogenesis, prevention and treatment. Clin Ge-
riatr Med 2001; 17: 643-659.
4. Fracassi P., Marottoli M.S. - Dizionario di Dermo-
cosmesi. Tecniche nuove, 2006.
5. Milani L. - Un nuovo e raffinato trattamento iniet-
tivo delle patologie algiche dell'apparato locomo-
tore. La Med. Biol., 2010/3; 3-15.
6. De Bellis M. - Omeomesoterapia in medicina
estetica, Scuola di Omeopatia-Omotossicologia
e Discipline Integrate. Dispense AA. 2011-2012.
Acknowledgements
The author thanks the BIOBASIC EUROPE SRL
staff for their collaboration as well as for the use of
their devices.
Author
Dr. E. Falconi Klein, MD
– Specialist in Dermatology
– Specialist in Allergology
Via Mauro Macchi, 42
I – 20124 - Milano
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