This document provides an introduction to microfluidics and lab-on-a-chip technologies for biomedical applications. It discusses the basic principles of microsystems and microfabrication. Specifically, it describes how microsystems integrate electrical and other functions on the micrometer scale using microsensors and microactuators. The document also provides examples of biosensors and discusses the history and commercial applications of glucose biosensors. Finally, it suggests that the global market for biosensors and bioelectronics will continue growing significantly in the coming years as the technology develops.
Biosensors: General Principles and ApplicationsBhatt Eshfaq
A biosensor is an analytical device, used for the detection of a chemical substance, that combines a biological component with a physicochemical detector.
Biosensors: General Principles and ApplicationsBhatt Eshfaq
A biosensor is an analytical device, used for the detection of a chemical substance, that combines a biological component with a physicochemical detector.
A Descriptive Review over the field of Biosensors has been given here; its origin history events; its working principle; its classification based on various parameters; applications and future scope
Synthesis of ZnO Nanoparticles using wet chemical method and its characteriza...Govind Soni
This is very intersting power point on ZnO NPs synthesized by me GOVIND SONI and my lab partnes KAUSHAL ,SANEHA & DINESH under the guidance of our PhD scholar Mr.SAHIL & Ms.KIRTI in the CYRSTAL LAB of DR.BINAY KUMAR in Department of Physics & Astrophysics .This presentation basically covers the Introduction to Nanoscience and Nanotechnology and synthesis of Zinc oxide nanoparticles using wet chemical method . its characterization has been done in Msc finals Nanoscience lab using X-Ray Diffraction and Particle size Analyzer.This presentation also contains an advance topic on introduction to Spintronics which is basically the study of internsic spin of electronics and its magnetic moment.I hope it will be an important tool to know about Nanoworld .
A Descriptive Review over the field of Biosensors has been given here; its origin history events; its working principle; its classification based on various parameters; applications and future scope
Synthesis of ZnO Nanoparticles using wet chemical method and its characteriza...Govind Soni
This is very intersting power point on ZnO NPs synthesized by me GOVIND SONI and my lab partnes KAUSHAL ,SANEHA & DINESH under the guidance of our PhD scholar Mr.SAHIL & Ms.KIRTI in the CYRSTAL LAB of DR.BINAY KUMAR in Department of Physics & Astrophysics .This presentation basically covers the Introduction to Nanoscience and Nanotechnology and synthesis of Zinc oxide nanoparticles using wet chemical method . its characterization has been done in Msc finals Nanoscience lab using X-Ray Diffraction and Particle size Analyzer.This presentation also contains an advance topic on introduction to Spintronics which is basically the study of internsic spin of electronics and its magnetic moment.I hope it will be an important tool to know about Nanoworld .
Un "lab on a chip" (LOC) es un dispositivo que integra una o varias funciones propias de un laboratorio en un único chip cuyas dimensiones van desde solo unos milímetros hasta unos pocos centímetros cuadrados.
These slides use concepts from my (Jeff Funk) course entitled analyzing hi-tech opportunities to show how the cost and performance of micro-fluidics are improving. Miro-fluidic devices have small micro-channels that analyze many types of fluidics. They can be fabricated from many materials including paper, textiles, and plastics. Plastics are the most recent to emerge and their fabrication relies on many of the same techniques that are used to fabricate integrated circuits. This means that they have been experiencing very rapid improvements as fabrication techniques are improved for ICs and then used to make micro-fluidic MEMS. (micro-mechanical electrical systems). Micro-fluidics are widely used in health care to analyze bacteria in water, glucose in sweat, nitrate contamination in water, and the blood of mosquitoes. Emerging applications include analysis of blood for early cancer detection.
Key technologies of the future. A must read for budding engineers and faculty.
The contents will be very useful for deciding areas and topics for seminars, projects and workshops.
Courtesy: TIFAC and Internet
Topic 1 introduction of biomedical instrumentationGhansyam Rathod
Basic Description of the Biomedical Instrumentation subject and basics of the physiological system of human body discussed as per the syllabus of 2EC42 subject offered at Birla Vishvakarma Mahavidyalaya, Engineering Autonomous Institution.
A micro electronic pill is basically a multi channel sensor used for remote bio medical measurements using microtechnology this has been developed for the internal study and detection of diseases and abnormalities in the gastro intestinal GI tract where restricted access prevents the use of traditional endoscopy the measurement parameters for detection include real time remote recording of temperature, pH, conductivity and dissolved oxygen in the GI tract This paper with the design of the micro electronic pill which mainly consists of an outer biocompatible capsule encasing 4 channel micro sensors a control chip, a discrete component radio transmitter and 2 silver oxide cells.
Biosensors, Types of Biosensors, Applications of Biosensors, Nanotechnology, Nanobiosensors, Components of Biosensor, Working of Biosensor, Principle of Biosensor, Examples of Biosensor, Advantages of Biosensor, Disadvantages of Biosensor, Limitations of Biosensor, Features of a Biosensor, Calorimetric Biosensors, Potentiometric Biosensors, Acoustic Wave Biosensors, Amperometric Biosensors, Optical Biosensors, Examples of a Nanobiosensor, Lab on a chip,
Applications of Lab on a chip, Glucose Biosensor
The revolution of nanotechnology in molecular biology gives an opportunity to detect and manipulate atoms and molecules at the molecular and cellular level.
Biosensors are nowadays ubiquitous in biomedical diagnosis as well as a wide range of other areas such as point-of-care monitoring of treatment and disease progression, environmental monitoring, food control, drug discovery, forensics and biomedical research. A wide range of techniques can be used for the development of biosensors. Their coupling with high-affinity biomolecules allows the sensitive and selective detection of a range of analytes. We give a general introduction to biosensors and biosensing technologies, including a brief historical overview, introducing key developments in the field and illustrating the breadth of biomolecular sensing strategies and the expansion of nanotechnological approaches that are now available
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Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
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Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
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1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
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As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
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Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
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2. CONTEN
T
Chapter 1: Introduction.
Chapter 2 : Basic principles of Microfluidics.
Chapter 3 : Basis of molecular biology and analytical tools.
Chapter 4 : Micromanufacturing.
Chapter 5 : Lab-on-a-Chip & applications.
Chapter 6 : Cancer diagnostics and monitoring.
3. WHAT IS « MICROSYSTEM » ?
MICROSYSTEM = microelectronic circuit + sensor(s) and/or
actuator(s)
Any engineering system that performs electrical and
« other » functions, with components in micrometer scale is
a MICROSYSTEM. (1 µm = 1/10 of human hair)
MICROSYSTEM products may include :
● Micro sensors (pressure, acceleration, acoustic wave,
biomedical, chemical, optical, radiation, thermal, etc.)
● Micro actuators (valves, pumps and microfluidics; microneedles for blood sampling or drug injection,
electrical and optical relays and switches;
grippers, tweezers and tongs; linear and rotary motors, etc.)
4. WHAT IS « MEMS » ?
MEMS = Micro Electro-Mechanical
System
This term is often used in USA and some other countries,
even in connection to systems which do not contain
mechanical parts in sensors and actuators.
e.g. BioMems, BioNems: MEMS/NEMS ‘bio’logical applications
In practice : MEMS = MICROSYSTEM
European Commission uses the abreviation MST for MICROSYSTEMS
or microsystem's technology.
In this lecture we will speak about Bio-Microsystems
MICROSYSTEMS – contain parts in the scale of micrometers
NANOSYSTEMS – contain parts in the scale of nanometers (<100 nm)
9. What are biosensors?
A biosensor is an analytical device which converts a
biological response into an electrical signal.
Schematic diagram showing the main components of a biosensor.
The biocatalyst (a) converts the substrate to product. This reaction
is determined by the transducer (b) which converts it to an electrical
signal. The output from the transducer is amplified (c), processed
(d) and displayed (e).
10. What are biosensors?
Biosensors sometimes are broadly defined as any
device designed to gather biological information,
such as the presence of a particular biomolecule, and
convert it into an analytical signal. This report uses
the stricter definition of biosensors used by The
National Research Council (NRC), part of the U.S.
National Academy of Sciences.
The NRC has defined a biosensor as a detection
device that incorporates a) a living organism or
product derived from living systems (e.g., an enzyme
or an antibody) and b) a transducer to provide an
indication, signal, or other form of recognition of the
presence of a specific substance in the environment.
11. What is a "miner's canary"?
The first bio-chemical sensor !
"Miner's canary" refers to the birds once used by miners to test the purity of the air in the
mines. At least three birds would be taken underground by a group of miners. If any one bird
showed signs of distress, it was taken as an indication that dangerously high levels of carbon
monoxide existed. Today, miners use sophisticated sensing equipment instead of canaries.
12. Biosensors - transduction
Most Biosensors work on the principle of interactions between the
biomolecules in the sample and the analyte (usually in solution)
in the sensor. Signal transduction is carried out by the sensing
element, which may use a wide range of different techniques.
14. Diabetes
Diabetes is a metabolic disorder, in which the pancreas underproduces
or does not produce insulin. Because cells need insulin to absorb
blood sugar (glucose) for their energy needs, the cells of people with
diabetes suffer from a shortage of glucose, while glucose levels build
up in the blood.
The disease is a major world health problem. It is estimated that there
are over 150 million diabetics worldwide. Worse still, incidence of the
disease has risen by an alarming 11% over the last five years, and a
further doubling of new cases is predicted in the next 25 years.
There are three types of diabetes:
Type 1 Diabetes of the young. Approximately 10 % of diabetics have Type 1.
Type 2 Diabetes of older patients. 90 % of people with diabetes have Type 2.
Type 3 Gestational diabetes is a temporary condition that occurs during
pregnancy. It affects 4 % of pregnancies with an risk of developing diabetes for
both mother and child.
15. Glucose Biosensor
s
When left untreated or improperly managed, diabetes is one of the
leading causes of death by disease.
Despite the many technological advances in biosensor and the
introduction of many different biosensors, glucose biosensors still
account for approximately 85% of the current world market, which
has recently been estimated to be around $5 billion.
There are, currently, over 40 blood glucose meters on the market.
The lion’s share of the market is shared between Roche Diagnostics,
Lifescan, Abbott and Bayer.
Many transducers could be used for the measurement of glucose, but
electrochemistry has dominated. This is partially historical, but the
primary reason is that they offer suitable sensitivity, reproducibility
and can be manufactured in great volumes at low cost.
16. A sensor for measuring the glucose
concentration of a patient.
17. CNT based Field Effect Transistor
for Glucose Detection
SWNT - single-walled carbon nanotubes
18. Example of Home Blood Glucose
Monitor
The main biosensors products sold by Roche are the Accu-Chek
blood glucose monitoring systems. Accu-Chek Active is one of the
fastest meters in the market, requiring just 5 seconds to obtain a
reading. It features an automatic on/off function, a 1 µl blood sample
requirement, 200 value memory storage (with times and dates, 7 and
14 day averaging and an underdosing monitor that detects when
insufficient blood has been applied.
19. Ion-Selective Field Effect Transistors
(ISFETs)
Enzyme membranes are coated on the ion-selective gates of
these
Field Effect Transistors, responding to the electrical potential
change via the current output. Thus, these are potentiometric
devices although they directly produce changes in the electric
current. The main advantage of such devices is their extremely
small size (<< 0.1 mm2) which allows cheap mass-produced
fabrication using integrated circuit technology.
21. Medical Telesensors
A chip on your fingertip may someday measure and transmit data on
your body temperature. An array of chips attached to your body may
provide additional information on blood pressure, oxygen level, and
pulse rate. This type of medical telesensor, which is being developed
at ORNL for military troops in combat zones, will report measurements
of vital functions to remote recorders. The goal is to develop an array
of chips to collectively monitor bodily functions.
These medical telesensors would send
physiological data by wireless transmission to
an intelligent monitor on another soldier's
helmet. The monitor could alert medics if the
data showed that the soldier's condition fit one
of five levels of trauma. The monitor also would
receive and transmit global satellite positioning
data to help medics locate the wounded
22. Biosensors printed directly onto clothing
Joseph Wang and colleagues at the University of California San
Diego, La Jolla have devloped a method for printing biosensors
directly onto clothing. To form the sensors, Wang screenprinted carbon electrode arrays directly onto the elastic bands
of mens' underwear. The tight contact and direct exposure to
the skin allows hydrogen peroxide and the enzyme NADH,
which are both associated with numerous biomedical
processes, to be monitored using the sensor.
24. The global market for biosensors and other bioelectronics
is projected to grow from $6.1 billion in 2004 to $8.2 billion
in 2009, at an AAGR (average annual growth rate) of about
6.3%.
25. Learning From the Experiences in Microelectronics
invention of transistors by three Nobel Laureates,
W.Schockley, J. Bardeen and W.H. Brattain of Bell
Laboratories in 1947.
concept of Integrated Circuits (IC) in 1955, and the
production of the first IC few years later by Jack
Kilby of Texas Instruments.
Moore’s law (1964) - number of transistors per chip
doubles every 1.5-2 years
ICs have made possible for miniaturization of many
devices and engineering systems in the last 50
years.
27. Learning From the Experiences in Mechanical
Microsystems and Microfabrication
1959: Richard Feyman says, “There is plenty of room at the
bottom.”
1969: Westinghouse creates the “Resonant Gate FET.”
1970s: Bulk-etched silicon wafers used as pressure sensors
(micromachining technologies...).
1982: Kurt Petersen published “Silicon as a Structural material.”
1980s: Early experiments in surface- micromachined polysilicon.
Micromachining leverages the micro-electronic industry in late
80s.
1990s: Introductionof new materials (piezoelectric, piezoresistive,
poly-Si ...).
28. WHAT IS « MICRO/NANOFABRICATION » ?
Micro/nano fabrication: it is a process used to
construct physical objects with dimensions in the
micro/nano-metre to millimeter range.
Micro/nano objects or devices are comprised of a
range of miniature structures, including moving parts
(cantilevers and diaphragms), static structures (flow
channels and wells), chemically sensitive surfaces
(proteins and cells) and electrical devices (resistors
and transistors).
In contrast to planar microelectronic devices,
micro/nanosystemns contains ALWAYS 3-dimmensinal
objects.
30. Evolution of Microfabrication
● There is no machine tool with today’s technology can produce
microsystem components of the size in the micrometer scale (or in mm
sizes).
● The microfabrication techniques originally developed for producing
integrated circuit (IC) components can help.
● The complex geometry of microsystem components can only be
produced by various complex physical-chemical processes.
● Despite the fact that many microelectronics technologies can be
used to fabricate silicon-based MEMS components, microsystems
engineering requires the application of principles involving
multidisciplines in science and engineering (new materials and new
technologies).
● Team effort involving multi-discipline of science and engineering is the
key to success for any microsystem industry.
35. MEMS as a part of CMOS
integrated systems
High complexity of
MEMS elements
possible (multifunctional
sensing) together
with advanced
electronic
detection/signal
processing.
36. 1 st level packaged microsystems &
smallest commercialised unit
Example of inkjet (microfluidic microsystem)
38. WHAT IS « MICROFLUIDICS » ?
Microfluidics deals with the behavior, precise control and
manipulation of fluids that are geometrically constrained to a
small, typically sub-millimeter, scale. Typically, micro means
one of the following features:
small volumes (nl, pl, fl)
small size
It is a multidisciplinary field intersecting engineering, physics,
chemistry, microtechnology and biotechnology, with practical
applications to the design of systems in which such small volumes
of fluids will be used. Microfluidics emerged in the beginning of the
1980s and is used in the development of inkjet printheads and in the
beginning of 1990s for bio-chemical analysis. DNA chips, lab-on-achip technology, micro-propulsion, and micro-thermal technologies.
39. MICROFLUIDICS - key application areas
To date, the most successful commercial
microfluidics is the inkjet printhead.
application
of
Advances in microfluidics technology are revolutionizing
molecular biology procedures for enzymatic analysis (e.g.,
glucose and lactate assays), DNA analysis (e.g., polymerase
chain reaction and high-throughput sequencing), and proteomics.
The basic idea of microfluidic biochips is to integrate assay
operations such as detection, as well as sample pre-treatment
and sample preparation on one chip.
An emerging application area for biochips is clinical pathology,
especially the immediate point-of-care diagnosis of diseases.
In addition, microfluidics-based devices, capable of continuous
sampling and real-time testing of air/water or food samples for
biochemical toxins and other dangerous pathogens, can serve as
an always-on "bio-smoke alarm" for early warning.
45. WHAT IS « Lab-on-a-Chip » ?
Lab-on-a-Chip are devices that integrate multiple laboratory
functions on a single chip of only millimeters to a few square
centimeters in size and that are capable of handling extremely small
fluid volumes down to pico liters.
Lab-on-a-chip devices belong to the family of MICROSYSTEMS.
Lab-on-a-chip devices are sometimes called "Micro Total Analysis
Systems" (µTAS).
Lab-on-a-chip concept extends the simple sensor functionality and
includes the integration of pre-treatment steps, additional cleaning
and separation steps towards a complete laboratory analysis.
Lab-on-a-Chip devices emerged in early 1990s (Manz, A., 1990,
Sensors & Actuators B Chem., B1, 1-6, 244)
47. Examples of LOC Applications
Real-time PCR ;detect bacteria, viruses and cancers.
Immunoassay ; bacteria, viruses, cancers based on antigen-antibody
reactions.
Dielectrophoresis : detecting cancer cells and bacteria.
Blood sample preparation ; can crack cells to extract DNA.
Cellular lab-on-a-chip for single-cell analysis.
Lab-on-a-chip technology may soon become an important part of efforts
to improve global health, particularly through the development of pointof-care testing devices.
Many researchers believe that LOC technology may be the key to
powerful new diagnostic instruments. The goal of these researchers is to
create microfluidic chips that will allow healthcare providers to perform
diagnostic tests such as immunoassays and nucleic acid assays with no
laboratory support.
48. Lab-on-a-Chip : Possible Functional Blocks
The detection of protein cancer markers will be obtained here by
the integration on the Chip of the following blocks :
The most general block diagram of the Chip for the detection
of molecular cancer markers is the following :
50. Miniaturization
Few cm 2
small laboratory which uses Labs-on-a-Chip = very big laboratory
Lab-on-a-Chip >>>> towards “point of care application”
51.
52. Example of a Lab-on-a-Chip
E-coli Germ detection chip, which combine target cell capture, cell
preconcentration and purification, cell lysis, DNA multiplication and
electrochemical detection.
55. Miniaturization Makes Engineering Sense !!!
• Small systems tend to move or stop more quickly due to low mechanical
inertia.It is thus ideal for precision movements and for rapid actuation.
• Miniaturized systems encounter less thermal distortion and mechanical
vibration due to low mass.
• Miniaturized devices are particularly suited for biomedical and aerospace
applications due to their minute sizes and weight.
• Small systems have higher dimensional stability at high temperature due
to low thermal expansion.
• Smaller size of the systems means less space requirements.
This allows the packaging of more components in a single device.
• Less material requirements mean low cost of production and
transportation.
• Ready mass production in batches.
57. Market breakout for 1 st level packaged
microsystems
3 products make 70% of the market in 2009
– Read-Write (RW) heads
– Inkjet heads
– MEMS displays
3 other products making each over $1 billion in 2009
– Pressure sensors
– RF MEMS
– Inertial sensors
12 emerging or niche products each < $100m in 2009
Lab-on-a-Chip, Microreaction, chip cooler, inclinometers,
MEMS memories, MEMS fingerprints, liquid lenses,
microspectrometer, wafer probes, micro-mirrors for optical
processing, micro-pumps, micromotors, chemical analysis
systems.