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SilkSkin Glove Presentation
- 2. What is SERICIN? • SERICIN is a protein created by Bombyx mori (silkworms) in the production of silk • Silk consists mainly of two proteins, SERICIN and fibroin • Fibroin being the structural center of the silk • SERICIN being the gum coating the fibres and allowing them to stick to each other. • Silk SERICIN has been used for over 3500 years by the world elite to rejuvenate their hair and skin
- 3. SERICIN Applications • Skin Creams (Anti-Aging) • Hair Care (Moisturizer) • Air Filters (Antimicrobial) • Textiles (Antimicrobial) • Edible Supplements (Antioxidant) • Serum for tissue culture • Tissue Scaffold
- 4. Why SERICIN? • SERICIN structure and the content of amino acids are similar to the skin of human body, thus it is highly compatible and absorbed easily with human skin (Padol 2012) • SERICIN benefits: • Moisturizing • Anti-Aging • Wound Healing • Anti-Microbial
- 5. SERICIN Content • SERICIN amino acid composition that resemble natural moisturizing factor (NMF), which is naturally part of our human make up.
- 6. SERICIN Moisturizing • Decrease skin impedance • • • Moisturizing of upper layer of skin Increase in water holding Increase hydroxyproline (protein binding capacity to stratum corneum) • • hydroproxyline important in stabilizing triple helical structure of collagen and connective tissue • • by restoration of amino acid protein used to restore moisturization and skin tightening Reduce excessive transepidermal water loss (TEWL) • • Occlusive effect preventing water loss from stratum corneum and allow water to accumulate horny layer Replacement of natural moisturizing factor (NMF) due to occurs by aging
- 7. SERICIN Moisturizing • Skin treated with SERICIN showed less flakes and white ridges • Decrease in flakes and ridges of the skin reveals the moisturization of the skin • SERICIN forms a moisturizing, semiocclusive, protective, anti wrinkle film on the skin surface imparting an immediate, long lasting, smooth, silky feeling.
- 8. Causes of Aging • Intrinsic factors • Biological aging • hormonal changes • metabolic processes
- 9. Causes of Aging • Extrinsic factors (also accelerate intrinsic factor) • UV radiation causing • Photo-aging • Generate Reactive Oxygen Species (ROS)/ Oxidative Stress leading to cell or tissue injury, they are responsible for many diseases such as cancer • over-production of elastase degrading elastin fiber (losing elasticity and wrinkle formation) • Sun exposure induces tyrosinase (Melanin production/blackened peeled potato)
- 10. SERICIN Anti-Aging • Reactive Oxygen species (ROS) scavenging/Antioxidant • • • Due to high content of hydroxy amino acids (Serine & Threonine) chelating trace elements such as copper and iron. Fan et al 2007 Evidenced by lipid peroxidation test by Kato et al 1997 Anti-tyrosinase (production of melanin e.g. blackening of sliced potato) • • SERICIN contains flavonoids and carotenoids elements. Chlapanidas et al 2013 confirmed SERICIN exhibits strong antityrosine properties. Anti-elastase • Chlapanidas et al 2013 concluded anti-elastase properties in SERICIN that prevents loss of skin elasticity and wrinkle formation
- 11. SERICIN Anti-Aging • UV protection • • SERICIN has suppressive activity against both chemical and UV radiation by inhibiting epidermal oxidative stress, suppression of COX-2 expression, and moisturizing effect. Zhaorigetu et al 2003 Anti-apoptosis (programmed cell death) • Western blotting test result indicates Sericin stimulated bcl-2 (an anti-apoptosis signal) by reducing the oxidative stress in fibroblast. Kitisin et al 2013 • Blocking the caspase activity by reducing oxidative stress in HaCat. Dash et al 2008
- 12. SERICIN Anti-Aging • Zhaorigetu et al 2003 conduct acute 7 days UVB radiation on mouse skin • Vehicle (control), BSA (control), SIREN • Rare 4-HNE (oxidative stress marker) on SERICIN treated skin • Hardly observed COX-2 (marker of epidermal UVB exposure) expression on SERICIN treated Skin
- 13. SERICIN Anti-Aging • Dash et al 2008 concluded anti-apoptotic effect of SERICIN in UVB-irradiated cells is through the blocking of caspace activities, possibly by reducing oxidative stress in HaCat (Human Skin)
- 14. SERICIN Anti-Aging • Dash et al 2007 test SERICIN antioxidant against H2O2. • H2O2 as a model oxidant has been well studied. • Report conclude SERICIN is an ideal molecule to prevent oxidative stress.
- 15. SERICIN Wound Healing • Methionine and cysteine promote cell growth and collagen synthesis. • Aramwit et al 2007 concluded that SERICIN has good hydrophilic properties, compatibility, and biodegradation. • SERICIN treated wound had much smaller inflammatory reactions and wound-size reduction greater than control. • Mean time in days for 90% healing for SERICIN treated wound is much lesser than control • Histological examination shows SERICIN treated wound revealed complete healing, no ulceration, no rash, and increase in collagen compared to control, which showed some ulceration and inflammatory.
- 18. SERICIN Antimicrobial • Senakoon et al 2009 & Rajendrana et al 2012 concluded that SERICIN antibacterial property against E. Coli and S. Aureus • E. Coli cell shrunk and deep roughening of cell surface • S. Aureus cell exhibits segregation, deformation, reduced size and shrinkage
- 19. SERICIN Antimicrobial • Jassim et al 2010 examined SERICIN antibacterial property by growing of spores colonies and examining tensile strength of SERICIN treated and untreated cotton fabric • The average of untreated fabric is 14.25 NIT, whereas treated fabric is 96 NIT (6.5X)
- 20. The End