The document discusses updates to genome mapping technology. It describes how high-throughput, high-resolution imaging can generate contiguous DNA molecules up to megabase lengths. Labeled DNA is imaged repeatedly to scan the entire genome. Genome maps can be used to discover structural variants by comparing patterns of labeled sequences. Genome maps can also be used as scaffolds to align sequencing contigs. The document provides examples of detecting insertions, deletions, and other structural variants between samples or to a reference genome. It also discusses using genome maps to validate structural variants found through other methods like PacBio sequencing.
Apollo is a web-based application that supports and enables collaborative genome curation in real time, allowing teams of curators to improve on existing automated gene models through an intuitive interface. Apollo allows researchers to break down large amounts of data into manageable portions to mobilize groups of researchers with shared interests.
Genome assembly: then and now — with notes — v1.1Keith Bradnam
This was a talk given on 2014-06-19 for the Genome Center’s Bioinformatics Core as part of a 1 week workshop on using Galaxy. It concerns the Assemblathon projects as well as other aspects relating to genome assembly.
A version of this talk is also available on Slideshare without embedded notes.
Note, this is an evolving talk. There are older and newer versions of the talk also available on slideshare.
Evento organizado pelo Instituto de Estudos Avançados da USP, Polo Ribeirão Preto (IEA-RP).
Mais informações: http://www.iearp.blogspot.com.br/2012/09/perspectivas-sobre-aplicacoes-de_18.html
This was a talk given on 2014-09-17 for the Genome Center’s Bioinformatics Core as part of a 1 week workshop. It concerns the Assemblathon projects as well as other aspects relating to genome assembly.
A version of this talk is also available on Slideshare with embedded notes.
Note, this is an evolving talk. There are older and newer versions of the talk also available on slideshare.
This was a talk given on 2014-06-19 for the Genome Center’s Bioinformatics Core as part of a 1 week workshop on using Galaxy. It concerns the Assemblathon projects as well as other aspects relating to genome assembly.
A version of this talk is also available on Slideshare with embedded notes.
Note, this is an evolving talk. There are older and newer versions of the talk also available on slideshare.
Apollo is a web-based application that supports and enables collaborative genome curation in real time, allowing teams of curators to improve on existing automated gene models through an intuitive interface. Apollo allows researchers to break down large amounts of data into manageable portions to mobilize groups of researchers with shared interests.
Genome assembly: then and now — with notes — v1.1Keith Bradnam
This was a talk given on 2014-06-19 for the Genome Center’s Bioinformatics Core as part of a 1 week workshop on using Galaxy. It concerns the Assemblathon projects as well as other aspects relating to genome assembly.
A version of this talk is also available on Slideshare without embedded notes.
Note, this is an evolving talk. There are older and newer versions of the talk also available on slideshare.
Evento organizado pelo Instituto de Estudos Avançados da USP, Polo Ribeirão Preto (IEA-RP).
Mais informações: http://www.iearp.blogspot.com.br/2012/09/perspectivas-sobre-aplicacoes-de_18.html
This was a talk given on 2014-09-17 for the Genome Center’s Bioinformatics Core as part of a 1 week workshop. It concerns the Assemblathon projects as well as other aspects relating to genome assembly.
A version of this talk is also available on Slideshare with embedded notes.
Note, this is an evolving talk. There are older and newer versions of the talk also available on slideshare.
This was a talk given on 2014-06-19 for the Genome Center’s Bioinformatics Core as part of a 1 week workshop on using Galaxy. It concerns the Assemblathon projects as well as other aspects relating to genome assembly.
A version of this talk is also available on Slideshare with embedded notes.
Note, this is an evolving talk. There are older and newer versions of the talk also available on slideshare.
The Story of Irys - Bringing Sport to BusinessGayle Partridge
This is a short presentation we've put together to introduce the story and background to our business. Irys specialises in Leadership training and performance coaching for staff. We take our experiences and knowledge from our professional sports background and apply it to business. Our aim is to challenge people to enjoy working on their business and help develop core values that the whole organisation can follow.
Using BioNano Maps to Improve an Insect Genome AssemblyJennifer Shelton
Algorithms and filters used to improve the Tribolium draft Assembly with Physical Maps Based on Imaging Ultra-Long Single DNA Molecules. Video of Webinar available at BioNano Genomics website http://www.bionanogenomics.com/bionano-community/webinars/ as "Using BioNano Maps to Improve an Insect Genome Assembly".
La encomienda consistía en la entrega de un grupo de indígenas a un español para su “protección, educación y evangelización” a cambio de cobrar(el encomendero) un tributo.
Los corregimientos eran territorios
gobernados por los Corregidores. Su
función principal era corregir los abusos
cometidos contra los indios.
Boulevard mode Nova Apresentação de Outubro AtualizadoAdriano-jose
Boulevard Mode com,
Estrutura com 14 anos, cerca de 700 certificações na Anvisa,
14 anos de ABEVD, produtos de altíssima qualidade e melhor roupagem do mercado, essa é a Boulevard Monde, uma empresa que já nasceu gigante!
Linha de perfumes com 28 fragrâncias de 100ml o vidro, 14 feminina e 14 masculina, 23 a 25% de essência.
Cosméticos e make-up, rejuvenescimento de pele, nutrição, linha de shampoos profissionais. Todos os produtos com 100% de lucro!
Temos um plano de carreira com 9 formas de ganhos sendo uma delas 100% de lucro.
1,500 reais a mais no seu orçamento ajudaria?
Aqui na Boulevard Monde, você pode acumular pontos e ganhar viagens inesquecíveis e muitas outras premiações...
E PODE FAZER UPGRADE!
Lembrando que a pontuação para premiações é cumulativa, nunca zera!
Link de Cadastro:
http://cadastro.boulevardmonde.com.br/adrianojdelima
Aqui na Boulevard Monde, você pode acumular pontos e ganhar uma viagem inesquecível e muitas outras premiações...
Lembrando que a pontuação para premiações é cumulativa, nunca zeram!
Não é necessário experiência.
Fale comigo hoje mesmo!
O meu Whatsapp para maiores informações:
Adriano: (61) 8333-3697
The Story of Irys - Bringing Sport to BusinessGayle Partridge
This is a short presentation we've put together to introduce the story and background to our business. Irys specialises in Leadership training and performance coaching for staff. We take our experiences and knowledge from our professional sports background and apply it to business. Our aim is to challenge people to enjoy working on their business and help develop core values that the whole organisation can follow.
Using BioNano Maps to Improve an Insect Genome AssemblyJennifer Shelton
Algorithms and filters used to improve the Tribolium draft Assembly with Physical Maps Based on Imaging Ultra-Long Single DNA Molecules. Video of Webinar available at BioNano Genomics website http://www.bionanogenomics.com/bionano-community/webinars/ as "Using BioNano Maps to Improve an Insect Genome Assembly".
La encomienda consistía en la entrega de un grupo de indígenas a un español para su “protección, educación y evangelización” a cambio de cobrar(el encomendero) un tributo.
Los corregimientos eran territorios
gobernados por los Corregidores. Su
función principal era corregir los abusos
cometidos contra los indios.
Boulevard mode Nova Apresentação de Outubro AtualizadoAdriano-jose
Boulevard Mode com,
Estrutura com 14 anos, cerca de 700 certificações na Anvisa,
14 anos de ABEVD, produtos de altíssima qualidade e melhor roupagem do mercado, essa é a Boulevard Monde, uma empresa que já nasceu gigante!
Linha de perfumes com 28 fragrâncias de 100ml o vidro, 14 feminina e 14 masculina, 23 a 25% de essência.
Cosméticos e make-up, rejuvenescimento de pele, nutrição, linha de shampoos profissionais. Todos os produtos com 100% de lucro!
Temos um plano de carreira com 9 formas de ganhos sendo uma delas 100% de lucro.
1,500 reais a mais no seu orçamento ajudaria?
Aqui na Boulevard Monde, você pode acumular pontos e ganhar viagens inesquecíveis e muitas outras premiações...
E PODE FAZER UPGRADE!
Lembrando que a pontuação para premiações é cumulativa, nunca zera!
Link de Cadastro:
http://cadastro.boulevardmonde.com.br/adrianojdelima
Aqui na Boulevard Monde, você pode acumular pontos e ganhar uma viagem inesquecível e muitas outras premiações...
Lembrando que a pontuação para premiações é cumulativa, nunca zeram!
Não é necessário experiência.
Fale comigo hoje mesmo!
O meu Whatsapp para maiores informações:
Adriano: (61) 8333-3697
Journal club slides for "Detection of structural DNA variation from next generation sequencing data: a review of informatic approaches" and a description of the software pipeline digit
I am Rebecca K. I am a Microbiology Assignment Expert at nursingassignmenthelp.com. I hold a Masters’ in Microbiology, from Bournemouth University, UK. I have been helping students with their assignments for the past 11 years. I solve assignments related to Microbiology.
Visit nursingassignmenthelp.com or email info@nursingassignmenthelp.com. You can also call on +1 678 648 4277 for any assistance with Microbiology Assignments.
Exploring DNA/RNA-Seq Analysis Results with Golden Helix GenomeBrowse and SVSGolden Helix Inc
GenomeBrowse, a free visualization tool for all types of sequence data, was introduced in 2012 to broad acclaim. Researchers using GenomeBrowse discovered a product far beyond the status quo with seamless navigation of sequence alignments and other genomic data using a fluid, fast, and intuitive interface that just "made sense." Recent updates to GenomeBrowse, including support for VCF files and BED files and the ability to export tables of data extracted from viewable annotation tracks, further improved the product and created new synergy with Golden Helix SNP & Variation Suite (SVS).
This webcast will demonstrate the ability of GenomeBrowse to stream sequence alignment data from the Amazon Cloud, seamlessly transitioning between whole genome views and base-pair resolution in the context of both public and custom annotation tracks. We will show how GenomeBrowse can be used in conjunction with SVS to highlight false variant calls, confirm the inheritance pattern of putative functional variants, and aid in the interpretation of a variant's impact. Examples of RNA-seq expression analysis, somatic variation in cancer, and family-based DNA-seq analysis will be included.
Genome to pangenome : A doorway into crops genome explorationKiranKm11
This seminar underpins the significance and need of formulating pan-genome oriented crop improvement strategies over single reference genome based studies. Pangenome graphs uncovers large repository of genetic variation which could we useful for planning and executing strategic crop improvement programmed
Gibson Assembly: a seamless molecular cloning techniqueyedeetay
This is an Open Educational Resource (OER) coursework for my Digital Education module. This OER compares and contrasts conventional restriction-based cloning with modern Gibson Assembly. The graphics in the Gibson Assembly sections can be easily reused and customized with freeware such as Inkscape to construct high-resolution PowerPoint animation in Molecular Cloning lecture.
Complete Sequencing – Clifford Reid, PhD; CEO, Complete Genomics as presented at the Personalized Health Care Conference at Ohio State. Dr. Reid discussed what complete human sequencing looks like and costs now and in the near future.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
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Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection