IEA - Expressão gênica: é complexo mesmo ou só estão faltando partes?
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Evento organizado pelo Instituto de Estudos Avançados da USP, Polo Ribeirão Preto (IEA-RP). Mais informações: http://www.iearp.blogspot.com.br/2012/09/perspectivas-sobre-aplicacoes-de_18.html
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IEA - Expressão gênica: é complexo mesmo ou só estão faltando partes?
- 1. USP – University of Sao Paulo LabPIB – Laboratório de Processamento de Informação Biológica http://labpib.fmrp.usp.br Prof. Dr. Vêncio rvencio@usp.br Gene Expression: is it really complex or is it just missing parts ?
- 2. Who are we ?
- 3. Who are we ?
- 7. 2+2>4
- 8. 2+2>4
- 9. 2+2=5 1) Do we know all parts to sum them up ? 2) What are the interactions among parts ?
- 10. Biological Motivation Joyce & Palsson, Nat Rev Mol Cell Biol (2006)
- 11. Biological Motivation ncRNA RNA-protein interaction RNA-RNA interaction structuromics 2012 update on Joyce & Palsson, Nat Rev Mol Cell Biol (2006)
- 12. Biological Motivation ncRNA RNA-protein interaction RNA-RNA interaction structuromics 2012 update on Joyce & Palsson, Nat Rev Mol Cell Biol (2006)
- 13. Biological Motivation … today ncRNA RNA-protein interaction RNA-RNA interaction structuromics 2012 update on Joyce & Palsson, Nat Rev Mol Cell Biol (2006)
- 14. ~ 5 μm from wikipedia's “halobacterium” entry ~ 1 cm Bonneau et al., Cell (2007) from webmineral.com Mineralogy Database's “halite” entry
- 15. Bonneau et al., Cell (2007)
- 16. Bonneau et al., Cell (2007)
- 17. 2+2=5 1) Do we know all parts to sum them up ? 2) What are the interactions among parts ? Bonneau et al., Cell (2007)
- 18. 2+2=5 1) Do we know all parts to sum them up ? No, ncRNAs are still missing 2) What are the interactions among parts ? Some are known, but protein-RNA are missing Bonneau et al., Cell (2007)
- 19. ncRNA discovery by high-throughput sequencing RNA-seq Wang et al., Nat Rev Gen (2009)
- 20. ncRNA discovery by high-throughput sequencing RNA-seq Felipe ten Caten, Diego Martinez, Lívia Zaramela - PhD Candidates
- 21. ncRNA discovery by high-throughput sequencing RNA-seq Felipe ten Caten, Diego Martinez, Lívia Zaramela - PhD Candidates
- 22. ncRNA discovery by high-throughput sequencing RNA-seq There is a transcript but there is no protein
- 23. Protein-RNA interaction discovery by RIP-Seq Very similar to known Chip-seq but for RNA interactions from wikipedia's “ChIP-sequencing” entry Lívia Zaramela - PhD Candidate
- 24. Protein-RNA interaction discovery by RIP-Seq Support Vectors Marcos Abraão - PhD Candidate
- 25. So... back to the original question is it really complex or is it just missing parts?
- 26. So... back to the original question is it really complex or is it just missing parts? Probably both. http://www.systemsbiology.org.au/
- 27. USP – University of Sao Paulo LabPIB – Laboratório de Processamento de Informação Biológica http://labpib.fmrp.usp.br Prof. Dr. Vêncio rvencio@usp.br
- 28. USP – University of Sao Paulo LabPIB – Laboratório de Processamento de Informação Biológica http://labpib.fmrp.usp.br Prof. Dr. Vêncio rvencio@usp.br Thank you for your attention! “ Simplicity is a great virtue but it requires hard work to achieve it and education to appreciate it. And to make matters worse: complexity sells better ” -- E. Dijkstra.