Koen Kas TEDx Flanders - Oct20, 2012

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Koen Kas TEDx Flanders - Oct20, 2012

  1. 1. Dealing with your personal genome Prof. Dr. Koen Kas TEDxFlanders Antwerp October 20, 2012
  2. 2. 1 thing in commonwith 7B people
  3. 3. Human genomeproject:1989 - 2001/2003
  4. 4. DNA (genome orgenetic code):3.000.000.000 99,9 % identical 2% differences x10 characters 3x longer genome
  5. 5. The building blocks of life 1% exome = 21.000 building block genes 14.000 meaning 3.500 disease
  6. 6. ENCODE :1% real parts – 79% - 99% instructions
  7. 7. Soon, essentially for free X 1.000
  8. 8. Personal genome analysers
  9. 9. Opportunities vs Challenges
  10. 10. Cancer:Collection of rare diseases of the genome
  11. 11. Cancer drugs get personal Treatment ‘V600E BRAF’
  12. 12. Fetal sequencingfrom 1 drop mom’sbloodNo more invasive testingIDs 3.500 disease/all
  13. 13. But can we handle ourpersonal genome ?
  14. 14. Incidental findingsto report
  15. 15. How many ‘personal genomes’ around?250.000+ 106K = 0,03%25.000+ Whole exome = 1%2.500+ Whole genomecf 1.000.000.000 accounts
  16. 16. Time for some introspection‘Typical odds’ not Could loose eyesight – being bald but when? Detailed numbers of SNPs Nr Number of SNPs in exome 22247 Number of missense mutations 10617 Number synonymous mutations 11121 Gain of stop codon mutations 83 Loss of stop codon mutations 15
  17. 17. So what does our codereally tells us today ?And can we act upon it ?
  18. 18. Life build/executedfrom 6 layers code (-omes)• Genome• Epigenome - methylome• Transcriptome• Proteome• Metabolome• Microbiome
  19. 19. Our genome interactswith the world around us
  20. 20. Need to combine -omes data
  21. 21. Need to combine -omes (and other) data• Personal Omics Profile (iPOP) - n=1, 1.5Y, 300 Tb• Quantified self movement• Tricorder-like devs & wearable sensors
  22. 22. Finding novel features mining shared genomes
  23. 23. Growing patient awareness - Participation
  24. 24. New findings start to pour in...Gene defends against Thrill seekingAlzheimer’s disease ‘cheating gene’
  25. 25. The promise of exploring your genomeJoin panel based on taste corianderRequest the right drugs subscribed
  26. 26. Incentives from exploiting your genome Online genome games Sign up for clinical trial based on your genome
  27. 27. 14 years ago“nonsense” to build search engine “There is not enough to search for”
  28. 28. To help dealing with your genomeLifeskout Summer 2013
  29. 29. Personalised PredictiveParticipatory Preventive

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