This document summarizes salivary markers of systemic diseases. Saliva is a non-invasive diagnostic fluid that has several advantages over blood, including being easy to collect. Saliva contains biomarkers that can indicate diseases like Sjogren's syndrome, cystic fibrosis, diabetes, and various cancers. New technologies are being developed to more precisely measure salivary proteomes, transcriptomes, and other biomarkers to diagnose diseases from saliva. Saliva is a promising diagnostic fluid that reflects the body's health status in a non-invasive way.