The gingiva is constantly exposed to trauma and bacteria. Its defense mechanisms include the epithelial surface, saliva, and inflammatory response. Gingival crevicular fluid (GCF) is an inflammatory exudate that contains over 40 compounds, including cells, electrolytes, proteins, and metabolic byproducts. GCF flow increases with inflammation, trauma like chewing, hormones, and smoking. Saliva also defends the oral cavity through antibacterial compounds like lysozyme and lactoperoxidase, enzymes, antibodies, and buffers that maintain pH. Both GCF and saliva play roles in periodontal pathology and health.
Periodontitis is a chronic infectious inflammatory disease caused by microbes; however the presence of microbes is not enough for the cause of its complex nature of disease. Inflammation is the prime cause of periodontal disease. It commences with the aggregation of pathogenic microbes that induce the host to stimulate a cascade of inflammatory response reactions which in-turn leads to the destruction of the host tissues itself. There is a complex interplay of innate and adaptive immune responses which fights against the pathogens by direct interaction or by release of certain molecules including cytokines.
Cytokines are cell signalling molecules that aid cell to cell communication in immune responses and stimulate the movement of cells towards sites of inflammation, infection and trauma. Cytokine biology reveals that there are some subsets of cytokines which are pro-inflammatory cytokines which stimulate the inflammatory responses and cause tissue destruction.
A periodontist is expected to have a sound basis of the cytokine profile to understand the pathogenesis of periodontitis and also to discover the new treatment modality of anti-cytokine therapy.
The defense mechanism of gingiva includes GCF, Saliva, epithelial barrier and connective tissue cells. All these protect the periodontium from bacterial invasion.
Periodontitis is a chronic infectious inflammatory disease caused by microbes; however the presence of microbes is not enough for the cause of its complex nature of disease. Inflammation is the prime cause of periodontal disease. It commences with the aggregation of pathogenic microbes that induce the host to stimulate a cascade of inflammatory response reactions which in-turn leads to the destruction of the host tissues itself. There is a complex interplay of innate and adaptive immune responses which fights against the pathogens by direct interaction or by release of certain molecules including cytokines.
Cytokines are cell signalling molecules that aid cell to cell communication in immune responses and stimulate the movement of cells towards sites of inflammation, infection and trauma. Cytokine biology reveals that there are some subsets of cytokines which are pro-inflammatory cytokines which stimulate the inflammatory responses and cause tissue destruction.
A periodontist is expected to have a sound basis of the cytokine profile to understand the pathogenesis of periodontitis and also to discover the new treatment modality of anti-cytokine therapy.
The defense mechanism of gingiva includes GCF, Saliva, epithelial barrier and connective tissue cells. All these protect the periodontium from bacterial invasion.
Porphyromonas gingivalis belongs to the phylum Bacteroidetes and is a nonmotile, Gram-negative, rod-shaped, anaerobic, pathogenic bacterium. It forms black colonies on blood agar.
It is found in the oral cavity, where it is implicated in certain forms of periodontal disease, as well as in the upper gastrointestinal tract, the respiratory tract, and the colon. It has also been isolated from women with bacterial vaginosis. Collagen degradation observed in chronic periodontal disease results in part from the collagenase enzymes of this species. It has been shown in an in vitro study that P. gingivalis can invade human gingival fibroblasts and can survive in them in the presence of considerable concentrations of antibiotics.P. gingivalis also invades gingival epithelial cells in high numbers, in which cases both bacteria and epithelial cells survive for extended periods of time. High levels of specific antibodies can be detected in patients harboring P. gingivalis. Dr Harshavardhan Patwal , explains the various enzymes enzyme peptidyl-arginine deiminase, which is involved in citrullination.[4] Patients with rheumatoid arthritis have an increased incidence of periodontal disease, and antibodies against the bacterium are significantly more common in these patients.
P. gingivalis is divided into K-serotypes based upon capsular antigenicity of the various types.
THIS PRESENTATION INCLUDES:
INTRODUCTION
MAIN BLOOD SUPPLY BRANCHES TO PERIODONTIUM
BLOOD SUPPLY TO MAXILLARY TEETH AND PERIODONTIUM
BLOOD SUPPLY TO MANDIBULAR TEETH AND PERIODONTIUM
VENOUS DRAINAGE OF MAXILLARY AND MANDIBULAR TEETH AND PERIODONTIUM
BLOOD SUPPLY TO EACH COMPONENT OF PERIODONTIUM
CLINICAL SIGNIFICANCE OF BLOOD SUPPLYING THE PERIODONTIUM
CLINICAL CORELATIONS WITH GINGIVITIS AND PERIODONTITIS
CONCLUSION
REFERENCES
A brief description of all topics to recent advances,SDD, host modulation and diabetes, host modulation in smokers, chemically modified tetracyclines, bisphosphonates
Dentists play an important role in the diagnosis and management of desquamative gingivitis. The importance of being able to recognise and properly diagnose this condition is accentuated by the fact that a serious and life threatening disease may initially manifest as desquamative gingivitis.
”Contemporary Biomarkers In Periodontitis”- Guest lecture as a part of Dr NTRUHS Zonal CDE programme at Government Dental College and Hospital, Hyderabad, India on 281/1/2011, SIBAR Institute of Dental Sciences, Guntur, India on 29/12/12 and at Meghna Institute of Dental Sciences, Nizamabad, India on 31/7/2013.
Defense mechanism of gingiva / /certified fixed orthodontic courses by Indi...Indian dental academy
Welcome to Indian Dental Academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy has a unique training program & curriculum that provides students with exceptional clinical skills and enabling them to return to their office with high level confidence and start treating patients
State of the art comprehensive training-Faculty of world wide repute &Very affordable.
Porphyromonas gingivalis belongs to the phylum Bacteroidetes and is a nonmotile, Gram-negative, rod-shaped, anaerobic, pathogenic bacterium. It forms black colonies on blood agar.
It is found in the oral cavity, where it is implicated in certain forms of periodontal disease, as well as in the upper gastrointestinal tract, the respiratory tract, and the colon. It has also been isolated from women with bacterial vaginosis. Collagen degradation observed in chronic periodontal disease results in part from the collagenase enzymes of this species. It has been shown in an in vitro study that P. gingivalis can invade human gingival fibroblasts and can survive in them in the presence of considerable concentrations of antibiotics.P. gingivalis also invades gingival epithelial cells in high numbers, in which cases both bacteria and epithelial cells survive for extended periods of time. High levels of specific antibodies can be detected in patients harboring P. gingivalis. Dr Harshavardhan Patwal , explains the various enzymes enzyme peptidyl-arginine deiminase, which is involved in citrullination.[4] Patients with rheumatoid arthritis have an increased incidence of periodontal disease, and antibodies against the bacterium are significantly more common in these patients.
P. gingivalis is divided into K-serotypes based upon capsular antigenicity of the various types.
THIS PRESENTATION INCLUDES:
INTRODUCTION
MAIN BLOOD SUPPLY BRANCHES TO PERIODONTIUM
BLOOD SUPPLY TO MAXILLARY TEETH AND PERIODONTIUM
BLOOD SUPPLY TO MANDIBULAR TEETH AND PERIODONTIUM
VENOUS DRAINAGE OF MAXILLARY AND MANDIBULAR TEETH AND PERIODONTIUM
BLOOD SUPPLY TO EACH COMPONENT OF PERIODONTIUM
CLINICAL SIGNIFICANCE OF BLOOD SUPPLYING THE PERIODONTIUM
CLINICAL CORELATIONS WITH GINGIVITIS AND PERIODONTITIS
CONCLUSION
REFERENCES
A brief description of all topics to recent advances,SDD, host modulation and diabetes, host modulation in smokers, chemically modified tetracyclines, bisphosphonates
Dentists play an important role in the diagnosis and management of desquamative gingivitis. The importance of being able to recognise and properly diagnose this condition is accentuated by the fact that a serious and life threatening disease may initially manifest as desquamative gingivitis.
”Contemporary Biomarkers In Periodontitis”- Guest lecture as a part of Dr NTRUHS Zonal CDE programme at Government Dental College and Hospital, Hyderabad, India on 281/1/2011, SIBAR Institute of Dental Sciences, Guntur, India on 29/12/12 and at Meghna Institute of Dental Sciences, Nizamabad, India on 31/7/2013.
Defense mechanism of gingiva / /certified fixed orthodontic courses by Indi...Indian dental academy
Welcome to Indian Dental Academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy has a unique training program & curriculum that provides students with exceptional clinical skills and enabling them to return to their office with high level confidence and start treating patients
State of the art comprehensive training-Faculty of world wide repute &Very affordable.
S. mutans was originally isolated from carious human teeth by Clarke in 1924.
Little attention was paid to this species until the 1960s when it was demonstrated that caries could be experimentally-induced and transmitted in animals artificially-infected with strains resembling S. mutans.
Besides functioning as a resistant structural matrix, insoluble extracellular polysaccharides can act as a diffusion barrier.
The transport of metabolites and salivary buffers into the plaque and the diffusion of acid out of the plaque may be affected by glucan.
Fructans, on the other hand, unlike the mutan homopolymer of glucan, are generally soluble and can be degraded by plaque bacteria, thus serving as a reservoir of fermentable sugars for oral bacteria.
A group of fructans produced by bacteria or created by breaking down other kinds of plant fructans are called levan .
Levans are both more soluble and more readily catabolized than glucans.
Since levan hydrolysis is rapid, it may function as a short-term reservoir for the sustenance of bacterial anaerobic glycolysis in times of relative unavailability of dietary carbohydrate.
Lipoteichoic acid is another extracellular polymer that is found in cultures of S. mutans. These highly negatively charged compounds might contribute to the adhesiveness of bacteria.
In addition to this, S. mutans strains have an ability to store intracellular glycogen amylopectin type polysaccharide, which provides a reservoir of substrate and enables prolonged periods of increased metabolic activity.
Intracellular glycogen and extracellular polysaccharides serve as substrate reservoirs, which the organism may utilize for energy production, as the exogenous supplies of readily metabolized carbohydrate are depleted. In this fashion, both types of polysaccharides may play a role in the survival of organisms and in their potential to prolong acid production via glycolysis well beyond meal time.
It is known that sucrose-adapted S. mutans strains possess significant levels of invertase activity, and this enzyme isknown to hydrolyze sucrose intracellularly to free glucose and fructose.
Invertase is activated by inorganic phosphate and since phosphate accumulation is coupled with acid production, it is probable that one of the several mechanisms by which sucrose degradation is regulated in S. mutans is the activation of invertase by inorganic phosphate.
Cariogenic features of mutans streptococci - Binding to and colonization of teeth
Accumulation on tooth surfaces & participation in the formation of dental plaque.
Production of acid at a high rate.
Tolerance of high concentration of sugar, high ionic strength & highly acidic conditions
Association with dental caries in humans
Causation of dental caries in animals
Transmissible in animals & apparently in man
Reduction or elimination of mutans results in reduction or elimination of dental caries
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
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New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
2. Gingival tissueGingival tissue
Constantly subjected to mechanical
trauma and bacterial aggression
Saliva,Epithelial surface and
inflammatory response provide
resistance to these actions
4. Gingival sulcular fluidGingival sulcular fluid
Inflammatory Exudate
Has been known since 19th
century
Composition and role in periodontal disease has
been elucidated by pioneering work of Brill and
Krasse in 1950
Filter paper in the sulcus of animals previously
injected im with flourescein; within 3 minutes
the flourescent from the filter paper
5. Method of collection of GCFMethod of collection of GCF
Absorbing paper strips
Twisted threads
Micropipettes
Intracrevicular Washings
7. Compounds found permeable to junctional andCompounds found permeable to junctional and
sulcular epitheliumsulcular epithelium
[Brill and krasse (flourecein dye)][Brill and krasse (flourecein dye)]
Albumin
Endotoxin
Thymidine
Histamine
Phenytoin
Horse radish Peroxidase
Substances with mol wt upto 1000KD were permeable
8. The amount of GCF on paper strip can beThe amount of GCF on paper strip can be
evaluatedevaluated
The wetted area on paper strip can be
visualized by staining with Ninhydrin and
measures plainimettrically or on enlarged
photograph with glass or a microscope
Electronically through blotter paper (Periopaper)
using electronic transducer (Periotron, Harco
Electronics,Winnipeg, Manitoba, Canada)
The wetness of paper affects the flow of
electronic current and gives digital readout
10. Amount of GCF is extremely small
1.5 mm wide filter paper inserted 1mm into
the pocket only absorbs 0.1mg of GCF in
3 minutes
Mean GCF volume in proximal surface of
molar teeth ranged from 0.43-1.56µl in
human volunteer with mean gingival index
less than 1
11. CompositionComposition
More than 40 compounds from GCF have been
analysed but their origin is not known with
certainity
They can be derived from host, bacteria like
Collagenases (MMPs), β-glucouronidases
12. Cellular elements:
Bacteria, Desquamated epithelial cells
and leukocytes(PMN’s, Lymphocytes,
Monocytes/ macrophages)
Electrolytes:
K, Na and Ca have been studied in GCF
Positive correlation of Ca and Na conc and
Na/K ratio with inflammation
13. Organic compounds:
Glucose hexosamine and hexuronic
acid are two compounds found in GCF
Blood glucose is 3-4 times greater than
serum
Total protein content is much less than
serum
14. Metabolic products in GCF
lactic acid,
urea,
hydroxyproline,
endotoxin,
cytotoxic substances,
Hydrogen sulphide and antibacterial
factors
15. Methods to analyse GCF compositionMethods to analyse GCF composition
Fluorometry: Metalloproteinases
ELISA: Enzymes and IL-1β
Radioimmunoassay: Cyclooxygenase derv. and
Procollagen III
HPLC: Timidazole
Direct & Indirect Immunodot test: Acute phase
proteins
16. Cellular and Humoral activity in GCFCellular and Humoral activity in GCF
IL-1α and IL-1β increase the binding of
PMNs and monocyte/macrophage to
endothelial cells and stimulate the
production of PGE-2 and release of
lysosomal enzymes and stimulate bone
resorption
17. Interferon-α present in GCF has
protective role in periodontal disease
because of its ability to inhibit bone
resorption activity of IL-1β
18. Clinical significanceClinical significance
GCF is inflammatory exudate and positively
correlates with amount and severity of
inflammation
GCF flow is increased by Mastication, coarse
food, toothbrushing, gingival massage, Ovulation,
Hormonal contraceptives and smoking
19. GCF secretion follows cicardian
periodicity increases 6am to 10 pm
then decreases afterwards
Female sex hormone increase GCF flow
as they enhance vascular permeability
20. Mechanical stimulation like chewing and vigorous
tooth brushing increases GCF flow
Smoking causes immediate transient but marked
increase in GCF flow
There is increase in GCF production during healing
peroid following periodontal surgery
22. Leukocytes in Dentogingival areaLeukocytes in Dentogingival area
PMNs are the most common leukocytes
present in the Gingival sulcus
Neutrophils are the first line of defense
in the Dentogingival area.
Gingival sulcus is the port of entry of
leukocytes into the oral cavity
23. Leukocytes are present in gingival sulcus
even when histologic area are free of
inflammatory infiltrate
Differential count of leukocytes from
clinically healthy human gingival sulci
have shown 91.2% to 91.5% PMNs and
8.5 - 0 8.8 % mononuclear cells
24. Mononuclear cells have 58% B cells, 24% T
cells and 18% mononuclear phagocytes
The ratio of T-lymphocytes to B-
lymphocytes is reversed from from
normal 3:1 in peripheral blood to 1:3 in
GCF
25. SalivaSaliva
It’s a physiologic secretion by various
major and minor salivary glands
Its has got certain major functions like
mechanical cleansing, lubricating and
buffering actions
It has got antibacterial property as well
28. Lysozyme: Hydrolytic enzyme that
cleaves the linkages of cell wall of both
Gm+ve and Gm –ve bacteria.
Targets Veillonella and A a
Lactoperoxide-thiocyanate system:
Bactericidal to Lactobacillus and
Streptococcus by preventing accumulation
of lysine and glutamic acid essential for
their growth.
2.Organic factors; includes enzymes like
29. Lactoferrin;
Effective against Actinobacillus species
Myelperoxidase:
Released by leukocytes and is bactericidal to
Actinobacillus .
Also inhibits attachment of Actinomyces to
Hydroxyapatite.
It is similar to salivary peroxidase
30. Salivary enzymesSalivary enzymes
Following Enzymes are increased in periodontal
disease
Hyaluronidase,
β-glucouronidase,
Chondroitin sulfate,
Aspartate aminotransferase,
Alkaline phosphatase,
Amino acid decarboxylases, Catalase, Peroxidase
and Collagenase
32. Salivary AntibodiesSalivary Antibodies
Predominant antibody in saliva is IgA although
IgG and IgM are present
IgG is more prevalent in GCF
Major and Minor salivary gland contribute to all
the secretory IgA (sIgA)
33. GCF contributes to most of IgG,
Complement and PMN that, in conjunction
with IgG or IgM, inactivate or opsonize
bacteria
34. Salivary Antibodies are synthesized
locally as they react with strains of
bacteria indigenous to mouth but not
that of intestinal tract
Antibodies in saliva impairs the abilty of
bacteria to attach to mucosal or tooth
surface
35. Salivary Buffers and CoagulationSalivary Buffers and Coagulation
factorsfactors
Salivary buffers maintain physiologic hydrogen
conc (pH) both at mucosal surface and tooth
surface
Bicarbonate-carbonic acid system is the
salivary buffer
36. Saliva also contains Coagulation factors
viz; (Factors VIII,IX and X, PTA, Hageman
factor) which hasten blood coagulation
and protect wound from invasion
37. LeukocytesLeukocytes
Saliva contains all types of leukocytes, but
principal cells are PMN
PMN numbers varies from person to person and at
different times of day and are increased in
gingivitis
38. PMN in saliva are called
Orogranulocyte
PMN reach the oral cavity through gingival
sulcus and this is called Orogranulocyte
migration.
39. Role in Periodontal pathologyRole in Periodontal pathology
Saliva effects plaque intiation, maturation and
metabolism
Salivary flow and composition also influences
calculus formation, periodontal disease and
dental caries
40. There is increase in prevalance and severity
of periodontal disease as a consequence of
reduced salivary flow in
Mikulicz’sdisease,
Sjogren’syndrome,
Sialothiasis,
Sarcoidosis and
Xerostomia following radiotherapy