A lecture on the echocardiographic evaluation of hypertrophic cardiomyopathy. Starts with an overview of the topic then a systematic approach to diagnosis and then a differential diagnosis followed by take-home messages and conclusion.
A lecture on the echocardiographic evaluation of hypertrophic cardiomyopathy. Starts with an overview of the topic then a systematic approach to diagnosis and then a differential diagnosis followed by take-home messages and conclusion.
Diabetes in surgery (evidence based management protocol)Hriday Ranjan Roy
25% diabetic patient need surgery. He or she may have surgical disease along with diabetes or diabetes may complicate to surgical conditions. So it is critical to manage diabetes during surgical events.
I need finding assessmentresolutionmon Chief Complaint.pdfsukhvir71
I need
finding, assessment,resolution,mon
= Chief Complaint "My chest hurts, I can't catch my breath, and this cough is getting worse." = HPI
Justin Case is a 60-year-old man with a past medical history significant for MI who was admitted to
the hospital 5 days ago to undergo a scheduled surgical procedure following a recent diagnosis of
colorectal adenocarcinoma with metastatic lesions to the liver. The patient was taken to the OR on
hospital day 2 and underwent an exploratory laparotomy, diverting ileostomy, and Hickman
catheter placement in preparation for chemotherapy. Postoperatively, the patient was transferred
to the progressive ICU for his recovery without complication. The patient had no new complaints
until hospital day 5 when he complained of retrosternal crushing chest pain radiating to the left
shoulder and left jaw, shortness of breath, and a worsening cough with sputum production. The
patient was noted to be in respiratory distress with a RR of 43 breaths/min, HR 153bpm, BP
162/103mmHg, and O2 saturation of 87%. He was then transferred to the medical ICU and
underwent endotracheal intubation due to worsening respiratory status. Cardiac markers were
obtained, given the patient's symptoms and history of MI. Imaging and blood & sputum cultures
were obtained after patient transfer. =PMH CAD, S/P MI 3 years ago for which he did not undergo
any surgical intervention =SH Lives with his wife Smokes one ppd 40 years Denies alcohol or illicit
drug use Meds Patient states that he did not take any medications at home. Hospital medications
include (ICU medication list): Aspirin 325mgPO1 dose, then 81mg PO daily Enoxaparin 70mg
subcutaneously every 12 hours Esomeprazole 40mg PO daily Fentanyl 25mcg /hour IV
continuous infusion Lorazepam 2mg hour IV continuous infusion Metoprolol 25mg PO every 12
hours Nicotine patch 21mg per day applied daily AIl NKDA =ROS Patient is experiencing
significant chest pain, shortness of breath, and a cough with sputum production. He denies
nausea, vomiting, or difficulty urinating. He complains of mild abdominal pain near his ostomy and
incision sites. - Physical Examination Gen WDWN Caucasian man, initially anxious, ill-appearing,
and in moderate respiratory distress; now, S/P endotracheal intubation and in NAD VS BP
162/103 mm Hg, P 147 bpm, RR 42 breaths/min, T 38.5C; Wt 70kg,Ht56 Skin Warm; no rash; no
skin breakdown HEENT PERRLA; moist mucous membranes Neck/Lymph Nodes Supple; no
lymphadenopathy Lungs/Thorax Scattered rhonchi with expiratory wheezing; diffuse bilateral
crackles; decreased breath sounds in bilateral bases; right U Hickman catheter intact without
erythemaAbd Soft; mildly distended; hypoactive BS; large liver palpated in RUQ; ileostomy in RLQ
is pink and functioning; surgical incision is C/D/I Genit/Rect Deferred MS/Ext 1+ pitting edema; 2+
pulses bilaterally; good peripheral perfusion Neuro Prior to intubation, A&O3; CN II-XII intact;
patient is now intubated and sedated m Labs - Cardiac Mark.
Broken Heart Syndrome: A Stress Responseasclepiuspdfs
Takotsubo cardiomyopathy, also known as broken heart syndrome, stress cardiomyopathy, or apical ballooning syndrome, is described as a type of emotional or physical stress response that may mimic acute coronary syndrome (ACS) or myocarditis. It is a form of reversible left ventricular dysfunction with characteristic apical ballooning, contributing to its’ name, along with diagnostic proof on coronary catheterization or angiography of the absence of significant coronary artery stenosis classically expected in ACS. The damage seen is typically transient, appearing to completely resolve within months with very low percentage of long-term sequelae or recurrence.
The spread of dengue and dengue haemorrhagic fever is increasing, atypical manifestations are also on the rise, although they may be under reported because of lack of awareness. We report two such cases of dengue hemorrhagic fever with hepatitis, intraocular hemorrhage, ARDS and myocarditis.
Post Operative (Gastro-Jejunostomy) Efferent Loop Obstruction due to Recurren...Hriday Ranjan Roy
A gastric operation (no documentation) was done in 1982 by an inexpert surgeon. This patient developed severe vomiting. Here the description to evaluate the case and its management.
I was fallen into a severe RTA (Road Traffic Accident) in 2005 between two buses. Everybody had given up hope of my survival. By the grace of almighty God, I was saved and thus I'm here in front of you and enjoying with you thereby. Here are details of my injury and events.....
Post operative pain management has no specific criteria. Lots of methods and procedures are suggested with various types of drugs. It is just a guideline for management of pain after surgery.
This patient's shock was reluctant to resuscitation by I/V fluids, blood transfusion and all sorts of effort. I opened his abdomen with taking double bond consent. So he was saved. Thanks God.
Miss Sathi was treated by many anti-hypertensive drugs. But her hypertension was not being controlled. Latter it was diagnosed as a case of Coarctation of Aorta. It was then operated on. Post op events were uneventful. Now she is fine and no more anti-hypertensive drugs needed.
Blunt chest trauma with surgical emphysema - A case reportHriday Ranjan Roy
This patient was presented to us with severe life threatening conditions. We treated him at ICU, Rangpur Medical College Hospital and he was completely cured. Later a case presentation was done at Seminar Room of the same institute.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
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Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
3. Mr. Jalal Ahmed- 45 years, a cultivator, hailing
from Cox’s Bazar admitted into NICVD on
21/11/2006 with the complaints of-
1) Intermittent Syncopal attack for 1 month
2) Dyspnoea for 11/2 months
3) Constitutional symptoms for 2 months
4. The presenting complaints was first noticed
by him 2 months back with low grade
fever- which was irregular and was not
associated with cough or hemoptysis. He
also developed headache, malaise and
some sorts of neurological dysfunction.
For the last 11/2 months, he developed
dysponoea- mostly while he lie on bed, but
did not relieve by sitting upright. It also
occasionally aggravated by exertion. He
has no H/O of asthma or tuberculosis.
5. During last 1 month, he began to have Syncopal
attack 2/3 times a day. Very occasionally, it
was associated with convulsion, palpitation
and tightness of chest. He has no H/O DM,
HTN or smoking.
For these above complaints, he was admitted
into Cittagong Medical College Hospital on
5/11/2006 and was treated by anti-epileptic
drugs (Discharge Certificate contains no
information). But as the symptoms did not
improve, he was referred to DMCH on
14/11/2006.
6. The diagnostic work out done in
DMCH were1) CBC- Hb-13.6 gm%, ESR-58, TC-11,500
DC- N-90%, L-8%.
2) RBS- 4 mmol/L
3) SGPT- 25 U/L
4) S. Billirubin- 1.16 mg%
5) S. Creatinine- 1.64 mg%
6) CXR- normal
7) ICT for malaria- negative
8) CT scan of brain- normal
7. With the above scenario, he was empirically
diagnosed as a case of cerebral malaria
and was treated as such ( Inj- Jasoquine).
But as the symptoms did not improve, an
echo was done and was diagnosed as a
case of RA myxoma and was referred to
NICVD on 21/11/2006.
8. General examination on
admission (in NICVD)Appearance- ill looking, confused.
P- 100/min
B.P- 100/70 mmHg
Neck veins- engorged
Heart- Diastolic murmur at tricuspid area,
localized.
Lung- clear
No jaundice, edema, enlarged L. nodes or
clubbing.
P/A- normal.
12. Other baseline investigations was
within normal limits
He was then submitted urgently to SU-III for
emergency surgery.
On 25/11/2006, Under G/A with CPB, open
heart surgery was performed.
ECCT was 96 min, XCT- 52 min.
13. Per-operative findings and
procedures wereA huge ( 9cm × 7cm) encapsulated mass,
occupying 2/3rd in RA and 1/3rd in RV and
was protruding into RVOT (as in Echo).
It was attached to the limbus of fossa ovalis
by a narrow stalk. Careful removal of the
mass was done to avoid pulmonary
embolism.
25. Post operative periodExtubation was done on 26/11/2006 morning with
smooth ICU outcome. Some sorts of inotropic
support was needed( Dopa, Dobuta) for 2/3
days.