summarization of of up to date data about common cardiomyopathies with special emphasis on Hypertrophic Cardiomyopathy

1. Cardiomyopathies
Ahmed Taha Abdelwahed, MD
Lecturer of Cardiology
Department of Cardiology, Faculty of Medicine,
Zagazig University, Egypt;
Heart Center, Department of Cardiology, Tampere University
Hospital, and School of Medicine, University of Tampere, Finland

3. classifications
• Etiology

4. classifications
• Pathophysiological

5. DILATED CARDIOMYOPATHY
1st subtype

6. Etiology
Doxorubcin
Daunorobocin
Cocaine
Amphetamine

7. Special entities
• Non-Compaction LV myopathy
• Peri-partum Cardiomyopathy
• Apical ballooning syndrome

8. LV- Non-Compaction LVNC

9. pathophysiology
• primary genetic cardiomyopathy
• may be associated with other congenital heart disease
• variable genetic mutations sarcomeric proteins
• broad range of phenotypes.
• Embryogenic theory: arrest of myocardial compaction after the first
trimester.
• acquired disease: pregnancy, atheletes, sickle cell anaemia and transient
incidence with duchenne myopathy.
• Non-Embryogenic theory: abnormal response of myocardial tissue to
preload factors, reflecting interaction of genotype and enviromental
factors.

10. symptoms

11. diagnosis
• Diagnosis mainly can be confirmed by TTE.
• More quantitative echocardiographic
parameters derived from strain, strain rate and
deformation analysis may help reliable
diagnosis.
• New imaging modalities like MRI, CT and
contrast ventriculography.
• CMR with gadolinium enhancement may help
in prognostic approach especially in cases with
normal systolic function.

12. Echocardiographic Diagnostic Criteria

13. Abnormal response of
myocardium to loading factors
Arrest of myocardial
morphogenesis and compaction
Thrombus formation
in the sinusoids
Thrombo-embolic
manifestations
Arrhythmia
VT / VF
SCD
ICD
AF
anticoagulant
LV contractile dysfunction
Systolic and diastolic
Congestive heart failure
EF <35%
QRS >150 ms
CRT
Heart
transplantatio
n

16. TakoTsubo

17. Proposed mechanism

18. RESTRICTIVE CARDIOMYOPATHY
2nd subtype

19. Etiology

20. Amyloidosis

21. Amyloidosis

26. ARVD
arrhythmogenic right ventricular cardiomyopathy

28. ECG

30. HYPERTROPHIC CARDIOMYOPATHY
3rd subtype

35. Genetic

38. Diverse morphology

39. ECG

41. management

50. Management

54. 70%
25%
5%

56. Septal reduction therapy

58. Septal reduction therapy

60. Conductive system