I am a medical student. I have one friend who is persuing his MBBS degree in Taishan Medical UNiversity. I got these notes from him.
These notes are by Dr. Bikesh, He is a famous lecturer of TMU.
These notes have helped me a lot and i also watch his lecture videos , which are great; highly simple and huge content.
I am uploading with Renal physiology. If you want some other topics i would upload for you.
"Let the Knowledge be spread" Dr. Bikesh
I am a medical student. I have one friend who is persuing his MBBS degree in Taishan Medical UNiversity. I got these notes from him.
These notes are by Dr. Bikesh, He is a famous lecturer of TMU.
These notes have helped me a lot and i also watch his lecture videos , which are great; highly simple and huge content.
I am uploading with Renal physiology. If you want some other topics i would upload for you.
"Let the Knowledge be spread" Dr. Bikesh
I am a medical student. I have one friend who is persuing his MBBS degree in Taishan Medical UNiversity. I got these notes from him.
These notes are by Dr. Bikesh, He is a famous lecturer of TMU.
These notes have helped me a lot and i also watch his lecture videos , which are great; highly simple and huge content.
I am uploading with Renal physiology. If you want some other topics i would upload for you.
"Let the Knowledge be spread" Dr. Bikesh
I am a medical student. I have one friend who is persuing his MBBS degree in Taishan Medical UNiversity. I got these notes from him.
These notes are by Dr. Bikesh, He is a famous lecturer of TMU.
These notes have helped me a lot and i also watch his lecture videos , which are great; highly simple and huge content.
I am uploading with Renal physiology. If you want some other topics i would upload for you.
"Let the Knowledge be spread" Dr. Bikesh
Tubular reabsorption (The Guyton and Hall physiology)Maryam Fida
It is the second step of urine formation.
It is defined as;
“ The process by which water and other substances are transported by renal tubules back to blood is called Tubular Reabsorption”.
Tubular reabsorption is highly selective.
Some substances like glucose and amino acids are completely absorbed from tubules. So, the urinary excretion is zero.
Ions such as Na+, Cl-, HCO3- are highly absorbed but rate of absorption and excretion varies, according to body needs.
Materials Not Reabsorbed
Nitrogenous waste products
Urea
Uric acid
Creatinine
Excess water
I am a medical student. I have one friend who is persuing his MBBS degree in Taishan Medical UNiversity. I got these notes from him.
These notes are by Dr. Bikesh, He is a famous lecturer of TMU.
These notes have helped me a lot and i also watch his lecture videos , which are great; highly simple and huge content.
I am uploading with Renal physiology. If you want some other topics i would upload for you.
"Let the Knowledge be spread" Dr. Bikesh
I am a medical student. I have one friend who is persuing his MBBS degree in Taishan Medical UNiversity. I got these notes from him.
These notes are by Dr. Bikesh, He is a famous lecturer of TMU.
These notes have helped me a lot and i also watch his lecture videos , which are great; highly simple and huge content.
I am uploading with Renal physiology. If you want some other topics i would upload for you.
"Let the Knowledge be spread" Dr. Bikesh
I am a medical student. I have one friend who is persuing his MBBS degree in Taishan Medical UNiversity. I got these notes from him.
These notes are by Dr. Bikesh, He is a famous lecturer of TMU.
These notes have helped me a lot and i also watch his lecture videos , which are great; highly simple and huge content.
I am uploading with Renal physiology. If you want some other topics i would upload for you.
"Let the Knowledge be spread" Dr. Bikesh
Tubular reabsorption (The Guyton and Hall physiology)Maryam Fida
It is the second step of urine formation.
It is defined as;
“ The process by which water and other substances are transported by renal tubules back to blood is called Tubular Reabsorption”.
Tubular reabsorption is highly selective.
Some substances like glucose and amino acids are completely absorbed from tubules. So, the urinary excretion is zero.
Ions such as Na+, Cl-, HCO3- are highly absorbed but rate of absorption and excretion varies, according to body needs.
Materials Not Reabsorbed
Nitrogenous waste products
Urea
Uric acid
Creatinine
Excess water
Renal blood flow (The Guyton and Hall physiology)Maryam Fida
In an average 70-kilogram man, the combined blood flow through both kidneys is about 1100 ml/min, or about 22 per cent of the cardiac output. Two kidneys makes about 0.4 % of total body weight but receive very high blood flow as compared with other body organ. The purpose of additional blood flow is to supply sufficient plasma for high rates of GF which is essential for regulating body fluid volumes & solute concentrations.
Characteristics of the renal blood flow:
1, High blood flow. 1100 ml/min, or 22 percent of the cardiac output. 94% to the cortex.
2, Two capillary beds
High hydrostatic pressure in glomerular capillary (about 60 mmHg) and low hydrostatic pressure in peritubular capillaries (about 13 mmHg)
Blood flow to renal medulla is supplied by vasa recta.
Blood flow in vasa recta of medulla is very low as compared to blood flow in cortex.
Blood flow in renal medulla is 1-2 % of total renal blood flow.
Vasa recta are important to form concentrated urine.
Kidney (STRUCTURE AND FUNCTIONS) (: The Guyton and Hall physiology)Maryam Fida
STRUCTURE AND FUNCTIONS OF KIDNEY
There are two kidneys in body , Rt & Lt, lying on post abdominal wall, outside peritoneal cavity.
There weight is aprx. 150 Gm and size is clenched fist.
On medial side, there is a region called hilum through which pass blood & lymphatic vessels, nerve fibers and ureterKidney is surrounded by a protective fibrous capsule.
Each kidney has two major zones, outer thick known as cortex and part known as medulla.
Medulla is divided into multiple cone shaped tissue masses called renal pyramid.
The base of pyramid begins at junction of cortex & medulla and terminates in papilla which projects into space of renal pelvis.
Renal pelvis is funnel shaped continuation of upper end of ureter.
1- Excretion of metabolic waste products such as urea, creatinine, uric acid, Bilirubin, hormones & drugs.
2-. ELIMINATE HARMFUL FOREIGN COMPOUNDS.
Such as toxins, drugs, heavy metals, pesticides.
3- Regulation of water & electrolyte balance to maintain normal homeostasis of body by re-absorption and adjustment of rate of excretion of various substances.
4- Regulation of Arterial Pressure.
*Long term regulation by excreting variable amounts of water and sodium
and
*short term by secreting vaso-active substance (renin).
I am a medical student. I have one friend who is persuing his MBBS degree in Taishan Medical UNiversity. I got these notes from him.
These notes are by Dr. Bikesh, He is a famous lecturer of TMU.
These notes have helped me a lot and i also watch his lecture videos , which are great; highly simple and huge content.
I am uploading with Renal physiology. If you want some other topics i would upload for you.
"Let the Knowledge be spread" Dr. Bikesh
The basics of autoregulation of Gloemrular filtration rate. This ppt deals with basic renal physiology, tubuloglomerular feedback, myogenic reflex, juxtaglomerular apparatus and renin angiotensin aldosterone system in brief. P.S.- The ppt has animations so kindly view in slide/presentation mode
Reabsorption In Renal Tubule (The Guyton and Hall physiology)Maryam Fida
Features of PCTPCT have high capacity of active & passive re-absorption.
This is due to special cellular features of epithelial cells.
They have increased no. of mitochondria due to high metabolic activity.
brush border on luminal (apical) side.
Brush border contains protein carrier molecules to transport Na+ by co-transport mechanism with other substances (a.acids, glucose etc).
Additional sodium is transported by COUNTER-TRANSPORT that reabsorb sodium while secreting hydrogen.
About 65 % of filtered load of Na+ & water is reabsorbed in PCT.
A lower % age of Cl- is also absorbed.
In 1st half of PC tubules, Na+ is re-absorbed by co-transport along with glucose, a.acids and other solutes.
In 2nd half of PC tubules, mainly Na+ is reabsorbed with Cl- and some of glucose + a.acids remain un-absorbed.
2nd half of PCT has high conc of Cl- (140 mEq/L) as compared to 1st half (105 mEq/L).
Renal blood flow (The Guyton and Hall physiology)Maryam Fida
In an average 70-kilogram man, the combined blood flow through both kidneys is about 1100 ml/min, or about 22 per cent of the cardiac output. Two kidneys makes about 0.4 % of total body weight but receive very high blood flow as compared with other body organ. The purpose of additional blood flow is to supply sufficient plasma for high rates of GF which is essential for regulating body fluid volumes & solute concentrations.
Characteristics of the renal blood flow:
1, High blood flow. 1100 ml/min, or 22 percent of the cardiac output. 94% to the cortex.
2, Two capillary beds
High hydrostatic pressure in glomerular capillary (about 60 mmHg) and low hydrostatic pressure in peritubular capillaries (about 13 mmHg)
Blood flow to renal medulla is supplied by vasa recta.
Blood flow in vasa recta of medulla is very low as compared to blood flow in cortex.
Blood flow in renal medulla is 1-2 % of total renal blood flow.
Vasa recta are important to form concentrated urine.
Kidney (STRUCTURE AND FUNCTIONS) (: The Guyton and Hall physiology)Maryam Fida
STRUCTURE AND FUNCTIONS OF KIDNEY
There are two kidneys in body , Rt & Lt, lying on post abdominal wall, outside peritoneal cavity.
There weight is aprx. 150 Gm and size is clenched fist.
On medial side, there is a region called hilum through which pass blood & lymphatic vessels, nerve fibers and ureterKidney is surrounded by a protective fibrous capsule.
Each kidney has two major zones, outer thick known as cortex and part known as medulla.
Medulla is divided into multiple cone shaped tissue masses called renal pyramid.
The base of pyramid begins at junction of cortex & medulla and terminates in papilla which projects into space of renal pelvis.
Renal pelvis is funnel shaped continuation of upper end of ureter.
1- Excretion of metabolic waste products such as urea, creatinine, uric acid, Bilirubin, hormones & drugs.
2-. ELIMINATE HARMFUL FOREIGN COMPOUNDS.
Such as toxins, drugs, heavy metals, pesticides.
3- Regulation of water & electrolyte balance to maintain normal homeostasis of body by re-absorption and adjustment of rate of excretion of various substances.
4- Regulation of Arterial Pressure.
*Long term regulation by excreting variable amounts of water and sodium
and
*short term by secreting vaso-active substance (renin).
I am a medical student. I have one friend who is persuing his MBBS degree in Taishan Medical UNiversity. I got these notes from him.
These notes are by Dr. Bikesh, He is a famous lecturer of TMU.
These notes have helped me a lot and i also watch his lecture videos , which are great; highly simple and huge content.
I am uploading with Renal physiology. If you want some other topics i would upload for you.
"Let the Knowledge be spread" Dr. Bikesh
The basics of autoregulation of Gloemrular filtration rate. This ppt deals with basic renal physiology, tubuloglomerular feedback, myogenic reflex, juxtaglomerular apparatus and renin angiotensin aldosterone system in brief. P.S.- The ppt has animations so kindly view in slide/presentation mode
Reabsorption In Renal Tubule (The Guyton and Hall physiology)Maryam Fida
Features of PCTPCT have high capacity of active & passive re-absorption.
This is due to special cellular features of epithelial cells.
They have increased no. of mitochondria due to high metabolic activity.
brush border on luminal (apical) side.
Brush border contains protein carrier molecules to transport Na+ by co-transport mechanism with other substances (a.acids, glucose etc).
Additional sodium is transported by COUNTER-TRANSPORT that reabsorb sodium while secreting hydrogen.
About 65 % of filtered load of Na+ & water is reabsorbed in PCT.
A lower % age of Cl- is also absorbed.
In 1st half of PC tubules, Na+ is re-absorbed by co-transport along with glucose, a.acids and other solutes.
In 2nd half of PC tubules, mainly Na+ is reabsorbed with Cl- and some of glucose + a.acids remain un-absorbed.
2nd half of PCT has high conc of Cl- (140 mEq/L) as compared to 1st half (105 mEq/L).
Urine is formed in three steps: filtration, reabsorption, and secretion.Filtration involves the transfer of soluble components, such as water and waste, from the blood into the glomerulus.
Reabsorption involves the absorption of molecules, ions, and water that are necessary for the body to maintain homeostasis from the glomerular filtrate back into the blood.
Secretion involves the transfer of hydrogen ions, creatinine, drugs, and urea from the blood into the collecting duct, and is primarily made of water.
Blood and glucose are not normally found in urine.
HORMONAL CONTROL OF TUBULAR REABSORPTION (The Guyton and Hall physiology)Maryam Fida
REGULATION OF SODIUM AND WATER BALANCE
by hormones
• Aldosterone
• Angiotensin II
• Atrial natriuretic Peptide
• Parathyroid Hormone
• Antidiuretic hormone (ADH) or vasopressin
ALDOSTERONE
Release: Aldosterone is secreted by the zona glomerulosa cells of the adrenal cortex in response to
Increased extracellular potassium concentration
Increased angiotensin II levels in conditions associated with sodium and volume depletion or low blood pressure.
Site of Action: Major renal tubular site of aldosterone action is on the principal cells of the cortical collecting tubule.
Effects on the Renal Tubules
Aldosterone increases sodium reabsorption and potassium secretion by stimulating the sodium-potassium ATPase pump on the basolateral side of the cortical collecting tubule membrane.
Aldosterone also increases the sodium permeability of the luminal side of the membrane.
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
3. Reabsorption RateReabsorption Rate
• It is the rate at which Filtrates
are reabsorbed per unit time.
• More than 99 per cent of the
filtrate are normally
reabsorbed.
• It is normally 124 ml/min.
5. Glomerulotubular BalanceGlomerulotubular Balance
• It is an intrinsic ability of the tubules to increase
their reabsorption rate in response to increased
tubular load.
• Mainly observed in PCT.
• Due to changes in physical forces in the tubule
and surrounding renal interstitium.
8. NatriuresisNatriuresis
• It is the process of excretion of sodium in the urine.
• If “Back – leak” of Sodium increases, more sodium is
excreted in urine.
• And, if, this condition is due to increase in Hydrostatic
pressure of interstitium; we call it “Pressure
Natriuresis”
• Hydrostatic pressure of interstitium can rise due to
over-accumulation of fluid as a consequence of
decreased “Bulk Flow”
9. Pressure-DiuresisPressure-Diuresis
• Hydrostatic pressure of interstitium can
rise due to over-accumulation of fluid as a
consequence of decreased “Bulk Flow”.
• Which increases “Back-Leak” and
subsequently causes the water to be more
in tubule; causing more urine excretion
(Diuresis).
10. Hormonal Control of ReabsorptionHormonal Control of Reabsorption
• Hormones provide specificity of tubular
reabsorption for different electrolytes and
water.
12. AldosteroneAldosterone
• Secreted by the zona
glomerulosa cells of
the adrenal cortex.
• The primary site of
aldosterone action is
on the principal cells of
the cortical collecting
tubule.
13. AldosteroneAldosterone
MechanismMechanism
• It stimulates Sodium-potassium
ATPase pump on the
basolateral side of the cortical
collecting tubule membrane.
• Aldosterone also increases the
sodium permeability of the
luminal side of the membrane.
15. Angiotensin IIAngiotensin II
• It is the most powerful sodium-retaining
hormone in human body.
• It also increases Water Reabsorption.
• Produced by RAAS.
• Stimulated when a person has low arterial
pressure.
16. Angiotensin IIAngiotensin II
MechanismMechanism
1. Stimulates aldosterone.
2. Constricts efferent arterioles.
– Efferent arteriolar constriction reduces peritubular capillary hydrostatic
pressure, which increases net tubular reabsorption.
– Efferent arteriolar constriction, increases the time for plasma to stay in
glomerulus , raises filtration fraction, & increases osmotic pressure in
the peritubular capillaries; this increases the reabsorption of sodium
and water.
3. Stimulates Na+/K+ pump on basolateral membrane.
4. Stimulates Na+/H+ exchange in the luminal membrane.
17. ADHADH
• Anti Diuretic Hormone (AKA
Vasopressin).
• Produced by Hypothalamus.
• Increases the water permeability of the
distal tubule, collecting tubule, and
collecting duct.
18. ADHADH
MechanismMechanism
• ADH binds to V2 receptors in the late distal tubules,
collecting tubules, and collecting ducts, increasing the
formation of cyclic AMP and activating protein kinases.
• This, in turn, stimulates the movement of an
intracellular protein, called aquaporin-2 (AQP- 2), to
the luminal side of the cell membranes.
• The molecules of AQP-2 cluster together and fuse
with the cell membrane to form water channels that
permit rapid diffusion of water through the cells.
19. ADHADH
MechanismMechanism
• There are other aquaporins,AQP-3 and AQP-4,
in the basolateral side of the cell membrane
that provide a path for water to rapidly exit the
cells, although these are not believed to be
regulated by ADH.
• When the concentration of ADH decreases, the
molecules of AQP-2 are shuttled back to the
cell cytoplasm, thereby removing the water
channels from the luminal membrane and
reducing water permeability.
20. Atrial Natriuretic PeptideAtrial Natriuretic Peptide
• Produced by Atrium of heart
• Stimulated by “stretch in cardiac atria”
• It can be said that “ANP has opposite
function of the aldosterone”
• Decreases Sodium and Water Reabsorption.
21. Atrial Natriuretic PeptideAtrial Natriuretic Peptide
MechanismMechanism
• Increased plasma volume stretches
cardiac atria which secretes ANP.
• Increased levels of ANP,
– Inhibit the reabsorption of sodium and water
by the renal tubules,especially in the
collecting ducts.
– Increases urinary excretion.
23. Sympathetic Nervous SystemSympathetic Nervous System
• Activation Increases Sodium Reabsorption.
• Constricts renal arterioles, thereby reducing
GFR.
• Increases sodium reabsorption in the PCT, the
thick ascending limb of the loop of Henle, and
perhaps in more distal parts of the renal tubule.
• It also stimulates RAAS which adds to the
overall effect to increase tubular reabsorption.
26. Renal ClearanceRenal Clearance
• If the plasma passing through the kidneys
contains 1 milligram of a substance in each
milliliter and if 1 milligram of this substance is
also excreted into the urine each minute.
• Then 1 ml/min of the plasma is “cleared” of the
substance.
• Which is regarded as Renal clearance.
27. Renal ClearanceRenal Clearance
• Renal clearance of a substance is the
volume of plasma that is cleared of the
substance by the kidneys per unit time.
• It is the measurement of the renal
excretion ability.
30. InulinInulin
• Inulin Clearance Can Be Used to Estimate GFR
(eGFR)
• Inulin is :
– Freely filtered
– Neither reabsorbed
– Nor secreted
• Whatever, inulin is filtered, all of it is excreted in
the urine.
34. CreatinineCreatinine
• It is not practical to measure urine
creatinine level to estimate GFR, so many
scientist has given many ways to calculate
GFR by being based upon only blood
creatinine.
• Widely accepted is :
35. CreatinineCreatinine
• Approximate relationship
between GFR and
plasma creatinine
concentration.
• Decreasing GFR by 50
per cent will increase
plasma creatinine to
twice normal if creatinine
production by the body
remains constant.
36. PAHPAH
• PAH Clearance Can Be Used to Estimate Renal Plasma
Flow.
• Theoretically, if a substance is completely cleared from
the plasma, the clearance rate of that substance is equal
to the total renal plasma flow.
• In other words, the amount of the substance delivered to
the kidneys in the blood (renal plasma flow X Ps) would
be equal to the amount excreted in the urine (Us X V).
Thus, renal plasma flow (RPF) could be calculated as