Micro-electromechanical systems (MEMS) are integral technologies that combine mechanical elements, sensors, actuators, and electronics on a silicon substrate, capable of producing significant effects on both micro and macro scales. The document discusses the wide-ranging applications of MEMS across various industries, including automotive and medical, as well as the materials and manufacturing processes involved in their fabrication. It also highlights current challenges in the MEMS industry related to access to fabrication facilities, design complexities, and packaging issues.