Needlestick injuries are accidental punctures caused by sharp medical instruments that expose healthcare workers to bloodborne pathogens. An estimated 3.5 million needlestick injuries occur globally each year. Proper use of safety devices can prevent over 90% of injuries. Employers must implement universal precautions, provide protective equipment, use engineering controls like safety devices, and follow proper sharps disposal procedures to protect healthcare workers from needlestick injuries and potential infections.