• Group 2
Radon Measurement Mitigation (part 1)
Discuss the following issues:
1. What is Radon? (best to include discussion on types of radiation)
2. Where does Radon come from? (source of Radon)
3. Why are we interested in Radon?
4. Radon testing and Radon gas measurement method
PM is a complex mixture of air borne particles that differ in size, origin and chemical composition, all of which are <10 µm in size.
US EPA described PM pollution as ‘mixture of mixtures’.
PM is among the most harmful of all air pollutants.
Unit 3 control of particulate contaminantsChockalingam T
The attached powerpoint presentation contains information about the Control of Particulate Contaminants. It is very useful for students studiying Air Pollution and Control Engineering either as an Open elective or Professional elective.
This Lecture is focussed on Environment Hazards of Nuclear Radiation and its Danger for the future of mankind; with special reference to Indo-Pak relations.
AIR POLLUTION CONTROL course material by Prof S S JAHAGIRDAR,NKOCET,SOLAPUR for BE (CIVIL ) students of Solapur university. Content will be also useful for SHIVAJI and PUNE university students
Air Pollution control- at source-equipments for control of air pollution-For particulate matter-Settling chambers-Fabric filters-Scrubbers-Cyclones-Electrostatic precipitators
, For Gaseous pollutants-control by absorption-adsorption-scrubbers-secondary combustion after burners, Working principles advantages and disadvantages
The above presentation describes the history,source,danger and effects,classification, and storage and disposal methods of radioactive waste. It also states the advantages and disadvantages of nuclear and radioactive waste
PM is a complex mixture of air borne particles that differ in size, origin and chemical composition, all of which are <10 µm in size.
US EPA described PM pollution as ‘mixture of mixtures’.
PM is among the most harmful of all air pollutants.
Unit 3 control of particulate contaminantsChockalingam T
The attached powerpoint presentation contains information about the Control of Particulate Contaminants. It is very useful for students studiying Air Pollution and Control Engineering either as an Open elective or Professional elective.
This Lecture is focussed on Environment Hazards of Nuclear Radiation and its Danger for the future of mankind; with special reference to Indo-Pak relations.
AIR POLLUTION CONTROL course material by Prof S S JAHAGIRDAR,NKOCET,SOLAPUR for BE (CIVIL ) students of Solapur university. Content will be also useful for SHIVAJI and PUNE university students
Air Pollution control- at source-equipments for control of air pollution-For particulate matter-Settling chambers-Fabric filters-Scrubbers-Cyclones-Electrostatic precipitators
, For Gaseous pollutants-control by absorption-adsorption-scrubbers-secondary combustion after burners, Working principles advantages and disadvantages
The above presentation describes the history,source,danger and effects,classification, and storage and disposal methods of radioactive waste. It also states the advantages and disadvantages of nuclear and radioactive waste
Radon is the second leading cause of lung cancer, causing an estimated 21,000 deaths in the United States annually. Unfortunately, Tennessee is a hotbed for radon.
Long term exposure to Radon Gas is the #1 cause of lung cancer in non-smokers. Radon is a naturally occuring, radioactive gas that can accumulate in dangerous levels inside your home. Testing is easy! Learn more today!
Measurement of Radon Exhalation Rates from the Samples of Soil and Rocksijtsrd
Radon and its daughter products are the major sources of radiation exposure and recognized as one of the health hazards for human beings. In the present work, I have reviewed 20 papers in which the soil samples are collected to different places of India and other countries. The Effective radium and radon exhalation rates in the samples of soil and rock have been used passive techniques for alpha particles emission with “Closed Can Technique”, “RRC passive Technique”, “Alpha guard equipment and Gamma tracer”. The soil samples belonging to different places of India and other countries. All the values of radium content in soil samples of study area were found to be quite lower than the permissible value of 370 BqKg 1 recommended by Organization for Economic Cooperation and development OECD1979 . The highest activity Ashima | Sandeep Kansal | Sanjay Aggarwal "Measurement of Radon Exhalation Rates from the Samples of Soil & Rocks" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-5 , August 2020, URL: https://www.ijtsrd.com/papers/ijtsrd32916.pdf Paper Url :https://www.ijtsrd.com/physics/nuclear-physics/32916/measurement-of-radon-exhalation-rates-from-the-samples-of-soil-and-rocks/ashima
Instrumentation presentation - Auger Electron Spectroscopy (AES)Amirah Basir
Group 5-AES
Normaizatul Hanissa Binti Hamdan
Amirah Binti Basir
-Introduction/Backgroud /History, fundamental/basic principle and
elaboration of the principle, related pictures, related
equations/expressions/derivations, components and it functions,
related models/brands, technologies and applications
OUTCOMES:
-Describes slips plane and slips direction
-Explain the types of dislocation.
-Understand the metallic crystal structure, FCC, BCC and HCP
-Understand the crystallographic direction and planes, and able to find the linear and planar density
-Explain about slip systems, the way to determine it and its effect on the metal characteritcs.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
5. How can Radon gas
lead to lung cancer?
Decay of Uranium will produce Radon
Decaying Radon emits alpha particle, beta
particle and gamma ray
The emitted radiation lead to lung cancer
6. Emission from decaying Radon
Type of radiation
Size of particle
emitted
Energy Penetration
Alpha particle Large Lot Poor
Beta particle Small Little Medium
Gamma ray Very small Little High
7. Effect Of Emission
Alpha particle
• Damage is concentrated on
the epithelial cells in the
immediate area
• Damage the chromosomes
(DNA) and other type of
cellular damage
Beta particle and gamma ray
• They are spread over a
larger volume causing less
concentrated and less
harmful
8. WHERE DOES RADON COME FROM?
Soil and air
Water
Natural gas
Homes and Buildings
9. Soil and Air
Radon generated within the upper few metres of
the Earth’s crust by the radioactive decay of
Radium. So, it is a common element found in
rock and soil.
Radon in soil can be partitioned into 3 states – in
the pore air, dissolved in the pore air and
absorbed to the soil grains.
Breathing Radon in indoor air can cause lung
cancer.
10. Water
Concentration of Radon in water from wells higher than from
surface sources
Groundwater tends to have more direct and longer contact with
rocks and soil
Most of the radon volatizes to air or decays before the water reaches
homes results in a small amount of residual radon
Drinking water containing Radon will risk in developing internal organ
cancer, primarily stomach cancer.
11. Natural Gas
Natural gas had previously been in contact with underground
uranium and thorium-bearing rock and soil that continually
release radon.
Radon and its progeny are released to breathing air when the
gas is burned in
Fireplaces
Furnaces
Heaters
Stoves
Water heaters
13. WHY ARE WE INTERESTED IN
RADON?
1. Radon is everywhere
around us:
14. Example: Radon in houses
Radon can enter the home through
1. Cracks in solid floors
2. Construction joints
3. Cracks in walls
4. Gaps in suspended floors
5. Gaps around service pipes
6. Cavities inside walls
7. Water supply
15. 2) Radon is a cancer-
causing radioactive gas
Radon is carcinogenic to humans due to alpha
particle emission.
Evidence:
16. RADON TEST AND
RADON GAS
MEASUREMENT
METHODS
RADON TEST
• METHOD: GAS
MEASUREMENT
17. RADON TEST
• What is Radon test?
• The test conducted to determine the Radon level in
a building; home
• Detect Radon or daughter of Radon radioactive
decay
• Who can do the test?
• A qualified professional radon testing service
(recommended by U.S. Environmental Protection
Agency (EPA))
• By ourselves – buy test kit
• When the test should be done?
• Home with passive Radon system, test immediately
after moving in
• Recommended average annual indoor level of
Radon by EPA: ≤ 4.0 pCi/L
• Where to test it?
• Lowest occupied level; greatest level of radon
may occur
• Frequently occupied area – living room,
bedroom
• Device placed out-of-the-way
• Below 3rd floor – radon from the soil
• Why is it important?
• Radon gas is radioactive – α-particles
• Invisible and odourless
• Radon levels vary from place to place even for
two rooms that was separated only by a wall
18. HOW TO DETECT
RADON?
Radon Gas Measurement Methods
• By detecting the amount of the Radon gas
built-up
Radon Decay Measurement
• By looking at the source material and
measuring how much radioactive decay had
taken place.
The most accurate and reliable
Radon measurements are those
that continuously monitor Radon.
The test made sure to meet the EPA
requirements. The U.S. EPA and the
Centers for Disease Control and
Prevention recommend that
buildings with radon levels 4 pCi/L, or
greater, be fixed.
20. TIME/PERIOD
OF THE TEST
• Faster way to test
• Getting the initial Radon level: lowest level occupied, frequently
occupied space
• Test kits to remain in the building depends on the device (2 days – 90
days)
• Not a very accurate estimation of average radon level for the whole year
Short-term test
• Can be used to determine the initial short terms results (4 – 10)pCi/L
• More than 90 days
• The average radon level more likely to be accurate
• If the results is ≥4 pCi/L, EPA recommends the problem to be corrected.
Long-term test
21. TYPE OF DEVICES
Passive devices
• Do not need power to function
• Trap Radon or daughter products
• Analysed in the laboratory
• Examples:
• Alpha track detectors, charcoal
canisters, charcoal liquid
scintillation detectors
Active devices
• Requires power
• Include continuous monitoring
devices (Radon, working level)
• Detect and record Radon or its
daughter products continuously
• Generally, more costly
• Require professionally trained
testers for operating the devices
22. PASSIVE:
CHARCOAL
LIQUID
SCINTILLATION
• Typically used for short-term tests
1. Absorb radon or its products on to the
charcoal.
2. After an exposure period of 2 to 7 days, the
container with the charcoal returned to the
laboratory for analysis
3. Analysis is accomplished by treating the
charcoal with a scintillation fluid, then
analysing the fluid using a scintillation
counter.
4. The radon concentration of the sample site
is determined by converting from counts
per minute.
23. PASSIVE: FILTERED ALPHA
TRACK DETECTORS
1. The detector is a small piece of special plastic or film
inside a small container.
2. Air being tested diffuses through a filter covering a
hole in the container.
3. When alpha particles from radon and its decay
products strike the detector, they cause damage
tracks.
4. The container is sealed and returned to a laboratory
for reading. The plastic is chemically treated to make
the tracks visible, then the tracks are counted.
• Usually exposed from 3 to 12 months, but because they
are true integrating devices, alpha track detectors may be
exposed for shorter lengths of time when they are
measuring higher radon concentrations.
24. PASSIVE: ELECTRET ION
DETECTORS
• Usually only available through laboratories, long
(1 – 12 months), short (2 – 7 days)
1. Have a Teflon disc, which is an
electrostatically charged disk detector
(electret) is situated in ion chamber.
2. When an ion generated from radon decay
strikes the Teflon disc, the electrical charge is
reduced.
3. In the laboratory, the charge reduction is
measured and the radon level is calculated.
25. ACTIVE: GRAB RADON/ACTIVATED CHARCOAL
• Requires a skilled technician
1. Sampling radon by using a pump or a fan to
draw air through a cartridge filled with
activated charcoal and takes from 15
minutes to 1 hour.
2. After sampling, the cartridge is placed in a
sealed container and taken to a laboratory
where analysis is approximately the same as
for the activated charcoal or charcoal liquid
scintillation methods.
26. ACTIVE: GRAB
RADON/
SCINTILLATION
CELL
1. A skilled operator draws air through a filter
to remove radon decay products into a
scintillation cell.
2. To analyse the air sample, the window end
of the cell is placed on a photomultiplier
tube to count the scintillations (light pulses)
produced when alpha particles from radon
decay strike the zinc sulphide coating on
the inside of the cell.
3. A calculation is made to convert the counts
to radon concentrations. This test takes less
than an hour to complete.
27. ACTIVE: GRAB
RADON/PUMP-
COLLAPSIBLE
BAG
• Uses a sample bag made of material
impervious to radon.
1. Skilled technician using a portable
pump fills the bag with air at the sample
site.
2. Then, transports it to the laboratory for
analysis.
3. Usually, the analysis method is to
transfer air from the bag to a
scintillation cell and perform analysis in
the manner described for the grab
radon/scintillation cell.