This document discusses two studies. The first study identifies an interconnected network of over 240 genes and 600 protein interactions that regulate cell wall thickening in plants. Understanding this network could help optimize biomass crops for biofuels by making the extraction process more efficient and cost effective. The second study finds that cell-free DNA in blood serum can be used as a biomarker for prostate cancer, identifying 20 points of chromosomal instability that correlate with tumor cells. This non-invasive diagnostic technique could allow for more precise cancer detection and monitoring.

1. Sebastián Calle Díaz
Molecular Biology
3° Semester

4. The globalization o f the
world brings itself the
development of new
technologyes and for
instance positive
consequences for the
science . One example
is the extraction of
biofuels; and the
identification own specific
DNA sequences of some
pathologies.

5. • M. Taylor-Teeples, L. Lin, M. de Lucas, G. Turco, T. W.
Toal, A. Gaudinier, N. F. Young, G. M. Trabucco, M. T.
Veling, R. Lamothe, P. P. Handakumbura, G. Xiong, C.
Wang, J. Corwin, A. Tsoukalas, L. Zhang, D. Ware, M.
Pauly, D. J. Kliebenstein, K. Dehesh, I. Tagkopoulos, G.
Breton, J. L. Pruneda-Paz, S. E. Ahnert, S. A. Kay, S. P.
Hazen, S. M. Brady. An Arabidopsis gene regulatory
network for secondary cell wall synthesis. Nature,
2014; DOI:10.1038/nature14099

6. Explored how a large number of
interconnected transcription factors
regulate xylem and cell wall
thickening

7. Allows the knowledge of the relationship
between the polymers that give
regulation of cell control wall thickening
This gives plants a
huge number of
possible
combinations for
responding and
adapting to
environment
most of the proteins
including regulators
of cell cycle and
differentiation bind
directly to genes
interconnected
network of more
than 240 genes and
more than 600
protein-DNA
interactions

9. The identification of this genetic control network possessing
plants for wall thickness, allow to create increasingly specific
the needs that arise when the extraction of biomass plants
needed for biofuels; which facilitate the process, costs will
decrease and thus may increase the use of these new fuels,
thus reducing environmental pollution.

10. • E. Schutz, M. R. Akbari, J. Beck, H. Urnovitz,
W. W. Zhang, K. Bornemann-Kolatzki, W. M.
Mitchell, R. K. Nam, S. A.
Narod. Chromosomal Instability in Cell-Free
DNA Is a Serum Biomarker for Prostate
Cancer. Clinical Chemistry, 2014; 61 (1): 239
DOI: 10.1373/clinchem.2014.226571

11. The research found 20 points of
chromosomic “inestability”
relationship with tumoral cells.

12. The cells die and
release the DNA
The new
technology,
specially "next-
generation
sequencing,"
distinguish and
quantify specific
cancer- DNA

14. The development of new tecniques of diagnosis will give the
possibility of less use of invasory tests and it could be more
precise and efficient.

15. The Reconnaissance network polymers that control the thickness of the
cell wall of plants, facilitate the extraction process, costs will decrease and
thus may increase the use of these new fuels; it will provide final results
with the decrease of the high levels of pollution and diseases such as
bronchitis, asthma, circulatory system diseases, lung cancer and genetic
mutations that have been proven in close relation to pollution.
Medical Utility

16. The utilization of new procedures such as biopsy liquid, allow for
more effective diagnosis and decrease adverse events, such as
the possibility to contaminated another tissues, at the moment to
give extraction of Cells.
Medical Utility

18. THANKS