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Biology folding
- 1. DNA replication: Molecular mechanism indicates novel routes to block uncontrolled cell division & New mechanism for neurodegeneration found Biology folding Professor: Lina María Martinez Ana María Ortiz Gil III Semester – Medicine Universidad Pontificia Bolivariana 2014
- 4. IntroductionIntroduction Over the years many experiments have been executed in order to find the exact point where the process of duplicating the genetic material is regulated so they can have an initial point to start developing different ways to stop it. These two studies reveal new discovering in the genetic field that will first, help us understand the importance of molecular researching nowadays; and second, let the world know that, by doing this experiments, science is everyday closer to the answers that the medical world is needing.
- 5. DNA replication: Molecular mechanism indicates novel routes to block uncontrolled cell division In this study a group of scientists from MRC Clinical Sciences Centre perfom an experiment where, being based in previous theories, they revealed where does a crucial enzyme of the replication start processing the DNA helix..
- 6. DNA replication: Molecular mechanism indicates novel routes to block uncontrolled cell division For a cell to divide it is necessary that the genetic material is duplicated so the resulting cell has the same information as the previous one. The process of dividing needs to have specific machinery composed by proteins and leaded by the helicase.
- 7. DNA replication: Molecular mechanism indicates novel routes to block uncontrolled cell division The helicase captures the DNA into its ring structure, unfolds and separates it so the next proteins can work on the duplication process. Although this had been perfectly known, the exact way it worked had remained a mystery.
- 8. DNA replication: Molecular mechanism indicates novel routes to block uncontrolled cell division By using sophisticated technology the research exposed the pinpoint of the helicase work. Since it is a gated system, there’s a specific gate where the DNA enters the enzyme; the point is located between the connection of MCM2-5 and it’s in there where we could talk about a main check-point of the process that if it could be regulated the cancer cell growth would be inhibited.
- 9. DNA replication: Molecular mechanism indicates novel routes to block uncontrolled cell division In my opinion, one of the most remarkable facts about this article is that they show how the cooperation between different studies is what allows the real success of a scientific process. And that is exemplified in this research where they accomplish the final objective of a long investigation.
- 10. New mechanism for neurodegeneration found All the cells in the human body need proteins to develop any metabolic process they need to survive. Even the protein production system itself is composed by a mechanism leaded by enzymes (which are also proteins) that translate the genetic material into new different proteins to be used in multiple processes.
- 11. New mechanism for neurodegeneration found This group of scientists found, by experimenting with sick mice, that neurodegeneration can be caused by a mutation in a gene that encodes one of the most important proteins for the translation process in the neurological system; the tRNA. The mutation impairs the protein production in neurons.
- 12. New mechanism for neurodegeneration found Besides revealing the mutation on the tRNA’s gene, they found also that another defect is necessary for neurodegeneration to appear and proteins are also involved. In this case the neurological disease requires another protein to be missing; the GTPBP2.
- 13. New mechanism for neurodegeneration found Even if the study could accomplish the objective of learning how the disease is caused in mice; the same process in higher organisms as humans is harder to understand since tRNAs are much more diverse and there are more genes that could codify for the enzyme.
- 14. New mechanism for neurodegeneration found In my opinion, even if the study was not directly done in humans; learning the pathophysiology of determined diseases in simpler organisms represents the foundations for future studies that aim to get every time closer to human solutions.
- 15. DNA replication: Molecular mechanism indicates novel routes to block uncontrolled cell division Since cancer is nowadays one of the main causes of morbimortality, this discovering is crutial in the long way to find a real cure for the disease, which would certainly be one of the greatest aacomplishments in medical history.
- 16. DNA replication: Molecular mechanism indicates novel routes to block uncontrolled cell division Showing the medical and scientific world the importance of learning the molecular systems of determined diseases, can encourage more scientists to keep on working together to find new treatments and cures.
- 17. New mechanism for neurodegeneration found The study of neurological diseases has a huge medical utility since those conditions are attacking giant populations all over the world.
- 18. New mechanism for neurodegeneration found As it’s been said before, neurodegeneration is possibly the main cause of most of the neurological diseases that are being diagnosed nowadays. That’s why the developing of these researches has an inmense utility, since they’re everytime closer to find a cure.
- 19. REFERENCESREFERENCES [http://www.sciencedaily.com/releases/2014/07/ 140731200952.htm] Checked : August 4th 2014. “DNA replication: Molecular mechanism indicates novel routes to block uncontrolled cell division” [http://www.sciencedaily.com/releases/2014/07/ 140724144251.htm] Checked: August 8th 2014. “New mechanism for degeneration found”