This document outlines the health and safety responsibilities of principal investigators and managers at the University of Nottingham. It discusses why health and safety is important from legal, financial, and reputational perspectives. It also summarizes key UK health and safety laws and regulations, such as the Health and Safety at Work Act and the Management of Health and Safety at Work Regulations. The document emphasizes that principal investigators and managers are legally responsible for ensuring risk assessments are conducted, staff receive proper training, hazardous activities are properly supervised, and that health and safety is adequately monitored. Failure to meet these responsibilities could result in prosecution, fines, and civil liability.