Malaria is a protozoal disease caused by Plasmodium parasites and transmitted by infected female Anopheles mosquitoes. It is a major global health issue, with an estimated 300-500 million cases and over 1 million deaths per year. The document discusses the classification, mechanisms of action, indications, adverse effects and combinations of various antimalarial drugs. It also covers treatment guidelines for uncomplicated and severe malaria, chemoprophylaxis, emerging vaccines and drug resistance in malaria parasites.
Pharmacology of antimalarial drugs with treatment of malaria. mechanism of action, uses, adverse effects of antimalarial drugs like chloroquine, quinine, artemisinin compounds.
synthetic antimicrobials having a quinolone structure that are active primarily against gram-negative bacteria, though newer fluorinated compounds also inhibit gram-positive ones.
Anthelmintics | B.Pharm 3rd year 2nd Sem | Medicinal Chemistry-III | History, Classification, Structures & Synthesis of anthelmintics, Synthesis of Diethylcarbamazine citrate, Synthesis of Mebendazole
Pharmacology of antimalarial drugs with treatment of malaria. mechanism of action, uses, adverse effects of antimalarial drugs like chloroquine, quinine, artemisinin compounds.
synthetic antimicrobials having a quinolone structure that are active primarily against gram-negative bacteria, though newer fluorinated compounds also inhibit gram-positive ones.
Anthelmintics | B.Pharm 3rd year 2nd Sem | Medicinal Chemistry-III | History, Classification, Structures & Synthesis of anthelmintics, Synthesis of Diethylcarbamazine citrate, Synthesis of Mebendazole
Hello friends. In this PPT I am talking about antiprotozoal drugs. If you like it, please do let me know in the comments section. A single word of appreciation from you will encourage me to make more of such videos. Thanks. Enjoy and welcome to the beautiful world of pharmacology where pharmacology comes to life. This video is intended for MBBS, BDS, paramedical and any person who wishes to have a basic understanding of the subject in the simplest way.
SImplified Malaria overview for practising pediatricians in India - north india more specifically with a low incidence of malaria. By Dr Gaurav Gupta MD Pediatrician, Charak Clinics, Mohali, Chandigarh
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
263778731218 Abortion Clinic /Pills In Harare ,ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group of receptionists, nurses, and physicians have worked together as a teamof receptionists, nurses, and physicians have worked together as a team wwww.lisywomensclinic.co.za/
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
11. Chloroquine Sulfa/Pyri Quinine Mefloquine
Artemissin
Efficacy +++ ++ +++ +++ ++++
Onset of
action
rapid slow rapid rapid fastest
Use Chemophrophyla
xis
-Treatment of
Chloroquine
sensitive malaria
Uncomplicat-
ed
resistant
P. falciparum
Only for
resistant
P.
falciparum
severe
malaria
cerebral
malaria
Only for
uncomplica
ted,
resistant
P.
falciparum
-resistant
P. falciparum.
- life threatening
complications of P.
falciparum due to
its rapid action
- severe malaria
12. Chloroquine Sulfa -pyr Quinine Mefloquine Artemissin
ADR GI ADR
IV-
Hypotension
,arrythmias
Retinal
damage
Steven
Johnson
Megaloblast
ic anemia
-Cinchonism
-Hypoglycemia
-Hypotension
-Arrhythmias
Neuropsychiatric
symptoms
-Sinus
bradycardia
Safe
A-V block
Reticulopenia
Transient
leucopenia
Contraindic
ation
-Psoriasis,
porphyrias
-Allergy to
sulfa drugs
-Prior
hypersensitivit
y
-Epilepsy
-Psychosis
-Heart block
-
Special
points
Not given
parenterally
in children
-5 % glucose
solution
-Infusion
-Not rapid iv
-Not given
parenterally
Not given with-
Halofantrine,
Beta blockers
Do not kill
hypnozoites
Cost cheap cheap moderate expensive expensive
13. Primaquine
• Radical cure
• prevents relapse in P vivax and P ovale malaria
• Hemolytic anemias- G-6PD status should be evaluated
• Not given parenterally- causes hypotension
• Contraindicated in Pregnancy and infants
13
14. Antimalarial Combination Therapy
Simultaneous use of two or more blood schizontocidal drugs
with independent modes of action
more effective than monotherapy
Higher cure rates
reduce the development of resistance
decrease transmission of drug-resistant parasites.
14
15. Combination therapies recommended by
WHO
• Artemether – Lumefanterine
• Artesunate- Amodiaquine
• Artesunate – Mefloquine
• Artesunate- SP
• Quinine - Tetracyclines/ Clindamycin
Oral Artemissin monotherapy is banned in
India
-never orally as monotherapy for
uncomplicated malaria
.
17. Early diagnosis and treatment of cases of malaria aims
at:
• Complete cure
• Prevention of progression of uncomplicated malaria to
severe disease
• Prevention of deaths
• Interruption of transmission
• Minimizing risk of selection and spread of drug
resistant parasites
18. Treatment of P. vivax Malaria
• Chloroquine 25 mg/kg for 3 days
• Primaquine 0.25 mg/kg for 14 days
19. Treatment of P. falciparum cases
• Artemisinin based Combination Therapy (ACT)
Artesunate 4 mg/kg for 3 days
Sulfadoxine (25 mg/kg body weight)-
Pyrimethamine (1.25 mg/kg body weight) on Day 0
• Primaquine 0.75mg/kg on Day 2
20. Treatment of malaria in pregnancy
P. falciparum:
• 1st Trimester: Quinine
• 2nd & 3rd Trimester: ACT
P vivax: Chloroquine
Note: Primaquine is
contraindicated in pregnant woman
20
21. Treatment based on clinical criteria
without laboratory confirmation
• Suspected cases – “clinical malaria”
Chloroquine 25 mg/kg for 3 days
• Once the parasitological diagnosis is
available, appropriate treatment as per the
species
22. General recommendations for the
management of uncomplicated
malaria
• Avoid starting treatment on an empty
stomach.
• if vomiting occurs within 30 minute- repeat
the dose .
• Ask the patient to report back- if there is no
improvement after 48 hours or if the situation
deteriorates.
23. Treatment of severe malaria
• Impaired consciousness/coma
• Repeated generalized convulsions
• Renal failure (Serum Creatinine >3 mg/dl)
• Jaundice (Serum Bilirubin >3 mg/dl)
• Severe anaemia (Hb <5 g/dl)
• Pulmonary oedema/acute respiratory distress syndrome
• Hypoglycaemia (Plasma Glucose <40 mg/dl)
• Metabolic acidosis
• Circulatory collapse/shock (Systolic BP <80 mm Hg, <50 mm Hg in
children)
• Abnormal bleeding and Disseminated intravascular coagu- lation
(DIC)
• Haemoglobinuria
• Hyperpyrexia (Temperature >106 F or >42C)
• Hyperparasitaemia
23
24. Medical emergency
Parenteral treatment
Parenteral Artemisinin derivatives or Quinine should be used irrespective of chloroquine sensitivity.
Artesunate 2.4 mg/kg i.v. or i.m. at admission 12 & 24hr
, then once a day
or
Artemether 3.2 mg/kg i.m. given on admission then
1.6 mg/kg per day;
or
Quinine 20 mg /kg on admission (i.v. infusion in 5 %
dextrose over 4 hours)
then maintenance dose 10 mg/kg every 8 hrly .
Arteether 150 mg daily i.m. for 3 days in adults only
(not recommended for children).
Parenteral treatment should be given for minimum of 24
hours once started
25. • Patients receiving parenteral Quinine should
receive-
oral Quinine 10 mg/kg three times a day to
complete a course of 7 days
Doxycycline 3 mg/ kg per day for 7 days.
• Doxycycline is contraindicated in pregnant
women and children under 8 years of age
• Instead, Clindamycin 10 mg/kg 12 hourly for 7
days should be used
27. Chemoprophylaxis
• Short-term chemoprophylaxis (less than 6 weeks)
Doxycycline: 100 mg daily in adults
1.5 mg/kg for children> 8 years old
The drug should be started 2 days before travel and
continued for 4 weeks after leaving the malarious area.
• Long-term chemoprophylaxis (more than 6 weeks)
Mefloquine: 5 mg/kg (up to 250 mg) weekly
administered two weeks before, during and
four weeks after leaving the area.
27
28.
29. Malaria Vaccine
Is Malaria vaccine feasible?
Current clinical studies have shown that new candidate
vaccines can induce complete protection against malaria
infection.
Complete protection against malaria can be induced by
infecting volunteers with irradiated malaria parasites.
People living in endemic areas who have been multiply exposed
to malaria develop immunity against severe malaria disease.
Antibodies purified from life-long residents of endemic areas
can be transferred into other individuals and can confer some
protection against the effects of malaria infection.
30. Leading transmission blocking antigens
(Sexual Stage)
Antigen Strengths Weakness
Pfs25/Pvs25
Pfs28/Pvs28
- Both antigens
cloned and expressed
- induces complete
transmission-blocking in model
systems
Not expressed in the
vertebrate host,
not subject to natural
boosting following
vaccination
Pfs48/45 -Monoclonal antibodies
completely block transmission
-Expressed on the gametocyte so
boosting of antibody response a
possibility.
------------------
Pfs230 -Monoclonal antibodies
completely block transmission
-compliment mediated antiparasite
activity
-Expressed on the gametocyte
A very large molecule, so
unclear which part/s to
make.
These antigen vaccines are currently in phase I/Preclinical stage.
31. New Malarial Vaccines Status
Parasite
stage
Vaccine Stage of
Development
Pre
Erythrocytic
Stage
CSP C-ter peptide + Montanide ISA 720 Phase Ib
ICC-1132: Hybrid CSP multiepitope-HBc VLPs Phase II
RTS,S: Hybrid P. falciparum CSP -HBsAg
particles + AS02 adjuvant
Phase IIb
DNA vaccines (including MuStDO-5:
CSP/LSA-1/ LSA-3/EXP1/TRAP)
Phase I
Live recombinant FPV- or MVA-CSP
+ LSA-1 epitope
Phase Ib
Live recombinant MVA-multiepitope
string + TRAP
Phase Ib
LSA-3 (long peptides; lipopeptide;
recombinant)
Phase Ia
32. New Malarial Vaccines Status
Parasite
stage
Vaccine Stage of
Development
Blood Stage PfCP 2.9: MSP-1-AMA-1 fusion
protein (yeast) + Montanide ISA 720
Phase I
MSP-3 long peptides Phase Ib
GLURP long peptide Phase I
MSP-3-GLURP hybrid long peptide +
Montanide ISA 720
Phase I
Combination B: MSP-1, -2, RESA +
Montanide
Phase II
SE36 Phase I
MSP-4, -5 Preclinical
34. Summary
• Antigen variability- vaccine development
• Resistance in plasmodium
• Insecticide resistance
• Judicious use of Anti malarials
• Early diagnosis and treatment
35. References
• Goodman & Gilman’s 12th edition
• K.D.Tripathi 6th edition
• KK Sharma 2nd edition
• Basic & clinical Pharmacology Katzung
• Guidelines for diagnosis and treatment of Malaria 2011 National Vector
Borne Disease Control Programme, National Institute
of Malaria Research