This document discusses malaria, its causes, symptoms, diagnosis and treatment. It focuses on Artemisinin-based combination therapy using Dihydroartemisinin and Piperaquine Phosphate. It summarizes that malaria is caused by a parasite transmitted through mosquito bites, causes millions of deaths annually, and its most deadly form is caused by the Plasmodium falciparum parasite. It recommends Artemisinin-based combination therapy as the most effective treatment according to WHO, with Dihydroartemisinin-Piperaquine being a fixed-dose formulation that is safe, effective and convenient for treating uncomplicated malaria.
This document discusses drugs used to treat peptic ulcers. It describes several classifications of drugs: gastric acid secretion inhibitors like H2 receptor antagonists and proton pump inhibitors; gastric acid neutralizers or antacids; and ulcer protectives like sucralfate. Specific drugs are discussed within each class, including their mechanisms of action, pharmacokinetics, uses, and side effects. The document also covers factors involved in gastric acid secretion and how different drugs work to inhibit this process to treat ulcers.
Systemic antifungal drugs work by exploiting differences between mammalian and fungal cells. They target ergosterol in fungal cell membranes. Amphotericin B is broad-spectrum but nephrotoxic, while azoles like fluconazole are less toxic but narrower. Echinocandins inhibit fungal cell wall synthesis. Topical agents like nystatin are used for superficial infections. Systemic antifungals require long treatment due to fungal infections being difficult to diagnose and eradicate.
Pseudomembranous colitis is caused by Clostridium difficile bacteria and is usually associated with antibiotic use. The bacteria releases toxins that damage the colon lining, causing symptoms like severe diarrhea. Risk factors include advanced age, hospitalization, and immunosuppression. Treatment involves stopping the culprit antibiotic if possible, rehydration, and antibiotic therapy targeted against C. difficile like vancomycin. Complications can include dehydration, perforation, and toxic megacolon requiring surgery in some cases.
Syphilis is a chronic venereal infection caused by the spirochete Treponema pallidum. It has various stages including primary, secondary, latent, and tertiary syphilis. Penicillin is the treatment of choice and can cure syphilis in all stages. Common side effects of treatment include allergic reactions and Jarisch-Herxheimer reactions, which cause flu-like symptoms.
The document discusses the resurgence of the antibiotic fosfomycin for treating infections caused by drug-resistant bacteria. It notes the increasing problems of antibiotic resistance have created a need to re-evaluate existing treatment options. Fosfomycin has a unique mechanism of action and activity against both gram-positive and gram-negative bacteria. It has demonstrated efficacy against common infections like UTIs and is particularly useful in combination with other antibiotics for multi-drug resistant infections in critical care settings.
This document discusses antiplatelet drugs used to treat arterial and venous thrombosis. It describes the role of platelets in arterial thrombosis, triggered by disruption of atherosclerotic plaque. Common antiplatelet drugs discussed include aspirin, clopidogrel, prasugrel, ticlopidine, dipyridamole, and glycoprotein IIb/IIIa inhibitors like abciximab and tirofiban. Their mechanisms of action, indications, and side effects are summarized. Clopidogrel resistance due to genetic factors is also mentioned.
This document discusses macrolide antibiotics. It begins by introducing macrolides as a class of antibiotics characterized by a macrocyclic lactone ring to which sugars are attached. It then focuses on individual macrolides including erythromycin, clarithromycin, azithromycin, roxithromycin, and spiramycin. The document discusses the mechanism of action, spectrum of activity, resistance, pharmacokinetics, uses, interactions, and adverse effects of macrolide antibiotics.
This document discusses malaria, its causes, symptoms, diagnosis and treatment. It focuses on Artemisinin-based combination therapy using Dihydroartemisinin and Piperaquine Phosphate. It summarizes that malaria is caused by a parasite transmitted through mosquito bites, causes millions of deaths annually, and its most deadly form is caused by the Plasmodium falciparum parasite. It recommends Artemisinin-based combination therapy as the most effective treatment according to WHO, with Dihydroartemisinin-Piperaquine being a fixed-dose formulation that is safe, effective and convenient for treating uncomplicated malaria.
This document discusses drugs used to treat peptic ulcers. It describes several classifications of drugs: gastric acid secretion inhibitors like H2 receptor antagonists and proton pump inhibitors; gastric acid neutralizers or antacids; and ulcer protectives like sucralfate. Specific drugs are discussed within each class, including their mechanisms of action, pharmacokinetics, uses, and side effects. The document also covers factors involved in gastric acid secretion and how different drugs work to inhibit this process to treat ulcers.
Systemic antifungal drugs work by exploiting differences between mammalian and fungal cells. They target ergosterol in fungal cell membranes. Amphotericin B is broad-spectrum but nephrotoxic, while azoles like fluconazole are less toxic but narrower. Echinocandins inhibit fungal cell wall synthesis. Topical agents like nystatin are used for superficial infections. Systemic antifungals require long treatment due to fungal infections being difficult to diagnose and eradicate.
Pseudomembranous colitis is caused by Clostridium difficile bacteria and is usually associated with antibiotic use. The bacteria releases toxins that damage the colon lining, causing symptoms like severe diarrhea. Risk factors include advanced age, hospitalization, and immunosuppression. Treatment involves stopping the culprit antibiotic if possible, rehydration, and antibiotic therapy targeted against C. difficile like vancomycin. Complications can include dehydration, perforation, and toxic megacolon requiring surgery in some cases.
Syphilis is a chronic venereal infection caused by the spirochete Treponema pallidum. It has various stages including primary, secondary, latent, and tertiary syphilis. Penicillin is the treatment of choice and can cure syphilis in all stages. Common side effects of treatment include allergic reactions and Jarisch-Herxheimer reactions, which cause flu-like symptoms.
The document discusses the resurgence of the antibiotic fosfomycin for treating infections caused by drug-resistant bacteria. It notes the increasing problems of antibiotic resistance have created a need to re-evaluate existing treatment options. Fosfomycin has a unique mechanism of action and activity against both gram-positive and gram-negative bacteria. It has demonstrated efficacy against common infections like UTIs and is particularly useful in combination with other antibiotics for multi-drug resistant infections in critical care settings.
This document discusses antiplatelet drugs used to treat arterial and venous thrombosis. It describes the role of platelets in arterial thrombosis, triggered by disruption of atherosclerotic plaque. Common antiplatelet drugs discussed include aspirin, clopidogrel, prasugrel, ticlopidine, dipyridamole, and glycoprotein IIb/IIIa inhibitors like abciximab and tirofiban. Their mechanisms of action, indications, and side effects are summarized. Clopidogrel resistance due to genetic factors is also mentioned.
This document discusses macrolide antibiotics. It begins by introducing macrolides as a class of antibiotics characterized by a macrocyclic lactone ring to which sugars are attached. It then focuses on individual macrolides including erythromycin, clarithromycin, azithromycin, roxithromycin, and spiramycin. The document discusses the mechanism of action, spectrum of activity, resistance, pharmacokinetics, uses, interactions, and adverse effects of macrolide antibiotics.
Beta lactamase inhibitors such as clavulanic acid, sulbactam, tazobactam, and avibactam work to inhibit beta-lactamase enzymes produced by bacteria that provide resistance to beta-lactam antibiotics like penicillins. They bind to and inactivate the beta-lactamase enzymes. When combined with beta-lactam antibiotics, the inhibitors can help the antibiotics overcome resistance and be effective against infections. Common combinations include amoxicillin-clavulanic acid, piperacillin-tazobactam, and ceftazidime-avibactam which are used to treat a variety of bacterial infections.
1) Aminoglycosides are polybasic amino groups linked glycosidically to aminosugar compounds. They are highly water soluble and excreted unchanged in urine.
2) They are bactericidal, inhibiting protein synthesis by binding to the 30S/50S interface of bacterial ribosomes. This causes misreading of mRNA and nonfunctional protein formation.
3) Common adverse effects include ototoxicity (hearing loss) and nephrotoxicity. Individual drugs vary in their specific toxicities.
This document discusses the pharmacotherapy of urinary tract infections and provides information on chloramphenicol and tetracyclines. It covers the epidemiology, pathogenesis, definitions, and drug therapy for UTIs. Common causative organisms are E. coli and other gram-negative bacteria. Drug choices depend on the site and severity of infection. For uncomplicated lower UTIs, short 3-day courses of antibiotics like TMP-SMX are often used. More severe infections involving the kidneys may require parenteral antibiotics in hospital. The document also discusses UTI in specific groups like children, pregnant women, and those with structural abnormalities.
Fluoroquinolones are a class of broad-spectrum antibacterial agents derived from nalidixic acid. They work by inhibiting bacterial DNA gyrase and topoisomerase IV, blocking DNA synthesis. Resistance can occur via mutations in the quinolone binding region of these target enzymes or changes in bacterial permeability. Fluoroquinolones are classified into generations based on spectrum of activity and are well-absorbed orally with varying tissue distribution and drug interactions. Adverse effects include gastrointestinal, central nervous system, and musculoskeletal issues. Ciprofloxacin and levofloxacin are two commonly used fluoroquinolones with activity against both gram-negative and gram-positive pathogens.
This document discusses antiepileptic drugs, including their mechanisms of action, classifications, pharmacokinetics, indications, and adverse effects. It classifies antiepileptic drugs based on their actions on ion channels and neurotransmitter systems. The main mechanisms of action are enhancement of GABA transmission, inhibition of sodium channels, and inhibition of calcium channels. Common antiepileptic drugs like phenytoin, carbamazepine, valproic acid, lamotrigine, ethosuximide, gabapentin, vigabatrin, and tiagabine are described in terms of their pharmacological properties and clinical uses.
This document discusses multi-drug resistant tuberculosis (MDR-TB). It provides global and country-specific data on TB incidence and burden. MDR-TB is defined as disease resistant to at least two anti-TB drugs. Countries with high MDR-TB burdens are identified. The Indian scenario of TB is described, noting prevalence of MDR-TB in new and previously treated cases. A case study from Andhra Pradesh reports findings from 75 MDR-TB patients. Clinical factors promoting drug resistance and mechanisms of resistance are outlined. Treatment of MDR-TB and new chemotherapeutic agents are discussed. Global plans to combat TB, including targets and strategies, are summarized.
Linezolid is an antibiotic that fights bacteria in the body by inhibiting monoamine oxidase. It is effective against aerobic Gram-positive bacteria as well as some Gram-negative and anaerobic bacteria. Linezolid can treat various bacterial infections like pneumonia, skin infections, and those resistant to other antibiotics.
Fibrinolytics, also known as thrombolytics, work to dissolve blood clots and are used to treat conditions like heart attacks, deep vein thrombosis, and pulmonary embolism. The main fibrinolytic agents discussed are streptokinase, tissue plasminogen activator (t-PA), and its variants reteplase and tenecteplase. These work by activating plasminogen and converting it to plasmin to break down fibrin clots. Their use comes with risks of hemorrhage, so antifibrinolytic drugs like tranexamic acid and aminocaproic acid are used to reduce bleeding when fibrinolytics are given.
Malaria is caused by Plasmodium parasites transmitted via mosquito bites. There are five species that infect humans, with P. falciparum being the most deadly. Treatment involves antimalarial drugs that target different stages of the parasite's lifecycle in the human body and mosquito. Common drugs include chloroquine, quinine, artemisinin compounds, and combinations like artemisinin-based combination therapies. Proper diagnosis and treatment according to the national guidelines is important to control malaria.
Silodosin versus tamsulosin in symptomatic benign prostatic hyperplasia-Our e...iosrphr_editor
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
A complete drug profile of Tacrolimus an immunosuppressant used for organ transplant. It consist of PK/PD, MOA, Indication & Uses, Contraindications, Warnings & Precautions, Drug-interaction, Doses & Administration, Dosage forms, Chemical Formula, Side-Effects, Adverse Drug Reactions, Therapeutic Drug Monitoring (TDM).
This document discusses oral hypoglycemic drugs and insulin used to treat diabetes. It describes the two main types of diabetes - type 1 caused by insulin deficiency and type 2 caused by insulin resistance. The document outlines several classes of oral hypoglycemic drugs including biguanides, sulfonylureas, meglitinides, thiazolidinediones, and alpha-glucosidase inhibitors. It provides details on the mechanism of action, pharmacokinetics, effects and side effects of drugs from each class.
This document summarizes different drugs used for treating diabetes. It discusses the types of diabetes, mechanisms and types of insulin preparations including rapid-acting, intermediate-acting, and long-acting insulins. It also covers oral antidiabetic drugs like sulfonylureas, meglitinides, DPP-4 inhibitors, metformin, thiazolidinediones, alpha-glucosidase inhibitors, and SGLT-2 inhibitors; describing their mechanisms of action, pharmacokinetics and adverse effects. It concludes by listing common oral hypoglycemic agents and their usual daily doses and frequencies.
This document discusses fluoroquinolone antibiotics, including their parent drug nalidixic acid, mechanisms of action, classifications, and individual drug profiles. It notes that fluoroquinolones act by inhibiting DNA gyrase and topoisomerase enzymes in bacteria. Common adverse effects include gastrointestinal upset and neurological toxicity. Resistance can develop through chromosomal mutations in bacterial targets or reduced drug permeability. First-generation fluoroquinolones like ciprofloxacin are often used to treat urinary tract infections and respiratory infections.
This ppt discusses pharmacological actions, toxic effects and clinical applications of corticosteroids. It also mentions precations to be taken while using steroids
This document discusses anti-tubercular drugs used to treat tuberculosis. It begins by stating tuberculosis is a major health problem, especially in developing countries, with over 1/3 of the world's population infected. It then discusses the goals and components of India's Revised National Tuberculosis Control Programme (RNTCP) to control and treat TB. The document primarily focuses on first-line anti-tubercular drugs, describing their mechanisms of action, resistance, administration, interactions, and adverse effects. Key drugs discussed include isoniazid, rifampin, pyrazinamide, ethambutol, and streptomycin.
Aminoglycosides are a class of antibiotics that are produced by soil bacteria. They are primarily used to treat infections caused by aerobic gram-negative bacteria and some are used for mycobacterial infections. Aminoglycosides work by binding to bacterial ribosomes which interferes with protein synthesis. They have concentration-dependent bactericidal activity against many gram-negative organisms but limited activity against gram-positive bacteria. Common adverse effects include ototoxicity and nephrotoxicity. Therapeutic drug monitoring is important when using aminoglycosides to minimize toxicity risks.
Protozoal infections and antiprotozoal drugs(therapy).Gagandeep Jaiswal
presentation comprising knowledge about various protozoal infections and therapy options available for the treatment of those infections. various different drugs used in the therapy with their proposed mechanism of action. Hope it will be useful for understanding the pharmacology of antiprotozoals.
Beta lactamase inhibitors such as clavulanic acid, sulbactam, tazobactam, and avibactam work to inhibit beta-lactamase enzymes produced by bacteria that provide resistance to beta-lactam antibiotics like penicillins. They bind to and inactivate the beta-lactamase enzymes. When combined with beta-lactam antibiotics, the inhibitors can help the antibiotics overcome resistance and be effective against infections. Common combinations include amoxicillin-clavulanic acid, piperacillin-tazobactam, and ceftazidime-avibactam which are used to treat a variety of bacterial infections.
1) Aminoglycosides are polybasic amino groups linked glycosidically to aminosugar compounds. They are highly water soluble and excreted unchanged in urine.
2) They are bactericidal, inhibiting protein synthesis by binding to the 30S/50S interface of bacterial ribosomes. This causes misreading of mRNA and nonfunctional protein formation.
3) Common adverse effects include ototoxicity (hearing loss) and nephrotoxicity. Individual drugs vary in their specific toxicities.
This document discusses the pharmacotherapy of urinary tract infections and provides information on chloramphenicol and tetracyclines. It covers the epidemiology, pathogenesis, definitions, and drug therapy for UTIs. Common causative organisms are E. coli and other gram-negative bacteria. Drug choices depend on the site and severity of infection. For uncomplicated lower UTIs, short 3-day courses of antibiotics like TMP-SMX are often used. More severe infections involving the kidneys may require parenteral antibiotics in hospital. The document also discusses UTI in specific groups like children, pregnant women, and those with structural abnormalities.
Fluoroquinolones are a class of broad-spectrum antibacterial agents derived from nalidixic acid. They work by inhibiting bacterial DNA gyrase and topoisomerase IV, blocking DNA synthesis. Resistance can occur via mutations in the quinolone binding region of these target enzymes or changes in bacterial permeability. Fluoroquinolones are classified into generations based on spectrum of activity and are well-absorbed orally with varying tissue distribution and drug interactions. Adverse effects include gastrointestinal, central nervous system, and musculoskeletal issues. Ciprofloxacin and levofloxacin are two commonly used fluoroquinolones with activity against both gram-negative and gram-positive pathogens.
This document discusses antiepileptic drugs, including their mechanisms of action, classifications, pharmacokinetics, indications, and adverse effects. It classifies antiepileptic drugs based on their actions on ion channels and neurotransmitter systems. The main mechanisms of action are enhancement of GABA transmission, inhibition of sodium channels, and inhibition of calcium channels. Common antiepileptic drugs like phenytoin, carbamazepine, valproic acid, lamotrigine, ethosuximide, gabapentin, vigabatrin, and tiagabine are described in terms of their pharmacological properties and clinical uses.
This document discusses multi-drug resistant tuberculosis (MDR-TB). It provides global and country-specific data on TB incidence and burden. MDR-TB is defined as disease resistant to at least two anti-TB drugs. Countries with high MDR-TB burdens are identified. The Indian scenario of TB is described, noting prevalence of MDR-TB in new and previously treated cases. A case study from Andhra Pradesh reports findings from 75 MDR-TB patients. Clinical factors promoting drug resistance and mechanisms of resistance are outlined. Treatment of MDR-TB and new chemotherapeutic agents are discussed. Global plans to combat TB, including targets and strategies, are summarized.
Linezolid is an antibiotic that fights bacteria in the body by inhibiting monoamine oxidase. It is effective against aerobic Gram-positive bacteria as well as some Gram-negative and anaerobic bacteria. Linezolid can treat various bacterial infections like pneumonia, skin infections, and those resistant to other antibiotics.
Fibrinolytics, also known as thrombolytics, work to dissolve blood clots and are used to treat conditions like heart attacks, deep vein thrombosis, and pulmonary embolism. The main fibrinolytic agents discussed are streptokinase, tissue plasminogen activator (t-PA), and its variants reteplase and tenecteplase. These work by activating plasminogen and converting it to plasmin to break down fibrin clots. Their use comes with risks of hemorrhage, so antifibrinolytic drugs like tranexamic acid and aminocaproic acid are used to reduce bleeding when fibrinolytics are given.
Malaria is caused by Plasmodium parasites transmitted via mosquito bites. There are five species that infect humans, with P. falciparum being the most deadly. Treatment involves antimalarial drugs that target different stages of the parasite's lifecycle in the human body and mosquito. Common drugs include chloroquine, quinine, artemisinin compounds, and combinations like artemisinin-based combination therapies. Proper diagnosis and treatment according to the national guidelines is important to control malaria.
Silodosin versus tamsulosin in symptomatic benign prostatic hyperplasia-Our e...iosrphr_editor
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
A complete drug profile of Tacrolimus an immunosuppressant used for organ transplant. It consist of PK/PD, MOA, Indication & Uses, Contraindications, Warnings & Precautions, Drug-interaction, Doses & Administration, Dosage forms, Chemical Formula, Side-Effects, Adverse Drug Reactions, Therapeutic Drug Monitoring (TDM).
This document discusses oral hypoglycemic drugs and insulin used to treat diabetes. It describes the two main types of diabetes - type 1 caused by insulin deficiency and type 2 caused by insulin resistance. The document outlines several classes of oral hypoglycemic drugs including biguanides, sulfonylureas, meglitinides, thiazolidinediones, and alpha-glucosidase inhibitors. It provides details on the mechanism of action, pharmacokinetics, effects and side effects of drugs from each class.
This document summarizes different drugs used for treating diabetes. It discusses the types of diabetes, mechanisms and types of insulin preparations including rapid-acting, intermediate-acting, and long-acting insulins. It also covers oral antidiabetic drugs like sulfonylureas, meglitinides, DPP-4 inhibitors, metformin, thiazolidinediones, alpha-glucosidase inhibitors, and SGLT-2 inhibitors; describing their mechanisms of action, pharmacokinetics and adverse effects. It concludes by listing common oral hypoglycemic agents and their usual daily doses and frequencies.
This document discusses fluoroquinolone antibiotics, including their parent drug nalidixic acid, mechanisms of action, classifications, and individual drug profiles. It notes that fluoroquinolones act by inhibiting DNA gyrase and topoisomerase enzymes in bacteria. Common adverse effects include gastrointestinal upset and neurological toxicity. Resistance can develop through chromosomal mutations in bacterial targets or reduced drug permeability. First-generation fluoroquinolones like ciprofloxacin are often used to treat urinary tract infections and respiratory infections.
This ppt discusses pharmacological actions, toxic effects and clinical applications of corticosteroids. It also mentions precations to be taken while using steroids
This document discusses anti-tubercular drugs used to treat tuberculosis. It begins by stating tuberculosis is a major health problem, especially in developing countries, with over 1/3 of the world's population infected. It then discusses the goals and components of India's Revised National Tuberculosis Control Programme (RNTCP) to control and treat TB. The document primarily focuses on first-line anti-tubercular drugs, describing their mechanisms of action, resistance, administration, interactions, and adverse effects. Key drugs discussed include isoniazid, rifampin, pyrazinamide, ethambutol, and streptomycin.
Aminoglycosides are a class of antibiotics that are produced by soil bacteria. They are primarily used to treat infections caused by aerobic gram-negative bacteria and some are used for mycobacterial infections. Aminoglycosides work by binding to bacterial ribosomes which interferes with protein synthesis. They have concentration-dependent bactericidal activity against many gram-negative organisms but limited activity against gram-positive bacteria. Common adverse effects include ototoxicity and nephrotoxicity. Therapeutic drug monitoring is important when using aminoglycosides to minimize toxicity risks.
Protozoal infections and antiprotozoal drugs(therapy).Gagandeep Jaiswal
presentation comprising knowledge about various protozoal infections and therapy options available for the treatment of those infections. various different drugs used in the therapy with their proposed mechanism of action. Hope it will be useful for understanding the pharmacology of antiprotozoals.
The document discusses antimalarial, antiprotozoal, and antihelmintic agents used to treat parasitic infections. It describes the life cycles and transmission of malaria, protozoal infections like amebiasis, and helminth infections. It outlines the mechanisms of action and therapeutic uses of various antimalarial, antiprotozoal, and antihelmintic drugs, as well as their potential side effects. Nursing implications are monitoring for side effects and ensuring treatment compliance.
This document discusses anthelmintic drugs used to treat helminth infections. It begins by describing common types of helminths including tapeworms, roundworms, and flukes. It then discusses ideal properties of anthelmintic drugs and classifications based on mechanism of action, spectrum of activity, and type of helminth targeted. Specific drug classes and examples are provided, including benzimidazoles, tetrahydropyrimidines, piperazine, diethylcarbamazine, ivermectin, and others. Their mechanisms of action, clinical uses, safety profiles and pharmacokinetics are summarized for key anthelmintic drugs.
This document summarizes information about quinolones and fluoroquinolone antibiotics. It discusses their classification, mechanism of action, and uses for treating bacterial infections like UTIs, sexually transmitted diseases, respiratory infections, and more. Common side effects include nausea, headaches, and photosensitivity. Newer fluoroquinolones are better absorbed and distributed in the body compared to older quinolones. The document also provides information on antifungal drugs and their uses for treating conditions like candidiasis, aspergillosis and cryptococcosis.
Antihelminthic and antiprotozoal drugs work by killing or expelling parasitic worms and protozoa. Common antihelminthics discussed include mebendazole, albendazole, pyrantel, and levamisole which are used to treat nematode, cestode, and trematode infections. Their mechanisms of action involve inhibiting microtubule assembly, inducing paralysis, or activating nicotinic receptors in the parasites. Common antiprotozoals discussed include metronidazole for amebiasis, giardiasis and trichomoniasis, and drugs for malaria such as chloroquine, primaquine, and antifol combinations. Adverse
Antihelminthic and antiprotozoal drugs are used to treat infections caused by helminths (worms) and protozoa. The major classes of antihelminthics discussed are mebendazole, albendazole, pyrantel, levamisole, and piperazine which are used against nematodes, trematodes, and cestodes. Antiprotozoal drugs discussed include metronidazole for amoebiasis, giardiasis, and trichomoniasis. Drugs for malaria discussed are quinine, chloroquine, antifolates, primaquine, and nitrofurans. Melarsoprol
Antihelminthic and antiprotozoal drugs work by killing or expelling parasitic worms and protozoa. Common antihelminthics discussed include mebendazole, albendazole, pyrantel, and levamisole which are used to treat nematode, cestode, and trematode infections. Their mechanisms of action involve inhibiting microtubule assembly, inducing paralysis, or activating nicotinic receptors in the parasites. Common antiprotozoals discussed include metronidazole for amebiasis, giardiasis and trichomoniasis, and drugs for malaria such as chloroquine, primaquine, and antifol combinations. Adverse
Antihelminthic and antiprotozoal drugs are used to treat infections caused by parasites. The major classes of antihelminthics discussed target nematodes, trematodes, and cestodes. Specific drugs mentioned include mebendazole, albendazole, pyrantel, levamisole, and praziquantel. These drugs work through various mechanisms including disrupting microtubule assembly, inducing muscle paralysis, or causing calcium leakage. Common side effects include abdominal pain, diarrhea, and allergic reactions. Antiprotozoal drugs discussed treat infections caused by protozoa like Entamoeba histolytica, Giardia lamblia, and Plasmodium
Antihelminthic and antiprotozoal drugs are used to treat infections caused by parasites. The major classes of antihelminthics discussed target nematodes, trematodes, and cestodes. Specific drugs mentioned include mebendazole, albendazole, pyrantel, levamisole, and praziquantel. These drugs work through various mechanisms including disrupting microtubule assembly, inducing muscle paralysis, or causing calcium leakage. Common side effects include abdominal pain, diarrhea, and allergic reactions. Antiprotozoal drugs discussed treat infections caused by protozoa like Entamoeba histolytica, Giardia lamblia, and Plasmodium
This document summarizes antiparasitic drugs used to treat various protozoal infections. It discusses the classes of antiparasitic agents and specific drugs used to treat amebiasis, malaria, trypanosomiasis, leishmaniasis, toxoplasmosis, and giardiasis. For each infection, the causative protozoan parasite is identified along with details about the life cycle, classification of treatment drugs, and descriptions of selected drugs including their mechanisms of action, pharmacokinetics, and adverse effects.
Mushroom poisoning occurs when toxic substances in mushrooms are ingested. There are 70-80 poisonous mushroom species that contain toxic alkaloids. Symptoms vary based on toxin but include nausea, anxiety, and organ damage. Mushrooms are classified based on toxin, with Amanita species containing amatoxins that cause liver damage. Treatment focuses on supportive care, decontamination, and use of antidotes like benzyl penicillin for amatoxin poisoning.
Chemotherapy involves using chemical substances to treat diseases, particularly cancer and microbial infections. The term was coined by Paul Ehrlich, who developed the first effective treatment for syphilis called Salvarsan. Chemotherapeutic agents can be synthetic chemicals or substances produced by microorganisms. Some common classes of antimicrobial agents used in chemotherapy include sulphonamides, fluoroquinolones, tetracyclines, and others. These work by interfering with bacterial growth and survival through various mechanisms such as inhibiting enzymes or DNA synthesis. While effective against many infections, these agents can sometimes cause side effects and the development of drug resistance remains a concern.
Anthelmintics are drugs that expel parasitic worms and internal parasites from the body without significantly damaging the host. They are classified based on the type of helminth they treat - drugs for roundworms, flatworms, and tapeworms. Common anthelmintic drugs include albendazole, mebendazole, ivermectin, pyrantel pamoate, piperazine, praziquantel, and niclosamide. They work by inhibiting the parasite's microtubules, nerve function, or cell membranes, causing paralysis or death of the worm. Side effects are generally mild and include nausea, vomiting, diarrhea, and headaches.
1. The document discusses anti-helminthic drugs used to treat infections caused by parasitic worms in humans. It describes the common types of helminths including tapeworms, roundworms, and flukes.
2. Various anti-helminthic drugs are classified based on their mechanism of action, spectrum of activity, and source. Broad spectrum benzimidazoles like mebendazole and albendazole are effective against many worm types.
3. Individual drugs are discussed in more detail, including their mechanisms of action, uses for specific worm infections, dosages, and side effects. Commonly used drugs include albendazole, mebendazole, pyrantel
This document summarizes cholinergic drugs and their mechanisms of action. It discusses the parasympathetic and sympathetic nervous systems and the organs they innervate. It describes the synthesis and mechanisms of the neurotransmitter acetylcholine. The different types of muscarinic receptors and their functions are outlined. Several cholinergic agonists like bethanechol, carbachol, and methacholine are compared. The uses and effects of cholinergic drugs like pilocarpine, physostigmine, neostigmine, and pyridostigmine are summarized. Poisoning by mushrooms, organophosphates and its treatment involving atropine and pralidoxime are briefly covered. Myasthen
This document discusses anthelmintic drugs used to treat helminth infections. It begins by describing common types of helminths including tapeworms, roundworms, and flukes. It then discusses the ideal properties of anthelmintic drugs and classifications based on mechanism of action, spectrum of activity, and type of helminth treated. Specific anthelmintic drugs are described for tapeworms (anticestodals), roundworms (antinematodals), and flukes (antitrematodals). Key drugs discussed include albendazole, mebendazole, praziquantel, pyrantel, and ivermectin. Clinical uses and mechanisms of action
Antimalarials are used to treat malaria caused by Plasmodium parasites transmitted via Anopheles mosquitoes. There are several classifications of antimalarial drugs including based on the stage of the parasite life cycle they affect and their chemical structure. First line treatment of acute, uncomplicated Plasmodium falciparum malaria as recommended by the WHO is artemisinin-based combination therapy (ACT) which combines a fast-acting artemisinin derivative with a long-acting partner drug to prevent recrudescence. Commonly used ACT regimens include artesunate with sulfadoxine-pyrimethamine, mefloquine, or lumefantrine-artemether.
This document summarizes information about malaria and its treatment. It discusses the life cycle and symptoms of the malaria parasite, as well as classifications, mechanisms of action, and adverse effects of various antimalarial drugs. These include chloroquine, quinine, proguanil, sulfonamides, tetracyclines, and artemisinin derivatives. It also covers the pharmacokinetics of these drugs and preventive measures against malaria.
This document discusses antimalarial drugs and their classification, mechanisms of action, and therapeutic uses. It begins by identifying the four main Plasmodium species that infect humans. It then covers individual drugs like chloroquine, primaquine, mefloquine, and artemisinin derivatives. It classifies drugs based on their therapeutic effects and chemical structures. Key points include how each drug works against the malaria parasite, their pharmacokinetics, adverse effects, and indications. Artemisinin-based combination therapy is highlighted as the recommended treatment for acute uncomplicated malaria.
Similar to Pharmacology of Antihelmintic and Antisyphilitic Drugs (20)
Rickets is a disease characterized by impaired bone formation and growth due to abnormalities in calcium and phosphorus metabolism. It is caused by vitamin D deficiency or impaired vitamin D activity. Symptoms include skeletal deformities, muscular weakness, and growth retardation. Treatment involves correcting the underlying vitamin D or calcium-phosphorus deficiency through supplementation and increased sunlight exposure.
This document discusses protein-energy malnutrition in children. It begins with an outline of the topics to be covered, including the frequency, etiology, pathogenesis, classification, clinical presentation, laboratory tests, and treatment of protein-energy malnutrition. It then discusses the global burden of malnutrition in children, contributors to childhood mortality, and the etiology and pathogenesis of protein-energy malnutrition in more detail. The document also covers the clinical features, laboratory evaluation, classification, diet and treatment of protein-energy malnutrition in children.
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2. ANTHELMINTIC DRUGS are used to treat parasitic
infections due to:
1. Roundworm – Nematodes :
Ascariasis , Enterobiasis (pinworm),
Ancylostomiasis, Strongyloidosis, Trichinosis,
Onchocerciasis, Dracontiasis
2. Flatworms:
– Flukes – Trematodes :
Blood fluke, Liver fluke, Lung fluke
– Tapeworms – Cestodes :
Beef tapeworm,
Pork tapeworm (Armed tapeworm)
Fish tapeworm
2
3. According the mechanism of action
ANTHELMINTICS are divided into:
1) Cellular poisons – Tetrachloroethylene (Perchlorethylene)
2) Disturbing the function of the neuromuscular apparatus
in nematodes – Pyrantel pamoate, Piperazine adipinate,
Ditrazin, Levamisole, Naphthamon
3) Paralyzing neuromuscular system predominantly of
flatworms (cestodes) and damaging their coating tissues –
Praziquantel, Niclosamide (Phenasal), Bithionol
4) Affecting predominantly the energy processes –
Mebendazole
Levamisole
Aminoacrichin
Pyrvinium pamoate3
5. CLASSIFICATION
on the basis of the type of helminth primarily affected :
I. Chemotherapy of NEMATODES:
Mebendazole (Vermox) Ivermectin
Thiabendazole Piperazine adipinate
Albendazole
Pyrantel Pamoate
Levamisole (Decaris )
Ditrazin citrate (Diethylcarbamazine)
II. Chemotherapy of TREMATODES:
Praziquantel
Bithinol
III. Chemotherapy of CESTODES:
Praziquantel
Niclosamide (Phenasal)
6. Mebendazole (Vermox) - Tab. 0.5 g –
a synthetic benzimidazole compound -
is a drug of choice in the treatment of infections by:
Pinworm (Enterobius vermicularis),
Roundworm (Ascariasis lumbricoides),
Whipworm (Trichuris trichiura)
Hookworm (Necator americanus and
Ancylostoma duodenale).
Mechanism of action:
Binding and Interfiaring with the synthesis of
β-tubulin and thus parasite’s microtubules =>
=> GLUCOSE UPTAKE by the worm.
The helminths become immobilized and die slowly,
so they may be expelled from the GIT up to 3 days
after drug therapy is completed.
7. Pyrantel pamoate - Tab 0.25; Susp.5%-15 ml
Pinworm (Enterobius vermicularis)
Roundworm (Ascariasis lumbricoides)
Hookworm (Necator americanus and
Ancylostoma duodenale)
Mechanism of action:
Depolarizes Neuromuscular Junction of
the helminth => its Spasm and Paralysis
Anticholinesterase activity
Adverse effects:
Nausea, vomiting, and diarrhea.
8. Levamisole (Decaris)- Tab. 50 and 150 mg
is a synthetic imidazothiazole derivative
Highly effective against:
Roundworms (Ascaris and Trichostrongylus)
Moderately effective:
Hookworm
Mechanism of action:
Nicotine-like action, stimulation and
subsequently block of the neuromuscular junctions.
The paralyzed worms are then passed in the feces.
Levamisole occurs IMMUNOMODULATING EFFECT and
is used as adjunct therapy with FLUOROURACIL
for the treatment of COLON CANCER
9. Praziquantel is a broad-spectrum anthelminthic
Schistosomes: Blood fluke,
Liver fluke, Lung fluke
Cestodes infections like Cysticercosis
Beef tapeworm
Pork tapeworm
Fish tapeworm
Mechanism of action:
Permeability to the Ca2+ =>
=> Musculature Contraction and
eventual Paralysis and death of the worm.
Modifies the parasite so that it becomes susceptible to
the host’s normal immune responses.
10. Phenasal (Niclosamide – Tab. 0.25 g)
CESTODES: Beef tapeworm
Pork tapeworm
Fish tapeworm
Mechanism of action: inhibition of the parasite's
Mitochondrial Anaerobic Phosphorylation of ADP, which
produces usable energy in the form of ATP.
Lethal for the Cestode's Scolex and Segments
but not for the Ova.
A Laxative is administered prior to
oral administration of Phenasal
11. Malaria is caused by parasitic protozoa of
the genus Plasmodium and is characterized by
fever with rigor, anemia and splenomegaly.
P. vivax P. ovale
P. falciparum P. malariae
After entry into the blood, sporozoites develop further
through several stages:
1. Pre-Erythrocytic (Primary Exo-Erythrocyte) Stage
(Hepatic Cycle)
2. Erythrocytic Stage
3. Development of sexual forms
P. vivax and P. Ovale have persistent Hepatic Cycle
due to presence of hypnozoites
(Secondary Tissue Phase or Exo-Erythrocytic phase).
13. ANTIMALARIAL DRUGS
I. Quinoline derivatives:
4-Quinolines:
Chloroquine (Chingamin)
Quinine
Mefloquine
8-Aminoquinolines: Primaquine, Tafeloquine
II. Antifolates:
Pyrimidine derivatives: Chloridine (Pyrimethamine)
Biguanides: Proguanil
Sulfones and Sulfonamides: Dapsone
III. Antibiotics:
Doxycycline, Tetracycline, Clindamycin
14. Antimalarial drugs
by their selective actions on different phases of
the parasite life cycle:
1. Blood Schizontocidal Drugs:
influence on Erythrocytic Schizonts
2. Tissue Schizontocidal Drugs:
influence on Tissue Schizonts:
a) Effective against Pre-Erythrocytic
(primary tissue form);
b) Effective against Exo-Erythrocytic
(secondary tissue form).
3. Gametocytocidal drugs:
influence on sexual forms
14
16. Chloroquine (Chingamin - Tab 0.25; amp. 5%-5 ml)
Mechanism of action.
Malarial parasites digest Hb
in their lysosomes to utilize amino acids.
The released Heme is highly reactive but is converted
by the Parasitic Polymerase to
nontoxic Hemozoin (malarial pigment).
Chingamin concentrates in the Acidic Lysosomes and
binds to liberated Heme.
The Heme-Quinoline complexes get incorporated into
the growing polymer chain
interrupting the Heme Polymerization.
Increased Heme levels exert cidal effects.
17. Pharmacological Effects of Chloroquine
Antimalarial action –
DNA synthesis: disrupts the tertiary structure of
the nucleonic acid in the parasite
Amebicidal action
Anti-inflammatory action –
Antagonizes Histamine and Serotonin;
Inhibits PG effects by inhibiting conversion of
Arachidonic Acid to PG F2.
Inhibits Chemotaxis of:
Polymorphonuclear Leukocytes, Macrophages, and
Eosinophils.
18. CLINICAL USES of CHLOROQUINE:
Treatment and Chemoprophylaxis of:
Malaria, Acute Attack of Malaria,
Extraintestinal Amebiasis
Rheumatoid Arthritis, Lupus Erythematosus
DOSAGE of CHINGAMIN
SUPPRESSIVE IN ACUTE ATTACK:
Initial dose 1 g followed by 0.5 g after 6 hours and
0.5 g daily thereafter for 2 days followed
by 0.5 g once a week for 3 months.
SUPPRESSIVE PROPHYLAXIS:
0.5 g PO on same day once weekly beginning
2 weeks prior to exposure
Adverse effects: skin reactions, dyspepsia,
depigmentation and loss of hair, retinopathy,
bone-marrow suppression.
19. Quinine is the levo rotatory alkaloid
obtained from Cinchona Bark.
It is an erythrocyte schizontocide
for all species of plasmodia and useful
only as suppressive;
less effective and more toxic than chloroquine.
CINCHONISM: resembles SALICYLISM :
ringing in the ears, headache, GI distress, cardiovascular effects
(hypotension, collapse, conduction disturbances), tinnitus,
deafness, vertigo, blurred vision, disturbances of colour vision,
photophobia and total blindness;
skin rashes, seizures, and delirium.
Death may occur due to respiratory arrest.
TREATMENT: gastric lavage,
fluid and electrolyte replacement, artificial respiration,
stabilization of hemodynamics and renal function.
Anaphylactic reactions may require
Adrenaline, Corticosteroids, and Antihistamines.
20. Chloridine (Pyrimethamine), a pyrimidine derivative
-an Antifolate agent that is frequently employed as a
blood schizontocide to produce a radical cure.
-It also acts as a strong sporontocide in the mosquito’s
gut when the mosquito ingests it with the blood
-Mechanism of action: Inhibits Dihydrofolate Reductase
In contrast to Trimethoprim, it has very poor action on
bacterial dihydrofolate reductase.
Under the influence Pyrimethamine, schizogony of
malarial parasite in blood gradually stops.
At high doses it inhibits Toxoplasma gondii.
Effective against the Erythrocytic Forms but its action
is slow.
Effective against the Pre-Erythrocytic forms,
INEFFECTIVE against the Exo-Erythrocytic forms.
21. II. TISSUE SCHIZONTICIDAL AGENTS
Chloridine (Pyrimethamine) is referred to drugs
suppressing the PRE-ERYTHROCYTIC forms,,
but it is ineffective against the Exo-erythrocytic forms.
ONLY the 8-aminoquinolines -
Primaquine, Tafenoquine are effective against
the EXO-ERYTHROCYTIC forms
Radical cure – by acting on the parasites in the Liver:
Destroy GAMETOCYTES and SPREAD of INFECTION.
Primaquine differs from other antimalarials in having
a marked effect on primary as well as secondary tissue
phases of the malarial plasmodium.
It is highly active against Gametocytes and Hypnozoites.
22. III. DRUGS for CHEMOPROPHYLAXIS –
block the link between the Exo-Erythrocytic Stage
and the Erythrocytic Stage :
Chloroquine
Mefloquine
Proguanil
Pyrimethamine
Dapsone
Doxycycline
23. IV. DRUGS to PREVENT TRANSMISSION:
Primaquine
Proguanil
Chloridine (Pyrimethamine)
Destroy the GAMETOCYTES,
Preventing Transmission by the Mosquito and
Preventing the Increase of the Human
Reservoir of the Disease
24. CHEMOTHERAPY of AMEBIASIS
I. Effective in any localization of pathological process:
Metronidazole
Tinidazole
II. Amoebicides of direct action, effective only in
intestinal amoebiasis (luminal amoebicides):
Chiniofon
Iodoquinol
III. Amoebicides of indirect action, effective in localization in
intestinal lumen and intestinal wall:
Tetracyclines
IV. Tissue amoebicides, effective in intestinal wall and
liver amoebiasis (tissue/mixed amoebicides):
Emetine hydrochloride
V. Tissue amoebicides, effective mainly in localization of amoebas
in the liver: Chloroquine (Chingamin)
25. Metronidazole kills the trophozoites of
E. histolytica but has no effect on the cysts.
Mechanism of action:
damage to the DNA by toxic oxygen products generated
from the drug by the parasite
Unwanted effects: a metallic, bitter taste in the mouth,
GIT disturbances, CNS symptoms (dizziness, headache,
sensory neuropathies).
The drug interferes with Alcohol Metabolism and
alcohol should be strictly avoided.