Preparation of percent solution and calculation. 2. Preparation of aromatic water. 3. Preparation of syrups. a) Phenobarbitione-Na syrup. b) Chlorpheniramine maleate syrup. c) Promethazine-HCl syrup. d) Iron syrup. 4. Preparation of suspensions a) Paracetamol suspension b) Antacid suspension c) Chalk powder suspension 5. Preparation of emulsion and identification of type of emulsion a) Primary emulsion by dry gum method and wet gum method b) Castor oil emulsion

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Exp. No. 01 Exp. Name Formulation and preparation of pediatric paracetamol oral solution.
Volume- 60 mL (Each 5 ml contains Paracetamol BP 120 mg)
Batch: 5A/5B Date: D D M M Y Y Y Y ID: 0 5 1 6 0 1 0 1 2 5 3
Syrups are sweet, viscous, concentrated aqueous preparations of sugar or sugar substitute with or without
flavours and medicinal substances. The concentration of sugar in syrup should be 66.7% (w/w) according to
BP. Paediatric Paracetamol Oral Solution is a solution containing 2.4% w/v of Paracetamol in a suitable flavoured vehicle.
Formula:
Apparatus:( To be updated as per utilization during formulation in the lab)
1. Beaker 2. Stirrer 3. Electric balance
4. Measuring cylinder 5. Bottle
Calculation:
Recipe: For 60 ml paracetamol syrup
Each 5 ml contains 120 mg of paracetamol BP
Since 5 ml contains 120 mg, thus 60 ml would contain 1440 mg or 1.44 gm paracetamol BP
Method of preparation:
1. Take 1.44 gm Paracetamol in a beaker.
2. Dissolve it by adding 5 ml propylene glycol.
3. Subsequently add 20 ml sucrose syrup & 5 ml glycerin. Mix them properly.
4. Afterwards add 10 ml sorbitol solution.
5. Now add the preservatives; namely 50 mg Methyl Hydroxybenzoate, 5 mg Propyl Hydroxybenzoate
(Better to dissolve in propylene glycol/Glycerin, with some DW).
6. After complete mixing of all the portions, add the flavor& color (e.g. Orange/Raspberry)
7. Later transfer the syrup to a measuring cylinder adjusts the volume to 60 ml by adding purified water.
8. Finally transfer the preparation into a bottle, close properly & label it.
Name of the ingredients Theoretical amount Amount Taken
Paracetamol BP 1.44 gm
Propylene glycol BP 5 ml
Sucrose Syrup (66.7%)BP 20 ml
Sorbitol Solution (70%) BP 10 ml
Glycerin BP 5 ml
Methyl 4-Hydroxybenzoate BP 50 mg / 0.05 gm
Propyl 4-Hydroxybenzoate BP 5 mg / 0.005 gm
Flavor Q.S.
Color Q.S.
Purified water Q.S. up to 60 ml
Remarks
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Department of pharmacy, Nortern University Bangladesh

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Exp. No. 02 Exp. Name
Formulation and preparation of Ferrous Sulphate oral solution.
Volume- 60 mL (Each 5 mL contains Ferrous Sulphate BP 200 mg)
Batch: 5A/5B Date: D D M M Y Y Y Y ID: 0 5 1 6 0 1 0 1 2 5 3
Syrups are concentrated, viscous, aqueous solutions of sugar or a sugar substitute with or without flavors and
medical substances.
Ferrous sulphate is an iron salt which contains elemental iron or ferrous iron and used for the prevention and
treatment of iron deficiency anemia before, during and after pregnancy as well as during lactation.
Formula: For 60 mL Iron syrup- Each 5 mL contains 200 mg of FeSO4
Apparatus:( To be updated as per utilization during formulation in the lab)
1. Beaker 2. Stirrer 3. Electric balance
4. Measuring cylinder 5. Bottle
Calculation:
Method of preparation:
1. Take 2.4 gm ferrous sulphate in a mortar & crush it properly with pestle.
2. Now take 10 mL DW in a 250 mL beaker. Add ascorbic acid and citric acid into it, mix them properly.
3. Afterwards add the ferrous sulphate (previously crushed in step 1) and dissolve in this beaker. Later add 20 mL sucrose
syrup to it.
4. Take 5 mL DW in a 50 mL beaker and add 0.05 gm Methyl Hydroxybenzoate, 0.005 gm Propyl Hydroxybenzoate
and dissolve in it (Better to dissolve in Propylene glycol/Glycerin. Add some DW & then add to the syrup).
Later add 5 mL Sorbitol & 5 mL Glycerin to it and blend them properly.
5. Add this new solution (made in the step 4) to the 250 mL beaker containing ferrous sulphate solution
(obtained in step 3). Blend them appropriately to get a uniform mixture.
6. After homogenous mixing of all the portions, add the flavor & color.
7. Now transfer the syrup in a measuring cylinder, adjust the volume to 60 mL by adding purified water Q.S.
8. Finally transfer the preparation in a bottle, close the bottle properly & label it.
Name of the ingredients Theoretical amount Amount Taken
Ferrous Sulphate BP 2.4 gm
Citric acid BP 200 mg / 0.2 gm
Ascorbic acid 100 mg / 0.1 gm
Sorbitol Solution (70%) BP 5 mL
Sucrose Syrup 20 mL
Methyl 4-Hydroxybenzoate BP 50 mg/ 0.05 gm
Propyl 4-Hydroxybenzoate BP 5 mg/ 0.005 gm
Glycerin BP 5 mL
Flavor Pharma Grade Q.S.
Color FDC Q.S.
Purified Water BP Q.S. to 60 mL
Remarks
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Department of pharmacy, Nortern University Bangladesh

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Exp. No. 03 Exp. Name
Formulation and preparation of Chlorpheniramine oral solution.
Volume- 60 mL (Each 5 mL contains Chlorpheniramine Maleate BP 2 mg)
Batch: 5A/5B Date: D D M M Y Y Y Y ID: 0 5 1 6 0 1 0 1 2 5 3
Syrups are concentrated, viscous, aqueous solutions of sugar or a sugar substitute with or without flavours and
medical substances.
Chlorpheniramine maleate is an antihistamine which reduces allergic vasodilatation and mucosal congestion.
Formula: For 60 mL Chlorphenamine maleate syrup- Each 5 mL contains Chlorphenamine maleate BP 2 mg.
Apparatus:( To be updated as per utilization during formulation in the lab)
1. Beaker 2. Stirrer 3. Electric balance
4. Measuring cylinder 5. Bottle
Calculation:
Method of preparation:
1. At first take 0.024 gm Chlorpheniramine maleate in a 250 mL beaker and dissolve it in 10 mL DW.
2. Afterwards add 20 mL sugar syrup, 6 mL sorbitol solution, 5 mL glycerol, 0.06 gm Na- citrate, 0.08 gm citric
acid, 0.08 gm Methylparaben, 0.008 gm Propylparaben step by step in the Chlorpheniramine maleate solution.
Carefully mix all the ingredients with proper stirring.
3. After uniform blending of all the portions, add the organic flavor and color and mix them appropriately.
4. Later transfer the whole content of the beaker in a 100 mL measuring cylinder and adjust the volume to 60 mL
by the addition of purified water.
5. Finally transfer the preparation in a bottle. Close & label the bottle properly.
Name of the ingredients Theoretical amount Amount Taken
Chlorpheniramine Maleate BP 24 mg / 0.024 gm
Sucrose Syrup BP 20 mL
Glycerin BP 5 mL
Sorbitol Solution (70%) BP 6 mL
Methyl 4-Hydroxybenzoate BP 80 mg / 0.08 gm
Propyl 4-Hydroxybenzoate BP 8 mg / 0.008 gm
Citric Acid BP 80 mg / 0.08 gm
Sodium Citrate BP 60 mg / 0.06 gm
Flavor Q.S.
Color Q.S.
Distilled water Q.S. up to 60 mL
Remarks
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Department of pharmacy, Nortern University Bangladesh

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Exp. No. 04 Exp. Name
Formulation and preparation of Antacid Suspension. Volume- 60 mL
(Each 5 mL contains Aluminum Hydroxide 200 mg and Magnesium Hydroxide 400 mg)
Batch: 5A/5B Date: D D M M Y Y Y Y ID: 0 5 1 6 0 1 0 1 2 5 3
Suspensions are preparations of finely divided drugs in a suitable fluid vehicle.
A gastric antacid is a chemical substance introduced into the stomach for the purpose of lowering the hydrogen
ion concentration, or acidity, of the gastric contents; resulting in an increase in the pH of stomach and
duodenum.
Formula: For 60 mL Antacid Suspension - Each 5 mL contains 200 mg of Al(OH)2 & 400 mg Mg(OH)3
Apparatus:( To be updated as per utilization during formulation in the lab.)
1. Beaker 2. Stirrer 3. Electric balance
4. Measuring cylinder 5. Bottle
Calculation:
Method of preparation:
1. Take 2.4 gm Al (OH) 3 & 4.8 gm Mg(OH)2 in a mortar. Crush them properly and then dissolve them in 10 mL DW
with continuous trituration by pestle in order to get a uniform mixture.
2. Then take 0.4 gm Na-CMC along with 10 mL DW in a 50 mL beaker. Mix it slowly to make uniform mucilage.
3. Now mix the Al(OH)3 & Mg(OH)2 solution (previously made in the step one) and Na-CMC mucilage (from the step
two) in a 250 mL beaker. Appropriately blend these two solutions to get a homogenous mixture.
4. Afterwards add 10 mL Sorbitol solution, 3 mL Glycerine, 0.1 gm Methyl Hydroxybenzoate, 0.01 gm Propyl
Hydroxybenzoate, 0.015 gm Saccharine sodium and 0.05 gm Na-Citrate. Mix them thoroughly with continuous stirring.
5. Finally add organic oil (Flavor) with triturate to mix it with the preparation properly.
6. Take the final solution in a measuring cylinder and adjust the volume to 60 mL by adding sufficient quantity of purified
water.
7. From the cylinder, transfer the final preparation in a well-polished bottle. Finally cork & label the bottle.
Name of the ingredients Theoretical amount Amount Taken
Ferrous Sulphate BP 3.6 gm
Citric acid BP 200 mg / 0.2 gm
Ascorbic acid 100 mg / 0.1 gm
Sorbitol Solution (70%) BP 5 mL
Sucrose Syrup 20 mL
Methyl 4-Hydroxybenzoate BP 50 mg/ 0.05 gm
Propyl 4-Hydroxybenzoate BP 5 mg/ 0.005 gm
Glycerin BP 5 mL
Flavor Pharma Grade Q.S.
Color FDC Q.S.
Purified Water BP Q.S. to 60 mL
Remarks
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Department of pharmacy, Nortern University Bangladesh

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Exp. No. 05 Ex. Name
Formulation and preparation of Metronidazole oral Suspension.
(Each 5 ml contains Benzoyl Metronidazole BP 320 equivalent to Metronidazole BP 200 mg)
Batch: 5A/5B Date: D D M M Y Y Y Y ID: 0 5 1 6 0 1 0 1 2 5 3
Suspension is a dispersion of finely divided, insoluble solid particles (the disperse phase) in a fluid (the
dispersion medium or continuous phase).
Metronidazole oral suspension is a suspension of Metronidazole Benzoate in a suitable flavoured vehicle.
Formula: For 60 mL Metronidazole oral Suspension - Each 5 mL contains Benzoyl Metronidazole BP 320 mg.
Apparatus:( To be updated as per utilization during formulation in the lab.)
1. Beaker 2. Stirrer 3. Electric balance
4. Measuring cylinder 5. Bottle
Calculation:
Method of preparation:
1. Take 0.5 gm of Na-CMC in a clean & dry 50 mL beaker and add 15 mL DW. Carefully stir and allow for proper
swelling to form homogenous mucilage.
2. Take 3.84 gm Benzoyl Metronidazole in a 250 mL beaker and dissolve it in 5 mL propylene glycol with proper
stirring. Then add the previously made Na-CMC mucilage (Step-1) in it.
3. Afterwards add 0.1 mg (0.0001 gm) Na-saccharine, 0.1 gm Methylparaben and 0.01 gm Propylparaben, 0.1 gm Citric
acid & 0.06 gm Na- Citrate to this solution with proper trituration.
4. Later add 20 mL sucrose syrup, 5 mL sorbitol solution and 5 mL glycerin with continuous stirring to obtain proper
homogeneous product.
5. Now add the organic flavor and color and mix them appropriately.
6. Transfer the whole content of beaker in a measuring cylinder and adjust the volume to 60 mL by the addition of
purified water.
7. Finally transfer the preparation in an amber colored glass bottle. Close & label the bottle properly.
Name of the ingredients Theoretical amount Amount Taken
Benzoyl Metronidazole BP 3.84 gm
Na-CMC BP 0.5 gm
Sucrose syrup BP 20 mL
Sorbitol Solution (70%) BP 5 mL
Glycerin/Glycerol BP 5 mL
Methyl 4-Hydroxylbenzoate BP 100 mg / 0.1 gm
Propyl 4-Hydroxbenzoate BP 10 mg / 0.01 gm
Saccharine –Na BP 0.1 mg / 0.0001 gm
Citric acid BP 100 mg / 0.1 gm
Na-Citrate BP 60 mg / 0.06 gm
Propylene glycol 3 drops
Organic flavor Q.S.
Organic color Q.S.
Distilled water Q.S. up to 60 mL
Remarks
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Department of pharmacy, Nortern University Bangladesh

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Exp. No. 06 Exp. Name
Formulation and preparation of Preparation of oil in water (O/W)
emulsion. (Each 5 ml contains 0.5 ml castor oil) Volume-100mL
Batch: 5A/5B Date: D D M M Y Y Y Y ID: 0 5 1 6 0 1 0 1 2 5 3
An emulsion may be defined as two immiscible liquids, one of which is finely subdivided and uniformly
distributed as droplets throughout the other.
Oil in Water emulsion (O/W), the oil is the dispersed phase and water is the dispersion medium. This type of
emulsion is preferable or preferred for internal use because the unpleasant taste & odour is masked by
emulsification. The aqueous phase constitutes > 45% of the total weight.
Formula: For 100 mL Castor oil Emulsion - Each 5 mL contains Castor oil 0.5 mL.
Apparatus:( To be updated as per utilization during formulation in the lab.)
1. Beaker 2. Stirrer 3. Electric balance
4. Measuring cylinder 5. Bottle
Calculation:
Method of preparation:
1. Take thoroughly cleaned and completely dried mortar and pestle. Transfer accurately weighed 2.5 mg acacia in the
mortar.
2. Slowly triturate the acacia by adding small quantity of purified water to obtain uniform mucilage.
3. Now add 10 mL castor oil in small portions with rapid trituration in one direction until a clicking sound is produced
and the product become white or nearly white. At this stage, the emulsion is known as primary emulsion. Later add
Methylparaben to the emulsion.
4. Afterwards add 10 mL sugar syrup and 10 mL sorbitol in small quantities at a time with constant unidirectional
trituration so as to get homogeneous product.
5. Transfer the emulsion in a measuring cylinder and add more vehicles with gentle stirring to produce the final volume
100 mL.
6. After the formation of a uniform emulsion, transfer the preparation in a bottle, close and label the bottle properly.
Name of the ingredients Theoretical amount Amount Taken
Castor oil 10 mL
Acacia 2.5 gm
Sugar syrup 10 mL
Methylparaben 0.2 gm
Sorbitol solution 10 mL
Raspberry oil 1-2 drops or Q.S.
Distilled water Q.S. to 100 mL
Remarks
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Data Sheet
Department of pharmacy, Nortern University Bangladesh