Preparations of mouth wash,gargle, throat pain,ear drop,nasal drip.

1. Sandip institute of
pharamaceutical science
Presented By : Ashish Pathak
Roll. No : 61
Sub : Pharmaceutics – I

2. Topic for preparation
1)Mouthwash
2) Gargle
3)Throat pain
4)Ear drope
5)Nasal drope

3. MOUTHWASH
• What Is Mouthwash ?
Mouthwash Is a Clear Solution Intended For External use to
Deodourised the buccal cavity.
Formulation Table :
Zinc Sulphate and Zinc Chloride Mouthwash I.P :
Sr.No Name Of
Ingredient
Quantity
Given
Quantity
taken
Roll Of
Ingredients
1) Zncl 2gm 0.4gm Astringent
2) ZnSO4 1gm 0.2gm Desanitizer
3) Compound
Tartarizine
Solution
1ml 0.2ml Colouring Agent
4) Dil.Hcl 1ml 0.2ml Remove Terbidity
5) Chloroform
H2O
50ml 10ml Preservative

4. Procedure
• Dissolve Zinc Sulphate and zinc chloride in 10ml.
• Add Dil.Hcl to get clear solution.
• Add chloroform to h2o and tartrazine solution and mix
well.
• Rinse the beaker with h20 and filter it in the same
solution.
• Adjust final volume with remaining water.

5. • Container And Storage :-
Store in tightly closed glass container in
cool place.
• Category :-
Astringent.
• Direction :-
Dilute 20 times with its volume with warm
water for external using.

6. GARGLE
• What is gargle ?
It is a clear solution used in posterior region of
mouth to treat throat infection. It is usually prescribed to
reduce sourness in mild throat infection. Povidone
iodine is a iodine product a complex of iodine and
povidone which is used as a antiseptic solution
povidone. Iodine gargle is clear and red brown solution.

7. Formulation Table
• Povidone iodine gargle (20ml):
Sr. No Name Of
Ingredient
Quantity
Given
Quantity
Taken
Role Of
Ingredient
1) Povidone
Iodine
1ml 0.2ml Antiseptic
2) Ethanol 8.38ml 1.67ml Solvent
3) Glycerin 4ml 0.80ml Viscosity
Enhancing Agent
4) Methyl
Salicylate
0.06ml 0.012ml Local Analgesic
5) Menthol 0.04ml 0.008ml Flavouring Agent
6) Sodium
Saccharate
0.1ml 0.02gm Sweetening
Agent
7) Purified
H2O Upto
100ml 20ml Vehicle

8. Procedure
1) Clean all the glassweare and dry them properly.
2) Dissolve povidone in same portion of purified H2O in
beaker add glycerin menthol and sodium Saccharate in it with
continuous stirring.
3) Dissolve Methyl salicylate in required quantity of ethanol in
separate beaker.
4) Mix both the solution and transfer into measuring cylinder.
5) Makeup volume Upto 20ml by addition of purified H2O
6) Transfer solution in a narrow mouth amber colour bottle and
clothes toughly with polypropylene screw cap label properly
and submit it.

9. • Container and storage
• store in amber colour bottle and
close tightly with the propylene screw cap. Store
below 25 C. Protect from light
• Category
• Antiseptic in management of local
infection of the mouth and oropharynx in dental
surgery
• Direction
• Dilute with equal volume of warm water,
for external use only and not to be swallowed in
large amount

10. THROAT PAINT
• What is a throat paint
• It is viscous liquid
preparation of medicament usually prescribed
to relieve cough , pharyngitis, laryngitis.
• Application of iodine to an inflammed throat for
the treatment , eliminates throat infections, kills
fungus and bacteria and eradicates the
underlying cause of sore throat

11. • Formulation Table :
Iodine throat paint ( mandls paint )1968 IP
Sr. No Name of
ingredients
Qty Given Qty Given Role of ingredient
1) Ki 24gm 0.48gm Solubility enhancer
2) Iodine 12gm 0.24gm Anti bacterial –
inflammation
3) Water 24gm 0.48ml Solvent
4) Alcohol 40ml 0.8ml Co-slvent
5) Peppermint
oil
4ml 0.08ml Flavouring agent
6) Glycerine
Upto
100ml 20ml vehicle

12. PROCEDURE
• Clean all apparatus and glass ware and dry them according to
sop
• Weigh required quantity of iodine an dtransfer into glass
mortar and triturate to get fine powder
• Weigh and dissolve to 20ml by adddition of glycerinerequired
quantity of KI in water
• To this solution add fine powdered iodine with continuous
stirring
• in another beaker containing alcohol (90%) V/v add required
quantity of peppermint oil , add half the quantity of glycerine
• Add this solution to above iodine and KI solution with
continuous stirring
• Pour content into measuring cylinder and make up the
volume
• Transfer content to amber colour wide mouth glass bottle ,

13. • CATEGORY
treatment of laryngitis,
pharyngitis,and follicular tonsillities
• Storage and direction
store in tightly closed
container in cool and dry place
Direction
apply with help of soft brush and
cotton swab, food and water before and after
apllication of thriat paint should be avoided for
one hour

14. EAR DROP
• What is ear drop ?
• These are solution or emulsion of drug in water
, glycerine and propylene glycol instilled into the
ear to remove exceesive wax , to treat infection
of ear to reduce inflammation or pain and for
cleaning of ear.
• Water is not preffered vehocle for ear drop
because it is aimmiscible with fatty secretions
present in the ear and presence of water also
make the ear canal and ideal location og of
growth of bacterial fungi

15. Formulation table
Sodium bicarbonate ear drop (BP)
Sr
no
Name of ingredients Quantity
taken
Role of
ingredients
1 Sodium bicarbonate 5g alkaline
2
3
Glycerine
Freshly boiled and
cooled water upto
30ml
100ml
Viscosity
enhancer
solvent

16. PROCEDURE
• Weigh required amount of sodium bicarbonate
added into sufficient amount of water and mix
well
• Make up the volume upto 70 ml and add
glycerine into it
• CATEGORY- wax softener
• STORAGE AND CONTAINER-plastic bottle inbuilt
with with container and store in cool place
• DIRECTION –for external use only

17. NASAL DROP
• What is a nasal drop?
• it is aqueous or oily solution
of medicament made isotonic with body fluid
instilled in nasal cavity in order to relief
conjation to reduce pain or inflammation and
subsequently pervent further infection in nasal
cavity
• Most commonly antibiotics ,antihistamine,and
symphathomonatic drug used for preparation of
nasal drops

18. Formulation table
• Ephedrine nasal drop (BP)
Name of ingredients Quantitu taken Role of ingredients
1) Ephendrine
hydrochloride
0.5g symphamamonatic
2)Chlor butol 0.5g preservative
3) NaCl 0.5g Tonicity adjusting
agent
4)Freshly boiled and
cooled water upto
100ml vehicle

19. PROCEDURE
• Weigh required amount of ephedrine
hydrochloride added to3/4th volume of water
• Weigh require amount of NaCl added to the
solution of ephedrine hydrochloride and finally
make up the volume with water
• CATEGORY-nasal decongestent
• CONTANER AND STORAGE- store in coloured
flutted bottle fitted with dropper
• DIRECTION –for external use only

20. THANK
You