Pet And Lymphoma
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- Positron emission tomography (PET) scans can help detect residual disease in lymphoma patients who appear to be in complete remission and predict relapse risk. - For Hodgkin's lymphoma, interim PET scans after 2 cycles of chemotherapy can accurately predict treatment outcome and prognosis. - For diffuse large B-cell lymphoma, a positive interim PET scan after 2 cycles is associated with lower event-free survival and overall survival rates compared to a negative scan. PET may help identify patients who would benefit from altered treatment intensity. - Ongoing clinical trials are exploring the use of interim PET results to individualize chemotherapy regimens and determine whether patients should receive high-dose chemotherapy with stem cell transplantation.
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The document provides instructions for a woman on how to properly hold and swing a golf club to hit the ball farther. It suggests holding the club like her husband's erect penis would provide the correct grip and swing, leading to a powerful hit. The instructor praises her hit but notes her grip could be improved by trying it with her hands.
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The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive function. Exercise causes chemical changes in the brain that may help protect against mental illness and improve symptoms for those who already suffer from conditions like depression and anxiety.
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The document discusses the shared missions and collaborations between the American Association for Cancer Research (AACR) and the National Cancer Institute (NCI) to advance cancer research and reduce the burden of cancer. It outlines their joint efforts in conferences, workshops, and think tanks. It also summarizes advances in cancer prevention, early detection, and treatment that have contributed to reduced cancer mortality rates in recent years but challenges remain.
Selective Use Of Postoperative Radiotherapy AftEr MastectOmy
The SUPREMO trial aims to determine whether postmastectomy radiotherapy (PMRT) improves outcomes for women with early-stage breast cancer with 1-3 positive lymph nodes. The trial will randomize approximately 3,500 patients to receive either chest wall irradiation or no chest wall irradiation after mastectomy and systemic therapy. The primary outcome is overall survival, with secondary outcomes including disease-free survival, acute/late morbidity, quality of life, and cost-effectiveness. Results from previous trials suggest PMRT may reduce locoregional recurrence and improve survival, especially for those with more positive nodes, but more evidence is still needed.
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This document describes a one-step model for online planning and treatment of palliative radiotherapy using cone beam CT (CBCT). In phase A, CBCT image quality was found to be adequate for treatment planning. Phase B involved online planning with CBCT for 45 patients, showing good agreement with conventional planning CT. Treatment plans were delivered in an average of 28 minutes from patient arrival. Phase C is ongoing to further test the efficacy of this one-step CBCT planning approach in reducing planning time and improving patient satisfaction compared to conventional multi-step planning CT.
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Full Handwritten notes of RA by Ayush Kumar M pharm - Al ameen college of pha...
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M.pharm - 1st year .The Nervous and Chemical Regulation of Respiration
These lecture slides, by Dr Sidra Arshad, offer a simplified look into the mechanisms involved in the regulation of respiration:
Learning objectives:
1. Describe the organisation of respiratory center
2. Describe the nervous control of inspiration and respiratory rhythm
3. Describe the functions of the dorsal and respiratory groups of neurons
4. Describe the influences of the Pneumotaxic and Apneustic centers
5. Explain the role of Hering-Breur inflation reflex in regulation of inspiration
6. Explain the role of central chemoreceptors in regulation of respiration
7. Explain the role of peripheral chemoreceptors in regulation of respiration
8. Explain the regulation of respiration during exercise
9. Integrate the respiratory regulatory mechanisms
10. Describe the Cheyne-Stokes breathing
Study Resources:
1. Chapter 42, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 36, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 13, Human Physiology by Lauralee Sherwood, 9th edition
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Pictorial and detailed description of patellar instability with sign and symptoms and how to diagnose , what investigations you should go with and how to approach with treatment options . I have presented this slide in my 2nd year junior residency in orthopedics at LLRM medical college Meerut and got good reviews for it
After getting it read you will definitely understand the topic.
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Pet And Lymphoma
- 1. Corinne Haioun Unité Hémopathies Lymphoides Hôpital Henri Mondor Créteil, France PET and Lymphoma
- 4. HD prognostic score: clinical variables Hasenclever d. NEJM 1998; 339:1506
- 5. HD prognostic score: 7y-FFP and OS Hasenclever d. NEJM 1988; 339:1506 7% of the patients
- 7. PET-0: 25.03.04 PET-2: 30.06.04 PET-6: 08.11.04 Gallamini: Hematologica 2006; 91, 475-81 Gallamini: JCO 2007; 25, 3743-52 Hutchings: Blood 2006; 107, 52-59 Kostakoglu: Cancer 2006; 107:2678-87
- 8. H10 Trial Randomisation Favourable Group F Unfavourable Group U Randomisation ABVD 2 cycles ABVD 2 cycles ABVD 2 cycles ABVD 2 cycles FDG- PET FDG- PET FDG- PET ABVD 2 cycles BEACOPP 2 cycles esca IN-RT 30 Gy (+ boost 6 Gy) ABVD 4 cycles 2 cycles BEACOPP esca IN-RT 30 Gy (+ boost 6 Gy) ABVD 2 cycles IN-RT 30 Gy (+boost 6 Gy résiduels) négative positive negative positive The results whatever The results Second registration First registration Hodgkin Lymphoma Stage I/II FDG- PET 1 cycle ABVD IN-RT 30 Gy (+boost 6 Gy résiduals) whatever
- 9. The situation in Diffuse Large B-Cell Lymphoma Weber W: J.Nucl. Med 2007: 48: 1580-82.
- 12. Early treatment evaluation Before treatment At 2 cycles At 4 cycles FDG-PET2 (+) Haioun C, et al. Blood 2005; 106(4): 1376–81
- 13. Early treatment evaluation FDG-PET2 (-) Before treatment At 2 cycles At 4 cycles Haioun C, et al. Blood 2005; 106(4): 1376–81
- 14. Current questions for DLBCL patients Jerusalem et al. Haematologica, 85(6): 613-8 2000; Spaepen et al. Ann Oncol, 13(9): 1356-63 2002; Kostakoglu et al. J Nucl Med, 43(8): 1018-27 2002; Haioun C et al. Blood 2005; 106(4): 1376–81; Mickaeel et al. 2005 Role of PET to individualize treatment ? 2-year outcome Study n PET after . . . PET- PET+ Jerusalem 2000 28 median: 3 cycles 62% (PFS) 0% (PFS) Spaepen 2002 70 median: 3 cycles 85% (PFS) 4% (PFS) Kostakoglu 2002 30 1 cycle 85% (PFS) <15% (PFS) Haioun 2005 90 2 cycles 82% (EFS) 43% (EFS) Michaël 2005 121 median: 2 cycles 87% (PFS) 34% (PFS)
- 15. (High negative predictive value): NPV= TN TN +FN (Low positive predictive value): PPV= TP TP +FP FN FP FDG-PET in DLBCL
- 16. Event-free survival and overall survival according to response at 2 cycles on the basis of PET (n = 90) PET– (n = 54) PET+ (n = 36) Probability of EFS p < 0.0001 Years after randomisation Event-free survival p = 0.006 median f/u: 2 years Overall survival 100 100 0 1 2 3 0 1 2 3 Years after randomisation probability of OS 80 60 40 20 0 80 60 40 20 0 Haioun C, et al. Blood 2005; 106(4): 1376–81 PET– (n = 54) PET+ (n = 36) PPV 50 % NPV 74 % Accuracy 68.5%
- 17. =1g/cm 3 (Bq/g) Activité injectée Poids du corps C* totale = (Bq/g) Activité mesurée Volume du foyer C* tissulaire = C* tissulaire C* totale SUV = Si distribution homogène, SUV = 1 SUV= Ci*( ) dose/poids
- 19. SUV-based Assessment versus Visual Analysis SUV and EFS : Optimal cut-off point of SUVmax reduction: 65.7% (ROC analysis) Lin C, Itti E. JNM 2007; 48:1626-32. PPV 81.3% NPV 75.0% Accuracy 76.1%
- 20. Visual Analysis versus SUV-based Assessment Months After Randomization > 65.7% 65.7% SUV max Reduction P < .0001 Probability of EFS (%) Visual Analysis PET (-) PET (+) P = .009 n=34 n=58 n=76 n=16 Linh C, Itti E. JNM 2007; 48:1626-32.
- 22. Moskowitz et al., Blood 108: Abstract 532, 2006 MSKCC 01-142-DLBCL: Risk Adapted Therapy Transplant-eligible, CS IIX, III or IV age-adjusted IPI 1, 2, or 3 Risk Factors