The document provides guidance on contouring the hippocampus on MRI images for radiation treatment planning. It describes in detail how to contour each section of the hippocampus - the head, body, and tail - on axial MRI slices from inferior to superior. Landmarks used to define the boundaries include the temporal horn of the lateral ventricle, uncal recess, quadrigeminal cistern, and atrium of the lateral ventricle. A 5mm expansion of the hippocampus contour is used to create the hippocampal avoidance zone.
EBCTCG METAANALYSIS
INDICATION OF POST OP RADIOTHERAPY
Immobilization devices
Conventional planning
Alignment of the Tangential Beam with the Chest Wall Contour
Doses To Heart & Lung By Tangential Fields
This document provides contouring and treatment planning guidelines for stereotactic body radiation therapy (SBRT). It discusses indications, contraindications, simulation, target volume delineation, organ at risk contouring, dose prescription, and plan evaluation for SBRT treatment of lung, spine, liver, and other cancers. Key considerations include ensuring accurate tumor targeting given organ motion, minimizing dose to nearby organs at risk, and prescribing ablative doses in a small number of fractions to achieve tumor control.
The document provides guidelines for contouring the clinical target volume (CTV) and organs at risk for carcinoma of the cervix treated with 3D conformal radiation therapy or intensity-modulated radiation therapy. The CTV includes the involved lymph nodes (GTV N) and relevant draining nodal groups. The CTV for the primary tumor (CTV-P) includes the gross tumor, uterus, cervix, parametrium, vagina, and ovaries. Detailed guidelines are provided for contouring the lymph node regions, uterus, vagina, and parametrium. A planning target volume (PTV) is created by adding a 10 mm margin to the total CTV. Additional margins are used to create an
Hypofractionation in early breast cancer is no more a research scholars topic. Multiple studies with robust data have proven its utility. It may hold an important role in many countries with constrained resources. This is a short presentation incorporating important completed and ongoing trials. Feel free to use this.
Prophylactic cranial irradiation (PCI) is used to prevent brain metastases in cancers with a high risk of spreading to the brain. It is indicated for small cell lung cancer and certain leukemias. PCI significantly reduces the rate of brain metastases in small cell lung cancer, especially when administered early at higher doses. For extensive stage small cell lung cancer, MRI surveillance may be an alternative to PCI. While PCI reduces brain metastases in leukemia, the risk of brain involvement is low for some types such as AML. The standard dose for PCI is 1200-1800 cGy in fractions, with timing and volumes depending on the cancer type. Potential toxicities include neurocognitive effects, endocrine disorders, and secondary cancers.
1) The document discusses various radiation techniques for treating cancer of the esophagus including 2D, 3D conformal radiation therapy, IMRT, and IGRT.
2) It covers topics like target volume delineation, field design considerations for different esophageal subsites, and evolution from 2D to 3D treatment planning.
3) While there is no consensus, most contemporary trials use margins of 3-5cm cranially and caudally on the gross tumor with approximately a 2cm radial margin.
1) Radiotherapy plays an important role in managing carcinoma of the cervix by delivering high doses through a combination of external beam radiotherapy and brachytherapy.
2) The disease has central and peripheral components - the central component confined to the cervix is best treated with brachytherapy, while the peripheral component involving surrounding tissues is treated with both external beam radiotherapy and brachytherapy.
3) External beam radiotherapy techniques include 3D conformal radiotherapy and IMRT to improve dose distribution and spare surrounding organs-at-risk.
Dr. Ashutosh Mukherji's document discusses contouring for rectal cancers. It provides guidelines for clinical target volume (CTV) delineation based on international consensus. The CTV should encompass the tumor, mesorectum, presacrum, and lymph node regions depending on tumor stage and location. Proper contouring is important for administering precise radiotherapy doses to treat rectal cancer while avoiding unnecessary radiation to healthy tissues.
EBCTCG METAANALYSIS
INDICATION OF POST OP RADIOTHERAPY
Immobilization devices
Conventional planning
Alignment of the Tangential Beam with the Chest Wall Contour
Doses To Heart & Lung By Tangential Fields
This document provides contouring and treatment planning guidelines for stereotactic body radiation therapy (SBRT). It discusses indications, contraindications, simulation, target volume delineation, organ at risk contouring, dose prescription, and plan evaluation for SBRT treatment of lung, spine, liver, and other cancers. Key considerations include ensuring accurate tumor targeting given organ motion, minimizing dose to nearby organs at risk, and prescribing ablative doses in a small number of fractions to achieve tumor control.
The document provides guidelines for contouring the clinical target volume (CTV) and organs at risk for carcinoma of the cervix treated with 3D conformal radiation therapy or intensity-modulated radiation therapy. The CTV includes the involved lymph nodes (GTV N) and relevant draining nodal groups. The CTV for the primary tumor (CTV-P) includes the gross tumor, uterus, cervix, parametrium, vagina, and ovaries. Detailed guidelines are provided for contouring the lymph node regions, uterus, vagina, and parametrium. A planning target volume (PTV) is created by adding a 10 mm margin to the total CTV. Additional margins are used to create an
Hypofractionation in early breast cancer is no more a research scholars topic. Multiple studies with robust data have proven its utility. It may hold an important role in many countries with constrained resources. This is a short presentation incorporating important completed and ongoing trials. Feel free to use this.
Prophylactic cranial irradiation (PCI) is used to prevent brain metastases in cancers with a high risk of spreading to the brain. It is indicated for small cell lung cancer and certain leukemias. PCI significantly reduces the rate of brain metastases in small cell lung cancer, especially when administered early at higher doses. For extensive stage small cell lung cancer, MRI surveillance may be an alternative to PCI. While PCI reduces brain metastases in leukemia, the risk of brain involvement is low for some types such as AML. The standard dose for PCI is 1200-1800 cGy in fractions, with timing and volumes depending on the cancer type. Potential toxicities include neurocognitive effects, endocrine disorders, and secondary cancers.
1) The document discusses various radiation techniques for treating cancer of the esophagus including 2D, 3D conformal radiation therapy, IMRT, and IGRT.
2) It covers topics like target volume delineation, field design considerations for different esophageal subsites, and evolution from 2D to 3D treatment planning.
3) While there is no consensus, most contemporary trials use margins of 3-5cm cranially and caudally on the gross tumor with approximately a 2cm radial margin.
1) Radiotherapy plays an important role in managing carcinoma of the cervix by delivering high doses through a combination of external beam radiotherapy and brachytherapy.
2) The disease has central and peripheral components - the central component confined to the cervix is best treated with brachytherapy, while the peripheral component involving surrounding tissues is treated with both external beam radiotherapy and brachytherapy.
3) External beam radiotherapy techniques include 3D conformal radiotherapy and IMRT to improve dose distribution and spare surrounding organs-at-risk.
Dr. Ashutosh Mukherji's document discusses contouring for rectal cancers. It provides guidelines for clinical target volume (CTV) delineation based on international consensus. The CTV should encompass the tumor, mesorectum, presacrum, and lymph node regions depending on tumor stage and location. Proper contouring is important for administering precise radiotherapy doses to treat rectal cancer while avoiding unnecessary radiation to healthy tissues.
Contouring in breast cancer current practice and future directions Anil Gupta
Contouring guidelines for breast cancer radiation therapy aim to define target volumes to adequately treat while minimizing toxicity. The RTOG and ESTRO guidelines provide consensus on contouring clinical target volumes (CTVs) for the breast/chest wall, lymph nodes, and organs at risk. However, some recurrences occur outside these guidelines. A study mapping 243 nodal recurrences found most were within RTOG or ESTRO CTVs, but out-of-field recurrences were often in the lateral and posterior supraclavicular region, particularly for young, triple-negative patients. While contouring guidelines provide standardization, individualized risk assessment may be needed to optimize local control versus toxicity.
This is a made easy summary of ICRU 89 guidelines for gynecological brachytherapy. Extra practical questions for MD/DNB Radiotherapy exams are also attached.
SBRT is a precise form of radiation therapy that delivers very high ablative doses of radiation to tumors in a small number of fractions. It has become the standard of care for early stage non-small cell lung cancer (NSC LC) that is not surgically resectable. Key aspects of SBRT planning and delivery include delineating targets and organs at risk on imaging, determining appropriate dose and fractionation based on tumor location, using motion management strategies to account for tumor motion, precise daily image guidance, and ensuring dose constraints are met to minimize risks to critical structures like the spinal cord. SBRT provides superior local tumor control compared to conventional fractionation for early stage NSCLC with a favorable toxicity profile.
This document provides an overview of breast contouring and radiotherapy treatment planning for breast cancer. It discusses contouring the clinical target volume (CTV) and planning target volume (PTV) for the breast or chest wall as well as lymph nodes. It also outlines dose volume histogram constraints for organs at risk. Various radiotherapy techniques are described including 3D conformal radiotherapy, forward planned intensity-modulated radiotherapy, volumetric modulated arc therapy, and prone positioning. Overall, the document provides guidance on delineating targets and organs at risk and generating optimized treatment plans for breast cancer patients.
Hippocampal sparing whole brain radiation therapy- Making a case!VIMOJ JANARDANAN NAIR
- A 58-year-old female nurse presented with headache, nausea, and mental status changes. Imaging showed 3 brain metastases with no known primary site.
- She had a KPS of 90, age <60, controlled primary (pending further workup), and no extracranial mets, placing her in RPA class I and GPA group with a predicted median survival of 7.1-11.3 months.
- Treatment options included WBRT alone or WBRT with boost to reduce risk of neurocognitive toxicity based on the RTOG 0933 trial, which showed reduced memory decline with hippocampal avoidance. Patient selection focused on tumor types likely to benefit and survival duration to gain
This document discusses several clinical trials comparing different treatment approaches for esophageal cancer, including:
- Preoperative chemotherapy improved survival compared to surgery alone in some trials but not in others. High toxicity reduced benefits in some studies.
- Perioperative chemotherapy with fluorouracil and cisplatin significantly improved resection rates, survival, and disease-free survival compared to surgery alone.
- Chemoradiotherapy resulted in improved survival over radiotherapy alone or surgery alone in some trials for resectable esophageal cancer.
- Existing evidence did not clearly show preoperative radiotherapy alone improved survival over surgery alone for resectable esophageal cancer. Larger trials were needed.
Radiotherapy For Non Small Cell Lung Cancerfondas vakalis
- The document discusses treatment options for non-small cell lung cancer (NSCLC), including surgery, radiotherapy, chemotherapy, and combinations.
- For early stage NSCLC (stages I-II), surgery is the standard treatment but radiotherapy is an alternative for medically inoperable patients. Adjuvant chemotherapy may improve outcomes for stage II.
- For locally advanced NSCLC (stage III), combined modality treatment is usually recommended, with concurrent chemoradiotherapy being superior to sequential treatment for stage IIIB.
Stereotactic body radiation therapy (SBRT) uses advanced technology to deliver high ablative doses of radiation to tumors in a precise manner. SBRT has been shown to be effective in treating various tumor types with acceptable toxicity. However, long term toxicity requires further study. New techniques aim to reduce treatment margins and account for organ motion to minimize dose to surrounding healthy tissues while ensuring accurate dose delivery to the tumor. SBRT shows promise but further prospective clinical trials are needed to fully evaluate efficacy and safety.
The document summarizes recommendations from ICRU Report 38 regarding dose specification, reporting, and volumes for intracavitary brachytherapy for gynecological cancers. It discusses:
1. Historical dose reporting systems like milligram-hours and Point A/B and introduces the concept of a reference volume receiving 60Gy.
2. Factors to report like treatment technique, time-dose patterns, and doses to organs at risk.
3. Volumes for reporting like the treated volume, high-dose volume, irradiated volume, and Point A volume.
4. Recommendations for specifying and reporting doses in a standardized way to allow comparison between different brachytherapy procedures
Gastric cancer contouring panel discussion, icc 2017Ashutosh Mukherji
This document provides guidance on contouring for gastric cancers receiving radiotherapy. It discusses:
1) When radiotherapy is indicated such as neoadjuvant, adjuvant, radical or palliative settings.
2) How to define the clinical target volume to include the stomach bed, regional lymph nodes depending on tumor location, and organs at risk like the kidneys, liver and bowel loops.
3) The simulation protocol including patient positioning, CT imaging and capturing essential structures to aid treatment planning.
4) Guidance on target volume margins, overlap with organs at risk and using motion management techniques to improve target coverage and reduce normal tissue doses.
1. Re-irradiation involves delivering a second course of radiation to patients who develop recurrent or new primary tumors in an area previously treated with radiation. It requires careful patient selection and consideration of normal tissue tolerance to minimize toxicity risks.
2. A multidisciplinary evaluation is necessary to determine if re-irradiation provides a survival or palliative benefit over other treatment options like chemotherapy or surgery. Factors like tumor type, initial treatment details, disease control, and patient performance status must be considered.
3. Advanced radiation techniques like IMRT can help spare nearby organs-at-risk and lower toxicity when used for re-irradiation. Close monitoring during treatment is still needed to watch for normal tissue complications.
Hypofractionated Radiation Therapy in Breast CancerDr.Ram Madhavan
This document discusses hypofractionation in breast cancer radiotherapy. It provides rationale for adjuvant whole breast irradiation after breast-conserving surgery based on evidence from clinical trials. It reviews current evidence from trials comparing conventional fractionation to hypofractionated schedules, which found no disadvantage to hypofractionation in terms of safety and efficacy. The document discusses implications of breast cancer's low alpha-beta ratio for sensitivity to high dose per fraction. It reviews patient factors, outcomes, and guidelines for suitable patients for hypofractionation based on the evidence. The author's own experience at their institution adopting hypofractionation is presented, showing comparable results to trials.
HOLISTIC APPROACH IN WHOLE BRAIN RADIATION IN BRAIN METSKanhu Charan
1. Whole brain radiotherapy is commonly used to treat brain metastases but can cause long-term side effects like memory loss and decreased quality of life.
2. A new study aims to spare structures like the hippocampus, cochlea, and parotid glands using IMRT and VMAT to reduce side effects while maintaining tumor coverage.
3. Dosimetry results found that IMRT and VMAT reduced hippocampal, parotid, and cochlear doses by 45-82% compared to conventional radiotherapy, allowing for improved quality of life.
This document summarizes key landmark clinical trials in breast cancer. It discusses trials related to prevention using tamoxifen and raloxifene, radiation therapy trials for DCIS and early stage breast cancer, breast-conserving therapy including accelerated whole-breast irradiation, neoadjuvant chemotherapy trials, and HER2 targeted neoadjuvant therapy trials. The trials demonstrated the effectiveness of tamoxifen and radiation therapy in breast cancer prevention and treatment, and showed that hypofractionated radiation regimens and partial breast irradiation are not inferior to standard radiation protocols. Neoadjuvant chemotherapy was found to increase breast-conserving surgery rates and pathologic complete response rates. Dual HER2 blockade neoadjuvant regim
Stereotactic body radiotherapy (SBRT) delivers high-dose radiation to tumors in a small number of fractions using high precision. For prostate SBRT, the target and organs at risk are contoured on planning CT. A dose of 35-38Gy in 5 fractions is used as primary treatment for low risk prostate cancer. Rigid image guidance and intrafraction monitoring are important to minimize setup errors. ExacTrac X-ray positioning co-registers X-rays with digitally reconstructed radiographs and corrects for rotational and translational deviations, achieving sub-millimeter accuracy. This allows safe dose escalation for prostate SBRT.
This document discusses hemi body irradiation (HBI) technique used to treat metastatic cancer. HBI involves irradiating only the upper or lower half of the body using parallel opposed radiation fields. It has advantages over total body irradiation like smaller field size and less side effects. HBI is used to palliate widely metastatic disease and as adjuvant therapy for certain cancers. Potential complications include nausea, diarrhea, pneumonitis and hematological effects. The document also provides an overview of cancer registries in India, which systematically collect cancer data to help understand cancer patterns and guide control programs. Population-based and hospital-based registries use active and passive methods to collect data on cancer incidence, stages and survival.
This document discusses reirradiation in recurrent head and neck cancer. It notes that radiation therapy plays a central role in head and neck cancer treatment but recurrence still occurs in 20-35% of patients. Reirradiation presents challenges due to prior radiation exposure and damage to normal tissues. The document discusses treatment options, appropriate patient selection, techniques like IMRT to minimize dose to organs at risk, optimal timing and dosing of reirradiation, and management of toxicities.
DR RAJ BUMIYA'S THYROID LESIONS USG - ULTRASONOGRAPHYRaj Bumiya
MOB NO. 09978345496 ULTRASONOGRAPHY FEATURES OF NORMAL ANATOMY OF THYROID , CHARACTERISTICS OF VARIOUS NODULAR AND DIFFUSE THYROID DISEASES ( LESIONS )
This document provides an overview of radiology of the spinal cord. It begins with an introduction and outlines the topics to be covered, including anatomy of the spinal cord and vertebral column, various radiological investigations such as plain X-rays, myelograms, CT, CT myelograms, and MRI. It then describes the anatomy of the spinal cord and vertebral bones, different radiological methods, and provides examples of the radiological presentation of some spinal cord diseases such as disk herniation, infection, fracture-dislocation, and spinal cord injury.
Contouring in breast cancer current practice and future directions Anil Gupta
Contouring guidelines for breast cancer radiation therapy aim to define target volumes to adequately treat while minimizing toxicity. The RTOG and ESTRO guidelines provide consensus on contouring clinical target volumes (CTVs) for the breast/chest wall, lymph nodes, and organs at risk. However, some recurrences occur outside these guidelines. A study mapping 243 nodal recurrences found most were within RTOG or ESTRO CTVs, but out-of-field recurrences were often in the lateral and posterior supraclavicular region, particularly for young, triple-negative patients. While contouring guidelines provide standardization, individualized risk assessment may be needed to optimize local control versus toxicity.
This is a made easy summary of ICRU 89 guidelines for gynecological brachytherapy. Extra practical questions for MD/DNB Radiotherapy exams are also attached.
SBRT is a precise form of radiation therapy that delivers very high ablative doses of radiation to tumors in a small number of fractions. It has become the standard of care for early stage non-small cell lung cancer (NSC LC) that is not surgically resectable. Key aspects of SBRT planning and delivery include delineating targets and organs at risk on imaging, determining appropriate dose and fractionation based on tumor location, using motion management strategies to account for tumor motion, precise daily image guidance, and ensuring dose constraints are met to minimize risks to critical structures like the spinal cord. SBRT provides superior local tumor control compared to conventional fractionation for early stage NSCLC with a favorable toxicity profile.
This document provides an overview of breast contouring and radiotherapy treatment planning for breast cancer. It discusses contouring the clinical target volume (CTV) and planning target volume (PTV) for the breast or chest wall as well as lymph nodes. It also outlines dose volume histogram constraints for organs at risk. Various radiotherapy techniques are described including 3D conformal radiotherapy, forward planned intensity-modulated radiotherapy, volumetric modulated arc therapy, and prone positioning. Overall, the document provides guidance on delineating targets and organs at risk and generating optimized treatment plans for breast cancer patients.
Hippocampal sparing whole brain radiation therapy- Making a case!VIMOJ JANARDANAN NAIR
- A 58-year-old female nurse presented with headache, nausea, and mental status changes. Imaging showed 3 brain metastases with no known primary site.
- She had a KPS of 90, age <60, controlled primary (pending further workup), and no extracranial mets, placing her in RPA class I and GPA group with a predicted median survival of 7.1-11.3 months.
- Treatment options included WBRT alone or WBRT with boost to reduce risk of neurocognitive toxicity based on the RTOG 0933 trial, which showed reduced memory decline with hippocampal avoidance. Patient selection focused on tumor types likely to benefit and survival duration to gain
This document discusses several clinical trials comparing different treatment approaches for esophageal cancer, including:
- Preoperative chemotherapy improved survival compared to surgery alone in some trials but not in others. High toxicity reduced benefits in some studies.
- Perioperative chemotherapy with fluorouracil and cisplatin significantly improved resection rates, survival, and disease-free survival compared to surgery alone.
- Chemoradiotherapy resulted in improved survival over radiotherapy alone or surgery alone in some trials for resectable esophageal cancer.
- Existing evidence did not clearly show preoperative radiotherapy alone improved survival over surgery alone for resectable esophageal cancer. Larger trials were needed.
Radiotherapy For Non Small Cell Lung Cancerfondas vakalis
- The document discusses treatment options for non-small cell lung cancer (NSCLC), including surgery, radiotherapy, chemotherapy, and combinations.
- For early stage NSCLC (stages I-II), surgery is the standard treatment but radiotherapy is an alternative for medically inoperable patients. Adjuvant chemotherapy may improve outcomes for stage II.
- For locally advanced NSCLC (stage III), combined modality treatment is usually recommended, with concurrent chemoradiotherapy being superior to sequential treatment for stage IIIB.
Stereotactic body radiation therapy (SBRT) uses advanced technology to deliver high ablative doses of radiation to tumors in a precise manner. SBRT has been shown to be effective in treating various tumor types with acceptable toxicity. However, long term toxicity requires further study. New techniques aim to reduce treatment margins and account for organ motion to minimize dose to surrounding healthy tissues while ensuring accurate dose delivery to the tumor. SBRT shows promise but further prospective clinical trials are needed to fully evaluate efficacy and safety.
The document summarizes recommendations from ICRU Report 38 regarding dose specification, reporting, and volumes for intracavitary brachytherapy for gynecological cancers. It discusses:
1. Historical dose reporting systems like milligram-hours and Point A/B and introduces the concept of a reference volume receiving 60Gy.
2. Factors to report like treatment technique, time-dose patterns, and doses to organs at risk.
3. Volumes for reporting like the treated volume, high-dose volume, irradiated volume, and Point A volume.
4. Recommendations for specifying and reporting doses in a standardized way to allow comparison between different brachytherapy procedures
Gastric cancer contouring panel discussion, icc 2017Ashutosh Mukherji
This document provides guidance on contouring for gastric cancers receiving radiotherapy. It discusses:
1) When radiotherapy is indicated such as neoadjuvant, adjuvant, radical or palliative settings.
2) How to define the clinical target volume to include the stomach bed, regional lymph nodes depending on tumor location, and organs at risk like the kidneys, liver and bowel loops.
3) The simulation protocol including patient positioning, CT imaging and capturing essential structures to aid treatment planning.
4) Guidance on target volume margins, overlap with organs at risk and using motion management techniques to improve target coverage and reduce normal tissue doses.
1. Re-irradiation involves delivering a second course of radiation to patients who develop recurrent or new primary tumors in an area previously treated with radiation. It requires careful patient selection and consideration of normal tissue tolerance to minimize toxicity risks.
2. A multidisciplinary evaluation is necessary to determine if re-irradiation provides a survival or palliative benefit over other treatment options like chemotherapy or surgery. Factors like tumor type, initial treatment details, disease control, and patient performance status must be considered.
3. Advanced radiation techniques like IMRT can help spare nearby organs-at-risk and lower toxicity when used for re-irradiation. Close monitoring during treatment is still needed to watch for normal tissue complications.
Hypofractionated Radiation Therapy in Breast CancerDr.Ram Madhavan
This document discusses hypofractionation in breast cancer radiotherapy. It provides rationale for adjuvant whole breast irradiation after breast-conserving surgery based on evidence from clinical trials. It reviews current evidence from trials comparing conventional fractionation to hypofractionated schedules, which found no disadvantage to hypofractionation in terms of safety and efficacy. The document discusses implications of breast cancer's low alpha-beta ratio for sensitivity to high dose per fraction. It reviews patient factors, outcomes, and guidelines for suitable patients for hypofractionation based on the evidence. The author's own experience at their institution adopting hypofractionation is presented, showing comparable results to trials.
HOLISTIC APPROACH IN WHOLE BRAIN RADIATION IN BRAIN METSKanhu Charan
1. Whole brain radiotherapy is commonly used to treat brain metastases but can cause long-term side effects like memory loss and decreased quality of life.
2. A new study aims to spare structures like the hippocampus, cochlea, and parotid glands using IMRT and VMAT to reduce side effects while maintaining tumor coverage.
3. Dosimetry results found that IMRT and VMAT reduced hippocampal, parotid, and cochlear doses by 45-82% compared to conventional radiotherapy, allowing for improved quality of life.
This document summarizes key landmark clinical trials in breast cancer. It discusses trials related to prevention using tamoxifen and raloxifene, radiation therapy trials for DCIS and early stage breast cancer, breast-conserving therapy including accelerated whole-breast irradiation, neoadjuvant chemotherapy trials, and HER2 targeted neoadjuvant therapy trials. The trials demonstrated the effectiveness of tamoxifen and radiation therapy in breast cancer prevention and treatment, and showed that hypofractionated radiation regimens and partial breast irradiation are not inferior to standard radiation protocols. Neoadjuvant chemotherapy was found to increase breast-conserving surgery rates and pathologic complete response rates. Dual HER2 blockade neoadjuvant regim
Stereotactic body radiotherapy (SBRT) delivers high-dose radiation to tumors in a small number of fractions using high precision. For prostate SBRT, the target and organs at risk are contoured on planning CT. A dose of 35-38Gy in 5 fractions is used as primary treatment for low risk prostate cancer. Rigid image guidance and intrafraction monitoring are important to minimize setup errors. ExacTrac X-ray positioning co-registers X-rays with digitally reconstructed radiographs and corrects for rotational and translational deviations, achieving sub-millimeter accuracy. This allows safe dose escalation for prostate SBRT.
This document discusses hemi body irradiation (HBI) technique used to treat metastatic cancer. HBI involves irradiating only the upper or lower half of the body using parallel opposed radiation fields. It has advantages over total body irradiation like smaller field size and less side effects. HBI is used to palliate widely metastatic disease and as adjuvant therapy for certain cancers. Potential complications include nausea, diarrhea, pneumonitis and hematological effects. The document also provides an overview of cancer registries in India, which systematically collect cancer data to help understand cancer patterns and guide control programs. Population-based and hospital-based registries use active and passive methods to collect data on cancer incidence, stages and survival.
This document discusses reirradiation in recurrent head and neck cancer. It notes that radiation therapy plays a central role in head and neck cancer treatment but recurrence still occurs in 20-35% of patients. Reirradiation presents challenges due to prior radiation exposure and damage to normal tissues. The document discusses treatment options, appropriate patient selection, techniques like IMRT to minimize dose to organs at risk, optimal timing and dosing of reirradiation, and management of toxicities.
DR RAJ BUMIYA'S THYROID LESIONS USG - ULTRASONOGRAPHYRaj Bumiya
MOB NO. 09978345496 ULTRASONOGRAPHY FEATURES OF NORMAL ANATOMY OF THYROID , CHARACTERISTICS OF VARIOUS NODULAR AND DIFFUSE THYROID DISEASES ( LESIONS )
This document provides an overview of radiology of the spinal cord. It begins with an introduction and outlines the topics to be covered, including anatomy of the spinal cord and vertebral column, various radiological investigations such as plain X-rays, myelograms, CT, CT myelograms, and MRI. It then describes the anatomy of the spinal cord and vertebral bones, different radiological methods, and provides examples of the radiological presentation of some spinal cord diseases such as disk herniation, infection, fracture-dislocation, and spinal cord injury.
This document provides an overview of radiology of the spinal cord. It begins with an introduction and outlines the topics to be covered, including anatomy of the spinal cord and vertebral column, various radiological investigations such as plain X-rays, myelograms, CT, CT myelograms, and MRI. It then describes the anatomy of the spinal cord and vertebral bones, different radiological methods, and provides examples of the radiological presentation of some spinal cord diseases such as disk herniation, infection, fracture-dislocation, and spinal cord injury.
Mixed intraosseous haemangioma of rib a rare entityJyotindra Singh
A 25-year-old female presented with upper back pain and shortness of breath. Imaging showed an osteolytic lesion involving the left second rib. The lesion showed heterogeneous enhancement on CT with peripheral calcification. Angiography demonstrated a vascular tumor. The rib lesion was excised and found to be a mixed capillary and cavernous hemangioma, a rare entity. Hemangiomas rarely involve the ribs and can be misdiagnosed due to variable imaging appearances. Complete resection is often curative for symptomatic rib hemangiomas.
The document discusses the anatomy, imaging appearance, and pathologies of the buccal space. It describes the buccal space as a deep facial space bounded by muscles and containing the parotid duct and minor salivary glands. A variety of developmental lesions, infections, neoplasms and other conditions can involve the buccal space. The document outlines the imaging characteristics of common benign and malignant tumors, such as pleomorphic adenoma and adenoid cystic carcinoma, as well as infectious processes and metastatic diseases that may affect this region.
This document discusses imaging in medial temporal lobe epilepsy. It begins by explaining why MRI is important for detecting epileptogenic lesions in refractory cases. It then describes the anatomy of medial temporal lobe structures like the hippocampus and amygdala. The document discusses how hippocampal sclerosis appears on MRI, including features like gliosis, neuronal loss, and atrophy. It also covers other imaging modalities that can help lateralize the seizure focus, such as hippocampal volumetry, relaxometry, MRS, PET, and SPECT. In conclusion, MRI is the best way to diagnose mesial temporal sclerosis by identifying hippocampal hyperintensity and atrophy.
This document discusses several new and emerging technologies in radiology, including pocket ultrasound devices, optical probes to detect tumor outlines in real time, portable CT scanners, intraoperative CT and MRI, microMRI, diffusion tensor imaging to visualize white matter tracts, live 3D holographic imaging for use in interventional cardiology, MRI spectroscopy to analyze tissue chemicals, ultra-high field MRI to map electromagnetic properties of the brain, high-frequency ultrasound to image the skin, nanoparticle-based contrast agents, PET/CT and PET/MRI scanners, xeroradiography, inter-species radiology applications, using imaging for non-destructive testing in aviation, and virtual autopsy with various imaging modalities as a
1. Paragangliomas arise from paraganglia tissue located along blood vessels and nerves throughout the body. In the head and neck region, they include carotid body tumors, jugulotympanic paragangliomas (glomus jugulare tumors), and vagal paragangliomas.
2. Jugulotympanic paragangliomas arise from paraganglia located near the jugular bulb in the temporal bone. They typically present with cranial nerve deficits or a mass in the middle ear/mastoid region.
3. Diagnosis involves imaging such as CT or MRI to identify the location and extent of the tumor. Genetic testing may be pursued
Rad Seminar CHEST IMAGING By Dr Siraj.pptxImanuIliyas
The document provides an overview of chest radiographic anatomy and an approach to interpreting chest x-rays (CXRs). It discusses the normal anatomy seen on CXRs including the lungs, heart, blood vessels, trachea, bronchi, ribs and diaphragm. CT anatomy is also reviewed. The presentation outlines a systematic approach to interpreting CXRs which involves identifying structures, assessing technical adequacy, and interpreting findings based on knowledge of normal radiographic anatomy.
RADIOLOGICAL ANATOMY OF THE PITUITARY GLAND AND TECHNIQUES.pptxmuhammadibrahim759561
MRI is used to image the pituitary gland and sella turcica. It provides excellent soft tissue contrast and thin slice images in multiple planes without radiation. Contrast enhancement helps delineate the pituitary gland and abnormalities. The normal pituitary gland appears isointense on T1 and T2 weighted images and enhances with contrast. The posterior lobe appears hyperintense without contrast due to its protein content. MRI is contraindicated in patients with implants but otherwise has no radiation risk.
Presentation1 radiological imaging of carpal tunnel syndrome.Abdellah Nazeer
- Carpal tunnel syndrome results from compression of the median nerve as it passes through the carpal tunnel in the wrist. It commonly occurs between ages 36-60 and is more frequent in women. Symptoms include pain, numbness, and tingling in the hand.
- Ultrasound and MRI are useful imaging modalities. Ultrasound can show bowing of the flexor retinaculum, flattening and swelling of the median nerve. MRI also demonstrates these findings and can detect additional causes like masses or arthritic changes.
- Various pathologies can cause carpal tunnel syndrome by decreasing the size of the tunnel or enlarging its contents, compressing the median nerve. Imaging allows visualization
This document discusses imaging techniques for evaluating Developmental Dysplasia of the Hip (DDH), including radiography, CT, MRI, ultrasound, and arthrography. Key imaging findings are described, such as the Hilgenreiner's line, Perkin's line, Tonnis grading of hip dysplasia, Andren von Rosen line, acetabular index, Shenton's line, CE angle of Wrisberg, alpha and beta angles on ultrasound, and the Kashiwagi classification on MRI. The document provides an overview of the anatomy and measurements used to classify and assess the severity of DDH.
This study examined the anatomy of the right coronary artery (RCA) in 158 pig hearts. The proximal diameter of the RCA was on average 3.85 mm. The posterior interventricular branch reached the cardiac apex in 49.3% of cases. The sinoatrial node branch and atrioventricular node branch originated from the RCA in all specimens. There was agreement with prior studies regarding the origin of these branches from the RCA. Knowledge of the anatomy and measurements of the RCA and its branches in pigs is relevant for modeling cardiovascular procedures and interventions.
A 5 year old male Labrador dog presented with anorexia and greenish black vomition for 6 days. Hematological tests showed elevated white blood cells with neutrophilia. Radiographs revealed a hyperechoic foreign body in the stomach and bile regurgitation. Endoscopy confirmed a stone in the stomach causing severe gastritis. The dog underwent jejunotomy to remove the foreign body.
This document summarizes guidelines developed by a consensus of expert pediatric radiation oncologists for target volume delineation for craniospinal irradiation in children. It describes in detail the recommended delineation of the cranial and spinal clinical target volumes to encompass the entire arachnoid space and extensions of cerebrospinal fluid along cranial nerves and nerve roots. Potential organs at risk are also outlined. The goal is to promote standardization when using high-precision photon and proton radiotherapy techniques to minimize the risk of marginal recurrence.
This study analyzed the anatomy and measurements of the right coronary artery (RCA) in 158 pig hearts. The proximal diameter of the RCA was on average 3.85 mm. In most cases (63.3%), the right branch of the cone originated from the RCA, and in some cases (5.1%) directly from the aorta. The posterior interventricular branch reached the cardiac apex in 49.3% of cases. The sinoatrial node branch and atrioventricular node branch always originated from the RCA. Knowledge of the anatomy and measurements of the RCA and its branches in pigs is relevant for designing cardiovascular models and procedures.
Radiology of ear - DR. ROHIT BHARDWAJ.pptxRohit Bhardwaj
This document describes the history and evolution of different x-ray views used to image the temporal bone, as well as the development and use of computed tomography (CT) for temporal bone imaging. It provides details on key x-ray views developed between 1906-1926 by Drs. Law, Schuller, Stenver and Town. It then discusses the invention of CT by Hounsfield in 1972 and how CT revolutionized temporal bone imaging by allowing multiplanar reformats. The document outlines anatomical structures visible on different CT projections and imaging windows.
This document discusses the evaluation and diagnosis of neck masses in children through imaging. It begins by stating that most neck masses in children are benign and congenital or inflammatory in origin. It then describes the various imaging modalities used to evaluate neck masses in children, including ultrasound, CT, MRI, and nuclear medicine imaging. The rest of the document focuses on discussing the imaging appearance and characteristics of common cystic and solid neck masses seen in children, including thyroglossal duct cysts, branchial apparatus cysts, dermoid cysts, lipomas, and lymphatic malformations. The goal of imaging is to determine the extent of disease and suggest a differential diagnosis to guide appropriate patient management.
April 2024 ONCOLOGY CARTOON by DR KANHU CHARAN PATROKanhu Charan
This document appears to be a newsletter or e-book with summaries of oncology research articles and case studies from March 2024 to mid-April 2024. It includes summaries on topics like radiotherapy dosing in head and neck cancer, genetic factors in breast cancer treatment, algorithms for surveillance of colorectal polyps, emerging tracers in neuro-oncology, target delineation workflows for various cancer sites, radiation therapy options for pituitary adenoma, comparisons of APBI guidelines for breast cancer, and associations between Chlamydia psittaci and orbital MALT lymphoma. The document also notes that April is National Oral Cancer Awareness Month.
TARGET DELINEATION OF THORACIC NODAL. STATIONKanhu Charan
The document discusses the different thoracic nodal stations that are relevant for staging lung cancer. It lists 24 different nodal station groups in the thoracic region, including supraclavicular, upper paratracheal, prevertebral, lower paratracheal, subaortic, para aortic, carinal, paraesophageal, and hilar nodal stations. Accurate identification of involved nodal stations is important for determining the stage and treatment planning for lung cancer patients.
TARGET DELINEATION IN RECTUM CANCER BY DR KANHUKanhu Charan
This document outlines the workflow for target delineation in radiation oncology for carcinoma of the rectum. It defines the gross tumor volume for the primary tumor (GTVp) and involved nodes (GTVn), as well as the clinical target volumes (CTVs) which add margins around the GTVs to cover microscopic disease. It describes the borders of the mesorectum and lists the lymph node regions included in the CTV for involved nodes. It concludes by specifying the planning target volumes (PTVs) which expand the CTVs and listing the dose schedules.
TARGET DELINEATION IN ANAL CANAL CANCER BY DR KANHUKanhu Charan
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TARGET DELINEATION IN VULVAL CANCER BY DR KANHUKanhu Charan
The document outlines the steps and guidelines for target delineation in vulval cancer radiation therapy planning. It discusses delineating the gross tumor volume (GTV), clinical target volume (CTV), organs at risk (OAR), and planning target volume (PTV). Specific guidelines are provided for contouring depending on the location and extent of the primary tumor, including the vulva, mons pubis, vagina, anorectum, urethra, and clitoris. Radiation dose parameters and OAR constraints are also reviewed. The target delineation workflow aims to adequately cover suspected disease while minimizing dose to surrounding healthy tissues.
TARGET DELINEATION IN CERVIX CANCER BY DR KANHUKanhu Charan
This document outlines the 10 step workflow for target delineation in cervical cancer radiotherapy treatment planning. It describes the clinical target volumes that should be contoured for the primary gross tumor (GTVp), primary clinical target (CTVp), nodal gross tumor (GTVn), nodal clinical targets (CTVn) and elective nodal volumes. It provides explanations and guidelines for delineating each target volume, including the parametrium and nodal regions. Diagrams and images are included to illustrate the anatomical locations and boundaries of the target volumes.
Oncology cartoons by Dr Kanhu Charan PatroKanhu Charan
This document provides guidance on target volume delineation for vulval cancer from the Royal College of Radiologists. It outlines the clinical target volume (CTV) for different disease sites, including the vulva, mons pubis, vagina, anorectum, urethra and pelvic nodes. Contouring workflows and organ-at-risk constraints are also discussed. Recommendations are given for radiation dose and treatment of resectable and unresectable head and neck cancer. The final item notes that smoking increases the risk of kidney cancer.
RADIATION THERAPY IN BILIARY TRACT CANCERKanhu Charan
This document provides information on biliary tract cancers and the role of chemoradiotherapy in their treatment. It discusses the anatomy and types of biliary cancers, risk factors, presentation, diagnosis, staging, and standard treatment approaches including surgery. It then focuses on the evidence and guidelines for use of radiation therapy, including as adjuvant therapy after surgery for positive margins or nodes, as radical/definitive therapy for unresectable disease, and for palliation of symptoms from local or metastatic disease. Key findings are that chemoradiation improves local control and survival as adjuvant or radical therapy, and brachytherapy and external beam radiation are effective for palliation. Optimal regimens involve fluorouracil or capec
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Dr Kanhu Charan Patro provides summaries of statistical concepts in 3 sentences or less, beginning each summary with the date. Summaries from January 19th to February 15th are presented, covering topics such as p-values, censoring in survival analysis, hazard ratios, and ISRS guidelines for stereotactic radiosurgery. On February 15th, a 3 sentence summary of World Cancer Day is provided, noting the date it is held, the organization that leads it, and the 2024 slogan of "Close the care gap".
Molecular Profile of Endometrial cancer.Kanhu Charan
The document discusses molecular analysis and classification of endometrial cancer, which impacts staging and treatment decisions. It describes aggressive histological subtypes and how molecular markers like POLE mutations, MMRd, and p53 abnormalities determine low, intermediate, or high risk stratification. Ongoing PORTEC trials are exploring the impact of molecular profiling on adjuvant treatment, with POLE mutations potentially downstaging while p53 mutations upstage disease. Molecular analysis provides predictive significance for personalized adjuvant therapies in endometrial cancer.
ONCOLOGY CARTOONS JANUARY 2024 BY DR KANHU CHARAN PATROKanhu Charan
This document discusses cervical cancer awareness month in January and provides 3 recommendations: 1) Be loyal to your partner to reduce risk of HPV infection, 2) Maintain genital hygiene, 3) Get vaccinated against HPV to prevent cervical cancer, and 4) Get screened regularly to detect cervical cancer early.
TYPES OF STATISTICAL DATA BY DR KANHU CHARAN PATROKanhu Charan
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WHY STEREOTATXY IN CRANIAL AVM / DR KANHU CHARAN PATROKanhu Charan
This document discusses stereotactic radiosurgery (SRS) for the treatment of cerebral arteriovenous malformations (AVMs). It begins by explaining what an AVM is and the risks they pose if untreated, such as bleeding in the brain. It then covers treatment options for AVMs and why SRS is often preferred for certain cases, such as when the AVM is in an eloquent or deep brain area. The document provides details on patient selection, imaging and planning for SRS, anticipated outcomes, and risks of treatment complications. It emphasizes the importance of multidisciplinary discussion and informed consent when determining if SRS is appropriate for a patient's individual AVM.
1) SBRT is an effective treatment for hepatocellular carcinoma (HCC) patients with portal vein tumor thrombosis (PVTT). In a study of 70 HCC patients with PVTT treated with SBRT, median survival was 10 months and 6-month and 12-month survival rates were 67.3% and 40% respectively.
2) Patients who received SBRT combined with transarterial chemoembolization (TACE) had significantly longer survival compared to those who did not receive TACE after SBRT.
3) SBRT is a promising bridging therapy prior to liver transplantation or hepatectomy by downstaging PVTT to make these curative procedures possible.
DR KANHU CHARTAN PATRO/ FOR ENT SURGEONSKanhu Charan
1. Radiotherapy plays a crucial role in the treatment of head and neck cancers, both as a primary treatment and in combination with surgery. It is used for cancers of the nasopharynx, larynx, hypopharynx, and as postoperative treatment for most oral cancers.
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Here are the key points about the hepatitis B vaccine and liver cancer:
- Hepatitis B virus (HBV) infection can lead to chronic hepatitis B and significantly increase the risk of developing liver cancer later in life.
- The hepatitis B vaccine is effective at preventing HBV infection and therefore helps prevent liver cancers caused by the virus. It was the first vaccine referred to as an "anti-cancer" vaccine by the FDA.
- Around 25% of people with chronic HBV infection may develop liver cancer according to the CDC. Getting vaccinated helps avoid this risk.
- The hepatitis B vaccine is available and affordable in India, ranging from around 45 rupees per pediatric dose to 250 rupees for the
Know the difference between Endodontics and Orthodontics.Gokuldas Hospital
Your smile is beautiful.
Let’s be honest. Maintaining that beautiful smile is not an easy task. It is more than brushing and flossing. Sometimes, you might encounter dental issues that need special dental care. These issues can range anywhere from misalignment of the jaw to pain in the root of teeth.
5-hydroxytryptamine or 5-HT or Serotonin is a neurotransmitter that serves a range of roles in the human body. It is sometimes referred to as the happy chemical since it promotes overall well-being and happiness.
It is mostly found in the brain, intestines, and blood platelets.
5-HT is utilised to transport messages between nerve cells, is known to be involved in smooth muscle contraction, and adds to overall well-being and pleasure, among other benefits. 5-HT regulates the body's sleep-wake cycles and internal clock by acting as a precursor to melatonin.
It is hypothesised to regulate hunger, emotions, motor, cognitive, and autonomic processes.
Nutritional deficiency Disorder are problems in india.
It is very important to learn about Indian child's nutritional parameters as well the Disease related to alteration in their Nutrition.
PGx Analysis in VarSeq: A User’s PerspectiveGolden Helix
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The purpose of this webcast is to:
Discuss and demonstrate the approaches with array and NGS genotyping methods for star allele calling to prep for downstream analysis.
Following genotyping, explore alternative tertiary workflow concepts in VarSeq to handle PGx reporting.
Moreover, we will include insights users will need to consider when validating their PGx workflow for all possible star alleles and options you have for automating your PGx analysis for large number of samples. Please join us for a session dedicated to the application of star allele genotyping and subsequent PGx workflows in our VarSeq software.
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- Video recording of this lecture in English language: https://youtu.be/Pt1nA32sdHQ
- Video recording of this lecture in Arabic language: https://youtu.be/uFdc9F0rlP0
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
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The biomechanics of running involves the study of the mechanical principles underlying running movements. It includes the analysis of the running gait cycle, which consists of the stance phase (foot contact to push-off) and the swing phase (foot lift-off to next contact). Key aspects include kinematics (joint angles and movements, stride length and frequency) and kinetics (forces involved in running, including ground reaction and muscle forces). Understanding these factors helps in improving running performance, optimizing technique, and preventing injuries.
The Children are very vulnerable to get affected with respiratory disease.
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Travel Clinic Cardiff: Health Advice for International TravelersNX Healthcare
Travel Clinic Cardiff offers comprehensive travel health services, including vaccinations, travel advice, and preventive care for international travelers. Our expert team ensures you are well-prepared and protected for your journey, providing personalized consultations tailored to your destination. Conveniently located in Cardiff, we help you travel with confidence and peace of mind. Visit us: www.nxhealthcare.co.uk
Nano-gold for Cancer Therapy chemistry investigatory projectSIVAVINAYAKPK
chemistry investigatory project
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Cancer remains one of the leading causes of death worldwide, prompting the need for innovative treatment methods. Nanotechnology offers promising new approaches, including the use of gold nanoparticles (nanogold) for targeted cancer therapy. Nanogold particles possess unique physical and chemical properties that make them suitable for drug delivery, imaging, and photothermal therapy.
Nano-gold for Cancer Therapy chemistry investigatory project
HIPPOCAMPUS TARGET DELINEATION
1. TARGET DELINEATION OF
HIPPOCAMPUS
DR KANHU CHARAN PATRO
MD,DNB(Radiation Oncology),MBA,FICRO,FAROI(USA),PDCR,CEPC
HOD,RADIATION ONCOLOGY
Mahatma Gandhi Cancer Hospital And Research Institute, Visakhapatnam
drkcpatro@gmail.com /M- +91-9160470564 1
2. Hippocampal Contouring:
A Contouring Atlas for RTOG 0933
Vinai Gondi, M.D.1
Wolfgang A. Tome, Ph.D. 1
Howard A. Rowley, M.D.2
Minesh P. Mehta, M.D. 3
Departments of 1Human Oncology and 2Neuroradiology, University of
Wisconsin Comprehensive Cancer Center
3Department of Radiation Oncology, Northwestern University Feinberg
School of Medicine 2
6. MRI-CT Fusion
• MRI:
– (3D-SPGR) axial MRI scan of the head with standard axial and
coronal FLAIR, axial T2-weighted and gadolinium contrast-enhanced
T1-weighted sequence acquisitions .
– 1.25mm slice thickness is preferred to contour the hippocampus
accurately. Slice thickness of 1.5mm or less is permitted.
– Obtain in supine position; immobilization devices used for CT
simulation and daily radiation treatments not necessary.
• CT Simulation:
– Non-contrast treatment-planning CT scan of the entire head region.
– 1.25-1.5mm slice thickness is preferred for accurate hippocampal
sparing planning. Slice thickness of 2.5mm or less is permitted.
– Immobilize patient in supine position using an immobilization device
such as an Aquaplast mask over the head. Treat patients in the
immobilization device.
• MRI-CT Fusion:
– Fuse the 3D-SPGR MRI and the treatment-planning CT. 6
7. General Principles
• Please note that we are not contouring the entire
hippocampus, but focusing mostly on the
subgranular zone (SGZ)
• Contour the hippocampus on T1-weighted MRI
axial sequences.
• Given the preponderance of gray matter in the
hippocampus, focus contouring on the T1-
hypointense signal medial to the temporal horn.
7
8. MR Images courtesy of: Holmes CJ, Hoge R, Collins L, et al. "Enhancement of MR Images Using Registration for Signal
Averaging" Journal of Computer Assisted Tomography 22, 324-333 (1998)
Red: Hippocampus
Begin contouring at the most caudal (inferior) extent of the crescentic-shaped floor of the
temporal horn of the lateral ventricle and contour the hypointense grey matter located medial to
the CSF hypointensity, not the white, bright white matter.
8
Temporal Horn
9. Red: Hippocampus
MR Images courtesy of: Holmes CJ, Hoge R, Collins L, et al. "Enhancement of MR Images Using Registration for Signal
Averaging" Journal of Computer Assisted Tomography 22, 324-333 (1998)
Fimbriae
9
Continue contouring in a cephalad (superior) direction, medial to the temporal horn of the lateral
ventricle and contour the hypointense grey matter, not the white, bright white matter.
10. Red: Hippocampus
MR Images courtesy of: Holmes CJ, Hoge R, Collins L, et al. "Enhancement of MR Images Using Registration for Signal
Averaging" Journal of Computer Assisted Tomography 22, 324-333 (1998)
10
Continue contouring in a cephalad (superior) direction. Avoid contouring the fimbriae, the T1-
hyperintense structures located superomedial to the hippocampus.
Fimbria
11. Red: Hippocampus
MR Images courtesy of: Holmes CJ, Hoge R, Collins L, et al. "Enhancement of MR Images Using Registration for Signal
Averaging" Journal of Computer Assisted Tomography 22, 324-333 (1998)
11
Continue contouring in a cephalad (superior) direction, medial to the temporal horn of the lateral
ventricle and contour the hypointense grey matter, not the white, bright white matter. Note that
the contours are progressively moving in a supero-posterior direction, keeping in line with the
curved banana shaped structure of the hippocampus. Avoid the fimbriae and also avoid the grey
matter (amygdala and uncus) located anterior to the tip of the temporal horn of the ventricles.
12. Red: Hippocampus
MR Images courtesy of: Holmes CJ, Hoge R, Collins L, et al. "Enhancement of MR Images Using Registration for Signal
Averaging" Journal of Computer Assisted Tomography 22, 324-333 (1998)
12
As contouring proceeds postero-cranially, the anterior boundary of the hippocampus is defined
by the anterior edge of the temporal horn, to distinguish the hippocampus from the T1-
hypointense gray matter of the amygdala, lying anterior and superior to the hippocampus.
The medial boundary of the hippocampus is defined by the “boomerang-shaped” uncus
Amygdala Uncus
13. Red: Hippocampus
MR Images courtesy of: Holmes CJ, Hoge R, Collins L, et al. "Enhancement of MR Images Using Registration for Signal
Averaging" Journal of Computer Assisted Tomography 22, 324-333 (1998)
13
Uncal
Recess
Uncal
Recess
Continue contouring in a cephalad (superior) direction, medial to the temporal horn of the lateral
ventricle and contour only the hypointense grey matter, not the white, bright white matter.
Continue to avoid the fimbriae and also avoid the grey matter (amygdala and uncus) located
anterior to the tip of the temporal horn of the ventricles.
14. Red: Hippocampus
MR Images courtesy of: Holmes CJ, Hoge R, Collins L, et al. "Enhancement of MR Images Using Registration for Signal
Averaging" Journal of Computer Assisted Tomography 22, 324-333 (1998)
The emergence of the uncal recess of the temporal horn defines the anterior boundary of the
hippocampus. This may not be seen on all axial image sets due to its limited size.
The medial boundary of the hippocampus becomes defined by the medial edge of the uncal
recess.
14
Medial edge of
Uncal Recess
Uncal recess
15. Red: Hippocampus
MR Images courtesy of: Holmes CJ, Hoge R, Collins L, et al. "Enhancement of MR Images Using Registration for Signal
Averaging" Journal of Computer Assisted Tomography 22, 324-333 (1998)
15
Continue contouring in a cephalad (superior) direction, medial to the temporal horn of the lateral
ventricle and contour only the hypointense grey matter, not the white, bright white matter.
Continue to avoid the fimbriae and also avoid the grey matter (amygdala and uncus) located
anterior to the tip of the temporal horn of the ventricles.
16. Red: Hippocampus
MR Images courtesy of: Holmes CJ, Hoge R, Collins L, et al. "Enhancement of MR Images Using Registration for Signal
Averaging" Journal of Computer Assisted Tomography 22, 324-333 (1998)
Postero-cranially, the medial boundary of the hippocampus is defined by the lateral edge of the
quadrageminal cistern which is the CSF containing space lateral to the pons.
16
Quadrageminal cistern
17. Red: Hippocampus
MR Images courtesy of: Holmes CJ, Hoge R, Collins L, et al. "Enhancement of MR Images Using Registration for Signal
Averaging" Journal of Computer Assisted Tomography 22, 324-333 (1998)
17
Continue contouring in a cephalad (superior) direction; note that at this level, the temporal horn
of the lateral ventricle may no longer be visible on every slice, but the quadrigeminal cistern
serves as a medial reference landmark. Contour only the hypointense grey matter, not the bright
white matter.
Quadrageminal cistern
18. Red: Hippocampus
MR Images courtesy of: Holmes CJ, Hoge R, Collins L, et al. "Enhancement of MR Images Using Registration for Signal
Averaging" Journal of Computer Assisted Tomography 22, 324-333 (1998)
The hippocampus remains medial to the temporal horn of the lateral ventricle throughout its
extent, and so on slices where you can visualize it, use it as a consistent reference. The
quadrigeminal cistern remains a good medial landmark.
18
Temporal horn of
the lateral ventricle
Quadrageminal cistern
19. Red: Hippocampus
MR Images courtesy of: Holmes CJ, Hoge R, Collins L, et al. "Enhancement of MR Images Using Registration for Signal
Averaging" Journal of Computer Assisted Tomography 22, 324-333 (1998)
19
Quadrageminal cistern
The hippocampus remains medial to the temporal horn of the lateral ventricle throughout its
extent, and so on slices where you can visualize it, use it as a consistent reference. The
quadrigeminal cistern remains a good medial landmark.
Temporal horn of
the lateral ventricle
20. Red: Hippocampus
MR Images courtesy of: Holmes CJ, Hoge R, Collins L, et al. "Enhancement of MR Images Using Registration for Signal
Averaging" Journal of Computer Assisted Tomography 22, 324-333 (1998)
20
The hippocampal tail remains posterior to the thalamus as it curves medially toward the
splenium of the corpus callosum. Note that it is still medially located relative to the lateral
ventricle. Also note that the thalamus, basal ganglia and internal capsule now become visible.
Thalamus
Quadrageminal cistern
Caudate
Putamen
21. Red: Hippocampus
MR Images courtesy of: Holmes CJ, Hoge R, Collins L, et al. "Enhancement of MR Images Using Registration for Signal
Averaging" Journal of Computer Assisted Tomography 22, 324-333 (1998)
21
Internal
Capsule
The hippocampal tail remains posterior to the thalamus as it curves medially toward the
splenium of the corpus callosum. Note that it is still medially located relative to the lateral
ventricle. Also note that the thalamus, basal ganglia and internal capsule now become visible.
22. Red: Hippocampus
MR Images courtesy of: Holmes CJ, Hoge R, Collins L, et al. "Enhancement of MR Images Using Registration for Signal
Averaging" Journal of Computer Assisted Tomography 22, 324-333 (1998)
22
The postero-cranial extent of the hippocampal tail is located just antero-medially to the atrium of
the lateral ventricle.
Atrium of the
lateral ventricle
Hippocampal tail
23. Red: Hippocampus
MR Images courtesy of: Holmes CJ, Hoge R, Collins L, et al. "Enhancement of MR Images Using Registration for Signal
Averaging" Journal of Computer Assisted Tomography 22, 324-333 (1998)
23
The postero-cranial extent of the hippocampal tail is located just antero-medially to the atrium of
the lateral ventricle.
Atrium of the
lateral ventricle
Hippocampal tail
24. Red: Hippocampus
MR Images courtesy of: Holmes CJ, Hoge R, Collins L, et al. "Enhancement of MR Images Using Registration for Signal
Averaging" Journal of Computer Assisted Tomography 22, 324-333 (1998)
Even in its cephalad (superior) extent, the hippocampal tail remains lateral to the lateral edge of
the quadrageminal cistern.
24
Quadrageminal cistern
25. Red: Hippocampus
MR Images courtesy of: Holmes CJ, Hoge R, Collins L, et al. "Enhancement of MR Images Using Registration for Signal
Averaging" Journal of Computer Assisted Tomography 22, 324-333 (1998)
25
Even in its cephalad (superior) extent, the hippocampal tail remains lateral to the lateral edge of
the quadrageminal cistern.
Quadrageminal cistern
26. Red: Hippocampus
MR Images courtesy of: Holmes CJ, Hoge R, Collins L, et al. "Enhancement of MR Images Using Registration for Signal
Averaging" Journal of Computer Assisted Tomography 22, 324-333 (1998)
Terminate hippocampal contours at the point where the T1-hypointense structure no longer
borders the atrium of the lateral ventricle. At this point, the crux of the fornix emerges anteriorly
and the splenium of the corpus callosum can be visualized posteriorly.
26
Splenium
27. Red: Hippocampus
MR Images courtesy of: Holmes CJ, Hoge R, Collins L, et al. "Enhancement of MR Images Using Registration for Signal
Averaging" Journal of Computer Assisted Tomography 22, 324-333 (1998)
27
The grey signal from the hippocampus is no longer visible. Do not contour any further.
28. MR Images courtesy of: Holmes CJ, Hoge R, Collins L, et al. "Enhancement of MR Images Using Registration for Signal
Averaging" Journal of Computer Assisted Tomography 22, 324-333 (1998)
Generate the hippocampal avoidance zone using a 5mm volumetric expansion on the
hippocampus.
28
Red: Hippocampus Green: Hippocampal Avoidance Zone
29. Red: Hippocampus Green: Hippocampal Avoidance Zone
MR Images courtesy of: Holmes CJ, Hoge R, Collins L, et al. "Enhancement of MR Images Using Registration for Signal
Averaging" Journal of Computer Assisted Tomography 22, 324-333 (1998)
29
Hippocampal
1) Tail
2) Body
3) Head
Generate the hippocampal avoidance zone using a 5mm volumetric expansion on the
hippocampus.
30. MR Images courtesy of: Holmes CJ, Hoge R, Collins L, et al. "Enhancement of MR Images Using Registration for Signal
Averaging" Journal of Computer Assisted Tomography 22, 324-333 (1998)
30
Hippocampal
1) Tail
2) Body
3) Head
Red: Hippocampus Green: Hippocampal Avoidance Zone
Hippocampal
1) Tail
2) Body
3) Head
The hippocampus has three anatomic subdivisions: the head, body, and tail; note that the head
is inferior or caudad, the body is superoposterior and the tail is most cephalad (superior) and
posterior, and an overall “banana” shape emerges on sagittal images, located in the plane of the
lateral ventricle.
31. MR Images courtesy of: Holmes CJ, Hoge R, Collins L, et al. "Enhancement of MR Images Using Registration for Signal
Averaging" Journal of Computer Assisted Tomography 22, 324-333 (1998)
31
Hippocampal
1) Tail
2) Body
3) Head
Red: Hippocampus Green: Hippocampal Avoidance Zone
The hippocampus has three anatomic subdivisions: the head, body, and tail; note that the head
is inferior or caudad, the body is superoposterior and the tail is most cephalad (superior) and
posterior, and an overall “banana” shape emerges on sagittal images, located in the plane of the
lateral ventricle.
32. MR Images courtesy of: Holmes CJ, Hoge R, Collins L, et al. "Enhancement of MR Images Using Registration for Signal
Averaging" Journal of Computer Assisted Tomography 22, 324-333 (1998)
On sagittal sections, confirm delineation of the hippocampus separate from neighboring
structures, such as the amygdala.
32
Hippocampal
1) Tail
2) Body
3) Head
Red: Hippocampus Green: Hippocampal Avoidance Zone
Amygdala
33. MR Images courtesy of: Holmes CJ, Hoge R, Collins L, et al. "Enhancement of MR Images Using Registration for Signal
Averaging" Journal of Computer Assisted Tomography 22, 324-333 (1998)
33
Hippocampal
1) Tail
2) Body
3) Head
Red: Hippocampus Green: Hippocampal Avoidance Zone
On sagittal sections, confirm delineation of the hippocampus separate from neighboring
structures, such as the amygdala.
Amygdala
34. MR Images courtesy of: Holmes CJ, Hoge R, Collins L, et al. "Enhancement of MR Images Using Registration for Signal
Averaging" Journal of Computer Assisted Tomography 22, 324-333 (1998)
34
Hippocampal
1) Tail
2) Body
3) Head
Red: Hippocampus Green: Hippocampal Avoidance Zone
On coronal sections, confirm delineation of the hippocampus separate from neighboring
structures, such as the parahippocampal gyrus, which has different signal intensity.
Parahippocampal Gyrus
35. MR Images courtesy of: Holmes CJ, Hoge R, Collins L, et al. "Enhancement of MR Images Using Registration for Signal
Averaging" Journal of Computer Assisted Tomography 22, 324-333 (1998)
35
Hippocampal
1) Tail
2) Body
3) Head
Red: Hippocampus Green: Hippocampal Avoidance Zone
On coronal sections, confirm delineation of the hippocampus separate from neighboring
structures, such as the parahippocampal gyrus, which has different signal intensity.
Parahippocampal Gyrus
36. MR Images courtesy of: Holmes CJ, Hoge R, Collins L, et al. "Enhancement of MR Images Using Registration for Signal
Averaging" Journal of Computer Assisted Tomography 22, 324-333 (1998)
On sagittal and coronal sections, confirm separation between the hippocampal tail and the crus
of the fornix. Note the location of the hippocampii medial to the ventricles on the coronal
images.
36
Hippocampal
1) Tail
2) Body
3) Head
Red: Hippocampus Green: Hippocampal Avoidance Zone
Crus of the fornix Crus of the fornix
37. MR Images courtesy of: Holmes CJ, Hoge R, Collins L, et al. "Enhancement of MR Images Using Registration for Signal
Averaging" Journal of Computer Assisted Tomography 22, 324-333 (1998)
37
Hippocampal
1) Tail
2) Body
3) Head
Red: Hippocampus Green: Hippocampal Avoidance Zone
On sagittal and coronal sections, confirm separation between the hippocampal tail and the crus
of the fornix. Note the location of the hippocampii medial to the ventricles on the coronal
images.