Microbodies are derived from smooth endoplasmic reticulum and replicate via fission. They are prominent in leukocytes and platelets, have a granular matrix, and contain peroxidase, catalase, and oxidase enzymes. Peroxisomes break down very long chain fatty acids, are involved in myelin production and bile acid production, and help destroy unwanted peroxides and free radicals in the body. They contain catalase and other oxidative enzymes to protect cells from hydrogen peroxide. Lysosomes contain hydrolases and are responsible for cellular digestion. Diseases associated with peroxisomal deficiencies include adrenoleukodystrophy, Zellweger syndrome, and primary hyperoxaluria.

2. ORGANELLE
MICROBODIE
S

3.  It is a derivation of smooth endoplasmic
reticulum and replication by fission.
 Prominent in leukocyte and platelets.
 Have granular (small grain) matrix.
 Contain peroxidase and catalase and
oxidases.
FUNCTION
•Breakdown of very long chain fatty acids through beta-oxidation. In animal
cells, the long fatty acids are converted to medium chain fatty acids, which are
subsequently shuttled to mitochondria where they are eventually broken down
to carbon dioxide and water
•Plasmalogen is the most abundant phospholipid in myelin. Deficiency of
plasmalogens causes profound abnormalities in the myelination of nerve cells,
which is one reason why many peroxisomal disorders affect the nervous
system
•Role in the production of bile,acids important for the absorption of fats and fat-
soluble vitamins, such as vitamins A and K. Skin disorders are features of
genetic disorders affecting peroxisome function as a result.

4.  Oxygen + hydrogen ion = hydrogen peroxide
 Strong oxidizing agents (metabolic byproduct)
 Catalases help (oxygen liberated)
 Poisonuos substances in body
 Example : alcohol consumption _liver cell
Destroy unwanted peroxide and other free radical.
Free radical = Reactive Oxygen Species (ROS)
ROS Lethal to cell
Example : Hydrogen Peroxide

5. PEROXISOMESLYSOSOMES
 Peroxisomes, on the other hand, contain
three oxidative enzymes such as catalase, D-
amino acid oxidase, and uric acid oxidase.
 Peroxisomes are responsible for the
protection of cells against hydrogen peroxide.
 Lysosomes containt hydrolase. This is the
component or enzyme that is responsible for
digestion.
 Lysosomes are responsible for the digestion
of cells

6.  Adrenoleukodystrophy (ALD) = Deficiency of
peroximal matrix.
 Zellweger syndrome = Empty peroxisome
 Primary hyperoxaluvia = Defective
peroxisomal metabolism
PROTEIN
CHAPERON

7.  Structure
 Function
i. Enzyme
 Difference
i. Golgi
 Diseases

8. THANK YOU