1. The document discusses perioperative mortality and safe anesthesia practices. It defines anesthetic death and classifies the causes of perioperative mortality.
2. Major causes of perioperative mortality include human error, communication failures, equipment failures, and underlying patient diseases. The document provides strategies to prevent complications through improved preoperative assessment, monitoring standards, anesthesia techniques, and postoperative care.
3. In the event of a complication or death, the document stresses the importance of general management practices like monitoring, diagnosis, and treatment, as well as thorough documentation, handling of deceased patients sensitively, and communicating with family members.
Regional anesthesia is anesthesia affecting only a specific area of the body when the patient is conscious, e.g. foot, arm, lower extremities, insensate to stimulus of surgery or other instrumentation.
Regional anesthesia is anesthesia affecting only a specific area of the body when the patient is conscious, e.g. foot, arm, lower extremities, insensate to stimulus of surgery or other instrumentation.
1. Safety is everybody’s business. According the Hippocratic oath from 5th century : “ Never do harm to anyone” Safer Surgery can be defined as a reduction in avoidable harm to a surgical patient
2. It is a part of medical specialty that uses operative manual and instrumental technique on a patient to investigate or treat a pathological condition. Surgical team: 1. Surgeon 2. Surgeon’s assistance 3. Anesthetist 4. Scrub nurse 5. Scouting nurse 6. Surgical technologist
3. Time or duration when patient admitted and discharge after completion of surgery. So, surgical safety has broadly included in different phases: 1. Preoperative(Diagnosis, investigation) 2. Per operative 3. Postoperative(Up to discharge)
4. 1. Adverse events: An incident which result in harm to the patient. 2. Near Miss: An incident which could resulted in unwanted harm but did not. 3. No-harm events: An incident that occur and reach to the patient but result in no injury.
5. An article in the Gurdian newspaper UK in March 2013 claimed that “five worst medical” nightmares a Pt faces, three related to surgery: 1. Wrong site surgery 2. Wrong patient surgery 3. Retained instruments and swabs The rate of harm in surgical patient is unknown but probably occur in about 10% surgical patient, though much of this harm will be minor.
6. 1. Patients themselves. 2. Healthcare professional 3. System failure. 4. Medical complexity
7. Patients Themselves 1. A variety of presentation. 2. Differing co-morbidities 3. Differing response to treatment 4. Patients are reluctant to speak up. 5. Refuse to co-operate 6. Hide and seek
8. Healthcare professional 1. Inadequate Pt assessment(delay or error in Diagnosis) 2. Failure to use or interpret appropriate test 3. Error in performance of an operation and test. 4. Inadequate monitoring or follow-up. 5. Deficient training or experience 6. Fatigue, overwork or time pressure. 7. Personal or psychological factor i.e. drug abuse or depression. 8. Lack of recognition of the danger of medical errors.
9. System failure 1. Poor communication between healthcare provider. 2. Inadequate staffing level 3. Overreliance on investigation 4. Lack of coordination at handover 5. Drug similarities. 6. Equipment failure due to lack of skilled operators. 7. Inadequate system to report and review patient safety incident.
10. Medical complexity 1. Advance and new technologies(laparoscopic, robotic surgery) 2. Potent drug and their side effects and interaction. 3. Working environment- Surgical ICU, HDU and Operation theatre
11. Surgery is one of the most complex health intervention to deliver. More than 100 million people worldwide require surgical treatment every year for different reason. Great Professor of Surgery Sir Alfred Cuschieri and other describes surgical errors in different categories that committed by the surgeons during care of the Patients.
12. 1. Diagnosis and management erro
emergency nursing (management in emergency) pptNehaNupur8
complete information about the emergency care provided to the
patients, in emergency ward, after accident, in life and death condition this contain definition, process, system nursing management, medical management, research.
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Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
4. ANESTHETIC DEATH
“Anaesthetic death” is often
defined as the death of a patient
who has had an anaesthetic,
within 24 hours of the procedure.
This is irrespective of the
contribution of anaesthesia to the
cause of death.
4
5. The recent studies defined
mortality associated with
anesthesia as a death under
anesthesia or as a result of
anesthesia and death within
24hrs of an anesthetic procedure.
5
8. Can be classified further
into 4 groups according
to the cause of the death
Journal of clinical pathology 1999 52 640-652
Roger. D. Start et al
8
9. Directly caused by the disease for which
anesthesia was being performed eg:
aneurysmal rupture during aneurysmal repair
Caused by a disease other than for which
anesthesia was being performed eg: CAD
patient dying in a whipples resection
Resulting from a mishap of the surgery eg:
rebleeding in Tonsillar surgeries
Resulting from a mishap of anesthesia eg:
slipped ETT in cleft lip and palate surgery
9
10. Incidence
High in the developing countries
High with emergency and complex surgeries
High with age
High with inadequate preop preparation
Inappropriate postop care
Lack of supervision
10
11. Timing of perioperative mortality
Majority occurs in the postoperative(51%)
Intraoperative(37%)and during induction(9%) of
anesthesia
11
Percentage
Postoperative
Intraoperative
Induction
27. 1. Drug overdose/ adverse reaction
2. Rhythm disturbances
3. Peri-op MI
4. Airway obstruction
5. High spinal
6. Lack of vigilance
7. Bleeding
8. Over-dosage of inhalation agent
9. Aspiration
10. Technical problem in anaesthesia system
10 common causes of cardiac
arrest under anaesthesia
29. 1. Preoperative assessment, investigation and counselling
of the patient
2. Preoperative checking of equipment and the assurance
of backup equipment
3. The availability of an appropriately trained Assistant
4. Preoperative consultation with more experienced
personnel, where necessary, regarding the Most
appropriate anaesthetic technique
5. The use of appropriate monitoring techniques
AVOIDANCE OF COMPLICATIONS
31. RECORD KEEPING
Vital sign & treatment
Trends in vital sign
Early intervension
safer sharing of care between
anesthetists
Handover long cases
Better team work
After the event investigations &
learning,thus reducing
complications
31
32. REDUNDENT SYSTEMS
Availability of at least two working
laryngoscopes
Maintenance of 2 or more IV line if
blood loss expected
Monitoring of expired volatile agent
conc . Alongwith depth of anesthesia
monitors
Minimizes risk of awareness
32
33. MONITORING
ASA & AAGBI have set minimum
standard of intraoperative
monitoring
Automatically activated alarm….
Values set by anesthetists
33
34. SUMMARY
Prophylactic measures
Improve the preoperative assessment
Provide preoperative preparations
Improve the monitoring standards
Provide balanced anesthesia
Provide adequate post operative care
Provide adequate supervision
Proper auditing of critical incidents
34
38. GENERAL
MANAGEMENT
Provision of high FiO2
Assurance of adequate cardiac output
Cessation of perfusion …more rapid
damage of organs than low level of
oxygenation
Brain & heart most sensitive
Liver & kidneys …potentially at risk
38
40. 4. Choice of a
working diagnosis,
which is either the
most likely or the most
dangerous possibility
5. Treatment of
the working
diagnosis
6. Assessment of the
response of the
problem to the
treatment
administered
40
41. 7. Refinement of the list
of differential diagnoses,
especially if the response
has not been as expected
8. Confirmation or elimination of
the choice of working diagnosis; if
the response to treatment has
been unexpected then
replacement with a more likely
working diagnosis is indicated
9. Go to step 5 and
repeat until the problem is
resolved
42. RECORD KEEPING &
DOCUMENTATION
Trends in pt physiological data apparent only
when charted
Generation of new DD of a problem with help
of data
Data of an incident & complication important in
preventing future repetition through education
in department
Detailed record available to defend the
practitioner
42
43. Put every moment in
black and white
The more detail, the better
43
44. Documentations after the
event
Prepare the accurate records
Don’t alter the original notes
Amendments and additions are recorded
separately
Preoperative visit details are included
Consent form and relevant investigation
reports are collected
44
45. Documentation checklist
When the patient was first seen by whom?
What was prescribed?
Investigation reports
Plan of anesthesia
Critical incidents
Remedial measures
Senior Help sought
45
49. Communicating with
relatives
Quiet comfortable room to sit
Help from a senior
Surgical and nursing colleague are
included
Explain the serious complications
Tried remedial measures detailed
Answer all immediate questions
49