This document discusses assessing the knowledge and perceived barriers of patients with end stage renal disease (ESRD) regarding kidney transplantation. ESRD is the final stage of chronic kidney disease and approximately 10% of ESRD patients in India receive renal replacement therapy like dialysis. The study aims to assess knowledge of kidney transplantation, identify perceived barriers, and examine associations between knowledge and demographic factors in ESRD patients in selected hospitals in Kannur District, India. A descriptive survey research design using interviews will be used to collect data which will then be analyzed using descriptive and inferential statistics.