Dr. Kim Solez presents "Tissue Engineering Pathology Meets Aviv Regev's Human Cell Atlas: A Glimpse Into the Future of Pathology" on March 8th, 2017 at the University of Alberta in Edmonton, Alberta, Canada Copyright (c) 2017, JustMachines Inc.
Kim Solez Renal transplant pathology and future perspectivesKim Solez ,
Dr. Kim Solez presents "Renal transplant pathology and future perspectives" as a TTS webinar on Dec. 8 at noon EST . Includes discussion of the new discipline of tissue engineering pathology. https://www.tts.org/education/advanced-renal-transplantation
Kim Solez Charles dickens and transplant pathologyKim Solez ,
Acceptance speech by Dr. Kim Solez receiving the Catalan Society of Transplantation Gold Medal on behalf of himself and Dr. Lorraine Racusen March 31, 2017
Kim Solez TEP meets Human Cell Atlas a glimpse into future of pathology winte...Kim Solez ,
Dr. Kim Solez TEP meets Human Cell Atlas Project, a glimpse into future of pathology, Technology and Future of Medicine course February 15, 2018 http://www.singularitycourse.com Copyright (c) 2018, JustMachines Inc.
Transition transplant path to tissue engineer path new banff class 2017 Kim Solez ,
Kim Solez "The transition between transplant pathology and tissue engineering pathology: Beginning a new Banff classification - 2017 Update". ATI Fellows Rounds Presentation Spept 12 2017
Kim Solez The bridge between transplant and regenerative med Tissue engineeri...Kim Solez ,
Dr. Kim Solez presents "The Bridge Between Transplantation & Regenerative Medicine: The Beginning of Tissue Engineering Pathology" at the ATI Fellows Lecture Series on August 18, 2015.
Kim Solez Renal transplant pathology and future perspectivesKim Solez ,
Dr. Kim Solez presents "Renal transplant pathology and future perspectives" as a TTS webinar on Dec. 8 at noon EST . Includes discussion of the new discipline of tissue engineering pathology. https://www.tts.org/education/advanced-renal-transplantation
Kim Solez Charles dickens and transplant pathologyKim Solez ,
Acceptance speech by Dr. Kim Solez receiving the Catalan Society of Transplantation Gold Medal on behalf of himself and Dr. Lorraine Racusen March 31, 2017
Kim Solez TEP meets Human Cell Atlas a glimpse into future of pathology winte...Kim Solez ,
Dr. Kim Solez TEP meets Human Cell Atlas Project, a glimpse into future of pathology, Technology and Future of Medicine course February 15, 2018 http://www.singularitycourse.com Copyright (c) 2018, JustMachines Inc.
Transition transplant path to tissue engineer path new banff class 2017 Kim Solez ,
Kim Solez "The transition between transplant pathology and tissue engineering pathology: Beginning a new Banff classification - 2017 Update". ATI Fellows Rounds Presentation Spept 12 2017
Kim Solez The bridge between transplant and regenerative med Tissue engineeri...Kim Solez ,
Dr. Kim Solez presents "The Bridge Between Transplantation & Regenerative Medicine: The Beginning of Tissue Engineering Pathology" at the ATI Fellows Lecture Series on August 18, 2015.
Kim Solez Introduction to regenerative medicine Fall 2015Kim Solez ,
Dr. Kim Solez presents "Introduction to Regenerative Medicine" on September 10, 2015 in the Technology and Future of Medicine course LABMP 590 http://www.singularitycourse.com at the University of Alberta in Edmonton, Canada. Copyright (c) 2015, JustMachines Inc.
Kim Solez Xenotransplantation- The Rest of the Story April 8 2022 6.pptxKim Solez ,
Nephrology Grand Rounds Presentation at the University of Alberta discussing the big picture issues surrounding xenotransplantation and its relation to stem cell generated organs and bioengineered organs in the future
Dr. Talita Resende - Organoids as an invitro model for enteric diseasesJohn Blue
Organoids as an invitro model for enteric diseases - Dr. Talita Resende, from the 2018 Allen D. Leman Swine Conference, September 15-18, 2018, St. Paul, Minnesota, USA.
More presentations at http://www.swinecast.com/2018-leman-swine-conference-material
Embryonic stem cells – Promises and IssuesTania Jabin
Introduction, Embryonic Stem Cells, Promises of Embryonic Stem cell research, Figure: The Promise of Stem Cell Research, Issues in Embryonic Stem cells - New embryonic stem cell lines from frozen embryos Informed consent for donation of materials for stem cell research Waiver of consent Consent from gamete donors Confidentiality of donor information Ethical concerns about oocyte donation for research (1. Medical risks of oocyte retrieval, 2. Protecting the reproductive interests of women in infertility treatment, 3. Payment to oocyte donors, 4. Informed consent for oocyte donation).
Kim Solez Introduction to regenerative medicine Fall 2015Kim Solez ,
Dr. Kim Solez presents "Introduction to Regenerative Medicine" on September 10, 2015 in the Technology and Future of Medicine course LABMP 590 http://www.singularitycourse.com at the University of Alberta in Edmonton, Canada. Copyright (c) 2015, JustMachines Inc.
Kim Solez Xenotransplantation- The Rest of the Story April 8 2022 6.pptxKim Solez ,
Nephrology Grand Rounds Presentation at the University of Alberta discussing the big picture issues surrounding xenotransplantation and its relation to stem cell generated organs and bioengineered organs in the future
Dr. Talita Resende - Organoids as an invitro model for enteric diseasesJohn Blue
Organoids as an invitro model for enteric diseases - Dr. Talita Resende, from the 2018 Allen D. Leman Swine Conference, September 15-18, 2018, St. Paul, Minnesota, USA.
More presentations at http://www.swinecast.com/2018-leman-swine-conference-material
Embryonic stem cells – Promises and IssuesTania Jabin
Introduction, Embryonic Stem Cells, Promises of Embryonic Stem cell research, Figure: The Promise of Stem Cell Research, Issues in Embryonic Stem cells - New embryonic stem cell lines from frozen embryos Informed consent for donation of materials for stem cell research Waiver of consent Consent from gamete donors Confidentiality of donor information Ethical concerns about oocyte donation for research (1. Medical risks of oocyte retrieval, 2. Protecting the reproductive interests of women in infertility treatment, 3. Payment to oocyte donors, 4. Informed consent for oocyte donation).
A first presentation of the Dandelion project, recently released in v0.10.0.
Slides are available online here: http://dandelion.github.io/slides/dandelion-0.10.0
Tissue engineering and regenerative medicine Suman Nandy
Tissue engineering is the use of a combination of cells, engineering and materials methods, and suitable biochemical and physicochemical factors to improve or replace biological tissues. Tissue engineering involves the use of a scaffold for the formation of new viable tissue for a medical purpose.
Kim Solez Bridge between transplantation and regenerative medicine vancouver3Kim Solez ,
Dr. Kim Solez presents "Bridge between Transplantation and Regenerative Medicine" at the Banff Transplant Pathology meeting in Vancouver October 5, 2015. Copyright (c) 2015, JustMachines Inc.
Kim Solez Transition transplant path to tissue engineering path new banffKim Solez ,
Dr. Kim Solez Presents "Transition Between Transplant Pathology and Tissue Engineering Pathology: Beginning A New Banff Classification" at the Alberta Transplant Institute Fellows Lecture Series January 10, 2017 at the University of Alberta in Edmonton, Alberta, Canada. Copyright (c) 2017, JustMachines Inc.
Solez Stem Cell and Future of TransplantationKim Solez ,
Dr. Kim Solez discusses "Confronting the Question of Stem Cells and the Future of Transplantation" for the Alberta Transplant Institute Fellows Lecture Series on September 2nd, 2014 at the University of Alberta in Edmonton, Canada.
Kim Solez Transplant Pathology Regen Med 2015Kim Solez ,
Dr. Kim Solez presents Transplantation Pathology, Regenerative Medicine, and Where We Go From Here at the Nephrology Core Lecture Series on January 7th, 2015 at the University of Alberta in Edmonton, Canada. See https://www.youtube.com/watch?v=5wfdhB_VyJw
CI4CC Moonshot Blue Ribbon Panel Report 20161010Warren Kibbe
Presentation to the Fall CI4CC meeting in Utah. CI4CC Moonshot Blue Ribbon Panel Report. Highlights of Vice President Biden's Cancer Moonshot and the NCI Blue Ribbon Panel Recommendations.
Advancing Convergence and Innovation in Cancer ResearchJerry Lee
Describes NCI's Center for Strategic Scientific Initiatives activities (2005 - 2017) as well as data and technology activities of the 2016 White House Cancer Moonshot Task Force (2016 - 2017).
Ishita Moghe Kim Solez Human cell atlas paradox and what you can do to promot...Kim Solez ,
Ishita Moghe Kim Solez Human cell atlas paradox and what you can do to promote it in context of world future 2018 human purpose. Slide set for Future Day presentation March 1st, 2018. Copyright (c) 2018, JustMachines Inc.
Kim Solez Renal transplant pathology and future perspectives corefall2016Kim Solez ,
Dr. Kim Solez presents "Renal transplant pathology and future perspectives. Nephrology core lecture series Fall 2016, on October 5, 2016, at the University of Alberta, Edmonton, Alberta, Canada. Copyright (c) 2016, JustMachines Inc.
Keynote at NVIDIA GPU Technology Conference in D.C.Jerry Lee
Presentation at NVIDIA GPU Technology Conference in D.C. on how the Cancer Moonshot Task Force under Vice President Biden is using AI to help end cancer as we know it. Dr. Lee will discuss global efforts to empower A.I. and deep learning for oncology with larger and more accessible datasets.
Kim Solez A renaissance in renal pathology brought about by regenerative medi...Kim Solez ,
Dr. Kim Solez presents A renaissance in renal pathology, nephrology and transplantation brought about by regenerative medicine: How to jump start the process.
Slide deck for annual meeting of Transplant Regenerative medicine Community of Practice of American Society of Transplantation at noon in Room 204 in John B. Hynes Convention Center. Everyone welcome! Many exciting initiatives to discuss!
Kim Solez Hooking-Up Physical Forces Optimism and Dark Energy Presentation Se...Kim Solez ,
Kim Solez Banff New Media Institute Presentation, "Smart, Sexy, Healthy" ThinkTank, Sept 6 2001
Hooking-Up, Physical Forces, Optimism and Dark Energy: Imagery, Hope, and Health.
Kim Solez 384 years of banff spirit new june 26 2019Kim Solez ,
Kim Solez 384 years of Banff spirit new June 26 2019 The most remarkable slide is number 137. "By Spring of 2019 every erroneous statement we complained about had been reversed. We celebrated by creating a new video trailer on our YouTube channel on June 25 2019." How about that!
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
263778731218 Abortion Clinic /Pills In Harare ,ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group of receptionists, nurses, and physicians have worked together as a teamof receptionists, nurses, and physicians have worked together as a team wwww.lisywomensclinic.co.za/
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
4. Worldwide 1.2 million people are in
need of transplantation for end
stage organ failure. Current
transplant protocols reach fewer
than 10% of this number.
Regenerative medicine can save the
remaining 90%, over one million
people annually!
5. Tissue engineered bladder.
Regenerative Medicine Already Here!
Working for Tubular Organs, Bladder,
Trachea, Esophagus, Vagina.
6. Something Missing In the Concept of
Tissue Engineering Pathology: The
Numbers – How Many Cells – How
Many Conditions Can Be Treated
7. Aviv Regev’s Human Cell Atlas Begins
to Answer This: 300 Main Cell Types
in Human Body – 20 in Kidney
8. Aviv Regev’s Human Cell Atlas Begins
to Answer This: 300 Main Cell Types
in Human Body – 1000s of subtypes
9. Aviv Regev’s Human Cell Atlas Begins
to Answer This Numbers Question:
Analysis is Inexpensive and Fast
10. Aviv Regev’s Human Cell Atlas Begins
to Answer This Numbers Question:
Analysis is Inexpensive and Fast
11. Aviv Regev’s Human Cell Atlas
Already Leading to Disease Insights
Variants, Acting on Them = Pathology
12. Aviv Regev’s Human Cell Atlas
Already Leading to Disease Insights
Variants, Acting on Them = Pathology
13. ViaCyte Announces Highly
Anticipated Encapsulation Clinical
Trial Site Expansion into Canada
JDRF-funded researcher, Dr. James Shapiro
will be the lead investigator at the Canadian
site. TORONTO, July 29, 2015 -- ViaCyte, Inc.
announced the opening of a second site in its
Phase 1/2 trial for Type I Diabetes which utilizes
PEC-01™ pancreatic progenitor cells and the
proprietary Encaptra® drug delivery system which
is designed to protect the transplanted cells from a
patient’s immune system.
Regenerative Medicine Already Here!
Viacyte Trial for Diabetes Therapy.
14. Double Think: Stem Cells are Greatest Hope
and Greatest Hype, Stem Cell Tourism
Estimated to be $3 Billion a Year Industry and
Growing, with More than 700 Clinics Worldwide
Mason C et al. Regen Med. 2011 May;6(3):265-72. doi:
10.2217/rme.11.28. Cell therapy industry: billion dollar
global business with unlimited potential.
Timothy Caulfield - Stem Cell Tourism June 2015
https://www.youtube.com/watch?v=B0r89nMtg10
15. University of Alberta Health Law Institute
http://www.hli.ualberta.ca/en/Publications.as
px Stem cell Publications
Combatting Unlicensed stem Cell interventions through
truthful advertising law: a survey of regulatory trends
January 3, 2017
From Kim Kardashian to Dr. Oz: The Future Relevance of
Popular Culture to Our Health and Health Policy
October 26, 2016
16. University of Alberta Health Law Institute
http://www.hli.ualberta.ca/en/Publications.as
px Stem cell Publications
Science, Celebrities, and Public Engagement Timothy
Caulfield and Declan Fahy on Science, Celebrities, and
Public Engagement in the Summer 2016 Issues in Science
and Technology. www.issues.org JUNE 16, 2016
Science: Confronting stem cell hype Professor
Timothy Caulfield co-authors new stem cell policy
guidelines. MAY 13, 2016
17. University of Alberta Health Law Institute
http://www.hli.ualberta.ca/en/Publications.as
px Stem cell Publications
Media portrayal of non-invasive prenatal testing: a
missing ethical dimension MARCH 04, 2016
Marginally scientific? Genetic testing of children and
adolescents for lifestyle and health
promotion JANUARY 15, 2016
Trafficking in Human Beings for the Purpose of Organ
Removal and the Ethical and Legal Obligations of
Healthcare Providers January 4, 2016
18. University of Alberta Health Law Institute
http://www.hli.ualberta.ca/en/Publications.as
px Stem cell Publications
Stem cell hype: Media portrayal of therapy
translation MARCH 30, 2015
Policy Options: Athletes and unproven stem cell
therapies JANUARY 01, 2015
Research ethics and stem cells Is it time to re‐think
current approaches to oversight? DECEMBER 04, 2014
19. University of Alberta Health Law Institute
http://www.hli.ualberta.ca/en/Publications.aspx
Stem cell publications continued
Representations of Stem Cell Clinics on
Twitter DECEMBER 01, 2014
Unproven stem cell-based interventions & physicians'
professional obligations; a qualitative study with
medical regulatory authorities in Canada. OCTOBER 14,
2014 Professional Regulation: A Potentially Valuable
Tool in Responding to "Stem Cell
Tourism" SEPTEMBER 09, 2014
20. University of Alberta Health Law Institute
http://www.hli.ualberta.ca/en/Publications.aspx
Stem cell publications continued
Stem Cell Tourism and Public Education: The Missing
Elements SEPTEMBER 04, 2014
Policy recommendations for addressing privacy
challenges associated with cell-based research and
interventions FEBRUARY 03, 2014 Commercialization
and Stem Cell Research: A Review of Emerging Issues
DECEMBER 20, 2013 A Role for Patient Advocacy
Groups in Countering the Premature Commercialization
of Stem Cell Interventions
OCTOBER 01, 2013
21. The Positive Aspects of Stem Cell Therapies,
The True Hope, Has Potential to Reverse Three
Looming Problems in Medicine:
1. The loss of “luster” in transplantation.
2. Workforce problems in nephrology due to lack of appeal
to young people/potential trainees worldwide.
3. Technological unemployment in medicine due to
22. “They will never be able to reverse those
trends.” Together we can do those things,
reverse those trends, make life good again!
1. The loss of “luster” in transplantation.
2. Workforce problems in nephrology due to lack of appeal
to young people/potential trainees worldwide.
3. Technological unemployment in medicine due to
24. Banff Classification of Kidney Transplant Pathology
Histologic criteria for the diagnosis of rejection and
other conditions in the transplanted kidney, began
1991, updated and expanded every two years in
consensus meeting.
25. Banff Lesion Scoring: Sign of Educated Tx Pathologist
imprimatur 1. The formula (=‘let it be printed’), signed by an official
authorizing printing of a book;hence as sb. an official license to print.
The Oxford English Dictionary (2nd. ed.)
Banff lesion scoring: g cg i ci t ct v cv ah mm ptc C4d
26. 1991 First Conference
1993 First Kidney International publication
1995 Integration with CADI
1997 Integration with CCTT classification
1999 Second KI paper. Clinical practice guidelines. Implantation biopsies.
2001 Classification of antibody-mediated rejection: Regulatory agencies
participating
2003 Genomics focus, ptc cell accumulation scoring
2005 Gene chip analysis. Elimination of CAN, identification of chronic
antibody-mediated rejection.
2007 First meeting far from a town called “Banff” – La Coruna, Spain.
2009 Working groups. Meeting in Banff, Alberta, Canada
2013 Establishment of Banff Foundation for Allograft Pathology
27. Significance of ‘Banff papers’
• More than 5,000 citations of the 14 Banff meeting reports
• 977 Banff / Transplantation papers in PubMed
• Banff 2003 meeting report (ABMR criteria) = most cited AJT
paper
• 3 Banff meeting reports are among the top 4 cited AJT articles
29. The Banff Process
Consensus communication in renal transplantation
a
The Banff
lesions
g, i, t, v - score
The Banff
community
Pathologists
Nephrologists
Tx-Surgeons
Lab-Medicine
established by
consensus in 1991
The Banff
classification
Current consensus for
diagnostics
moderated
Banff meetings
thesis-antithesis-synthesis
tentative
thresholds
participate
refinementBanff Working
Groups
Feedback concerning weaknesses and strengths by results
from independent research
New members
Biostaticians
Molecular Biologists
“Omics”-specialists
Off-springs
Liver
Pancreas
Lung, Heart
CTA
30. Organizational structure of the Banff Foundation For Allograft Pathology
Board of Trustees:
K. Solez (Chair), L. Racusen, D. Glotz, J. Demetris, M. Mengel, M. Mihatsch, D. Seron
2015 Local Conference
chair: Michael Mengel
Organ Steering committee
Chairs:
Composite tissues: Linda Cendales
Heart : Patrick Bruneval
Kidney: Mark Haas
Liver: Jake Demetris
Lung: William Wallace and Carol
Farver
Pancreas: Cinthia Drachenberg
Banff Working Group (BWG) Leads:
Molecular transplantation pathology: Michael Mengel, Banu Sis
Isolated v-lesions: Banu Sis, Ed Kraus
Quality assurance in transplantation diagnostics: Michael Mengel and
Parmjeet Randhawa
C4d-negative ABMR: Mark Haas, Banu Sis, Alexandre Loupy
Fibrosis scoring: Robert Colvin, Brad Farris, Michael Mengel
Digital Pathology in Transplantation: Jake Demetris
2015 Scientific program committee:
Alex Loupy (Chair)
Mark Haas, Banu Sis, Kathryn Tinkham, Candice
Rofousse, Chris Bellamy, Lynn Cornell, Carmen
LeFaucheur
Composite tissues: Linda Cendales
Heart : Patrick Bruneval
Liver: Jake Demetris
Lung: William Wallace and Carol Farver
Pancreas/Islets: Cinthia Drachenberg and John
Papadimitriou
Secretary/Treasurer:
Michael Mengel
funding
collaboration
reports to
reports to
collaboration
collaboration
reports to
collaboration
progress
reports to Budged
proposal and
accountability
for meeting
costs
support
41. Many problems with stem cell generate
organs not being discussed. Do not exclude
yourself from the action in this area!
42. Many problems with stem cell generate
organs not being discussed. Need to get
those conversations to happen.
The recellularized organ clots like crazy, impossible to
regenerate more than 80% of endothelial surface. Artificial
heparized surface not fenestrated. Cell traffic abnormal.
Hard to get right types of cells to right places.
Podocytes seems to be terminally differentiated cells,
when attempt to culture them they turn into different type of
cell.
Kidney progenitor stem cell difficult to identify, kidney work
has lagged behind.
Easy to make stem cell generated kidneys that lack loop of
Henle. Could produce lethal polyuria. What is “function”?
Many old fashioned questions of physiology about how the
stem cell generated organ works, not just true for kidney,
true for every organ.
43. Transplant
pathologists will also
become tissue
engineering
pathologists,
pathologists who
analyse organs grown
from stem cells. This is
not something beyond
us, we can adapt to a
work life that includes
stem cells.. Someone
needs to cross the
disciplines,
44. Many of the questions
that need to be posed
about stem cell
generated organs are old
fashioned questions,
intact nephron
hypothesis, cell
regeneration, stunned
myocardium, contraction
band necrosis etc. Use
your nostalgia! Stimulate
conversations between
stem cell researchers and
transplant physicians.
45. Beginning at the Very Beginning!
“We are at the very beginning of time for the human race. It
is not unreasonable that we grapple with problems. But
there are tens of thousands of years in the future. Our
responsibility is to do what we can, learn what we can,
improve the solutions, and pass them on.” - Richard P.
Feynman, (1918-1988) Physicist, Nobel Prize Winner
"The sense of the future is behind all good policies. Unless
we have it, we can give nothing either wise or decent to
the world." - Snow CP, (1905-1980) Novelist and
Philosopher.
"To a large extent, the future lies before us like a vast
wilderness of unexplored reality. The God who created and
sustained the evolving universe through eons of progress
and development has not placed our generation at the tag
end of the creative process. God has placed us at a new
beginning. We are here for the future." - Sir John
Templeton (1912-2008 ), Financial Analyst
46. Beginning at the Very Beginning!
Like 1851 when the first International Classification of
Diseases was presented in the Grand Exhibition of
Technology at London’s Crystal Palace
Emphasis was on cause of death
47. Classification focus is on sustaining life.
Native and transplanted organ diseases can also occur in
tissue engineered organs.
The classification focus of the new pathology discipline of
Regenerative Medicine/Tissue Engineering Pathology is
exactly the opposite of traditional classification of disease
which starts with causes of death. In Regenerative
Medicine/Tissue Engineering Pathology the emphasis is on
the degree of normality necessary to sustain life:
Normal,
Abnormalities of unknown functional significance,
Abnormalities which will impair the main functions of the
organ,
Abnormalities leading to severe organ dysfunction where
function may not be great enough to sustain life.
48. Song et al. Interstitium, vessels, and glomeruli with missing cells.
Disordered tubule formation with multiple interconnecting
lumina of differing sizes. “Can you really call this a kidney?” (Yes!)
49. Song et al. In addition to missing cells and disordered structures,
you have cells in the wrong places. Podocytes in the interstitium.
50. Focus of Tissue Engineering Pathology
The focus of tissue engineering pathology will shift to
the question: “Is this organ structurally intact enough to
function safely and adequately in the recipient?” Using
the kidney as an example, the specific questions
become: (Images by Korey Fung)
1. Are there too many missing cells, distorted
structures for the organ to function adequately?
51. Focus of Tissue Engineering Pathology
The focus of tissue engineering pathology will shift to
the question: “Is this organ structurally intact enough to
function safely and adequately in the recipient?” Using
the kidney as an example, the specific questions
become: (Images by Korey Fung)
2. Are there too many cells in the wrong places (e.g.
podocytes in the interstitium)
52. Focus of Tissue Engineering Pathology
(Images by Korey Fung)
3. Are there missing/distorted structural elements that
represent a risk to the patient? (missing loops of Henle
causing lethal polyuria)
53. Focus of Tissue Engineering Pathology
Using the kidney as an example, the specific questions
become:
4. Is there too much endothelial disruption
for the organ to be properly perfused?
5. What are the risks of neoplastic transformation?
Classification categories should be not one-off, but
reproducible, generalizable.
Tissue engineering pathology has been up to now
really dull, since most reports were of scaffolds with no
inflammatory reaction "Move along, nothing to see
here" pathology, but from today becomes really
exciting with novel morphological changes and lives
hanging in the balance!