Open fractures occur when a bone fracture communicates with the external environment through a break in the skin. They were classified and early management was discussed, including irrigation, debridement, antibiotics, tetanus prophylaxis, and splinting. Options for fracture stabilization include external fixation, plating, and intramedullary nails. Wound closure considerations involve primary versus delayed closure, skin grafting, and flaps. The goal is thorough debridement and stable fixation to prevent infection while obtaining soft tissue coverage.
Open fractures are unique, complex, and emergently presenting injuries that expose sterile bone to the contaminated environment.
Because a fracture disrupts the intramedullary blood supply, the additionally stripped soft tissue envelope further devitalizes the bone.
The more severe the soft tissue injury or open wound, the more severe the osseous injury.
Historically, open fractures were associated with infection, delayed union, nonunion, amputation, or death.
Open fractures are unique, complex, and emergently presenting injuries that expose sterile bone to the contaminated environment.
Because a fracture disrupts the intramedullary blood supply, the additionally stripped soft tissue envelope further devitalizes the bone.
The more severe the soft tissue injury or open wound, the more severe the osseous injury.
Historically, open fractures were associated with infection, delayed union, nonunion, amputation, or death.
Hoffa's Fracture: Diagnosis, management & New Classification System by BAGARI...Vaibhav Bagaria
Hoffa's Fracture - coronal split fracture of distal femur, its diagnosis, management strategy, a new classification and tips and tricks of management. First described Hoffa, a new classification system by Bagaria et al helps plan the surgery for these tricky fracture. The most crucial step is not to miss these fractures in ER.
Hoffa's Fracture: Diagnosis, management & New Classification System by BAGARI...Vaibhav Bagaria
Hoffa's Fracture - coronal split fracture of distal femur, its diagnosis, management strategy, a new classification and tips and tricks of management. First described Hoffa, a new classification system by Bagaria et al helps plan the surgery for these tricky fracture. The most crucial step is not to miss these fractures in ER.
This lecture covers the basics of suturing i.e wound healing, indications and contraindications of suturing, wound assessment, wound aftercare, suture and needle types, suturing techniques, knot types.
This topic comes under the General Principles of Surgery for MBBS Students. The student should know the various types of wounds, their assessment and dressing methods.
With the pandemic overclouding the whole world it has effected every strato of people including the Orthopaedic groups. This is to highlight the impact of COVID 19 on the orthopaedic in general.
Conservative management in 3 and 4 part proximal humerus fractureBipulBorthakur
Proximal humerus fracture is common in both young as well as elderly people with most of the elderly patients unable to undergo operative management. This study is to see the aspect of conservative management in proximal humerus fracture.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stockrebeccabio
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Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
3. DEFINITION
Open fractures is defined as an injury
the fracture and fracture hematoma
communicate with the external
through a traumatic defect in the
surrounding soft tissues and overlying skin.
4. Assessment and Classification of
Open Fractures
• Patient is evaluated and resuscitated according
to ATLS protocols.
• Injured extremities then should be assessed for
neurovascular injury and compartment
• Photographic documentation of the wound
should ideally be undertaken.
5. • If immediate operative intervention is planned do
not irrigate , debride or probe the wound in ER.
• If surgical delay (>24hrs) is anticipated ,gentle
irrigation with normal saline can be done.
• Gross contamination should be removed.
• Wound is covered with saline soaked dressing
under impervious seal.
6. SPLINTAGE :-
• Any skeletal trauma must be splinted with
whatever best available before shifting the
patient for any investigation or OT
• After temporary splintage, stabilization with
external fixator or definitive internal fixation
is done.
7. ROLE OF CULTURES IN EMERGENCY ROOM
• There is disparity between the organism grown on the initial
wound swabs and organism grown subsequently after the
development of wound infection.
• The practice of obtaining routine cultures from the wound
either pre or post debridement is no longer advocated.
9. • For most of the open fracture
modified Gustilo and Anderson’s
classification is used.
• But for open tibia fracture Ganga
Hospital open injury score is used.
• Classification of open fracture is done
in OT not in emergency room.
10.
11. DISADVANTAGES OF GUSTILO`S AND ANDERSON`S CLASSIFICATION
• Definition has undergone many modification and
does not have uniformity in application.
• Includes wide spectrum of injuries in type IIIB
• Mainly depends on size of the skin wound.
• Does not address the question of salvage
• Poor interobserver reliability.
12. PREVENTION OF INFECTION
• All open fracture wounds should be considered
contaminated.
• Infection is enhanced by the following:-
# bacterial contamination
# colonization of the wound
# presence of dead space with
devitalized tissues
# foreign material
13. ANTIBIOTICS COVERAGE FOR OPEN FRACTURE
TYPE I & II :- First generation cephalosporin
TYPE III:- add an Aminoglycoside.
Antibiotics should be started as soon as possible
14. • Tetanus prophylaxis should be given in
emergency department.
• Current dose of toxoid is 0.5ml regardless of
age.
• DOSE OF IMMUNOGLOBULIN :-
< 5 years of age:- 75 IU
5-10 years of age:- 125 IU
> 10 years of age :- 250 IU
15. • Toxoid and immunoglobulin should be given
intramuscularly with two different syringes in two
different locations.
GUIDELINES FOR TETANUS PROPHYLAXIS:-
Depends on 3 factors:-
* complete or incomplete vaccination history ( 3 doses)
*date of most recent vaccination
*severity of wound.
16. Immunization history Clean, minor wound (type I
open fracture)
Type II & III open fracture
Unknown history or < 3 doses Give vaccine only *Give vaccine
*Give Ig
Vaccination complete (3 prior
doses)
*No prophylaxis if last dose
given within 10 years
*Give vaccine if > 10 years since
last dose
*No prophylaxis if last dose given within
years
*Give vaccine if > 5 years since last dose
18. Irrigation and Debridement
• Adequate Irrigation and debridement are the
important steps in open fracture treatment.
• The most commonly used irrigant is normal saline.
• High pressure irrigation removes more bacteria and
necrotic tissue than syringe.
19. • The current consensus seems to lean towards
high volume , low pressure lavage repeated
adequate number of times in pulsatile manner
to effect the best healing and prevention of
infection.
• Debridement is done by senior surgeon.
20. TECHNIQUE OF DEBRIDEMENT:-
Wash and drape the wound as for normal surgical procedure
Remove devitalizes skin untill bleeding is visible
Remove the subcutaneous tissue including all contaminated tissue
Remove devitalized fat beneath the flaps
Open the fascia to allow exposure of the muscle tendon and removal of all devitalized
muscle
Trim completely severed tendon back to viable tendon
Enlarge the wound for proper debridement and exposure of the fracture.
Irrigate the wound with NS after removal of all dead tissue
Close the surgically created wound first
Loosely close the remaining wound over a drain if necessary.
21. VOLUME OF FLUID REQUIRED:-
• FOR TYPE I OPEN FRACTURE :- 3 L
• FOR TYPE II OPEN FRACTURE :- 6L
• FOR TYPE III OPEN FRACTURE :- 9L
.
22. • Retained avascular bones and small fragments which
are completely devoid of soft tissues must be
removed.
23. FRACTURE STABILIZATION :-
For type I open fracture, any technique that is suitable
for closed fracture management is satisfactory.
Upto type IIIA closed internal fixation can be done
24. The method to reduce and stabilize the fracture
depends on following:-
#Bone that is involved
#Type of fracture
#The efficacy of the debridement
#patient`s general condition
#Surgeons choice.
25. OPTIONS AVAIALABLE FOR FRACTURE STABILIZATION :-
# EXTERNAL FIXATOR
# INTRAMEDULLARY NAILING
# OCCASIONALLY PLATE AND SCREW FIXATION
27. • External fixators are mainly used as temporary
stabilizers.
• Can be used as a definitive treatment when a stable
fracture configuration with good reduction and
circumferential contact is achieved.
• Pin tract infection is the most frequent complication
With external fixation
• External fixation is preferred for metaphyseal -
diaphyseal fracture
28. PRIMARY INTERNAL FIXATION :-
• Done by interlocking nails and plate fixation.
• Open diaphyseal femoral and tibial fractures have been
treated successfully with nailing.
29. PLATE FIXATION :-
Disadvantage:-
• Need increased soft tissue exposure and periosteal
stripping
INDICATION:-
• Most open upper limb fracture
• Femoral fractures involving periarticular and articular regions
• All intra-articular and juxta articular fractures
30. INTRAMEDULLARY NAILS :-
• Often the first choice for lower limb diaphyseal fractures.
• Ideally suited for Type I & Type II & even in Type III injuries
where contamination is minimal.
.
31. UNREAMED NAILS:-
ADVANTAGE:-
• Causes less devascularization
• Shorter operating time.
• Lower incidence of fat embolism and thermal
necrosis.
DISADVANTAGE:-
• Increased rate of implant failure
• Fracture disruption during surgery
• Higher rate of nonunion and malunion
32. Wound Closure:-
Primary wound closure is controversial, but good results
are reported after primary closure.
INDICATIONS :-
• Type I & II & IIIA & B injuries of limb..
• Wounds without primary skin loss or secondary skin loss after
debridement.
• Injuries to debridement interval is less than 12hrs.
• Presence of bleeding wound margins which can be apposed
without tension.
• Stable fixation achieved by internal or external fixation.
33.
34. SKIN GRAFTING PRINCIPLES:-
• Harvest skin from donor site to cover the
defect.
• Split thickness skin graft:- when a graft
includes only portion of dermis.
• Full thickness skin graft:- when a graft
contains entire dermis.
• Split thickness skin graft survive in
conditions with less vascularity but they
have likelihood of contracture.
35. FLAP COVERAGE :-
• Unlike grafts , flap maintains its own blood supply.
• Used for large wounds or to cover underlying bone and
tendons that may not be managed by graft alone..
36. NEGATIVE PRESSURE WOUND THERAPY (NPWT):-
Useful treatment in all injuries where soft tissue cover
is not immediately possible is vacuum assisted wound
closure (VAC) using NPWT.
37. BENEFICIAL EFFECTS OF VAC THERAPY:-
• Promotes wound contraction and increases the chance of
delayed primary closure.
• Removes excess oedematous fluid
• Causes reactive increase in blood flow and promotes
• Decreases bacterial burden
• Removes protein and electrolytes that are harmful for
healing.
39. SUMMARY:-
• Assessment and classification of open fractures should be
done intra operatively based on the degree of bacterial
contamination, soft-tissue damage, and fracture
characteristics.
• To avoid the complication the wound should be thoroughly
irrigated and debrided.
• Tetanus toxoid and immun oglobulins should be given in
emergency department.
• Early, systemic, wide-spectrum antibiotic therapy is
to cover both gram-positive and gram negative organisms.
40. • In the presence of extensive soft-tissue loss and exposed
bone, coverage is accomplished with early transfer of local or
free muscle flaps.
• Stable fracture fixation is important; the method chosen
depends on the bone and soft-tissue characteristics.
• Early bone grafting is indicated for bone defects, unstable
fractures treated with external fixation, and delayed union.