POSTERIOR URETHRAL VALVES- Pediatric Surgery
• Dear viewers,
• Greetings from “ Surgical Educator”
• Today I have uploaded one more video in Pediatric Surgery/Pediatric Urology- “ Posterior Urethral Valves”
• Posterior Urethral Valves is the congenital cause for Bladder Outlet Obstruction, resulting in abnormal development of the kidneys as well as the bladder.
• In this video, I talked about the learning outcomes, introduction, etiopathogenesis, clinical features, investigations, differential diagnosis, treatment, follow-up and prognosis of “ Posterior Urethral Valves”
• I hope you will enjoy the video for its educational value.
• You can watch all my teaching videos in the following links
• surgicaleducator.blogspot.com youtube.com/c/surgicaleducator
• Thank you for watching the video.
Please find the power point on Renal and bladder stones. I tried present it on understandable way and all the contents are reviewed by experts and from very reliable references. Thank you
Pancreatitis is an inflammatory condition of the pancreas. Two major forms : acute pancreatitis (is reversible) and chronic pancreatitis(is irreversible).
POSTERIOR URETHRAL VALVES- Pediatric Surgery
• Dear viewers,
• Greetings from “ Surgical Educator”
• Today I have uploaded one more video in Pediatric Surgery/Pediatric Urology- “ Posterior Urethral Valves”
• Posterior Urethral Valves is the congenital cause for Bladder Outlet Obstruction, resulting in abnormal development of the kidneys as well as the bladder.
• In this video, I talked about the learning outcomes, introduction, etiopathogenesis, clinical features, investigations, differential diagnosis, treatment, follow-up and prognosis of “ Posterior Urethral Valves”
• I hope you will enjoy the video for its educational value.
• You can watch all my teaching videos in the following links
• surgicaleducator.blogspot.com youtube.com/c/surgicaleducator
• Thank you for watching the video.
Please find the power point on Renal and bladder stones. I tried present it on understandable way and all the contents are reviewed by experts and from very reliable references. Thank you
Pancreatitis is an inflammatory condition of the pancreas. Two major forms : acute pancreatitis (is reversible) and chronic pancreatitis(is irreversible).
RENAL STONES & STONES IN PREGNANCY .pptxBipul Thakur
THis presentation discusses about the formation of kidney stones the different theories related to formation of stones, thdifferent types of stones and management of kidney stones in case of pregnant female and various considerations required regarding the fetus and the pregnant female.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
2. Introduction
Urinary calculi in children, account 2–3% of all
patients with stone disease.
Infection remains a major aetiological factor
the proportion of affected children with an
underlying biochemical predisposition appears to
be increasing.
Metabolic evaluation is essential for every child.
The rate of stone recurrence is lower in children
compared with adults.
The majority of stone disease is now managed, as
in adults, by lithotripsy or endourological
techniques
Open surgery has decreased dramatically.
3. Epidemiology
Geographical variations in the incidence of stone in
children reflect differences in the prevalence of
environmental, dietary and genetic factors.
In the UK the incidence of urinary calculi in children is 3
new cases per million of the population per year.
infective calculi are more common in boys under 5 years
of age
there is an increased incidence of metabolic
abnormalities.
The greater frequency of infection in uncircumcised
infants explain the higher incidence of stone in certain
European countries compared with the US where
circumcision remains common.
4. Epidemiology
stones is twice as high in boys as it is in girls.
the peak age of presentation is younger in
boys, being 3 years vs 4 years in girls.
This gender difference reflects in part the role
of bacterial colonisation and subsequent UTI
in uncircumcised boys.
A geographical ‘stone belt’ extending from the
Balkans across Turkey, Pakistan and northern
India is characterised by a high incidence of
endemic bladder stones in children.
5. Pathology/aetiology
Urinary calculi are composed of crystalline and
matrix components in varying proportions.
Matrix, a gelatinous glycoprotein, is a particular
feature of infective stones, which are typically soft
and crumbly in composition.
Metabolic stones, e.g. cystine and xanthine, are
predominantly crystalline and correspondingly
harder.
The terminology historically used to describe the
crystalline structure of urinary calculi (‘struvite’,
‘brushite’, ‘weddellite’, etc.) is uninformative
stones are categorised by chemical composition.
6. Pathophysiology
Formation of stone
Urinary volume
pH
Presence of promoters or inhibitors of
lithogenesis
Central event is supersaturation
Crystallization occurs via homogenous vs.
heterogenous nucleation
8. Factors involved in stone
formation
1. Urinary concentration, ionic activity and
solubility of stone-forming constituents.
2. Presence of abnormal urinary metabolites or
pathologically elevated concentration of
normal urinary constituents.
3. Urinary infection
4. Anatomical abnormalities of the urinary tract.
5. Foreign materials.
6. Prematurity.
9. Urinary concentration, ionic activity and
solubility of stone-forming constituents.
Stone formation is initiated by the precipitation
of urinary constituents from solution, followed
by crystal formation.
In turn, this process is influenced by the
urinary excretion rate of the stone-forming
substance, the level of hydration and the
urinary pH.
10. Presence of abnormal urinary metabolites or
pathologically elevated concentration of
normal urinary constituents.
When a metabolite is excreted in high
concentrations its saturation
point in the urine is exceeded and crystal
deposition occurs, progressing to stone
formation.
Reduced urinary output, leading to a higher
urinary concentration of the metabolite
unfavourable urinary pH, will accelerate this
process.
11. Urinary infection
Proteus, Klebsiella and Pseudomonas, are
capable of the enzymatic splitting of urea to
produce NH3, elevation of the urinary pH and
precipitation of ammonium salts.
Infection is a factor in the production of the
proteinaceous matrix component of calculi.
12. Anatomical abnormalities of the
urinary
tract.
Stasis of urine within an obstructed or dilated
urinary tract creates an environment in which
stone-forming substances are more likely to
precipitate out of solution and thus initiate
stone formation.
This process can occur in sterile urine, but not
uncommonly infection and stasis coexist.
13. Foreign materials
Non-absorbable foreign bodies, usually
surgical in origin act as a nidus of encrustation
and stone formation:
i. stents
ii. fragments of catheters
iii. non-absorbable sutures
iv. staples
14. Prematurity
premature children are much greater risk of
nephrocalcinosis and nephrolithiasis.
20% of babies born under 32 weeks gestation
develop nephrocalcinosis and 5–9% have calculi.
The risks are increased with increasing prematurity
of birth, decreasing birth weight, co-morbidity and
the use of furosemide, thiazides.
formula-fed babies have increased solute excretion
(e.g. oxalate).
parenteral nutrition have a higher oxalate and
calcium but lower citrate excretion
15. Frequency
calcium with phosphate or oxalate (57%),
struvite (24%),
uric acid (8%),
cystine (6%),
endemic (2%),
mixed (2%),
other types (1%).
22. Absorptive Hypercalciuria
Type I (Diet Independent)
High urinary calcium despite diet
Type II (Diet dependent)
Responds to calcium restriction
Type III (phosphate leak)
Low serum phosphate with increased Vit D and increased GI
absorption
Sarcoidosis
Increased Vit D-->increased GI absorption
26. Hyperuricosuria
Diet high in purines
Renal tubular defects
Defect in renal tubular urate reabsorption
Chemotherapy
Recurrent calcium oxalate stones (nidus)
Chemotherapy
Catabolic State
Urine pH <5.5
Serum uric acid and calcium normal
27. Primary Hyperoxaluria
• Inherited disorder of glyoxylate metabolism
• Type I: Alanine-glyoxylate aminotransferase (1 in
120,000 births)
• Median age at presentation 5 yrs
• Oxalate deposition occurs in bones
• Screen all patients with stones for hyperoxaluria
• Type II
• D-glycerate dehydrogenase
• ESRD less common
28. Primary Hyperoxaluria
• ESRD
• 50% of patients by age 15 and 80% by age 30
• Therapy
• High urinary flow
• Pyridoxine supplements
• Liver/Kidney Transplant
30. Hypocitraturia
Citrate is potent stone inhibitor
Caused by
acidosis (RTA)
Hypokalemia
High animal protein diet
UTI
31. RTA
Type I
Defect in distal tubule to excrete acid
Dx with systemic acidosis and urine pH>5.5
Osteomalacia in children
Infants: growth retardation/vomitting/diarrhea
Type II
Defect in bicarb reabsorption (nephrocalcinosis not
seen)
Type IV
Nephrocalcinosis not seen
32. Type I RTA
May be a secondary manifestation
Sjogren’s, Wilson’s, Jejunoileal bypass
Hypokalemic,hyperchloremic metabolic acidosis
Diagnostic workup indicated when
nephrocalcinosis or recurrent nephrolithiasis
Ammonium chloride load testing (urinary pH
should fall below 5.5)
Stones composed of calcium phosphate
33. Calcium Stones Misc
Immobilization of children is most common
cause of secondary hypercalciuria
Hypomagnesuria increases solubility of Ca,
phosphate
Most common cause is IBD
34. Uric Acid Lithiasis
5% of calculi in pediatric patients
Orange (can be mistaken for blood)
Dysfunction of tubular reabsorption
Wilson’s disease
Fanconi syndrome
Overproduction of uric acid
Lesch-Nyhan (deficiency of hypoxanthine-guanine
phosphoribodyl transferase)
Neurological disabilties, present between 3-12 “orange sand in
diaper”
Type I glycogen storage disease
Myeloproliferative disorders
35. Uric Acid Lithiasis
Increased intake
Uricosuric drugs (probenecid, salicylate)
Chronic diarrheal syndromes (net alkali defecit and
lowered urine volume)
Treatment
Increasing oral fluid intake
Urinary alkalinization pH 6.5 to 7.0
Allopurinal (but can lead to xanthine stones)
36. Cystinuria
Autosomal recessive disorder
1 in 15,000 live births
1-3% of children with metabolic urolithiasis
Defective transport of cystine, ornithine, lysine
and arginine
Treatment
High fluid intake (<300 mg cystine/L of urine)
Urinary alkalinzation
D-peniclliamine or Thiola (better tolerated)
Captopril
37. Xanthinuria
Enzymatic deficiency of xanthine
dehydrogenase
Urolithiasis, arthropathy, myopathy, crystal
nephropathy, or renal failure
40. Underlying urological
conditions
In 20–30% of children with urinary calculi,
VUR play an aetiological role by promoting
urinary infection
PUJ obstruction are characteristically small
and multiple (fancifully likened to melon
seeds).
megaureters
The use of intestinal segments for bladder
reconstruction (enterocystoplasty)
41. Clinical presentation
1. Age
Stones may develop from as early as 2–3
months of life.
a higher prevalence in early childhood (less
than 5 years due to an excess of infective
stones
2. Urinary infection
older children present with symptoms of UTI
In infants: vague ill health, low-grade fever and
failure to thrive.
42. 3. Haematuria
Macroscopic or microscopic
4. Passage of stone
5. material per urethra
a fragment or some softer matrix material
43. 6. Pain
Acute renal colic of the pattern and severity
encountered in adults is not a prominent
feature of the symptomology in children.
When pain does occur it is often a poorly
localised symptom in a fractious, unwell child.
7. Abdominal mass
45. Diagnosis
Two levels.
A. Initial screening for possible calculi
1. Urine analyis
2. Ultrasound
3. Abdominal X-ray
4. Unenhanced spiral computed tomography
46. Diagnosis
2. Evaluation prior to treatment of proven
stone disease
1. DMSA
2. Dynamic renography
3. Intravenous urography
4. Micturating cystography
5. Metabolic investigations
6. Stone screening
47. Ultrasound
a sensitive modality for the detection of renal
calculi.
Depending on their physical characteristics
(chemical composition, hardness, etc.), calculi
can be directly visualised on ultrasound.
Ureteric calculi and small bladder calculi may
sometimes be difficult to detect on ultrasound.
50. KUB
mandatory to look for possible calculi in any
child with:
haematuria.
urinary infection in boys less than 5 years of
age.
a documented Proteus urinary infection at any
age
53. Unenhanced spiral computed
tomography
provides an accurate diagnosis within minutes,
avoids the risk of adverse reaction to contrast
media
Detection of radiolucent calculi
the radiation dosage is three to five times greater
than that of IVU
Radiation dosage amounts to only a quarter of the
recommended limit of medical radiation exposure
for a child in a year.
greater difficulty in interpreting the images of the
collecting system.
54. Unenhanced spiral computed
tomography
children are 3 to 10 times more radiosensitive
than adults
Long-term risks of radiation exposure in children
are not completely understood
a single abdominal CT in a one-year-old imparts
a 1 in 550 risk of subsequent lethal tumor
development
Recently, there has been interest in development
of low-dose CT techniques for use in the
diagnosis of renal stones.
56. CT with 3D reconstruction volume rendering.
Shows stone configuration in PA, Oblique and AP
view
57. Intravenous urography
IVU permitting visualisation of nonopaque
stones
Information on calyceal anatomy for PCNL
and ESWL
Ureteric calculi are best localised IVU
detection of anatomical abnormality
predisposing to urolithiasis.
59. DMSA
differential function in the affected kidney(s)
should be documented on DMSA
(dimercaptosuccinic acid), and re-evaluated
after treatment.
60. Dynamic renography
Dynamic renography, e.g. MAG3
(mercaptoacetyltriglycine), DTPA
(diethylenetriamine pentaacetic acid)
undertaken if obstruction is suspected.
the diagnosis of obstruction should not be
made in the presence of a large calculus
within the renal pelvis.
Diagnosis of junction PUJ obstruction can only
be made after a period of time following the
complete removal of the stone.
61. Micturating cystography
MCU is not routinely required.
Infection and the passage of stone
material to the bladder may result in
transient VUR
If ureteric dilatation persists
postoperatively, an MCU should be
performed.
62. METABOLIC EVALUATION
The goals of the metabolic evaluation
identify children at increased risk for recurrent
stone disease
diagnose specific treatable metabolic
derangements.
64. Spot’, i.e. untimed, urine sample 2–5 ml (divided
in the laboratory into two aliquots)
First aliquot acidified and analysed for
creatinine, calcium, magnesium, cystine,
oxalate
Second aliquot alkalinised and analysed for
creatinine and uric acid
65. URINALYSIS/CULTURE
The urine pH can suggest the types of crystals
that are most likely to form.
A low urine pH, associated with uric acid
stones.
A high pH associated with infection stones and
renal tubular acidosis.
urine pH varies over the course of the day
Microscopic urinalysis may identify distinctive
crystal structure, such as the flat hexagonal
crystals formed by cystine stones.
66. Urinary leukocytes, nitrites, and leukocyte
esterase may suggest the presence of infection.
A urine culture should be obtained to investigate
bacterial colonization of the urinary tract.
A calcium-to-creatinine ratio can be derived from a
single specimen and is often used as an initial
screening test for hypercalciuria.
If hypercalciuria is suspected based on a random
spot sample this should be confirmed with a 24-h
urine collection.
If cystiunuria is suspected, a nitroprusside test
can verify the presence of cystine
73. SERUM TESTING
not as informative as urine studies,
Provide information for interpretation of urine test
results.
Serum creatinine can identify renal insufficiency
and is used to calculate the expected excretion
of creatinine in a given urine sample.
Bicarbonate and pH levels can help diagnose
and classify renal tubular acidosis.
Serum calcium and phosphate levels are used to
evaluate for hypercalcemic conditions.
74. SERUM TESTING
If abnormal, specific investigation of
parathyroid function (i.e. PTH) should be
obtained.
Irregularities of serum potassium and
magnesium can be associated with
abnormalities of urinary stone inhibitors.
Elevated serum urate found with
abnormalities in the metabolism of
purines.
75. 24-H URINALYSIS
Because of variation in diet and fluid intake,
results from two separate 24-h urine
collections, ideally six weeks after the patient
achieves a stone-free status, should be used
to guide treatment.
To ensure that there is a complete 24-h
collection of urine, a total creatinine should be
greater than 15-20 mg/kg.
When interpreting 24-h urine results, it is
important to remember that adult reference
values are not necessarily applicable to the
pediatric population.
77. Bonn risk index (BRI)
better predict recurrent calcium oxalate stone
formation.
The BRI is the ratio of ionized urinary calcium
to the amount of ammonium oxalate required
to induce calcium oxalate crystallization in 200
ml of urine.
BRI values in children with renal stones are
15-fold higher when compared to healthy
children.
Future research on the BRI is required to
define its potential as a predictor of stone
formation in asymptomatic children.
78. Management
The overall goals of care are as follows:
1. To prevent additional renal damage, which
may lead to loss of renal parenchyma
2. To manage pain associated current stone(s)
3. To expedite passage or removal of any
stones present
4. To prevent new stones from forming.
may include medical approaches, surgical
interventions, and dietary modification.
79. Conservative Treatment
Medical care largely depends on the type of
presentation.
Care may range from observation to emergency
treatment.
An obstructed infected portion of the urinary tract is a
surgical emergency
A child presenting with acute colic and gross
hematuria can be managed with analgesics.
Narcotics may be required, as well as enteral or
parenteral hydration.
When a stone is small and at the ureteropelvic or
ureterovesical junction, it may pass spontaneously; a
few days of observation for spontaneous passage
may be indicated prior to more aggressive
intervention.
80. A stone that completely obstructs the bladder
outlet should be treated with catheterization
using a Foley catheter.
Children with asymptomatic stones detected
while screening for another problem should
have blood and urine testing performed to
identify underlying metabolic abnormalities.
81. Treatment Options
ESWL
Up to 75-98% stone free rates at 3 months with
stones up to 2.5 cm
Children can pass larger stone fragments than adults
Long term functional studies on pediatric patients
show no change in RPF or height after 4 yrs
Abdominal/flank discomfort in early post-op period
should have eval for hematoma/obstruction
Hemoptysis in small stature and skeletal deformities
Prone positioning may be necessary
82. Treatment Options
ESWL relative contraindications
Morbid obesity
Large stone burden
Increased stone density
Congenital skeletal/renal abnormalities
Previously failed ESWL
83. Treatment Options
Ureteroscopy
First reported in 1929 by Young
2 types of ureteroscopes: mini-rigid and flexible
Varying lengths
Distal tip as small as 4.7 Fr
Working channel 3.6 Fr
84. Treatment Options
Ureteroscopy: Instruments
Stone retrieval devices can vary
Size, position, and condition (impacted?)
Grasping forceps will disengage from a stone if it
is lodged (more effective for solitary stone)
Helical basket for steinstrasse
Nitinol baskets for caliceal stones and lower pole
stones
86. Treatment Options
Ureteroscopy technique
Dilation required in up to 30%
Graduated single shaft dilator from 6 to 10 Fr (dilate to 2 Fr
sizes greater than diameter of endoscope)
May require passive dilation with stent
Smallest access sheath 9.5 Fr
Presence of previous reimplant can require initial
cannulation with actively deflecting guidewire
Recurrent reflux after URS has never been reported
Intrarenal access after UPJ repair is straightforward
Impacted stones may require dislodging into proximal
dilated ureter for lithotripsy
87. Treatment Options
Percutaneous Endourology
11 Fr and 15 Fr peel away sheaths have been used
A 24 Fr adult defect equals a 72 Fr defect in a child
A larger sheath is necessary for treatment of larger
stones >3 cm
Multiple punctures may be needed
Upper pole access can cause pneumo/hydrothorax
Uncontrolled hemorrhage refractory to a tamponade
balloon requires angiography
Dilutional hyponatremia is possible
88. Treatment Strategies
Renal Calculi
ESWL for stones <2 cm
Contraindication with UPJ obstruction, caliceal
diverticulum, or infundibular stenosis
Less effective for ectopic or horseshoe kidneys
Overall, best suited for solitary renal stones <1.5 cm
not contained within an abnormal lower pole calyx or
abnormal renal anatomy
90. Treatment Strategies
Ureteral calculi
ESWL effective 54-100%
Ureteroscopic lithotripsy is 77-100%
Orifice dilation only necessary 33%
Becoming first line for ureteral stones
Percutaneous approach with impacted stones,
significant hydro, or urosepsis
91. Treatment Strategies
Bladder Calculi
Open cystolithotomy
Cystolithopaxy
EHL can perf augmented bladder
Percutaneous approach
92. MET in children
MET in children cannot be recommended due
to the limited data in this specific population
(small study).
Alpha-1 adrenergic blocker agents, such as
doxazosin (0.03 mg/kg/day), have been used
as medical expulsive treatment in children with
distal uretral stones
93. Treatment (cont.)
In children with hypercalciuria:
- Some reduction in calcium and sodium
intake is necessary
-Thiazide diuretics also reduce renal
calcium
excretion.
-Addition of potassium citrate, an inhibitor
of calcium stones, with a dosage of
1-2 mEq/kg/24hr is beneficial.
94. Treatment (cont.)
In patients with uric acid stones:
- allopurinol is effective
In patients with cystine stones:
- Alkalinization of urine with sodium
bicarbonate or sodium citrate is effective.
D- penicillamine, which is a chelating
agent that binds to cysteine or
homocysteine, increasing the solubility of
the product
95. Treatment (cont.)
Treatment of type 1 RTA
- Involves:
*Correcting the metabolic acidosis
*Replacing lost potassium and sodium
Treatment of primary hyperoxaluria
- Involves:
* Liver transplantation
* Kidney transplantation
96. Question #1
What are the 5 most important chemical
abnormalities in stone formers?
Low urinary volume
Hyperoxaluria
Hyperuricosuria
Hypocitraturia
Hypercalciuria
97. Question #2
What is the strongest chemical promoter of
stone production?
Oxalate
98. Question #3
What are the three types of hypercalciuria?
Resorptive
Renal
Absorptive
99. Question #4
What is the medication of choice for renal
hypercalciuria?
Thiazide diuretics augment calcium reabsorption in the
distal and proximal tubules
100. Question #5
The stones least suitable for ESWL are:
1. Calcium oxalate dehydrate
2. Uric Acid
3. Struvite
4. Calcium oxalate monohydrate
5. Cystine
101. Question #6
The ideal treatment for large staghorn calculi
>2.5 cm is:
1. ESWL
2. Multi Access PCNL
3. ESWL followed by PCNL
4. PCNL followed by ESWL
5. Anatrophic pyelolithotomy
102. Question #7
The factors predicting stone clearance after ESWL
for lower pole stones include all except:
1. Infundibulopelvic angle
2. Laterality
3. Renal function
4. Infundibular length
5. Infundibular width
103. Question #8
The best treatment for a 2 cm renal stone with a
UPJO
1. Open pyelolithotomy
2. URS
3. ESWL
4. PCNL with endopyelotomy
5. Retrograde endopyelotomy with laser litho
104. Question #7
The mechanism of stone fragmentation during
ESWL include all the following except
1. Compression fracture
2. Spallation
3. Cavitation
4. Passive Expansion
5. Dynamic fatigue
105. Question #8
What is the most common renal structural
abnormality identified in patients with calcium
containing stones?
1. UPJ obstruction
2. Infundibular obstruction
3. Calyceal obstruction
4. Medullary sponge kidney
5. Proximal tubule obstruction
106. Question #9
Adverse reactions to D-penicllamine include
1. Constipation
2. Diarrhea
3. Melena
4. Visual disturbances
5. Liver toxicity
107. Question #10
Urease-producing bacteria hydrolyze urea
to which of the following?
1. Uric acid
2. Carbon monoxide
3. Carbon dioxide
4. Ammonium and carbon dioxide