This document discusses various cytological features seen in different types of lesions and malignancies. It describes cellular polymorphism, nuclear polymorphism, mitotic figures, and nuclear hyperchromatism seen in malignant lesions. Necrosis is also noted as a feature of tumors related to ischemia. Specific lesions described include a benign leiomyoma of the uterus, a well-circumscribed breast neoplasm, and an adenocarcinoma of the colon showing mitosis and nuclear abnormalities. Malignant fibrous histiocytoma is also summarized as consisting of spindle cells, histiocyte-like cells, and giant malignant cells with frequent mitoses.

2. Cytological features of malignancy
Lesion : Remarkable variation in cell size and shape (Cellular
polymorphism )and nuclear size and shape (nuclear polymorphism )
mitotic figures (M) and nuclear hyperchromatism.

3. • Cytological features of malignancy
• Necrosis (N) of the tumor related to ischaemia.

4. • Organ: myometrium
• Lesion: benign neoplasm of the uterine smooth
muscle (L) surrounded by normal myometrium.
• Diagnosis: Leiomyoma .

5. • Organ: myometrium ( higher magnification)
• Lesion: tumor margin well circumscribed and
no evidence of local invasion and their is
pseudocapsule (C).

6. • organ: Breast
• Lesion: the neoplasm has an irregular outline and the
neoplastic cells invading the fatty tissue and
collagenous stroma of the breast.
• Diagnosis: malignant neoplasm of Breast.

7. • organ: Breast ( higher magnification)
• Lesion: hyperchromatic malignant cells can be
seen infiltrating the surrounding adipose tissue.
• Diagnosis: malignant neoplasm of Breast.

8. • Lesion: the cells are commonly arranged in broad
sheets and large nests (N) , formation of keratin*
known as dyskeratosis (D), and forms lamellated
pink-stained masses known as keratin pearls (KP).
• Squamous cell Carcinoma.

9. • Organ: Colon
• Lesion: mitosis are seen and nuclear hyperchromatism
and higher nuclear to cytoplasmic ratio.
• Diagnosis: Adenocarcinoma ( well Differentiated )

10. • Organ: Connective tissue
• Lesion: Consist of various combination of spindle cells
(S) ,cells resembling histiocytes (H) with pale foamy
cytoplasm and malignant giant cells (G) mitotic figures are
plentiful.
• Diagnosis: Malignant Fibrous Histiocytoma.

11. Pathology: the Hidden Science that SavesPathology: the Hidden Science that Saves
LivesLives
Pathology: is the Science behind the CurePathology: is the Science behind the Cure
 This pathology lab is prepared by, Dr. Omar EmadThis pathology lab is prepared by, Dr. Omar Emad
Ibrahim , Pathology Dep. Faculty of Medicine &Ibrahim , Pathology Dep. Faculty of Medicine &
Health Sciences, Thamar UniversityHealth Sciences, Thamar University ..
 The images is taken fromThe images is taken from
Atlas of Basic Histopathology.