Parkinson's disease is a neurological syndrome caused by degeneration of dopaminergic neurons in the substantia nigra. This leads to dopamine deficiency in the basal ganglia and symptoms like tremors, muscle stiffness, slow movement, and impaired balance and coordination. Worldwide prevalence is around 6 million people. Primary causes include genetic mutations and environmental toxins. Secondary causes include infections, head injuries, and certain drugs. Treatment involves replacing dopamine or stimulating dopamine receptors to restore balance between dopamine and acetylcholine in the basal ganglia.