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Parkinsonism
THE PHARMACOLOGICAL OVERVIEW
SYNONYMS
• Shaking Palsy
• Parkinsonism
• Parkinson Disease
• Hypokinetic Rigid syndrome
• Paralysis Agitans
• Chronic neurodegenerative disease
At Risk
•Men : Women = 1.5 : 1
•Age: more than 50
Increase in motor
activity
Feedback
Rigidity
Feedback
DRUGS USED IN PARKINSONISM
• https://healthblog.uofmhealth.org/health-management/13-
medications-to-help-control-parkinsons-disease-symptoms
Easy Way to Remember
• Selegiline (MAO-B inhibitor)
• Anticholinergic agents (Benzhexol, trihexiphenedyl)
• L-Dopa + Carbidopa
• Amantadine (Glutamate Receptor antagonist)
• Dopamine Agonists: Pergolide, Bromocriptine

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Parkinsonism