Parathyroid hormone regulates calcium and phosphate levels in the blood. Too much or too little parathyroid hormone can cause hypercalcemia or hypocalcemia, respectively. The parathyroid glands are normally four small glands located behind the thyroid gland that secrete parathyroid hormone. Parathyroid hormone is synthesized from a precursor molecule and packaged into secretory granules to increase blood calcium levels when it detects low calcium. Calcitonin from the thyroid has opposing effects to lower blood calcium. Vitamin D deficiency can cause rickets in children or osteomalacia in adults by impairing calcium absorption, leading to low blood calcium if left untreated.
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Parathyroid hormone (The Guyton and Hall physiology)Maryam Fida
Parathyroid hormone
Calcium salts in bone provide structural integrity of the skeleton
Calcium ions in extracellular and cellular fluids is essential to normal function of a host of biochemical processes
Neuoromuscular excitability
Blood coagulation
Hormonal secretion
Enzymatic regulation
The important role that calcium plays in so many processes dictates that its concentration, both extracellulary and intracellulary, be maintained within a very narrow range.
Normal level of calcium is about 9.4 mg/dl.
0.1 % extracellular fluid
1 % stored in cells (mitochondria and ER)
99% stored in bones in hydroxyapatite crystals. Very little Ca2+ can be released from the bone– though it is the major reservoir of Ca2+ in the body.
Calcium in Plasma is present in three forms:
1. Ionized and diffusible calcium 50%
2. Protein-bound calcium 41% non diffusible form
90% bound to albumin
Remainder bound to globulins
3. Calcium complexed to serum constituents 9%
Citrate and phosphate
Hyperparahyroidsm is an endocrinal disorder majorly affecting the parathyroid glands which secrete parathyroid hormone and calcitonin.
A condition characterised by excessive secretion of calcium in blood and Bone resorption and inanbility to metabolise calcium in blood.
Vitamins UNIT-7 biochemistry and clinical pathology, D.Pharm 2nd year.pptxAanchal Gupta
Vitamins, unit-7 for D.Pharm second year, According to PCI syllabus.
Definition and classification with examples
Sources, chemical nature, functions, coenzyme form, recommended dietary requirements, deficiency diseases of fat-and water-soluble vitamins
Parathyroid hormone (The Guyton and Hall physiology)Maryam Fida
Parathyroid hormone
Calcium salts in bone provide structural integrity of the skeleton
Calcium ions in extracellular and cellular fluids is essential to normal function of a host of biochemical processes
Neuoromuscular excitability
Blood coagulation
Hormonal secretion
Enzymatic regulation
The important role that calcium plays in so many processes dictates that its concentration, both extracellulary and intracellulary, be maintained within a very narrow range.
Normal level of calcium is about 9.4 mg/dl.
0.1 % extracellular fluid
1 % stored in cells (mitochondria and ER)
99% stored in bones in hydroxyapatite crystals. Very little Ca2+ can be released from the bone– though it is the major reservoir of Ca2+ in the body.
Calcium in Plasma is present in three forms:
1. Ionized and diffusible calcium 50%
2. Protein-bound calcium 41% non diffusible form
90% bound to albumin
Remainder bound to globulins
3. Calcium complexed to serum constituents 9%
Citrate and phosphate
Hyperparahyroidsm is an endocrinal disorder majorly affecting the parathyroid glands which secrete parathyroid hormone and calcitonin.
A condition characterised by excessive secretion of calcium in blood and Bone resorption and inanbility to metabolise calcium in blood.
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Biological screening of herbal drugs: Introduction and Need for
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Antifertility, Toxicity studies as per OECD guidelines
4. PARATHYROID HORMONE
Parathyroid hormone provides a powerful mechanism for controlling
extracellular calcium and phosphate concentrations
Excess activity of the parathyroid gland causes rapid release of calcium
from the bones, with resultant hypercalcemia in the extracellular fluid
conversely, hypofunction of the parathyroid glands causes hypocalcemia,
often with resultant tetany
5. Physiological Anatomy of the Parathyroid Glands.
Normally humans have four parathyroid glands, which are located
immediately behind the thyroid gland—one behind each of the upper and each
of the lower poles of the thyroid.
Each parathyroid gland is about 6 millimeters long, 3 millimeters wide, and
2 millimeters thick and has a macroscopic appearance of dark brown fat.
The parathyroid gland of the adult human contains mainly chief cells and a
small to moderate number of oxyphil cells
6. Chemistry of Parathyroid Hormone.
It is first synthesized on the ribosomes in the form of a preprohormone, a
polypeptide chain of 110 amino acids.
The endoplasmic reticulum and Golgi apparatus first cleave this
preprohormone to a prohormone with 90 amino acids
then to the hormone itself with 84 amino acids, and it is finally packaged in
secretory granules in the cytoplasm of the cells.
The final hormone has a molecular weight of about 9500.
7. CALCITONIN
Calcitonin, a peptide hormone secreted by the thyroid gland, tends to
decrease plasma calcium concentration and, in general, has effects
opposite to those of PTH.
Synthesis and secretion of calcitonin occur in the parafollicular cells, or C
cells, lying in the interstitial fluid between the follicles of the thyroid gland.
Calcitonin is a 32–amino acid peptide with a molecular weight of about
3400.
8. Increased Plasma Calcium Concentration Stimulates Calcitonin
Secretion.
The primary stimulus for calcitonin secretion is increased extracellular fluid
calcium ion concentration.
In contrast, PTH secretion is stimulated by decreased calcium
concentration.
9.
10. Rickets Caused by Vitamin D Deficiency
Rickets occurs mainly in children. It results from calcium or phosphate
deficiency in the extracellular fluid, usually caused by lack of vitamin D.
If the child is adequately exposed to sunlight, the 7-dehydrocholesterol in the
skin becomes activated by the ultraviolet rays and forms vitamin D3, which
prevents rickets by promoting calcium and phosphate absorption from the
intestines
Children who remain indoors through the winter in general do not receive
adequate quantities of vitamin D without some supplementation in the diet.
In addition, calcium and phosphate mobilization from the bones can prevent
clinical signs of rickets for the first few months of vitamin D deficiency.
11.
12.
13. Treatment of Rickets.
The treatment of rickets entails supplying adequate calcium and
phosphate in the diet and, equally important, administering large amounts
of vitamin D.
If vitamin D is not administered, little calcium and phosphate are absorbed
from the gut.
14. Osteomalacia—“Adult Rickets.”
Adults seldom have a serious dietary deficiency of vitamin D or calcium
because large quantities of calcium are not needed for bone growth as is
the case in children.
15. Osteomalacia and Rickets Caused by Renal Disease.
“Renal rickets” is a type of osteomalacia that results from prolonged
kidney damage.
The cause of this condition is mainly failure of the damaged kidneys to form
1,25- dihydroxycholecalciferol, the active form of vitamin D.
In patients whose kidneys have been removed or destroyed and who are
being treated by hemodialysis, the problem of renal rickets is often severe
16. congenital hypophosphatemia, resulting from congenitally reduced
reabsorption of phosphates by the renal tubules.
This type of rickets must be treated with phosphate compounds instead
of calcium and vitamin D, and it is called vitamin D–resistant rickets.
17. Osteoporosis—Decreased Bone Matrix
Osteoporosis is the most common of all bone diseases in adults,
especially in old age.
It is different from osteomalacia and rickets because it results from
diminished organic bone matrix rather than from poor bone
calcification.
In persons with osteoporosis the osteoblastic activity in the bone is
usually less than normal, and consequently the rate of bone osteoid
deposition is depressed.
18.
19.
20. The many common causes of osteoporosis are
(1) lack of physical stress on the bones because of inactivity
(2) malnutrition to the extent that sufficient protein matrix cannot be formed
(3) lack of vitamin C, which is necessary for the secretion of intercellular
substances by all cells, including formation of osteoid by the osteoblasts
(4) Postmenopausal lack of estrogen secretion because estrogens
decrease the number and activity of osteoclasts
(5) old age, in which growth hormone and other growth factors diminish
greatly, plus the fact that many of the protein anabolic functions also
deteriorate with age, so bone matrix cannot be deposited satisfactorily
21. (6) Cushing syndrome because massive quantities of glucocorticoids
secreted in this disease cause decreased deposition of protein
throughout the body and increased catabolism of protein and have the
specific effect of depressing osteoblastic activity.
Thus, many diseases of deficiency of protein metabolism can cause
osteoporosis