This document discusses quality assurance (QA) in e-learning and the E-xcellence instrument launched in 2007 to complement existing internal and external QA systems. The basic tool in E-xcellence is the quick scan, which can be done as a quick orientation, with a review at a distance, or with an on-site assessment. It aims to reward continuous educational improvement through the E-xcellence Associates label. QA agencies and universities need to cooperate on e-learning QA and work towards a common definition and understanding of e-learning standards. The SEQUENT project also aims to promote excellence in ICT use in higher education and prepare universities for cross-border collaboration.