This orthodontic case involves a 16-year-old male patient presenting with a class 3 malocclusion and an impacted upper left canine. The proposed treatment plan is camouflage non-extraction therapy using removable appliances for anterior expansion and fixed appliances to align the teeth, correct rotations, relieve crowding, and traction the impacted canine into occlusion. Retention will involve removable and permanent retainers to maintain the corrected results.
Frankles appliance Is a myofunctional appliance
Functional appliance are removable or fixed appliances that aim to utilize eliminate or guide the forces arising from muscle function,tooth eruption and growth inorder to alter skeletal and dental relationship
Frankles appliance Is a myofunctional appliance
Functional appliance are removable or fixed appliances that aim to utilize eliminate or guide the forces arising from muscle function,tooth eruption and growth inorder to alter skeletal and dental relationship
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
263778731218 Abortion Clinic /Pills In Harare ,ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group of receptionists, nurses, and physicians have worked together as a teamof receptionists, nurses, and physicians have worked together as a team wwww.lisywomensclinic.co.za/
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
4. Medical & Dental History
• Medical history:
Patient denies any medical problems.
• Dental history:
Patient has no dental history, this is his first visit to a
dentist.
8. Study Models
Right side : Angle Class 3 molar Full unit Left side : Angle Class 3 molar 1/4 unit
Molar Relationship
Left side :N/A
Canine Relationship
Right side :Full unit Class 3 canine
14. • Transverse assessment
Facial symmetry
• Pt has a symmetrical face
• Facial midline showing
alignment of the middle part
of the upper lip at the
vermillion border and chin point
15. Lips -> Upper is normal
Lower slightly everted
Competent at rest
Soft Tissue Examination
20. • Central lines:
lower shifted to the left 3mm
• Incisors classification:
Right: Class 1 Left: Class 3
• OJ:
Right: positive left : negative
• OB:
3mm
• Crossbites:
Anterior cross bite UL1 & UL2
Unilateral posterior crossbite
Displacement : to the left
Intraoral Examination
21. Right side : Angle Class 3 molar Full unit Left side : Angle Class 3 molar 1/4 unit
Intraoral Examination
Molar Relationship
22. Right side :Full unit Class 3 canine Left side : palataly impacted
Intraoral Examination
Canine Relationship
23. •Upper Arch
• U-shaped
• Asymmetric
• Mild Spacing
• No left canine shown
(remaining c)
• asymmetrical incisors inclination
• Rotated UR3, UL4
30. Estimation of canines size
• Tanaka and Johnston :
• ½ the MD width of incisors +11mm = width of ( 3,4,5 )
(24/2) +11= 23 mm
23 = X + 14.5 X = 8.5 mm
Study Models Examination
31. Space analysis
• Upper arch:
• Asymmetric
• Space available= 93mm
• Space needed= 91mm
Study Models Examination
39. Impacted canine Prognosis
1. Canine angulation to the midline
2. A-P position of the canine apex
3. Vertical height of the canine crown
4. Canine crown overlap to the adjacent incisor
40. Impacted canine Prognosis
1. Canine angulation to the midline
• Grade 1=0-15 degree
• Grade2=16-30
• Grade 3= more than 30
41. Impacted canine Prognosis
2. A-P position of the canine apex
• Grade 1: Above the region of the
canine position
• Grade 2: Above the upper first
premolar region
• Grade 3: Above the upper second
premolar region
42. Impacted canine Prognosis
3. Vertical height of the canine crown
• Grade 1: Below the level of the CEJ
• Grade 2: Above the CEJ, but less than half way up the root
• Grade 3: More than half way up the root, but less than full
root length
• Grade 4: Above the full length of the root
43. Impacted canine Prognosis
4. Canine crown overlap to the
adjacent incisor
• Grade 1: No horizontal overlap
• Grade 2: Less than half the root width
• Grade 3: More than half, but less than the whole root
width
• Grade 4: Complete overlap of root width or more
45. Diagnostic Summary
16 years old male, MF, complaining of speech difficulty and
teeth appearance. Patient has fair OH. Class 3 malocclusion
based on skeletal class 3 with average vertical dimension.
He has a symmetrical face complicated by an impacted
upper left canine. He also has mandibular displacement to
the left, upon closing. A class 3 molar & canine relationship,
lower midline shifted to the left 3 mm, asymmetrical Upper
dental arch with mild spacing and mild crowding in the lower
arch.
46. Dental:
1) Mild crowding in the lower arch
2) Rotated LL3
3) Lower midline shifted 3mm to the left
4) Slightly proclined lower labial segment
5) Mild spacing in the upper arch
6) Asymmetrical upper arch
7) Rotated UR3, UL4
8) Class 3 incisor, canine & molar relationship
9) Retained upper left C
10) Impacted upper left canine
11) Cross bite on the left side
12) Mandibular displacement to the left
Pathological problems:
• Pathological problems:
• Fair OH
Patient concern:
• “ sometimes people don't understand what
I'm saying & i don't like the appearance of my
teeth”
• Skeletal:
1)Class 3 skeletal base
2) slightly convex profile
3) Anteriorly divergent
Problem List
47. •Improve Oral hygiene
•Relieve crowding in the lower arches , and align the teeth
•Correct rotated teeth
•Open space and Traction for the impacted UL3
•Correct the mandibular displacement
•Correct lower midline shift
•Accept class 3 skeletal base( achieve better facial profile)
•Achieve positive OJ
•Achieve class 1 incisor relationship
•Flatten Curve of Spee
•Finishing and detailing of the occlusion.
•Retain corrected results
•
Treatment Aims
48. Camouflage, Non extraction
space provided by expansion in the upper and lower stripping
1. OHI + Refer for speech specialist for consultation
2. Start with upper removable appliance with posterior bite block & ant
expansion to correct the left anterior crossbite and correct the mandibular
displacement
3. Anchorage: TPA
4. Upper & lower fixed appliance (MBT 0.22)
5. Surgical exposure of impacted canine
6. Retention
Treatment Plan
49. • Short term:
• Upper and lower modified Hawley retainers (full time wear for 6
months, night time wear for another 6 months)
• Long term :
• Upper and lower permeant retainers from 3-3 (braided steel wire of
17.5 mil
Retention Protocol
50. 1. Camouflage:
- patient chief complaint
- Mild skeletal problem
- Acceptable facial proportions
2. Non extraction:
- Facial profile
- Space can be provided by other means
( Upper —> expansion Lower —> Stripping )
- Presence of displacement which complicate the relation
- Normal inclination of upper & lower incisors
Justification
51. 3. Anterior expansion:
- correct the displacement
4. Lower stripping:
-Provide space for mild crowding
- Retrocline LLS
5. Removable appliance:
- pt internally motivated
- good compliance is expected
Justification
52. 6. Anchorage:
• Traction of the displaced canines to the occlusion.
• Transverse & vertical anchorage during canine traction.
7. Fixed Appliance:
• Bodily teeth movement is required.
• Alignment of teeth & leveling
• Preserve / correct teeth torque.
Justification
53. 8. MBT prescription :
- (-6) torque in the lower incisors to prevent further proclination
- increase torque in upper incisors
- lower contralateral inverted canine will be placed on the palataly impacted
canine
Justification
54. 9. retention protocol:
- Hawley retainer —-> to retain expanded upper arch
- Better interdigitation than VFR
- permanent retainer :
Upper —-> palataly erupted canine
Lower ——> rotation of the LL3
LLS more prone to relapse
Justification
55. 1. Impression for Upper removable anterior expansion screw with posterior bite blocks
2. One turn every day .25 mm for 7-10 days
3. Construction of TPA
4. Bonding Upper & Lower
- swaping lower canines brackets
5. Laceback on lowers
6. On reaching Rigid arch wire Extraction of Retained c
7. Apply open coil spring to provide space
8. Open exposure for impacted canine with direct
bonding of the gold chain
9. Start traction ( ballista spring or piggy back)
10. when canine is in the line of the arch complete alignment normally using conventional NiTi wires
11. leveling of both arches using continuous mechanics
12. Finishing and detailing
13. Retention of achieved results
Treatment (Special) Mechanics